sevoflurane / Generic mfg. - LARVOL DELTA

Erector spinae plane block versus thoracic paravertebral block in pediatric patients undergoing percutaneous nephrolithotomy: a prospective randomized clinical trial. (PubMed, Braz J Anesthesiol) - "ESPB was not found to be more effective than thoracic PVB for postoperative pain management in children undergoing PCNL procedure. Moreover, intraoperative hemodynamics and maximum sevoflurane concentration were comparable. The time to conduct ESPB was significantly shorter; hence, it could be considered as an easy alternative to thoracic PVB for this procedure."

Clinical • Journal • Anesthesia • Pain • Pediatrics • Renal Calculi

Trends in general anesthesia for pediatric dental treatment: a 10-year retrospective analysis at a regional university dental hospital in South Korea. (PubMed, J Dent Anesth Pain Med) - "Inhalational induction with sevoflurane and nasotracheal intubation were the predominant anesthetic approaches used in both groups...This 10-year retrospective review demonstrates the increasing use of GA in pediatric dentistry at a regional disability oral health center. Distinct differences in dental treatment patterns were observed according to disability status, whereas anesthetic management remained standardized and safe, with a low incidence of serious complications."

Journal • Retrospective data • Anesthesia • Pediatrics

PEPSI: Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia (clinicaltrials.gov) - P4 | N=204 | Recruiting | Sponsor: Sun Yat-sen University | Trial primary completion date: Sep 2025 ➔ Jun 2026

Adverse events • Trial primary completion date • Anesthesia • Immunology

Targeting the SIRT1-NAT10-GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane-Induced Cognitive Impairment in Aging. (PubMed, CNS Neurosci Ther) - "SIRT1 alleviates POCD by deacetylating NAT10 to reduce Gababr1 mRNA acetylation, thereby normalizing synaptic inhibition and restoring metabolic-autophagic balance. The SIRT1-NAT10-GABABR1 axis represents a novel therapeutic target for anesthesia-related neurotoxicity."

Journal • Alzheimer's Disease • Anesthesia • Cognitive Disorders • NAT10

Comparing Inhalation and Total Intravenous Anesthesia Methods (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: TC Erciyes University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia • Gastroenterology • Pediatrics

The Effect of Sevoflurane and Desflurane on Clara Cell Protein in the Lung in Liver Transplant Donors. (PubMed, Niger J Clin Pract) - "When used at clinical doses, sevoflurane and desflurane had no adverse effects on CC16, an important marker of acute airway injury, in healthy lungs. We found that sevoflurane decreased the CC16' level more than desflurane."

Clinical • Journal • Anesthesia • Inflammation • Pulmonary Disease • Respiratory Diseases • Transplantation

EEG-Guided Anesthesia for the Prevention of Emergence Delirium in Children: A Systematic Review and Meta-Analysis. (PubMed, JAMA Pediatr) - "Included studies reported at least 1 of the following outcomes: emergence delirium, pediatric anesthesia emergence delirium score, postanesthesia care unit length of stay, end-tidal sevoflurane concentration, or burst suppression...There was no statistically significant difference in the number of burst suppression episodes between the 2 groups (12% vs 17%; RR, 0.69; 95% CI, 0.42-1.12; P = .14). This systematic review and meta-analysis reveals that use of EEG-guided anesthesia was associated with a significantly lower risk of emergence delirium compared with standard practice in children."

Clinical • Journal • Retrospective data • Anesthesia • CNS Disorders • Pediatrics

Sevoflurane, but not alphaxalone, causes lasting autism spectrum disorder-like pathology in male mice after exposure occurs during synaptogenesis. (PubMed, Neuropharmacology) - "Unlike sevoflurane, alphaxalone does not cause long-lasting ASD-type behaviors and does not affect the mTOR activation and histomorphology, suggesting that alphaxalone could be a safer alternative to sevoflurane."

Journal • Preclinical • Anesthesia • Autism Spectrum Disorder • Genetic Disorders • Pediatrics • CASP3

Sevoflurane-induced antigen presentation switching of OPCs is ameliorated by 2-D08 via Kir4.1-dependent mechanism in the developing rat brain. (PubMed, Eur J Pharmacol) - "2-D08 significantly upregulated Kir4.1 protein expression, and its protective effect against sevoflurane-induced antigen-presenting OPCs was abolished under Kir4.1 knockdown conditions. In conclusion, our study indicates that sevoflurane induces antigen presentation switching in OPCs through the activation of the Kir4.1 channel, an effect that can be ameliorated by 2-D08."

Journal • Preclinical • Ataxia • Solid Tumor • IL1B • IL6

SEVO-PROP-MMSE: COMPARISON OF SEVOFLURANE AND PROPOFOL ADMINISTRATION ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN SPINAL SURGERY USING THE MINI-MENTAL STATE EXAMINATION (MMSE) (clinicaltrials.gov) - P=N/A | N=20 | Completed | Sponsor: Universitas Sumatera Utara

New trial • Cognitive Disorders

Effect of Non-Opioid Anesthetic Strategies on Postoperative Recovery Quality Following Knee Arthroplasty (ChiCTR) - P=N/A | N=98 | Completed | Sponsor: Hebei Medical University Third Hospital; Hebei Medical University Third Hospital | Not yet recruiting ➔ Completed

Trial completion • Anesthesia • Orthopedics

Comparing Two Anesthesia Methods: Which Helps Elderly Colon Surgery Patients Recover Better? (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: People's Hospital of Jianyang City; People's Hospital of Jianyang City

New P4 trial • Anesthesia • Colon Cancer • Colorectal Cancer • Oncology • Rectal Cancer • Solid Tumor

Effect of remimazolam-based total intravenous anesthesia on postoperative sleep quality in patients undergoing laparoscopic colorectal cancer surgery: A randomized controlled study (ChiCTR) - P4 | N=140 | Not yet recruiting | Sponsor: People's Hospital of Jianyang City; People's Hospital of Jianyang City

New P4 trial • Anesthesia • CNS Disorders • Colorectal Cancer • Oncology • Sleep Disorder • Solid Tumor

Comparison of ciprofol and volatile anesthetics on quality of recovery after abdominal surgery in elderly patients: a randomized controlled study. (ChiCTR) - P4 | N=312 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New P4 trial • Anesthesia

Study on the Dose-Response Relationship of Respiratory Depression Induced by Single Bolus Injection of Sevoflurane Combined with Oliceridine in Elderly Patients: A Randomized, Double-Blind, Controlled Trial Protocol (ChiCTR) - P4 | N=78 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Wenzhou Medical University; The Second Affiliated Hospital of Wenzhou Medical University

New P4 trial • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry

Effects of Different Doses of Nalbuphine on Sevoflurane MAC during Cervical Dilation in Patients Undergoing Hysteroscopic Surgery (ChiCTR) - P4 | N=80 | Not yet recruiting | Sponsor: Guangyuan Central Hospital; Guangyuan Central Hospital

New P4 trial

Impact of combination of dexmedetomidine and azasetron on the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery (ChiCTR) - P=N/A | N=94 | Completed | Sponsor: Suzhou Ninth Hospital Affiliated to Soochow University; Suzhou Ninth Hospital Affiliated to Soochow University

New trial

Application of Hydromorphone Combined with Inhalation Anesthesia in Pediatric Amblyopia Surgery (ChiCTR) - P=N/A | N=78 | Completed | Sponsor: Wenzhou Medical University Affiliated Eye Hospital; Wenzhou Medical University Affiliated Eye Hospital

New trial • Anesthesia • CNS Disorders • Ophthalmology • Pediatrics • Strabismus

Efficacy and Safety of Ciprofol versus Propofol for Dental Treatment Under General Anesthesia in Pediatric Patients (ChiCTR) - P=N/A | N=162 | Not yet recruiting | Sponsor: School of Stomatology , The Fourth Military Medical University; School of Stomatology , The Fourth Military Medical University

New trial • Anesthesia • Dental Disorders • Pediatrics

Comparison of the effects of remimazolam tosilate combined with sevoflurane general anesthesia versus sevoflurane general anesthesia on postoperative sleep disturbances in patients undergoing abdominal surgery: a prospective, randomized controlled study (ChiCTR) - P=N/A | N=90 | Not yet recruiting | Sponsor: Sun Yat-sen Memorial Hospital of Sun Yat-sen University; Sun Yat-sen Memorial Hospital, Sun Yat-sen University

New trial • Anesthesia • CNS Disorders • Sleep Disorder

Comparing the effects of different anesthesia methods on lung microbiota composition and postoperative pulmonary complications in patients undergoing pulmonary resection surgery. (ChiCTR) - P=N/A | N=330 | Not yet recruiting | Sponsor: Nanfang Hospital, Southern Medical University; Nanfang Hospital, Southern Medical University

New trial • Anesthesia • CD40LG

Comparison of Tegileridine and Sufentanil for Multimodal Analgesia in Gynecological Laparoscopic Surgery: A Randomized Double-blinded Controlled Trial (ChiCTR) - P=N/A | N=168 | Not yet recruiting | Sponsor: Obstetrics and Gynecology Hospital, Fudan University; Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and D

New trial • Pain

Effect of ultrasound-guided stellate ganglion block on perioperative stress inflammatory factors and postoperative cognitive function in elderly patients with lower limb fractures (ChiCTR) - P=N/A | N=160 | Not yet recruiting | Sponsor: The People's Hospital of Shihezi City, Xinjiang; The People's Hospital of Shihezi City

New trial • Cognitive Disorders • Musculoskeletal Diseases • Orthopedics

Evidence for the use of total intravenous anaesthesia versus inhalant anaesthetics in dogs: a systematic review. (PubMed, Vet Anaesth Analg) - "There is currently limited evidence supporting the use of TIVA in preference to inhalant anaesthesia in dogs."

Journal • Review • Anesthesia • Cardiovascular

Effect of Sevoflurane Concentration, Blood Pressure, Arterial Carbon Dioxide Tension, Temperature, and Stimulation on Spinal Cord Blood Flow in Patients Undergoing Spinal Surgery: An Exploratory Study. (PubMed, Anesthesiology) - No abstract available

Journal