sevoflurane / Generic mfg. - LARVOL DELTA

Comparison of the safety and efficacy of desflurane versus sevoflurane on postoperative cognitive function and early recovery quality in elderly orthopedic patients: a prospective, randomized controlled trial. (PubMed, Front Med (Lausanne)) - P4 | "General anesthesia was maintained through continuous infusion of remifentanil (0.05-0.20 μg/kg/min) and a sevoflurane expiratory concentration of 1-2% or desflurane 2-5%, in combination with air containing 40% oxygen to maintain bispectral index (BIS) values 40-60. However, it demonstrated faster recovery times and higher patient satisfaction scores than sevoflurane. ChiCTR2400093852."

Clinical • Journal • Anesthesia • Orthopedics

Evaluating sedation strategies in acute respiratory distress syndrome: A meta-analysis of inhaled versus intravenous agents. (PubMed, J Clin Anesth) - "Inhaled sedation with volatile anesthetics may offer advantages over intravenous sedation in reducing ICU stay and mechanical ventilation duration in ARDS patients. However, the associated alterations in gas exchange parameters warrant cautious interpretation. Further large-scale studies are needed to confirm these findings and to optimize sedation strategies in this population."

Journal • Retrospective data • Review • Acute Respiratory Distress Syndrome • Anesthesia • Critical care • Pulmonary Disease • Respiratory Diseases

Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis. (PubMed, Open Med (Wars)) - "The occurrence of adverse reactions was not significantly different between the two groups (P > 0.05). The combination of sevoflurane and propofol anesthesia in children with acute appendicitis can enhance the anesthesia effect and recovery quality and stabilize the body's hemodynamics and stress state."

Journal • Anesthesia • Gastroenterology • Gastrointestinal Disorder • Pain

Extracellular vesicles from Akkermansia muciniphila block NACHT, LRR, and PYD domains-containing protein 3 inflammasome activation to promote cognitive recovery in aged mice under sevoflurane anesthesia. (PubMed, Behav Pharmacol) - "In addition, Akk.m-EV treatment decreased inflammatory response and suppressed NLRP3 inflammasome activation in hippocampal tissues of POCD mice, accompanied by elevated zona occludens 1 and occludin protein levels in colonic tissues, suggesting that Akk.m-EVs reduced neuroinflammation and improved intestinal barrier disorder. Akk.m-EVs ameliorate POCD in elderly patients by decreasing neuroinflammation and improving intestinal barrier dysfunction, providing a theoretical basis for the development of prevention and treatment strategies for POCD based on probiotic extracellular vesicles."

Journal • Preclinical • Anesthesia • Cardiovascular • Cognitive Disorders • Gastrointestinal Disorder • Inflammation • Reperfusion Injury • NLRP3 • OCLN • TJP1

Effects of different anesthetics on remifentanil-induced postinfusion hyperalgesia in patients undergoing percutaneous endoscopic interlaminar discectomy: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - "In this study, we investigated the effects of different anesthetics (remimazolam, propofol or sevoflurane) on RPH. The mechanical pain thresholds for the dominant inner forearm, postoperative pain intensity, sufentanil consumption, and side effects were similar among the three groups. Continuous infusion of Propofol or remimazolam attenuated RPH but not acute pain or analgesic consumption after PEID, potentially lowering the risk of chronic pain."

Journal • Anesthesia • Pain

Effects of remimazolam on hemodynamics in children with congenital heart disease undergoing cardiac catheterization. (PubMed, Front Pharmacol) - "No adverse reactions such as bradycardia, hypotension, or hypertension were observed after intravenous injection of remimazolam. During sevoflurane-maintained anesthesia, co-administration of remimazolam provides good hemodynamic stability for children with left-to-right shunt congenital heart disease undergoing cardiac catheterization."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Heart Failure • Hypertension • Hypotension • Psychiatry

RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness. (PubMed, Sci Rep) - "One of the two expression profiles was obtained from mice treated with sevoflurane, a type of inhaled anaesthesia, whereas the other two expression profiles were obtained from sleeping and awake mice...Additionally, both sets of genes were enriched in the RHO GTPase pathway. Based on these results, we hypothesised that L1 GABAergic neurons in the frontal cortex and L6 glutamatergic neurons in the prefrontal cortex use RHO GTPase to differentiate between the states of unconsciousness induced by general anaesthesia and sleep."

Journal • Anesthesia

Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers (clinicaltrials.gov) - P=N/A | N=40 | Not yet recruiting | Sponsor: Ain Shams University

New trial • Anesthesia • Gastroenterology

Comparison of the effects of different general anesthesia methods on the quality of early postoperative recovery in patients undergoing metabolic bariatric surgery: A randomized controlled trial. (PubMed, J Physiol Pharmacol) - "In both groups, patients received propofol, remifentanil and rocuronium for induction...In Group S, anesthesia was maintained with sevoflurane and remifentanil...No significant intergroup difference in QoR-40 scores was observed at 48 h postoperatively, and NRS scores were comparable between groups at both time points. The study results indicate that propofol intravenous anesthesia is associated with better recovery quality at 24 h after metabolic bariatric surgery, while the recovery difference between the two methods diminishes by 48 h."

Clinical • Journal • Anesthesia • Genetic Disorders • Obesity • Pain

Agreement between arterial blood pressures measured non-invasively and invasively in anaesthetised sheep. (PubMed, Acta Vet Scand) - "Doppler SAP and OD MAP demonstrated acceptable accuracy over a broad blood pressure range, supporting their utility for sheep as surrogate of invasive methods of measuring blood pressure. Auricular EPT was the best surrogate of central arterial pressure to be used in clinical conditions."

Journal • Anesthesia • Cardiovascular • Hypertension • Hypotension

Effects of Different Anesthetic Drugs on Immune Function in Healthy Volunteers (clinicaltrials.gov) - P=N/A | N=80 | Enrolling by invitation | Sponsor: Henan Provincial People's Hospital

New trial • Anesthesia

Anesthetic Management Using Remimazolam for Dental Treatment in a Pediatric Patient With Dravet Syndrome. (PubMed, Anesth Prog) - "After a slow mask induction with sevoflurane, RMZ, remifentanil, and rocuronium were administered to facilitate oral intubation, after which general anesthesia was maintained with air, oxygen, and continuous infusions of RMZ and remifentanil. Intraoperative temperature and other vital signs were stable, and no fever or convulsions were observed during the perioperative period. RMZ is an ultrashort-acting benzodiazepine that may be useful for the anesthetic management of pediatric patients with DS because of its potential to prevent seizures."

Journal • Anesthesia • CNS Disorders • Epilepsy • Pediatrics

Anesthetic-induced epigenetic alterations: mechanisms and long-term clinical implications. (PubMed, Epigenetics) - "Common anesthetics, including propofol, isoflurane, sevoflurane, and local or regional agents, trigger epigenetic alterations. Future studies should prioritize large-scale human trials, detailed mechanistic insights, and identification of epigenetic biomarkers to guide safer anesthetic development. This review highlights anesthesia's broader systemic consequences, extending beyond immediate cognitive impacts, and underscores its relevance to personalized medicine."

Journal • Review • Anesthesia • Cognitive Disorders • Developmental Disorders • Inflammation • Pediatrics

Validation of iCare IC200 tonometry during natural sleep in children under 3 years with glaucoma: reducing anesthesia dependence in clinical monitoring. (PubMed, BMC Ophthalmol) - "Natural-sleep rebound tonometry supports bias-aware, clinic-based trend monitoring and can reduce anesthesia exposure in children under 3 years."

Journal • Anesthesia • Glaucoma • Ophthalmology • Pediatrics

Anesthetic Management in a Patient with Dandy-Walker Syndrome Undergoing Supraglottoplasty and Adenotonsillectomy: A Case Report. (PubMed, Cureus) - "Anesthetic management prioritized spontaneous ventilation using inhalational induction with sevoflurane followed by propofol infusion. Airway topicalization with lidocaine and adjunctive dexmedetomidine facilitated atraumatic airway manipulation...Given the extensive airway instrumentation and severe OSA, the patient remained intubated postoperatively and was extubated uneventfully in the pediatric intensive care unit after 24 hours. This case highlights the challenges of anesthetic management in children with complex syndromic airways and emphasizes the importance of strategies that maintain spontaneous ventilation, attenuate airway reflexes, and allow for safe postoperative monitoring."

Journal • Anesthesia • CNS Disorders • Critical care • Epilepsy • Infectious Disease • Obstructive Sleep Apnea • Pediatrics • Pneumonia • Respiratory Diseases • Sleep Disorder

Assessing the carbon footprint of anaesthesia techniques in Caesarean delivery: a single centre prospective observational study. (PubMed, Br J Anaesth) - No abstract available

Journal • Observational data • Anesthesia

Feasibility of Basal Ganglia Microelectrode Recordings Under General Anesthesia with Combined Nitrous Oxide and Sevoflurane: A retrospective Single-Center Experience. (PubMed, Stereotact Funct Neurosurg) - "In the 14 patients received the N2O-GA, anesthetic depth was maintained at 0.97 ± 0.06 MAC, compared to 0.525 ± 0.04 MAC in the sevoflurane-only cases. Conclusion MER under N2O-GA is feasible for DBS target nuclei identification for both STN and GPi and offers a safe and accurate surgical approach for PD patients unable to tolerate awake mapping."

Journal • Retrospective data • Anesthesia • CNS Disorders • Movement Disorders • Parkinson's Disease

Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook. (PubMed, Front Psychiatry) - "Clinical and preclinical studies increasingly support the antidepressant potential of several anesthetic agents, including ketamine, propofol, nitrous oxide (N2O), sevoflurane, and isoflurane. This review summarizes recent advances in both experimental and clinical research on the antidepressant effects of anesthetics, highlighting their underlying molecular and neural mechanisms, therapeutic potential, and current limitations. By integrating mechanistic insights with translational evidence, this article provides new perspectives and serves as a reference for future research aimed at developing safe and effective anesthetic-based therapies for treatment-resistant depression."

Journal • Review • Anesthesia • CNS Disorders • Depression • Inflammation • Major Depressive Disorder • Mood Disorders • Psychiatry

Medetomidine-vatinoxan-methadone and acepromazine-methadone: comparison of sedative and cardiovascular properties as a preanaesthetic medication in healthy dogs. (PubMed, Acta Vet Scand) - "When used as a preanaesthetic medication in combination with methadone, medetomidine-vatinoxan causes faster onset of sedation, without statistically significant differences in cardiovascular interventions, compared to acepromazine."

Journal • Aesthetic Medicine • Anesthesia • Cardiovascular • Hypotension

Comparison of Sevoflurane With Laryngeal Mask Airway Versus Propofol Infusion With Facemask for Eye Examination Under Anesthesia in Children: A Randomized Controlled Trial. (PubMed, J Pediatr Ophthalmol Strabismus) - "Propofol with oxygen facemask resulted in shorter operating room discharge time and less emergence agitation compared to sevoflurane with LMA in pediatric ophthalmic EUAs. Both techniques yielded high ophthalmologist satisfaction and low respiratory event rates."

Journal • Anesthesia • Ophthalmology • Pain • Pediatrics

Reducing use of desflurane in the anaesthetic department: A controlled interrupted time series analysis. (PubMed, Anaesth Intensive Care) - "The intervention, while not directly targeting sevoflurane use, was similarly associated with a downward trend in sevoflurane usage of an average of 0.5 units per month per 100 surgeries from September 2021 onwards (95% CI -189.74 kg to -10.43 kg, P = 0.004)...There were no changes in CO2e emissions or costs at the control site. A clinician-led intervention highlights the importance of creating opportunity and motivation for change amongst staff as well as ongoing education, advocacy and engagement with department and executive to achieve positive environmental and financial outcomes."

Journal • Anesthesia

Beyond Anakinra and Tocilizumab: Additional Adjunctive Therapies in Pediatric New Onset Refractory Status Epilepticus and Febrile Infection-Related Epilepsy Syndrome - A Narrative Review. (PubMed, Pediatr Neurol) - "A number of publications (mainly case reports and case series) have described various adjunctive therapies in the management of new onset refractory status epilepticus/febrile infection-related epilepsy syndrome, including neuromodulatory therapies (such as vagal nerve stimulation, deep brain stimulation, and electroconvulsive therapy), surgical resection, noninterleukin immunotherapies (such as intrathecal dexamethasone, intravenous rituximab, and cyclophosphamide), infusions (such as lidocaine and magnesium), and anesthetic agents (such as sevoflurane). Utilizing a modified Preferred Reporting Items for Systematic reviews and Meta-Analyses approach, this narrative review summarizes the effectiveness and safety of second-line immunotherapies such as tocilizumab and anakinra, as well as the various adjunctive third-line therapies that aim to abort seizures and mitigate comorbidities within an intensive care setting, such as prolonged sedation and secondary systemic..."

Journal • Review • Anesthesia • CNS Disorders • Critical care • Epilepsy • Infectious Disease • Pediatrics

Sevoflurane and Dexmedetomidine's Contrasting Renal Impacts After Non-Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=90 | Completed | Sponsor: Tanta University | Trial completion date: Mar 2024 ➔ Dec 2024 | Initiation date: Nov 2023 ➔ May 2024

Trial completion date • Trial initiation date • Acute Kidney Injury • Cardiovascular • Immunology • Nephrology • Renal Disease

Capture efficiency of CONTRAfluran™ absorbers for sevoflurane in routine anaesthesia practice: a prospective observational single-center study. (PubMed, BMC Anesthesiol) - "If CONTRAfluran™ absorbers are used until they are fully saturated, almost one-third of the sevoflurane can be recaptured. The capture efficiency may be affected by various patient- and procedure-related factors, including the fresh gas flow used and the duration of anaesthesia."

Journal • Observational data • Anesthesia

Omega-3 Polyunsaturated Fatty Acids Prevent Sevoflurane-induced Cognitive and Fine Motor Dysfunctions in Neonatal Mice by Enhancing Phosphorylated Tau Glymphatic System Clearance Pathway. (PubMed, Mol Neurobiol) - "Our study found that sevoflurane disrupted the glymphatic system in neonatal mice, and that reduced glymphatic transport was directly related to the buildup of phosphorylated tau protein in the developing brain. More importantly, ω-3 PUFAs can prevent cognitive and fine motor deficits induced by multiple exposures to sevoflurane in neonates through rescuing the decreased AQP4 polarization via PDGF-B/PDGFRβ signaling, enhancing phosphorylated tau glymphatic system clearance pathway, and attenuating mitochondrial dysfunction and neurotoxicity."

Journal • Preclinical • CNS Disorders • Cognitive Disorders • Inflammation • Metabolic Disorders • Vascular Neurology • PDGFRB