sevoflurane / Generic mfg. - LARVOL DELTA

Beneficial effects of dexmedetomidine with sevoflurane inhalation in abdominal surgery: Quality of anesthesia, intestinal flora, and serum pain mediators. (PubMed, Int J Clin Pharmacol Ther) - "Evidence was provided showing that anesthesia with DEX plus closed-loop target-controlled inhalation with sevoflurane improves the quality of the anesthesia, reduces the levels of serum pain mediators, and has potentially beneficial effects on the intestinal flora in patients undergoing abdominal surgery."

Journal • Anesthesia • Oncology • Pain • TNFA

Developmental stage-dependent neurotoxicity of sevoflurane: evidence from brain organoids. (PubMed, Front Cell Neurosci) - "It also discusses key limitations of current organoid systems and considers how more mature, vascularized, and microglia-containing models, integrated with perioperative cohorts and targeted interventions, may eventually inform exposure-aware anesthetic planning without delaying necessary surgery. Overall, this review advances a developmental stage-aware, organoid-centered conceptual framework that integrates animal and human-based evidence to better understand and stratify the risk of sevoflurane-induced neurotoxicity."

Journal • Review • Anesthesia • Inflammation • Metabolic Disorders • Pediatrics

Sevoflurane protects against testicular ischaemia-reperfusion injury in rats. (PubMed, Br J Pharmacol) - "Sevoflurane exerts acute and chronic protective effects against bilateral testicular ischaemia-reperfusion injury via ERK1/2 signalling and offers a novel pharmacological strategy to mitigate complications following de-torsion."

Journal • Preclinical • Anesthesia • Infertility • Inflammation • Reperfusion Injury • Sexual Disorders • BAX • BCL2 • IL6 • TNFA

Evaluation of clinically relevant sevoflurane concentrations in the development of malignant hyperthermia in an Ryr1 mutant mouse model. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Preclinical • RYR1

Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH/NLRP3 Inflammasome pathway. (PubMed, Int Immunopharmacol) - "RC and its active compound THC significantly attenuate POD comorbid SD-induced cognitive impairment and sleep disturbances, likely through modulation of TH activity and inhibition of NLRP3 inflammasome activation. These findings provide mechanistic insight and preclinical evidence supporting the development of novel perioperative neuroprotective strategies targeting neuroinflammatory and neurotransmitter pathways."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain • Sleep Disorder • DRD2 • IL1B • NLRP3

The Important Role of miR-96 in Depression: New Research Progress and Future Prospects. (PubMed, Curr Neuropharmacol) - "Notably, miR-96 is associated with sevoflurane-induced memory impairment in neonatal rats...These preclinical findings suggest that miR-96 has potential as a candidate biomarker for depression diagnosis and prognostic evaluation, though this requires validation in large-scale clinical cohorts. To the best of our knowledge, this is the first review to describe the research on the diagnostic value of miR-96 for depression, which can provide a reference for future clinical studies."

Journal • Alzheimer's Disease • CNS Disorders • Depression • Mood Disorders • Oncology • Psychiatry • MIR96

Opioid-Free Versus Opioid-Based Anesthesia for Quality of Recovery Following Laparoscopic Hysterectomy: A Randomized Controlled Non-Inferiority Trial. (PubMed, Anaesth Crit Care Pain Med) - P4 | "Opioid-free anesthesia demonstrated non-inferiority to opioid-based anesthesia for recovery quality while reducing the incidence and severity of PONV. These findings support opioid-free protocols as effective alternatives for laparoscopic hysterectomy, particularly for patients at high PONV risk."

Head-to-Head • Journal • Anesthesia • CNS Disorders • Depression • Gynecology • Pain • Psychiatry

Prophylactic Efficacy of Cipepofol Against Postoperative Nausea and Vomiting in Moderate to High-Risk Patients of Apfel Score: A Multicenter, Randomized, and Parallel-Group Comparative Trial. (PubMed, Drug Des Devel Ther) - "In addition, cipepofol was associated with a lower incidence of intraoperative hypotension than sevoflurane (9.73% vs 19.34%, p=0.009). Compared with sevoflurane alone, cipepofol significantly reduced PONV incidence at 24 and 48 h after surgery, with more stable intraoperative hemodynamics."

Clinical • Journal • Anesthesia • Cardiovascular • Hypotension

Sevoflurane activates ATF4/NSUN7/PRKCD axis to induce neurotoxicity and cognitive impairment by promoting neuron mitochondrial fission. (PubMed, Chem Biol Interact) - "Meanwhile, SEV aggravated neurotoxicity and cognitive impairment in mice by activating the ATF4/NSUN7/PRKCD axis. Collectively, SEV-induced neurotoxicity is associated with mitochondrial fission and ATF4/NSUN7/PRKCD pathway activation, providing new ideas for alleviating SEV-induced neurotoxicity."

Journal • Alzheimer's Disease • Cognitive Disorders • Metabolic Disorders • ATF4 • NOP2 • TCF4

Closed-Loop Anesthesia: Advances in Automated Drug Delivery and Perioperative Monitoring. (PubMed, J Pharm Bioallied Sci) - "Various technologies and drugs, including propofol, remifentanil, and sevoflurane, support its function. As technology progresses, future systems may combine control of anesthesia, fluids, and blood pressure medications, working closely with electronic health records. Despite automation, human supervision remains essential for safe and effective anesthesia care."

Journal • Review • Anesthesia

Development of a machine learning algorithm model to predict intraoperative hypotension in elderly patients undergoing thoracic and abdominal surgeries. (PubMed, Open Med (Wars)) - "Key predictors included anesthesia protocol, Charlson comorbidity index, preoperative sodium, creatinine, BUN/creatinine ratio, intraoperative drug use (e.g., sevoflurane, lidocaine, morphine), preoperative MAP and MHR, surgical and anesthesia duration, and surgical site. A robust ML-based model was established to accurately predict IOH in elderly patients. These findings may support individualized anesthesia management and targeted preventive strategies to reduce IOH incidence."

Journal • Anesthesia • Hypotension

General anesthesia and depth of anesthesia (DoA) evaluation methods in laboratory animals: a comprehensive review. (PubMed, Vet Res Commun) - "Injectable agents (ketamine with α2-agonists, barbiturates, propofol) and inhalational agents (isoflurane, sevoflurane, desflurane) act primarily via NMDA antagonism or GABA-A/glycine modulation, with distinct profiles for analgesia, hemodynamics, respiration, and recovery. Priorities include validated EEG algorithms for nonhuman species, standardized autonomic indices, and broader adoption of awake models when compatible with scientific aims. These strategies will improve animal welfare and enhance the reproducibility and interpretability of preclinical findings."

Journal • Review • Anesthesia • Cardiovascular

A prospective, randomised trial comparing the quality of recovery between full inhalation anaesthesia and total intravenous anaesthesia post gynaecological surgery. (PubMed, Qatar Med J) - "One hundred and eight consenting adult patients posted for open gynaecological surgeries under GA were randomly allocated to Sevoflurane-based full inhalation anaesthesia (Group FIA) or propofol-based TIVA (Group TIVA)...There was no significant difference in extubation time (P = 0.207) and MOAA/S score (P = 0.548) between the groups. Our study found no significant difference in QOR-40 score, extubation time, and MOAA/S score between group FIA and TIVA."

Journal • Anesthesia • Gynecology

Propofol versus sevoflurane: how many RCTs is enough? (PubMed, Crit Care) - No abstract available

Journal • Anesthesia

Inhaled Volatile Sedation vs IV Sedation in Mechanically Ventilated Patients: A Systematic Review (SCCM 2026) - "Emerging alternatives, i.e., inhaled volatile anesthetics (IVA) (such as isoflurane, sevoflurane, and desflurane) to traditional intravenous (IV) sedatives like propofol or midazolam have shown promise in various Randomized controlled Trials (RCTs). Inhaled volatile anesthetics are a safe and effective alternative to traditional IV sedation in mechanically ventilated ICU patients. In all RCTs, volatile agents achieved non-inferior sedation control with faster wake-ups, extubating times, and similar outcomes in delirium, adverse events, and mortality. Still, most trials were single-center and underpowered for patient-centered outcomes."

Clinical • Review • Acute Respiratory Distress Syndrome • CNS Disorders • Hypotension

Refractory Status Asthmaticus in a Patient on VV ECMO Augmented by Rescue Therapy With Omalizumab (SCCM 2026) - "For patients who fail standard ICU management, VV ECMO or inhaled anesthetics such as sevoflurane may be offered. There is growing numbers of case reports of "off label" or compassionate use of biologic agents such as anti-IGE omalizumab, anti-IL-5Ra benralizumab, and anti-TSLP tezepelumab...The patient was discharged home on room air five days later to follow up with pulmonology for his asthma. Our patient showed improved ventilation at 48 hours and was able to be extubated and decannulated at day 9, this is consistent with the limited established literature and tracks with omalizumab's onset of action of 7-8 days. Our case adds to the growing number of case reports describing the use of biologic agents in refractory status asthmaticus and is one of a handful of cases in a patient on VV ECMO."

Clinical • Asthma • Chronic Obstructive Pulmonary Disease • Eosinophilia • Immunology • Respiratory Diseases

Comparing Deep Sedation to LMA for Pediatric Sedation Cases (SCCM 2026) - "The DEEP cases received Midazolam, Fentanyl and Propofol infusion using our weight/kinetic based dosing algorithm. The LMA cases had a sevoflurane induction, IV and then LMA placed, maintenance with Sevoflurane and morphine administered... In this early evaluation additional airway interventions are more common in the DEEP group with more delayed recovery but sedation quality appears equal. It is too early to determine which technique is better."

Clinical • Pediatrics

Low-flow Versus Minimal-flow Sevoflurane Anesthesia During Robot-assisted Laparoscopic Radical Prostatectomy (clinicaltrials.gov) - P=N/A | N=70 | Not yet recruiting | Sponsor: Ankara City Hospital Bilkent

New trial • Anesthesia • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Sevoflurane-Associated Diffuse Alveolar Hemorrhage-A Rare Pediatric Presentation. (PubMed, Pediatr Pulmonol) - No abstract available

Journal • Hematological Disorders • Pediatrics

State-Dependent Remodeling of Astrocytic Proteome and Phosphorylation Signaling Networks Across Wake, Sleep, and General Anesthesia. (PubMed, Int J Mol Sci) - "This study conducted proteomic and phosphoproteomic analyses of rat cortical astrocytes across these states using sevoflurane...Clustering analysis showed that sleep was associated with upregulated mRNA processing, while anesthesia indicated potential enhancement of synaptic signaling and suggested possible suppression of development-related programs. In summary, astrocytes undergo extensive molecular reprogramming during transitions of consciousness; while they share common features in morphological remodeling, sleep and anesthesia differ fundamentally in astrocytic molecular outcomes, offering new insights into astrocytic roles in unconsciousness."

Journal • Anesthesia

Sevoflurane induces developmental cardiotoxicity via AMPKα2 dysregulation in zebrafish. (PubMed, Cell Biosci) - "Critically, pharmacological activation of AMPK using A-769662 effectively mitigated sevoflurane-induced cardiotoxicity, identifying AMPKα2 as a potential therapeutic target. Collectively, these findings delineate the molecular mechanisms underlying sevoflurane-induced developmental cardiotoxicity following prolonged exposure in zebrafish and suggest that targeting AMPKα2 signaling merits investigation as a potential strategy to mitigate anesthetic-related cardiac developmental risks."

Journal • Anesthesia • Cardiomyopathy • Cardiovascular • Obstetrics • IL1B • IL6 • PRKAA2 • SLC8A1 • TNFA

Factors for the development of graft pancreatitis following pancreas transplantation: A Systematic Review. (PubMed, Transplant Rev (Orlando)) - "This systematic review identified a range of potential associated factors and mitigating factors for graft pancreatitis."

Journal • Review • Cardiovascular • Pancreatitis • Transplantation

Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (clinicaltrials.gov) - P=N/A | N=120 | Recruiting | Sponsor: University of Kansas Medical Center | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2026 ➔ Dec 2027 | Trial primary completion date: May 2026 ➔ May 2027

Enrollment open • Trial completion date • Trial primary completion date • Anesthesia • Cardiovascular • Ischemic stroke

Perioperative Hypothermia and Sevoflurane Consumption in Elderly Patients (clinicaltrials.gov) - P=N/A | N=70 | Not yet recruiting | Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

New trial • Orthopedics

Effects of Minimal and Metabolic Flow Sevoflurane Anesthesia in Gynecological Surgery Patients (clinicaltrials.gov) - P=N/A | N=97 | Completed | Sponsor: Baskent University

New trial • Anesthesia • Gynecology