sevoflurane / Generic mfg. - LARVOL DELTA

Author's Reply to Peek: "Kinetics of Sevoflurane Vaporized Directly in Extracorporeal Membrane Oxygenators-Ex Vivo Findings and Pharmacokinetic/Pharmacodynamic Simulations". (PubMed, Eur J Drug Metab Pharmacokinet) - No abstract available

Journal • PK/PD data • Preclinical

Comparing Gas and Inhaled Pharmacologic Interventions During Ex Vivo Lung Perfusion: A Systematic Review. (PubMed, Transplant Direct) - "Among the interventions examined, 10% carbon dioxide, carbon monoxide (CO), 40% oxygen (O2), hydrogen, 40 ppm nitric oxide (NO) with 60% O2, 2% sevoflurane with 40%-50% O2, 2-S-amino-6-boronohexanoic acid, fasudil, and β2-adrenoreceptor agonists most effectively improved lung function...In contrast, argon, xenon, N-acetylcysteine, sevoflurane or NO with 6% O2, and liquid ventilation demonstrated minimal benefit. Inhaled interventions can attenuate both mechanical damage and inflammatory pathways, particularly when used in tailored combinations with 40%-60% O2. Future research should prioritize standardizing protocols, optimizing gas composition and timing, and assessing long-term posttransplant outcomes to translate these findings into clinical practice."

Journal • Preclinical • Cardiovascular • Reperfusion Injury • Respiratory Diseases • Transplantation

"The Dual Benefit of TIVA-TCI: A Real-World Analysis of Economic and Environmental Superiority over Inhaled Anaesthesia". (PubMed, Anaesth Crit Care Pain Med) - "These findings provide compelling real-world evidence supporting the adoption of TIVA-TCI as a financially and environmentally superior strategy in modern anaesthetic practice."

Head-to-Head • Journal • Real-world evidence • Anesthesia

The environmental footprint and ecotoxicity of sevoflurane and propofol anaesthesia: do conservative modelling assumptions overstate the ecotoxicity of propofol? Comment on Br J Anaesth 2026; 137: 89-98. (PubMed, Br J Anaesth) - No abstract available

Journal • Anesthesia

Effects of inhalation anesthesia with sevoflurane combined with oxygen inhalation on cerebral oxygen metabolism and cognitive function in lung cancer patients undergoing unilateral lung ventilation. (PubMed, Am J Transl Res) - "Sevoflurane inhalation anesthesia can improve cerebral oxygen metabolism, accelerate the post-anesthesia recovery process, and enhance pulmonary function in patients undergoing one-lung ventilation for lung cancer surgery compared with propofol, but it is also associated with a higher risk of postoperative cognitive dysfunction at 24 hours after surgery."

Journal • Anesthesia • Cognitive Disorders • Lung Cancer • Oncology • Solid Tumor

A Rapid and Cost-effective Method to Identify the Mitochondrial Variant m.11232T>C Associated with Adverse Neurologic Effects in Patients Exposed to Sevoflurane. (PubMed, Anesthesiology) - No abstract available

HEOR • Journal

Comment on: "Kinetics of Sevoflurane Vaporized Directly in Extracorporeal Membrane Oxygenators-Ex Vivo Findings and Pharmacokinetic/Pharmacodynamic Simulations". (PubMed, Eur J Drug Metab Pharmacokinet) - No abstract available

Journal • PK/PD data • Preclinical

Sevoflurane Inhibits Colon Cancer Progression by Inducing Cell Autophagy and Apoptosis through the ROS/Nrf2/P62 Pathway. (PubMed, Oncol Res) - "Moreover, NAC reversed the SEV-induced effects in vitro. SEV inhibits CC progression by inducing autophagy and apoptosis via the ROS/Nrf2/p62 pathway."

IO biomarker • Journal • B Cell Lymphoma • Colon Cancer • Colorectal Cancer • Lymphoma • Oncology • Solid Tumor • BAX • BECN1 • MAP1LC3B • NFE2L2 • SQSTM1

Methodological considerations regarding propofol versus sevoflurane induction in patients with mitral stenosis. (PubMed, Braz J Anesthesiol) - No abstract available

Journal

Paternal neonatal sevoflurane exposure induces intergenerational anxiety via epididymal DNMT2-dependent sperm transfer RNA derived small RNA remodelling in rats. (PubMed, Br J Anaesth) - "Neonatal sevoflurane exposure triggers a paternal GR-DNMT2 pathway in the epididymis, reprogramming sperm tsRNA profiles and driving intergenerational anxiety in a rat model. Epididymal DNMT2 is a key epigenetic mediator of anaesthesia-induced inheritance, and the alleviating effects of decitabine suggest additional mediating mechanisms."

Journal • Preclinical • Anesthesia • Mood Disorders • Psychiatry

20 Hz tACS engages striatal THINs to enhance β-band synchrony and motor drive. (PubMed, Front Neurosci) - "Eighteen-month-old male mice received 20 Hz tACS or sham stimulation over M1 for 7 days under sevoflurane anesthesia...Optogenetic THIN inhibition reduced successful attempts per minute and β-band power, but no statistically significant reduction in success rate was detected. These findings suggest that 20 Hz tACS over M1 may improve post-anesthesia motor performance in aged mice, with converging evidence implicating striatal dopamine release, THIN engagement, and β-band synchrony as functionally coupled elements in the context of post-anesthesia motor recovery in aged mice."

Journal • Anesthesia

Sevoflurane suppresses circ_SMG6 to inhibit TLR4/mTOR signaling and attenuate myocardial ischemia-reperfusion injury. (PubMed, Mol Biol Rep) - "circ_SMG6 may exacerbate MIRI through TLR4/mTOR-associated inflammatory and apoptotic signaling in cardiomyocytes, while sevoflurane attenuates myocardial injury, at least in part, by suppressing this circ_SMG6-related pathway. These findings identify circ_SMG6 as a potential therapeutic target in sevoflurane-based cardioprotection against MIRI."

Journal • Cardiovascular • Myocardial Infarction • Myocardial Ischemia • Reperfusion Injury • IL1B • IL6 • TLR4 • TNFA

Total intravenous anesthesia in kidney transplantation: A narrative review. (PubMed, World J Transplant) - "Propofol-based TIVA is a safe and effective alternative to volatile anaesthesia in kidney transplantation. Whether the cellular-level biomarker signal translates into clinically meaningful renoprotection in higher-risk grafts requires adequately powered multicentre trials with standardised perioperative protocols."

Journal • Anesthesia • Chronic Kidney Disease • Nephrology • Reperfusion Injury • Transplant Rejection • Transplantation • KIM1

Sevoflurane Consumption During Cardiac Surgery With Extracorporeal Circulation: The Effect of Carbon Dioxide Field Flooding. (PubMed, J Cardiothorac Vasc Anesth) - "CO2 field flooding significantly increases hourly sevoflurane consumption during ECC. The findings highlight a potential trade-off between embolic protection and environmental sustainability in cardiac surgery."

Journal • Cardiovascular

Safety and Efficacy of Esketamine Versus Remifentanil as Adjuncts to Propofol Sedation in Children Undergoing Hematologic-Oncologic Procedures: A Randomized Crossover Controlled Trial (ChiCTR) - P=N/A | N=140 | Not yet recruiting | Sponsor: Children's Hospital of Soochow University; Children's Hospital of Soochow University | N=80 ➔ 140

Enrollment change • Acute Lymphocytic Leukemia • Anesthesia • Hematological Disorders • Hematological Malignancies

Effects of inhalational versus intravenous anaesthesia on postoperative lung injury in patients with sepsis undergoing surgery: a study protocol for a single-centre, assessor-blinded, randomised controlled trial (ChiCTR) - P=N/A | N=480 | Not yet recruiting | Sponsor: The Sixth Affiliated Hospital , Sun Yat-sen University; The Sixth Affiliated Hospital , Sun Yat-sen University

New trial • Anesthesia • Infectious Disease • Respiratory Diseases • Septic Shock

Effect of Remimazolam versus Sevoflurane on the Incidence of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gynecologic Oncology Surgery (ChiCTR) - P=N/A | N=116 | Completed | Sponsor: Sun Yat-sen University Cancer Center; Sun Yat-Sen University Cancer center

New trial • Gynecologic Cancers • Oncology

A single-arm, open-label, single-center study to evaluate the efficacy and safety of low-concentration sevoflurane in patients with learning disabilities (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Guangzhou Medical University Affiliated Women and Children's Medical Center; Guangzhou Medical University Affiliated Women and Children's Medical Cent

New trial • Cognitive Disorders • Developmental Disorders

Dexmedetomidine combined with sevoflurane in anesthesia maintainance: a randomized double-blind study (ChiCTR) - P=N/A | N=92 | Not yet recruiting | Sponsor: Cancer Hospital Chinese Academy of Medical Sciences; Cancer Hospital Chinese Academy of Medical Sciences

New trial • Anesthesia • Oncology

Safety and Effectiveness of Remifentanil and Sevoflurane for Maintaining General Anesthesia in Different Surgical Procedures — A Single-Center, Prospective Randomized Controlled Trial (ChiCTR) - P4 | N=500 | Not yet recruiting | Sponsor: North China University of Science and Technology Affiliated Hospital; North China University of Science and Technology Affiliated Hospital

New P4 trial • Anesthesia

Anesthesia and Postoperative Sleep Quality in Gynecological Minimally Invasive Surgery (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen Un

New P4 trial • Anesthesia • CNS Disorders • Sleep Disorder

Application of Remimazolam Combined with Sevoflurane Anesthesia in Neuroelectrophysiological Monitoring during Carotid Endarterectomy (ChiCTR) - P=N/A | N=72 | Recruiting | Sponsor: Hengshui People's Hospital; No. 180, People's East Road, Taocun District, Hengshui City, Hebei Province | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia • Cardiovascular

Application of remimazolam tosylate-based anesthesia in enhanced recovery for liver transplantation (ChiCTR) - P=N/A | N=120 | Completed | Sponsor: Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia • Transplantation

In-depth exploration of the dynamic effects of different anesthetic drugs on the immune function of healthy volunteers through single-cell sequencing analysis. (ChiCTR) - P=N/A | N=80 | Recruiting | Sponsor: Henan Provincial People's Hospital; Henan Provincial People's Hospital

New trial • Anesthesia

A CASE OF SEVOFLURANE-INDUCED MULTIORGAN TOXICITY (CHEST 2026) - No abstract available

Clinical • Critical care • Interstitial Lung Disease