sevoflurane / Generic mfg. - LARVOL DELTA

Association between pyramidal neurone spiking in the medial prefrontal cortex and the sedative potency of volatile anaesthetics in mice. (PubMed, Br J Anaesth) - "The excitability of pyramidal neurones in the mPFC primarily determines the sedative potency of volatile anaesthetics in mice."

Journal • Preclinical • Anesthesia • NAV1

Effect of sevoflurane-based or propofol-based anesthesia on acute kidney injury after surgery for gastric cancer: a retrospective propensity score-matched analysis. (PubMed, BMC Anesthesiol) - "In this retrospective study, no significant difference was found in the incidence of postoperative AKI after gastrectomy between patients who received propofol-based TIVA and those who received sevoflurane-based INHA in this retrospective study."

Journal • Retrospective data • Acute Kidney Injury • Anesthesia • Gastric Cancer • Nephrology • Oncology • Renal Disease • Solid Tumor

Effect of fixed-dose intravenous dexmedetomidine on emergence delirium after general anesthesia for a surgery in pediatric patients - A randomized controlled trial. (PubMed, Qatar Med J) - "The incidence of ED in the control group was 42% (14/33), whereas it was 15% (5/33) in the dexmedetomidine group (p = 0.014). The use of 0.2 mcg/kg intravenous dexmedetomidine reduces the incidence of ED in patients undergoing general anesthesia with sevoflurane."

Clinical • Journal • Anesthesia • CNS Disorders • Pain • Pediatrics • Psychiatry

Comparison of Rocuronium and Cisatracurium in Ophthalmic Surgeries in Association with the Incidence of Intraoperative Bradycardia- A Retrospective Study. (PubMed, Drug Des Devel Ther) - "Patients received either cisatracurium with neostigmine (n = 388) or rocuronium with sugammadex (n = 455) as neuromuscular blocking and reversal agents, respectively. Additionally, this group exhibited a significantly higher rate of BIS monitoring during surgery, alongside a significant reduction in total opioid (p = 0.039) and sevoflurane consumption (p < 0.001). The use of rocuronium is associated with a significant reduction in the incidence of intraoperative bradycardia in adult patients undergoing ophthalmic surgery under general anaesthesia."

Clinical • Journal • Retrospective data • Anesthesia • Cardiovascular • Ophthalmology

Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways. (PubMed, J Nanobiotechnology) - "Behavioral assays further confirmed improved cognitive and motor function in nanoparticle-treated mice. Our findings highlight the potential of Ang/SIRT1-NPs as a promising neuroprotective strategy for preventing anesthesia-related DNT and support their translational application in pediatric neuroprotection."

Journal • Anesthesia • Inflammation • Pediatrics • SIRT1

Reducing Medication Burden and Accelerating Recovery Through Tubeless Thoracic Surgery: A Large-Scale Real-World Study (IASLC-WCLC 2025) - "The tubeless approach demonstrated remarkable reduction in medication use (standardized mean dosages), including muscle relaxants (rocuronium: 256.81 vs 931.12; cisatrocurium: 47.13 vs 204.02), opioids (sulfentanil: 163.08 vs 258.57; remifentanil: 6076.43 vs 7873.43), and sevoflurane used (335 vs 4119 patients) (all P<0.001). Conclusions : Based on the largest dataset to date, our findings demonstrate that tubeless VATS enables dramatically faster recovery through substantial reductions in medication use and ventilation pressures, while promoting remarkable resource efficiency. This study provides new evidence for the tubeless approach."

Clinical • Real-world • Real-world evidence • Surgery • Anesthesia • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer

Intraoperative Polyuria as a Possible Complication of Anesthetic Agents and Spinal Procedures: A Case Series. (PubMed, Cureus) - "Dexmedetomidine, sevoflurane, ketamine, and/or propofol were used. None of the patients had a history of diabetes or AVP disorders, and no other causes of polyuria were identified. Awareness of the link between anesthetic medications, spinal procedures, and polyuria can improve the diagnosis and management of intraoperative polyuria."

Journal • Aesthetic Medicine • Anesthesia • Diabetes • Metabolic Disorders

Effects of anesthesia on tumor perfusion and infiltration during brain tumor neurosurgery. (PubMed, Ann Med Surg (Lond)) - "This mini-review examines the effects of various anesthetic agents, such as propofol, isoflurane, and sevoflurane, on tumor perfusion and infiltration, highlighting their potential to modulate tumor biology through mechanisms involving immune response, angiogenesis, and molecular pathways. Furthermore, it explores innovative strategies, including targeted anesthesia delivery and the integration of genomic and proteomic data, to enhance personalized patient care. By synthesizing current knowledge and identifying areas for future research, this mini-review aims to provide a foundation for optimizing anesthetic protocols in brain tumor surgeries to improve both short- and long-term patient outcomes."

Journal • Review • Anesthesia • Brain Cancer • Oncology • Solid Tumor

Inhibition of astrocytic toll-like receptor 4 contributes to sevoflurane pretreatment-induced anti-neuroinflammation following focal cerebral ischemia. (PubMed, J Neuroimmunol) - "Our findings demonstrate that sevoflurane preconditioning attenuates ischemia-mediated neuroinflammation by suppressing astrocytic TLR4 expression, highlighting its therapeutic potential against neuroinflammation induced by focal cerebral ischemia."

IO biomarker • Journal • Anesthesia • Cardiovascular • Inflammation • CASP3 • IL6 • TLR4 • TNFA

[Retracted] Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia‑reperfusion rats. (PubMed, Mol Med Rep) - "The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 21: 123‑130, 2020; DOI: 10.3892/mmr.2019.10832]."

Journal • Preclinical • Cardiovascular • CNS Disorders • Reperfusion Injury • Vascular Neurology

Improved efficiency of the new Mirus™ system challenged by ventilatory settings-a bench study. (PubMed, J Clin Monit Comput) - "Isoflurane (sevoflurane) target concentrations were stepwise increased to 1.5 MAC and then decreased. The new system demonstrates high accuracy, precision, and improved efficiency, suggesting reduced anaesthetic consumption in clinical use. However, high concentrations combined with very short IF times substantially increase consumption, indicating potential limitations."

Journal • Anesthesia

High Multiband Acceleration Degrades Resting-State Functional MRI Reliability and Signal Quality Under Anesthesia. (PubMed, J Neuroimaging) - "Hight multiband acceleration reduces both signal quality and reliability of rs-fMRI under anesthesia. Sevoflurane had no measurable effect. The lack of correlation between tSNR and reliability underscores the need for more robust metrics when evaluating scan quality."

Journal • Retrospective data • Anesthesia

Protective effect of lipoic acid on brain oxidative stress injury in patients undergoing sevoflurane anesthesia during hepatectomy surgery (ChiCTR) - P4 | N=156 | Completed | Sponsor: Xuzhou Central Hospital; Xuzhou Central Hospital | Recruiting ➔ Completed | Phase classification: PN/A ➔ P4 | N=46 ➔ 156

Enrollment change • Phase classification • Trial completion • Anesthesia

Comparison of effects of different anesthesia methods on postoperative recovery quality of patients with moyamoya disease (ChiCTR) - P=N/A | N=76 | Completed | Sponsor: The First Affiliated Hospital of University of Science and Technology of China; The First Affiliated Hospital of University of Science and Technology | Not yet recruiting ➔ Completed | N=30 ➔ 76

Enrollment change • Trial completion • Anesthesia • Vascular Neurology

Regional Anesthesia EMG Study (clinicaltrials.gov) - P=N/A | N=80 | Active, not recruiting | Sponsor: Nationwide Children's Hospital | Recruiting ➔ Active, not recruiting | N=124 ➔ 80 | Trial completion date: Jun 2025 ➔ Dec 2025

Enrollment change • Enrollment closed • Trial completion date • Anesthesia

Protective effect of sevoflurane on lung during necrotizing enterocolitis surgery: a randomized controlled trial (ChiCTR) - P4 | N=154 | Not yet recruiting | Sponsor: Chongqing Health Center for Women and Children; Chongqing Health Center for Women and Children

New P4 trial • Gastrointestinal Disorder

Intranasal Esketamine Premedication Reduces Sevoflurane Requirements During Laryngeal Mask Airway Insertion in Pediatric Patients: A Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "The 1.0 mg/kg dose provides optimal clinical benefits without prolonging recovery or increasing complications. This approach offers pediatric anesthesiologists a practical method to reduce volatile anesthetic exposure while improving patient outcomes and potentially minimizing anesthetic-related risks."

Clinical • Journal • Anesthesia • CNS Disorders • Ophthalmology • Pediatrics • Strabismus

Anesthesia and ACTH: Unveiling the Challenges in Petrosal Sinus Sampling (ASA 2025) - "A 13-year-old boy with suspected Cushing's disease underwent IPSS under sevoflurane and dexmedetomidine anesthesia, which he tolerated well, leading to a confirmed diagnosis and subsequent transsphenoidal resection. Given evidence that propofol may significantly alter hormone levels, sevoflurane is recommended for IPSS to minimize hormonal interference and ensure diagnostic accuracy in pediatric endocrine testing."

Anesthesia • Cushing’s Disease • Endocrine Disorders • Pediatrics • Pituitary Gland Carcinoma

Comparative Analysis of the Effects of Propofol and Sevoflurane on Coagulation and Immune System Function in Patients Undergoing Radical Surgery for Colon Cancer. (PubMed, Int J Gen Med) - "Propofol and sevoflurane have similar effects on perioperative blood rheology in colon cancer patients. However, propofol has a lesser impact on coagulation and immune function compared to sevoflurane, making it more effective in promoting postoperative recovery and reducing the risk of related postoperative complications."

Journal • Anesthesia • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • CD4 • CD8

Impact of Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=450 | Recruiting | Sponsor: Xijing Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia • Cardiovascular • CNS Disorders • Diabetes • Geriatric Disorders • Metabolic Disorders

Neonatal sevoflurane anesthesia induces persistent cognitive deficits in mice through CypD-dependent mitochondrial impairment in parvalbumin interneurons. (PubMed, Chem Biol Interact) - "Synaptic plasticity evaluation using Golgi staining and whole-cell patch-clamp recordings confirmed that sevoflurane reduced dendritic spine density and decreased frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs), which was rescued by PV-interneuron-specific CypD deletion. These findings indicate that neonatal exposure to sevoflurane impairs cognition through CypD-dependent mitochondrial dysfunction in PV interneurons, and that targeting CypD in these neurons represents a viable neuroprotective strategy."

Journal • Preclinical • Alzheimer's Disease • Anesthesia • Cognitive Disorders • Metabolic Disorders • PPIF

Atypical Presentation of Malignant Hyperthermia in a Pediatric Patient (ASA 2025) - "We present an 18-month-old male who underwent a circumcision with an LMA placement maintained on sevoflurane. Transferred to PICU, he remained intubated on 24-hour Ryanodex until an uncomplicated discharge three days later."

Clinical • Anesthesia • Cardiovascular • Metabolic Disorders • Pediatrics

Safe and Effective Outpatient Anesthesia in an Infant With SMA Type 1 and OSA: A Case Report (ASA 2025) - "10-month 7.1 kg full term male presented for spinal nusinersen infusion...Induction oxygen/sevoflurane, intravenous access unsuccessful...Anesthesiologists may encounter affected patients in their practice. Anesthetic considerations include hypersensitivity to muscle relaxants, respiratory difficulties, and difficult intubation."

Case report • Clinical • Anesthesia • Genetic Disorders • Immunology • Movement Disorders • Muscular Atrophy • Obstructive Sleep Apnea • Rare Diseases • Respiratory Diseases • Sleep Disorder

Anesthetic Management of Pediatric Congenital Cardiac Patient Undergoing Posterior Spine Fusion (ASA 2025) - "The anesthesia care plan included Sevoflurane, Propofol, Remifentanil, Ketamine, and vasoactive agents. Arrhythmias occurred with epinephrine, requiring adjustments to vasoactive support. Despite the challenges, surgery was successful demonstrating the importance of tailored anesthetic management in high-risk pediatric patients."

Clinical • Anesthesia • Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Pediatrics • Primary Immunodeficiency

Inducible Ankle Clonus: Implications for Lower Extremity Procedures (ASA 2025) - "A multimodal technique including sevoflurane, ketamine, and remifentanil is implemented in the context of avoidance neuromuscular blockade for nerve identification and monitoring. Intraoperatively, surgeons observed persistent lower extremity rigidity and inducible ankle clonus despite increasing sevoflurane concentrations. Switching to propofol as primary anesthetic resolved rigidity and clonus."

Anesthesia • Orthopedics