bambuterol / Generic mfg. - LARVOL DELTA

Thermodynamic and Kinetic Parameters of Four Drugs Toward Beta-2 Adrenergic Receptor Were Measured Robustly and Accurately Through a Chromatographic Column With CotB1 Peptide-Mediated Immobilization. (PubMed, J Sep Sci) - "Two experimental models, such as the injection amount-dependent method and nonlinear chromatography, were employed to measure equilibrium constants and rate constants of four drugs, including bambuterol, salbutamol, clorprenaline, and tulobuterol, toward β2AR. Thermodynamic analysis revealed that four drugs were spontaneously bound to β2AR, and the bindings between them were mainly driven by electrostatic interactions. Our results indicated that the CotB1p-mediated immobilization strategy, resulting in the robust and accurate measurement of the binding parameters of ligand-receptor interaction, will bring new perspectives in applying affinity chromatography in the research fields of drug screening and drug-protein interaction."

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Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis. (PubMed, Sci Rep) - "Overall, the method offers a robust, greener alternative for routine assay and dissolution testing of BBL and MTK in pharmaceuticals. The online version contains supplementary material available at 10.1038/s41598-026-41125-x."

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A functionalized polymer adsorbent for effective extraction of β-adrenergic agonists from meat prior to their sensitive detection by HPLC-FLD. (PubMed, J Chromatogr A) - "A polyhydroxy hyper-cross-linked polymer (HCP), named as TP/BCMBP-HCP, was successfully synthesized by copolymerizing 4,4',4''-trihydroxytriphenylmethane (TP) and 4,4'-bis(chloromethyl)biphenyl (BCMBP) to target at the selective extraction of the β-adrenergic agonists (ractopamine and bambuterol)...The method recoveries ranged from 87.5 % to 115 %, with the RSDs below 9.4 %. With conventional HPLC-FLD instrument, the method achieved satisfactory sensitivity, repeatability and accuracy for the analysis of the analytes in complex meat samples."

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SERS fingerprinting of β2-agonists for anti-doping based on Au-COF substrate. (PubMed, Anal Chim Acta) - "This study develops a novel analytical method utilizing Au-COF composites for highly sensitive SERS detection. It pioneers the application of this strategy in the qualitative and quantitative analysis of trace β2-agonists. The research not only significantly expands the scope of Au-COF composites but also provides a technologically promising approach with substantial practical value for ensuring medical safety through clinical medication monitoring and for detecting banned substances in sports."

Journal • Asthma • Fatigue • Immunology • Pulmonary Disease • Respiratory Diseases

A new HPTLC-image analysis approach for assessing interactions and antioxidant profiles of adrenergic drugs. (PubMed, J Chromatogr A) - "Results revealed that highly polar compounds, that is norepinephrine, etilefrine, metaraminol and midodrine exhibited strong interactions with silica gel but limited retention on reversed-phase, while lipophilic derivatives, namely naphazoline, xylometazoline, clenbuterol and bambuterol demonstrated strong affinity for non-polar and moderately polar phases, predicting good membrane penetration and blood-brain barrier permeability. Interestingly, some β-agonists (bambuterol, fenoterol, buphenine and irsoxsuprine) with polar groups showed unexpectedly weak silica gel retention, highlighting their dominant lipophilic contributions...Thus, the polar phases (silica gel, DIOL) enhanced radical scavenging activity, whereas non-polar phases often reduced it. The developed HPTLC-IA method, integrating selective stationary phases and two-radical assays, offers a novel and cost-effective approach for screening the possible variation of antioxidant activity of drugs after their..."

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(R)-bambuterol Ameliorates DSS-Induced Colitis in Mice Fed a High-Fat Diet via Modulating Immune Response, Intestinal Barrier Integrity, Gut Microbiota, and Metabolomic Profiles. (PubMed, Arch Biochem Biophys) - "In addition, 16S rDNA sequencing results indicated that (R)-BMB regulated the structure of the intestinal microbiome and relieved imbalances in this microbiome, and non-targeted metabolomics analysis revealed that (R)-BMB reversed the metabolic changes in mice with colitis fed a high-fat diet. In summary, these results indicate that (R)-BMB can serve as a novel alternative strategy for treating colitis in the context of high-fat diet consumption."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

(R)-Bambuterol Attenuates DSS-Induced Chronic Colitis by Suppressing Inflammation, Repairing Intestinal Barrier, and Modulating Gut Microbiota and Serum Metabolomic Profile. (PubMed, Eur J Pharmacol) - "Furthermore, 16S rDNA amplicon sequencing revealed that (R)-BMB restored the homeostasis of the intestinal microbiota, and untargeted metabolomics analysis revealed that the changes in the metabolomics profiles were restored after (R)-BMB treatment. In conclusion, (R)-BMB alleviated the mice with DSS-induced chronic colitis via inhibiting the immune response and reshaping the intestinal microbiota and metabolic profiles, which provides a preclinical foundation for future development of novel therapeutics for chronic colitis."

Journal • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Respiratory Diseases • Ulcerative Colitis • OCLN • TGFB1 • TJP1

Extensive electronic investigation of BMBH structure and adsorption locator on graphene with molecular dynamics of human serum albumin interaction. (PubMed, Sci Rep) - "A comprehensive electronic investigation of Bambuterol Hydrochloride (BMBH) was conducted to explore its structural properties, adsorption behavior on graphene, molecular docking interactions, and molecular dynamics perturbations...Additionally, molecular dynamics simulations were employed to evaluate the structural perturbations and dynamic behaviour of the BMBH/graphene and BMB/target complexes over time. The study offers a detailed understanding of the electronic and interactional properties of BMB, contributing to its potential applications in nanomaterial-based drug delivery and therapeutic interventions."

Journal • Alzheimer's Disease • CNS Disorders • Dementia

Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal route. (PubMed, Commun Biol) - "Indeed, even if the latter is more selective than other β2-mimetics towards bronchial β2-AR, cardiovascular effects (tachycardia, arrhythmias…) could occur upon cardiac β1-AR activation. Finally, intranasal administration of low doses of bambuterol gel in mice intoxicated with Aβ peptides, prevented long-term spatial memory impairment and showed beneficial effects on the survival of neurons and on synapse preservation."

Journal • Preclinical • Alzheimer's Disease • Asthma • Cardiovascular • CNS Disorders • Immunology • Respiratory Diseases

Determination of 13 potential anti-obesity agents in hair by dispersive liquid-liquid microextraction-assisted UHPLC-MS/MS. (PubMed, J Pharm Biomed Anal) - "The developed method successfully detected 13 anti-obesity agents within 11 min, including bambuterol, clenbuterol, ractopamine, clorprenaline, formoterol, salbutamol, terbutaline, procaterol, phentermine, bupropion, sibutramine, desmethyl sibutramine, and N,N-didesmethyl sibutramine, which improved the screening efficiency. The validated method was successfully applied to 369 real cases and detected six analytes, including bambuterol, salbutamol, terbutaline, sibutramine, desmethyl sibutramine, and N,N-didesmethyl sibutramine. This method offers several advantages, including simple pretreatment, high extraction efficiency, rapid extraction, solvent economy, and pollution mitigation, making it highly suitable for large-scale surveillance of usage of added anti-obesity agents."

Journal • Cardiovascular • Genetic Disorders • Obesity

Stability indicating eco-friendly quantitation of terbutaline and its pro-drug bambuterol using quantitative proton nuclear magnetic spectroscopy. (PubMed, BMC Chem) - "The method enables the assay of the two drugs in pure drug and pharmaceutical preparations. The method also enables the assay of the two drugs in the presence of each other; thus, it is considered a stability-indicating method where terbutaline is an acid degradation product of bambuterol."

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Rivastigmine-Bambuterol Hybrids as Selective Butyrylcholinesterase Inhibitors. (PubMed, Molecules) - "Further investigations indicated that MTR-3 (IC > 100,000 nM, IC = 78 nM) was the best compound in the series, showing high butyrylcholinesterase selectivity and inhibition potency, the potential to permeate the blood-brain barrier, and longer-lasting BChE inhibition than bambuterol. These compounds could be used to discover novel specific BChE inhibitors for the treatment of Alzheimer's disease."

Journal • Alzheimer's Disease • CNS Disorders • Pain

Determination of 14 β-agonists in animal meat by ultra high performance liquid chromatography-tandem mass spectrometry (PubMed, Se Pu) - "In this study, a method based on ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was established for the rapid detection of 14 β-agonists (clenbuterol, salbutamol, ractopamine, clorprenaline, terbutaline, tulobuterol, bromobuterol, bambuterol, zilpaterol, mabuterol, fenoterol, arformoterol, cimaterol, and cimbuterol) in animal food sources. The results were close to those of the national standard method, indicating that the method is accurate and reliable. Moreover, the proposed method has good stability and high accuracy; thus, it is suitable for the qualitative and quantitative determination of β-agonists in animal meat."

Journal • Cardiovascular • Movement Disorders

Application of wastewater-based epidemiology to estimate the usage of beta-agonists in 31 cities in China. (PubMed, Sci Total Environ) - "Salbutamol, clorprenaline and terbutaline were observed in practically all wastewater samples at concentrations of up to several ng/L, whereas the formoterol and bambuterol concentrations were below the detection limit in all samples...Beta-agonist consumption based on WBE was higher in some cities than that based on medical survey data, indicating potential illegal use. These results show that WBE can be a straightforward and supplementary method for monitoring beta-agonist usage at the population level and spatially."

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Idiopathic systemic capillary leak syndrome: a case report. (PubMed, BMC Nephrol) - "ISCLS is an extremely infrequent and commonly misdiagnosed disease. However, early diagnosis, treatment and prophylaxis through accumulated clinical data can prevent ISCLS recurrence and the development of related fatal complications. Therefore, clinicians need to be well aware of the variety of clinical characteristics and treatment options of this disease."

Journal • Acute Kidney Injury • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pain • Rare Diseases • Renal Disease

Investigating the Effect of Silver Nanoparticles on the Fluorescence Intensity of Bambuterol and its Active Metabolite Terbutaline Using FRET. (PubMed, J Fluoresc) - "The estimated Stern-Volmer quenching constant at several temperature settings proved that the quenching mechanism of the two drugs was dynamic quenching in case of BAM while it was static quenching in case of TER. The number of binding sites, binding constants, and corresponding thermodynamic parameters depending on the interaction system were estimated at 293, 313, and 333 °K and the results obtained were interpreted."

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Micelle-enhanced spectrofluorimetric method for the rapid determination of bronchodilator terbutaline and its prodrug bambuterol: Application for content uniformity test. (PubMed, Luminescence) - "The high sensitivity of the proposed approach allows its application in evaluating the content uniformity testing of the studied drugs in their tablets through using the official United States Pharmacopeia criteria (USP). Statistical analogies of the findings with that of the reported methods showed really good harmony and indicated no major differences in precision and accuracy."

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(RS)-bambuterol and its enantiomers: Potential improvement of (R)-bambuterol in mice with colitis. (PubMed, Int Immunopharmacol) - "The efficacy of (R)-BMB was more notable than aminosalicylic acid (5-ASA). (R)-BMB is either butyrilcholinesterase inhibitor or β2AR agonist which offers new treatment of colitis."

Journal • Preclinical • Asthma • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Pulmonary Disease • Respiratory Diseases • Ulcerative Colitis • IL17A • IL6

Identification of Compounds for Butyrylcholinesterase Inhibition. (PubMed, SLAS Discov) - "From the primary screening, we identified a group of 125 compounds that were further confirmed to inhibit BChE activity, including previously reported BChE inhibitors (e.g., bambuterol and rivastigmine) and potential novel BChE inhibitors (e.g., pancuronium bromide and NNC 756), representing diverse structural classes. The binding modes of these compounds were further studied using molecular docking analyses to identify the differences between the interactions of these BChE inhibitors within the active sites of AChE and BChE. Our qHTS approach allowed us to establish a robust and reliable process to screen large compound collections for potential BChE inhibitors."

Journal • Alzheimer's Disease • CNS Disorders • Pain

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice. (PubMed, Biology (Basel)) - "In conclusion, this study found that inhibition of BChE ameliorated episodic and spatial memories. This study also suggested that (R)-bambuterol as a BChE inhibitor has the potential application in the treatment of post-traumatic stress disorder (PTSD) and early cognitive decline."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Solid Tumor

Rapid Detection of Ractopamine and Salbutamol in Swine Urine by Immunochromatography Based on Selenium Nanoparticles. (PubMed, Int J Nanomedicine) - "No cross-reaction occurred with clenbuterol, bambuterol and phenylethanolamine A. Samples were tested consistently across different batches of kits for swine urine...It is easy to operate, sensitive, specific, and stable This kit is suitable for the rapid and real-time detection of RAC and SAL residues in swine urine samples. Swine urines samples were used under approval from the Experimental Animal Ethics committee of the Joint National Laboratory for Antibody Drug Engineering, Henan University."

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Quick simultaneous analysis of bambuterol and montelukast based on synchronous spectrofluorimetric technique. (PubMed, R Soc Open Sci) - "Additionally, the validation criteria were assessed in accordance with International Council of Harmonization (ICH) guidelines. The method was used for the estimation of both drugs in their raw materials, synthetic mixtures as well their combined tablets with good agreement between its results and those from the comparison method."

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G protein-coupled receptor-in-paper, a versatile chromatographic platform to study receptor-drug interaction. (PubMed, J Chromatogr A) - "The association constants of salbutamol, terbutaline and bambuterol to β-AR were calculated to be 2.02 × 10 M, 1.15 × 10 M, 1.75 × 10 M by adsorption energy distribution, which were in good line with the values from frontal analysis, zonal elution and previous literatures. We demonstrated that the GPCR-in-paper platform was cost-effective, easy to be modified for protein immobilization, and applicable in the receptor-drug interaction analysis. We believe such a platform sheds new light on paper chromatography for receptor-drug interaction analysis and other applications."

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β2- Adrenergic Signaling Regulates Graft Versus Host Disease after Allogenic Transplantation While Preserving Graft Versus Leukemia Effect (ASH 2019) - "There was no difference in BP and HR at day 21 and 28 after allo-HCT between mice receiving Bambuterol compared to mice receiving vehicle. In conclusion, these data reveal how β-AR signaling can influence donor T cell differentiation and function in murine GvHD models without decreasing GvL effect pointing to the feasibility of manipulation of β2-AR signaling to ameliorate clinical GvHD."

Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • Transplantation • CD44 • FOXP3 • IFNG • IL10 • IL17A

β2-adrenergic receptor activation on donor cells ameliorates acute GvHD. (PubMed, JCI Insight) - "Bambuterol preserved the GvT effect by inducing NKG2D+ effector cells and central memory T cells. These data reveal how β-AR signaling can be targeted to ameliorate GvHD severity while preserving GvT effect."

Journal • Graft versus Host Disease • Transplantation • NKG2D