Telcyta (canfosfamide) / MabVax - LARVOL DELTA

Human GST P1-1 Redesigned for Enhanced Catalytic Activity with the Anticancer Prodrug Telcyta and Improved Thermostability. (PubMed, Cancers (Basel)) - "The mutation Q85R was identified as an important contributor to the regained thermostability. These results represent a first step towards a functional ADEPT application for Telcyta."

Journal • Oncology

Characterization of Dog Glutathione Transferase P1-1, an Enzyme Relevant to Veterinary Medicine. (PubMed, Int J Mol Sci) - "Among established GST inhibitors, Cibacron Blue showed positive cooperativity with an IC value of 43 nM. Dog GST P1-1 catalyzes activation of the prodrug Telcyta, but the activity is significantly lower than that of the human homolog."

Journal • Immunology • Inflammatory Arthritis • Lupus • Oncology

"My memory says don’t believe in Telcyta." (@matthewherper)

Management and Outcomes of Patients with Fistulized Mesenchymal Tumors (SSO 2019) - "...At last follow up, one patient is deceased after 286 days while all others are alive...Percutaneous drainage, traditionally felt to be contraindicated, can be helpful in controlling symptoms without compromising oncologic outcome. Oncologic resection with good outcomes can be achieved once patients are medically optimized."

Clinical