GM641 / Genervon - LARVOL DELTA

Scorpion Venom Heat-Resistant Synthetic Peptide Alleviates Neuronal Necroptosis in Alzheimer's Disease Model by Regulating Lnc Gm6410 Under PM2.5 Exposure. (PubMed, Int J Mol Sci) - "These findings offer new insights into the mechanism through which PM2.5 exposure accelerates the progression of AD, examined from the perspective of LncRNA. Furthermore, we offer new targets for the treatment and prevention of AD following PM2.5 exposure by investigating the mechanism of action of SVHRSP in alleviating AD."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders

Intrinsic and TDP-43 dysfunction-driven cellular degradation loads evoke Tfe3a- assoicated neuroprotective autophagy in large spinal motor neurons (ALS-MND 2024) - "Funding This work was supported by The Nakabayashi Trust for ALS Research, The Kato Memorial Trust for Nambyo Research, Daiichi-Sankyo Foundation of Life Science, Takeda Science Foundation, KAKENHI [grant numbers JP20H05345, JP22H04657, JP19K06933, JP22H02958, JP23H04266], and AMED-PRIME under [grant number JP23gm6410011h0003]... We identified motor neurons as the cell type that exhibits the highest autophagic flux in the spinal cord. Basal autophagic flux was enhanced more in ALS-susceptible larger SMNs than in ALS-resistant smaller SMNs and brainstem ocular motor neurons. The enhanced autophagic flux was neuro-protective, as its perturbation led to impaired motor axon outgrowth and was further amplified by knock-out (KO) of the ALS-related protein TDP-43."

Amyotrophic Lateral Sclerosis • CNS Disorders • TARDBP

The Relationship Between Gene Expression in the Placenta, Maternal Cytokine Levels, and Postpartum Depression (SOBP 2024) - "Funding Source : 1R01MH127315-01A1, 3R01MH127315-02S1, CDC-funded “Impact of the COVID-19 pandemic on adverse pregnancy outcomes”, and PREP scholars grant 5R25GM064118-22 Background: The inflammatory response is a potential mechanism underlying the onset of depression... We saw no association between the immune/inflammation genes associated with EPDS scores and cytokine levels, however our study was limited by variable timing of the blood draw. These results are exploratory, utilizing genes associated with EPDS scores at a nominal p-value, and we hope to replicate this analysis in a larger sample."

CNS Disorders • Depression • Mood Disorders • Psychiatry • IL1B • IL6

Reorganization of centralcarbon metabolism rescues TDP-43proteostasis collapse in spinalmotor neurons (ALS-MND 2023) - "Funding for this study was provided by the Nakabayashi Trust For ALS Research, The Kato Memorial Trust For Nambyo Research,Daiichi-Sankyo Foundation of Life Science, Takeda Science Foundation, KAKENHI grants (JP16K07045, JP19K06933, JP22H02958,JP23H04266) and AMED-PRIME (JP23gm6410011h0003), and the National Bio Resource Project (NBRP)... We identified an inherent cell-size-dependent differ-ence in intracellular ATP levels among the spinal motor neu-rons. Larger spinal neurons had lower intracellular ATP levelsassociated with lower intra-mitochondrial Ca2þlevels andmore enhanced cellular reduction. These metabolic disparitieswere exaggerated by perturbations of ALS-related factors,including TDP-43."

Amyotrophic Lateral Sclerosis • CNS Disorders • Metabolic Disorders • TARDBP

Gastrin releasing peptide-producing neurons in the hypothalamic suprachiasmatic nucleus mediate photic entrainment (Neuroscience 2023) - "Supported By AMED JP19dm0908001, AMED JP20dm0107162, AMED JP21zf0127003, AMED JP22gm6410030, KAKENHI (C):19 K08037, The Naito Foundation, TMFC Japan Foundation for applied Enzymology, JSPS 21J20226Most organisms display 24-hour fluctuations of various physiological phenomena (circadian rhythms)...We discovered that mice entrained significantly faster to the new light-dark cycle when the GRPNs are stimulated. From these results, we conclude that the SCN GRPNs may not be necessary for the generation of circadian rhythms but are essential for photic entrainment."

CNS Disorders • CASP3 • GRP-10

lncRNA Gm16410 Mediates PM.-Induced Macrophage Activation via PI3K/AKT Pathway. (PubMed, Front Cell Dev Biol) - "Thus, lncGm16410 might provide new insight into the prevention of PM. injury."

Journal • Immunology • Inflammation • Pneumonia

LncRNA Gm16410 regulates PM-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway. (PubMed, Ecotoxicol Environ Saf) - "The relationship of EndMT and lncRNA Gm16410 was verified in mouse lung tissues and MHC cells by PM exposure. The involvement of lncRNA Gm16410 in PM-induced EndMT highlights the potential of lncRNA to promote pulmonary fibrosis under environmental pollution."

Journal • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Respiratory Diseases