EC001 / Evolution BioThera - LARVOL DELTA

Whole-genome sequencing and antibiotic resistance analysis of a clinical carbapenem-resistant Enterobacter chuandaensis. (PubMed, Microbiol Spectr) - "The antimicrobial susceptibility analysis revealed that E. chuandaensis EC001 was resistant to the majority of commonly used antimicrobial agents, except for amikacin, chloramphenicol, and minocycline...In addition, an IS3000 element (3,018 bp) was detected upstream of blaNDM-1, while the bleomycin resistance-related gene bleMBL was located downstream of blaNDM-1, followed by trpF, dsbD, cutA, groS, groL, and ISKpn19...This study performed detailed genome characterization of the two plasmids (p1_EC001 and p2_EC001) carried by E. chuandaensis EC001 and analyzed their resistance gene profiles, plasmid features, and potential transmission mechanisms. The findings provide a theoretical foundation for the formulation of hospital infection control strategies, improve the capability for early warning and prevention of carbapenem-resistant Enterobacterales, and exhibit substantial scientific significance, as well as promise clinical application value."

Journal • Infectious Disease