CB101 / Cantabio Pharma - LARVOL DELTA

The promise of crowdfunding to finance R&D of novel diagnostics and therapeutics for incurable diseases that are underfunded. (PubMed, Drug Discov Today) - "Crowdfunding is a promising way to increase funding for R&D of D&T for incurable diseases such as Alzheimer's and Parkinson's disease that are underfunded, which has not been exploited to its full capacity. Investing into efforts to educate patients and researchers about its prospective is a worthwhile endeavor, which could lead to the generation of substantial new capital to finance the development of novel therapeutics for these diseases."

Journal • Alzheimer's Disease • CNS Disorders • Developmental Disorders • Movement Disorders • Parkinson's Disease

Evaluation of the antioxidant potential of Capsicum annuum L., C. baccatum L. and C. chinense Jacq. cultivars. (PubMed, Acta Sci Pol Technol Aliment) - "This study found useful results concerning the antioxidant potential of the fruits of Capsicum cultivars. The data obtained demonstrate the strong antioxidant activity of cultivars of Capsicum, which can be used in the food industry because of the commercial importance of these fruits."

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First assessment of persistent organic pollutants in the Greater rhea (Rhea americana), a near-threatened flightless herbivorous bird of the Pampas grasslands. (PubMed, Environ Sci Pollut Res Int) - "This study provides a new contribution to the scarce data on POP concentrations in South American bird species. Further investigations are needed to evaluate their potential effects on the health of individuals and populations."

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Evaluationn of Tolerability and Safety of CBT101, an Autologous Natural Killer Cell, in Patients With Solid Cancer (clinicaltrials.gov) - P1; N=12; Not yet recruiting; Sponsor: CHABiotech CO., Ltd

Clinical • New P1 trial • Oncology • Solid Tumor

Modeling primary and secondary fractionation effects and atmospheric transport of polychlorinated biphenyls through single-source emissions. (PubMed, Environ Geochem Health) - "Within ChnGIPERM, these phenomena were mainly controlled by the temperature and soil organic carbon content. The secondary fractionation of PCBs is a slow process, with model results suggesting a timescale of several decades."

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Complete Genome Sequence of Subcluster 5.2 Synechococcus sp. Strain CB0101, Isolated from the Chesapeake Bay. (PubMed, Microbiol Resour Announc) - "Here, we report the complete genome sequence of CB0101, obtained with PacBio sequencing. CB0101 contains a specialized array of genes which are involved in sensing, responding to, and persisting in the presence of environmental stress."

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A NOVEL DJ-1 PROTEIN TARGETING SMALL MOLECULE FOR THE POTENTIAL TREATMENT OF PARKINSON’S DISEASE (ADPD 2019) - "Lastly, we showed that this compound binds to native and oxidized DJ-1 potently and stabilizes the active 3D structure of the protein in vitro. Conclusion We showed that DJ-1 protein can be targeted by a variety of drug-like small molecules, and that the presented compound is a promising drug candidate for further optimization and development for the treatment of PD."

IDENTIFICATION OF A BIOLOGICALLY ACTIVE NOVEL SMALL MOLECULE BINDER OF MONOMERIC ALPHA-SYNUCLEIN BY A COMPUTATIONAL STRUCTURE-BASED FRAGMENT SCREENING APPROACH (ADPD 2019) - "Objectives : Alpha-synuclein (αSyn) fibril formation is a pathological hallmark of Parkinson’s disease (PD)... We identified a novel small molecule fragment binder (AS1) of monomeric αSyn with the ability to protect against oxidative stress caused toxicity in neuroblastoma cells. AS1 and AS1-S are therapeutic candidate hits for the treatment of PD."

DJ-1 MISFOLDS INTO BETA-SHEET STRUCTURED AGGREGATES THAT CO-LOCALIZE WITH PATHOLOGICAL AMYLOID DEPOSITS IN POST-MORTEM PARKINSON’S AND ALZHEIMER’S DISEASED HUMAN BRAIN TISSUE (ADPD 2019) - "These results suggest that DJ-1 loss of native function in disease may result from its structural destabilization due to its over-oxidation and consequently its aggregation. These findings suggest that the aggregation of DJ-1 may be a critical player in the development of the pathology of PD and AD."

Targeted and non-target screening of persistent organic pollutants and organophosphorus flame retardants in leachate and sediment from landfill sites in Gauteng Province, South Africa. (PubMed, Sci Total Environ) - "Common compounds identified by non-target screening with high-resolution mass spectrometry of leachate were diethyl [2‑(1, 3‑dioxolan‑2‑yl) ethyl] malonate (CHO) and 4‑(benzyloxy) cyclohexanone (CHO). These compounds are possibly associated with plasticizers used in the production of plastic and plastic coatings."

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