clindamycin phosphate / Generic mfg. - LARVOL DELTA

Microbiological Diversity and Antimicrobial Resistance in Adult Deep Neck Abscesses: A Tertiary Care Center Study (AAO-HNSF 2026) - "Deep neck abscesses demonstrate considerable microbiological diversity and a high prevalence of antimicrobial resistance in the studied population. Knowledge of local etiological agents and antibiotic susceptibility patterns is crucial to optimize empirical antibiotic therapy and improve clinical outcomes"

Clinical • Diabetes • Infectious Disease • Metabolic Disorders

Impact of Intravenous Antibiotic Selection on Postoperative Head and Neck Osseous Free Flap Reconstruction Outcomes (AAO-HNSF 2026) - "They were categorized according to post-op IV antibiotic regimen, including Ampicillin-Sulbactam, Cefazolin-Metronidazole, Clindamycin, and Lexofloxacin, administered within 3, 7, or 14 days post-op...There was a higher risk of pneumonia with 14 day course of Levofloxacin and both 7 and 14 day courses of Cefazolin-Metronidazole... Unasyn was associated with a decreased overall risk of post-op complications after osseous free flap reconstruction compared to other regimens. These results emphasize the importance of evidence-based post-op antibiotic selection considering complication risks."

Cardiovascular • Infectious Disease • Nephrology • Otorhinolaryngology • Pneumonia • Respiratory Diseases

Navigating Treatments in Folliculitis Decalvans: A Comprehensive Systematic Review. (PubMed, J Dtsch Dermatol Ges) - "Antibiotic-based therapies, particularly rifampicin-clindamycin combinations, showed favorable initial responses but frequent relapse after discontinuation. Isotretinoin demonstrated comparatively durable responses, with remission rates up to 82%. Biologic and targeted immunomodulatory therapies, including TNF-α inhibitors, apremilast, and various JAK inhibitors, showed promising outcomes in refractory cases. Current evidence supports individualized long-term treatment strategies focused on inflammation control and prevention of irreversible scarring."

Journal • Review • Alopecia • Immunology • Inflammation

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial. (PubMed, J Thorac Oncol) - P2 | "An uncomplicated, widely available, prophylactic regimen (COCOON DM) reduced the incidence of DAEIs with amivantamab-lazertinib and the impact of symptoms on QoL."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Characterization of the microbial resistome in a prospective trial of CBM588 in metastatic renal cell carcinoma (mRCC) offers mechanism for interplay between antibiotic (abx) use and immune checkpoint inhibitor (ICI) activity. (ASCO 2022) - P1 | " Pts with newly diagnosed mRCC with clear cell and/or sarcomatoid histology and intermediate/high risk disease per IMDC criteria were randomized to nivolumab/ipilimumab (nivo/ipi) or nivo/ipi/CBM588 in a 1:2 ratio...More specifically, nivo/ipi/CBM588 treatment led to a significant reduction in fosfomycin RGs and nitroimidazole (e.g., metronidazole) RGs in both pts with R (p = 0.019 and 0.042, respectively) and NR (p = 0.031 and p = 0.031, respectively). A multitude of other clinically relevant abx RGs were downregulated in pts receiving CBM588, including those mediating resistance to glycopeptide (e.g., vancomycin) and lincosamide (e.g., clindamycin) abx... In the first interrogation of the resistome in mRCC, we demonstrate that CBM588 decreases abx RGs associated with multiple commonly used classes of abx. Abx clear commensals and increase pathogenic (abx resistant) bacteria in the gut. Based on our data, we formulate the hypothesis that combining abx with CBM588..."

Checkpoint inhibition • Clinical • Genito-urinary Cancer • Immune Modulation • Inflammation • Lung Cancer • Oncology • Renal Cell Carcinoma • Sarcoma • Solid Tumor

Bacterial Contamination in Stored Blood for Transfusion and Associated Infectious Risks Among Patients with Cancer at Mbarara Regional Referral Hospital, in Uganda. (PubMed, J Blood Med) - "The isolates exhibited variable resistance to erythromycin, clindamycin, teicoplanin, vancomycin, tetracycline, nitrofurantoin, rifampicin, and trimethoprim-sulfamethoxazole. The four bacterial isolates were resistant to common antibiotics, which poses a risk of transmission of antibiotic-resistant strains to immunocompromised recipients with cancer. Notably, there was no infectious risk posed post-transfusion presumably due to the concurrent antibiotic therapy."

Journal • Infectious Disease • Oncology • Renal Cell Carcinoma

Effectiveness and tolerability of low dose clindamycin for treatment of prosthetic joint infections, a retrospective cohort study. (PubMed, BMC Infect Dis) - "Clindamycin (300 mg three times daily), administered as monotherapy or in combination with other antibiotics including rifampicin, appeared to be an effective and well-tolerated treatment for PJI. However, these regimens may be less effective in infections caused by S. aureus."

Journal • Retrospective data • Infectious Disease • Musculoskeletal Diseases

Methicillin resistance and antimicrobial non-susceptibility trends among Staphylococcus aureus clinical isolates in Aseer, Saudi Arabia (2013-2024): A retrospective laboratory-based surveillance study. (PubMed, PLoS One) - "In this single-center Aseer surveillance, MRSA became the majority of S. aureus during 2013-2024 and showed broad multidrug non-susceptibility, while vancomycin and daptomycin retained full in vitro activity. These local findings support sustained laboratory-based surveillance, Aseer-tailored empirical and stewardship guidance, and confirmatory testing of the emerging low-level linezolid non-susceptibility signal."

Journal • Retrospective data • Infectious Disease

Dermatologic prophylaxis and impact on patient-reported outcomes in first-line EGFR-mutant advanced NSCLC treated with amivantamab plus lazertinib: Results from the phase 2 COCOON trial. (ASCO 2025) - P2 | "COCOON DM included oral doxycycline/minocycline (100 mg BID Wks 1–12), clindamycin 1% lotion on scalp (QD Wks 13–52), chlorhexidine 4% to wash hands and feet QD, and non-comedogenic ceramide-based moisturizer to body and face QD. Among pts with EGFR-mutant advanced NSCLC, COCOON DM reduced the severity of dermatologic AEs and reduced the impact of those AEs on QoL compared to SoC DM."

Clinical • Metastases • P2 data • Patient reported outcomes • Dermatopathology • Infectious Disease • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

CAT GOT YOUR ARM: CLINDAMYCIN-RESISTANT STREPTOCOCCAL TOXIC SHOCK SYNDROME (CHEST 2026) - No abstract available

Infectious Disease • Septic Shock

Primary cutaneous cryptococcosis in a renal transplant recipient : A case-report (TTS 2026) - "He had complaints of pain in left foot for 15 days along with erythematous papular lesion on sole of left foot, for which he was started on oral Clindamycin...Mycophenolate mofetil was stopped... Cryptococcosis occurs in 2.8% solid organ transplant recipients, maximum being kidney and liver transplant recipients. A strong cellular immune response is essential for limiting Cryptococcal infection, which is why these infections are more common and more aggressive in immunocompromised patients. Anatomic site of infection and the host immune status are the determinants for the choice of treatment for Cryptococcal disease."

Case report • Clinical • Cardiovascular • CNS Disorders • Diabetes • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Solid Organ Transplantation • Transplantation

ADJUNCTIVE IVIG AND CLINDAMYCIN THERAPY IN SEVERE STREPTOCOCCAL TOXIC SHOCK SYNDROME PRESENTING AS BENIGN SKIN INFECTION (CHEST 2026) - No abstract available

Dermatology • Infectious Disease • Septic Shock

Antibiotic-induced gut microbiota dysbiosis in the PICU: mechanisms, clinical outcomes, and management strategies - a narrative review. (PubMed, Front Immunol) - "Anti-anaerobic antibiotics-particularly piperacillin-tazobactam, meropenem, and clindamycin-cause the most pronounced disruption, as quantified in adult ICU cohorts...Live probiotics require caution in high-risk populations, while non-live interventions are promising but need larger trials. Future research should employ longitudinal, multicentre studies with standardised reporting to elucidate host-microbe interactions in critically ill children."

Clinical data • Journal • Review • Critical care • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases • Septic Shock • Transplantation

Early Postoperative Inflammatory Responses Following Primary Total Hip Arthroplasty Using Different Antibiotic-Loaded Bone Cement Formulations: A Prospective Observational Cohort Study. (PubMed, J Clin Med) - " In this prospective observational cohort study, 35 patients undergoing primary cemented THA between January 2025 and January 2026 were allocated to one of five ALBC regimens according to routine clinical practice: gentamicin alone, gentamicin-vancomycin, gentamicin-clindamycin, gentamicin-meropenem, or gentamicin-tobramycin (n = 7 per group). Different antibiotic-loaded PMMA formulations were associated with distinct early postoperative inflammatory profiles. Gentamicin-meropenem was associated with comparatively lower CRP and ESR values; however, these exploratory findings do not establish superior infection-preventive efficacy and require confirmation in larger studies."

Journal • Observational data • Infectious Disease • Inflammation • Orthopedics • CRP

Various antibiotics susceptibility of acute hematogenous osteomyelitis caused by Staphylococcus aureus in children: A retrospective study. (PubMed, Medicine (Baltimore)) - "The MRSA group showed significantly higher resistance rates to levofloxacin, moxifloxacin, gentamicin, erythromycin, clindamycin, tigecycline, and sulfamethoxazole/trimethoprim compared with the MSSA group (P < .05). Currently, children with acute hematogenous osteomyelitis infected with MRSA show resistance to multiple antibiotics. MRSA infection is associated with more severe inflammatory responses, higher fever, longer hospital stays, higher medical costs, and a greater risk of complications."

Journal • Retrospective data • Anesthesia • Infectious Disease • Inflammation • Pediatrics • Septic Shock • CRP

Molecular Characterization of Listeria monocytogenes Isolated from Retail Yak Meat in Nyingchi, Xizang, China. (PubMed, Animals (Basel)) - "These 28 isolates exhibited varied antimicrobial resistance profiles, with universal resistance to trimethoprim-sulfamethoxazole, high resistance to erythromycin and clindamycin, and low resistance to vancomycin. Functional annotation revealed enrichment of genes involved in carbohydrate transport and metabolism and amino acid biosynthesis pathways. Our findings provide the first genomic insight into L. monocytogenes contamination in yak meat from Nyingchi, Xizang, China, highlighting the urgent need to strengthen food safety monitoring and hygiene management in this region."

Journal • Infectious Disease

Canine cholecystitis in the presence of Hammondia spp. infection. (PubMed, Vet Parasitol Reg Stud Reports) - "Treatment with clindamycin, and in one case additional enrofloxacin, resolved clinical and clinicopathologic changes in both dogs. This report highlights the importance of multilocus sequencing in protozoal identification in atypical infections, clinical manifestations of canine hepatobiliary hammondiasis, and need for regional Sarcocystidae prevalence studies."

Journal • Gastroenterology • Hepatology • Infectious Disease • Inflammation

Antibiotic prophylaxis in shoulder arthroplasty - increased number of early infection revisions in patients treated with clindamycin compared to cefuroxime. (PubMed, JSES Int) - "Clindamycin antibiotic prophylaxis may result in more early infection revisions in shoulder arthroplasty when compared to cefuroxime prophylaxis. This finding suggests that cefuroxime may be preferred over clindamycin for routine prophylaxis, although missing data warrant cautious interpretation."

Journal • Infectious Disease • Orthopedics

Supercritical Solution Impregnation: A Strategy to Prevent Prosthetic Infections. (PubMed, Glob Chall) - "Materials were impregnated with the antibiotic clindamycin dissolved in CO2 at 35-55°C and 100-200 bar...Drug loading increased with the CO2 density and the depressurization rate. The impregnated prosthesis pieces were free of solvent residues and exhibited antibacterial activity against S. epidermidis, evidenced by the formation of inhibition halos, confirming the effectiveness of this approach in preventing bacterial colonization."

Journal • Infectious Disease • Orthopedics

Oral antibiotics prescribing patterns and associated diarrhea risk: Public health implications. (PubMed, J Public Health Res) - "Amoxicillin/clavulanic acid, cefixime, and clindamycin ranked highest for diarrhea risk based on combined utilization and pharmacovigilance indicators. Considerable variability was observed in probiotic product composition and reporting across the market. Findings highlight antibiotics with higher AAD-related public health burden and support antimicrobial stewardship strategies, including evidence-based probiotic co-administration."

Journal

Leveraging Data Science for Conducting Observational Studies: Highlighting Advantages and Limitations Throughout the Evaluation of a Use Case. (PubMed, Mayo Clin Proc Digit Health) - "Skin excision cases exposed to intra-incisional clindamycin (from February 5 to October 14, 2025) and nonexposed (from January 1 to December 31, 2022) were defined as our cohorts of interest...The implementation of medical informatics tools and robust artificial intelligence algorithms will enable the conduct of end-to-end research pipelines. However, it is important to always consider humans in the loop, as oversight ensures reliability, accuracy, and robustness."

Journal • Observational data • Infectious Disease

Molecular epidemiology and antimicrobial resistance of human Streptococcus suis isolates in Guangxi, China, 2015-2021. (PubMed, Front Public Health) - "All isolates remained susceptible to ampicillin, ceftriaxone, levofloxacin, linezolid, vancomycin, and meropenem. Resistance to tetracycline, erythromycin, and clindamycin was common, while susceptibility to the β-lactams tested was largely preserved. Differences in virulence- and resistance-associated gene profiles were also observed between the major lineages, indicating distinct genetic characteristics among the locally circulating isolates."

Journal • Retrospective data • CNS Disorders • Infectious Disease

Cutibacterium acnes in Elective Spine Surgery: A 24-Year Characterization of Treated and Untreated Culture-Positive Patients. (PubMed, Spine J) - "Treated and untreated episodes differed across every culture-derived measure and in CRP and wound complications, whereas demographics and onset category were similar. Because the treating team's decision drove both the extent of sampling and the treatment itself, these features describe that decision rather than a proven infection status. Polymicrobial growth, a short TTP, more positive specimens and a higher CRP were each independently associated with the decision and remained so when sampling intensity was accounted for. They are candidate features for classifying a C. acnes-positive culture and require prospective validation against an accepted definition of low-grade spinal infection."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics • CRP

Brevibacterium casei: An Unusual Cause of Peritoneal Dialysis-Associated Peritonitis Managed by Catheter Salvage. (PubMed, Cureus) - "They are typically resistant not only to first-line beta-lactams but also to third-generation cephalosporins, clindamycin and trimethoprim-sulfamethoxazole, while usually remaining susceptible to vancomycin. Prompt microbiological identification enabled targeted intraperitoneal antibiotic therapy, resulting in complete clinical and cytological resolution, catheter preservation, and no relapse. This case highlights the potential for catheter salvage in selected cases, with early diagnosis, organism-directed treatment, and close monitoring."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease • Transplantation

Assessment of drug allergy and determination of safe alternative medications: a retrospective observational study. (PubMed, Front Med (Lausanne)) - "Among 167 patients with beta-lactam hypersensitivity, 104 underwent a standardized alternative non-beta-lactam antibiotic challenge protocol routinely implemented in our clinic, consisting of azithromycin, ciprofloxacin, metronidazole, clindamycin, tetracycline, and sulfamethoxazole-trimethoprim...Tramadol induced urticaria/angioedema in a subset of patients with NSAID-induced or NSAID-exacerbated cutaneous disease but was tolerated by all patients with NSAID-exacerbated respiratory disease...Celecoxib emerged as a safe alternative for patients with NSAID hypersensitivity, while azithromycin and tetracycline were well tolerated among selected patients with beta-lactam allergy. These findings support the use of structured diagnostic assessment to improve patient safety, prevent unnecessary drug avoidance, and guide evidence-based selection of alternative therapies."

Journal • Observational data • Retrospective data • Allergy • Anesthesia • Cardiovascular • Dermatology • Immunology • Respiratory Diseases • Urticaria