Gatiflox (gatifloxacin) / Orient Europharma - LARVOL DELTA

High-efficiency photocatalytic degradation of multiple quinolone antibiotics using a hybrid heterojunction with synergistic doping of boron and bismuth. (PubMed, J Colloid Interface Sci) - "This configuration exhibited exceptional reduction capacity and optimized photogenerated carrier separation and migration efficiency, leading to excellent degradation performance for gatifloxacin ((26.89 ± 1.94) × 10-2 min-1), sparfloxacin ((10.48 ± 2.03) × 10-2 min-1), moxifloxacin ((8.43 ± 1.02) × 10-2 min-1), and gemifloxacin ((4.13 ± 0.13) × 10-2 min-1). The degradation disparities among these quinolone antibiotics were systematically elucidated through analyses of steric hindrance, frontier molecular orbital energies, Mulliken charge distribution, reaction sites, and active species contribution rates. This study offers guidance for the systematic development of heterojunction photocatalysts to address fluoroquinolone pharmaceutical pollutants in aquatic ecosystems."

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Genomic Diversity of the tet(X)-Positive Myroides Species. (PubMed, Microorganisms) - "All of them were MDR to tetracycline, ceftazidime, gentamicin, amikacin, colistin, ciprofloxacin, gatifloxacin, and trimethoprim-sulfamethoxazole, with elevated minimum inhibitory concentrations (MICs) for tigecycline, florfenicol, and macrolides, but exhibited susceptibility to meropenem (100%), ampicillin-sulbactam (66.7%), and cefotaxime (33.3%). The phylogenetic analysis highlighted interspecies transmission risks, with ISCR2-mediated transposons of tet(X6) and estT-2 across Myroides, Riemerella, Empedobacter, Providencia, Acinetobacter, and Proteus species. These findings illuminate the genomic diversity driving antibiotic resistance in understudied bacterial taxa, with implications for global One Health strategies."

Journal • Infectious Disease

Rapid oxidation of gatifloxacin by ozone/sulfite process: Generation of reactive species and radical-mediated mechanisms. (PubMed, Water Res) - "Besides, using O3/S(IV) process as a pretreatment process can effectively control the formation of disinfection by-products (DBPs) during post-chlorination. The results provide new avenues for designing S(IV)-based AOPs and removing GAT efficiently."

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Structural insight in understanding the impact of mutation at position 88 and 94 of DNA gyrase A of Mycobacterium tuberculosis in developing resistance against delafloxacin. (PubMed, J Biol Phys) - "Based on literature information on drug-resistance related study for DNA gyrase, we generated 4 different mutant models 3ILW_G88A, 3ILW_G88C, 3ILW_D94G, and 3ILW_D94H by inserting two mutations at each position 88 and 94 in DNA gyrase chain A. Antibiotics Clinafloxacin, Gatifloxacin, Moxifloxacin, Sitafloxacin, Prulifloxacin, Besifloxacin, Delafloxacin, Ozenoxacin were docked with 3ILW_wild to understand their stability, binding affinity, and interaction pattern with the wild-type DNA gyrase (3ILW_wild). It is worth noting that mutation at position 94 of DNA gyrase A has a very profound effect as it shows a positive contribution towards increased resistance due to reduced binding affinity with delafloxacin. This study explains the structural changes and mechanism behind the resistance against Delafloxacin, and may also guide the structural changes required in existing Delafloxacin or other antibiotics to develop new therapeutics to overcome the issue of resistance."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Research on the Effects of Environmentally Friendly Additives on Mild Steel Electroless Plating. (PubMed, ACS Omega) - "During the plating procedure, green additives such as moxifloxacin and gatifloxacin were utilized as stabilizers. The data from the X-ray photoelectron spectral measurement showed that the binding energies 0.020 of the metallic components present in the preventive coatings demonstrated that the inner layer of the coatings contained Sn2 p3/2 and Sn2p accounted for high protection against corrosion resistance by this coatings methodology, and the outer layer of the coatings consisted of Cu3P, Cu2P3/2 O 1s, and O KLL. Electrochemical and quantum mechanical experiments were used to screen the additives' performance."

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Virulence factors and strain similarity of Staphylococcus aureus from a dairy farm demonstrate an increased risk of environmental transmission. (PubMed, Res Vet Sci) - "Genomics and proteomics analyses revealed various virulence factors, encompassing cytolytic toxins, immune evasion mechanisms, extracellular matrix (ECM)-binding proteins, proteases, enterotoxins, and chromosomal point mutations. In addition to virulence factors, this study shows how this bacterium moves around the farm, potentially becoming an environmental pathogen, increasing the risk of transmission and infection for humans and animals."

Journal • Infectious Disease

Deep eutectic solvent-based extraction approach for separation of fluoroquinolones from soil and sediment followed by their chromatographic determination. (PubMed, Talanta) - "Various hydrophilic deep eutectic solvents were investigated for separation of fluoroquinolone antibiotics (ciprofloxacin, fleroxacin, gatifloxacin, lomefloxacin, and ofloxacin) from soil and sediment. The proposed approach eliminates the need for additional tedious and time-consuming purification by solid-phase extraction. It was successfully applied to real soil and sediment samples, showing no significant matrix interference."

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Defect-rich Co,N-doped Ti3C2Tx/C/poly (3,4-ethylenedioxy thiophene) molecularly imprinted sensor for ultrasensitive electrochemical detection of gatifloxacin. (PubMed, Talanta) - "Experimental results indicated that the sensor has a wide linear response range (0.005-50 μM), a low detection limit (2 nM), and test RSD values are all less than 5 % in honey, milk and lake water, and reliable recoveries were achieved in comparison with standard chromatographic methods. Highlight its potential for practical antibiotic monitoring applications."

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Lasiodiplodia keratitis: A case series of 27 patients. (PubMed, Indian J Ophthalmol) - "Medical management with natamycin was effective in treating patients with Lasiodiplodia keratitis. However, advanced cases necessitated surgical intervention for complete resolution."

Journal • Infectious Disease • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

Green synthesis of selenium nanoparticles, and its conjugation with antibacterial proteins for enhancing their antibacterial activity. (PubMed, Bioorg Chem) - "The highest percentages of resistance were found for Amikacin (AK; 43 %), Cefuroxime (CXM; 42 %), Gatifloxacin (GAT; 38 %), Clindamycin (DA; 38 %), Ciprofloxacin (CIP; 36 %), Ceftriaxone (CRO; 35 %), Cefoperazone/Sulbactam (CES; 34 %), Nitrofurantoin (F; 31 %), Piperacillin (PRL; 26 %), and Amoxicillin/Clavulanic acid (AMC; 23 %). Results showed that 11S globulin had the highest antibacterial activity of 7S globulin and isolated protein, recording the MIC at 125 μg/mL. Conjugation between Se-NPs with antibacterial proteins (protein isolates, 7S, and 11S) has MBC (125 μg/mL) and MIC (125 μg/mL) values against tested bacteria."

Journal • Infectious Disease • Nephrology • Pneumonia

Screening of dry eye scheme based on cyclosporine, dexamethasone, perfluoroethyloctane eye drops for the treatment of diabetes patients with cataract and interpretation of its internal mechanism (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The First People's Hospital of Zigong City; The First People's Hospital of Zigong City

New trial • Cataract • Diabetes • Dry Eye Disease • Metabolic Disorders • Ophthalmology

Oxygen vacancy-mediated BiVO4/Bi3O4Br S-scheme heterojunction for enhanced photocatalytic degradation of antibiotics. (PubMed, J Colloid Interface Sci) - "A novel S-scheme heterojunction nanocomposite, BiVO4/Bi3O4Br, was designed and successfully synthesized in this work, which exhibits superior performance in degrading fluoroquinolone antibiotics (gatifloxacin hydrochloride (GAT) and lomefloxacin hydrochloride (LOM)) and tetracycline antibiotics (tetracycline hydrochloride (TCH)). Furthermore, the possible degradation routes of GAT were thoroughly explored, and the photocatalytic degradation mechanism of BiVO4/Bi3O4Br was comprehensively elucidated. This study highlights the combined action of S-scheme heterojunctions and OVs in boosting photocatalytic performance, thus providing a fresh perspective for developing OVs-rich S-scheme heterojunction photocatalysts for wastewater treatment."

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Microbiological Profile of Bacterial and Fungal Corneal Ulcers at a National Institute of Ophthalmology in Perú. (PubMed, Arch Soc Esp Oftalmol (Engl Ed)) - "Gram-positive bacteria were the most isolated, with S. epidermidis being the most frequent pathogen, followed by P. aeruginosa. S. epidermidis exhibited alarmingly low susceptibility to commonly used antibiotics."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Epidemiological and Antimicrobial Resistance Trends in Bacterial Keratitis: A Hospital-Based 10-Year Study (2014-2024). (PubMed, Microorganisms) - "The susceptibility to gatifloxacin, moxifloxacin, and ciprofloxacin significantly declined in both Gram-positive cocci and bacilli during the COVID-19 period (all p < 0.01). A similar trend was observed in Streptococcus and Corynebacterium, where resistance rose sharply from 12.0% and 22.2% pre-COVID-19 to 42.9% during COVID-19, and remained elevated at 40.0% and 46.4% post-COVID-19, respectively (p < 0.01). These findings emphasize the rapid rise of fluoroquinolone resistance in several bacterial groups, underscoring the urgent need for continuous surveillance and improved antimicrobial stewardship to enhance treatment outcomes."

Journal • Infectious Disease • Keratitis • Novel Coronavirus Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Deciphering the Transformed Bacterial Ocular Surface Microbiome in Diabetic Mice and Its Consequential Influence on Corneal Wound Healing Restoration. (PubMed, Exp Eye Res) - "The corneal epithelium of diabetic mice healed more rapidly after the application of gatifloxacin eye drops. The changes in the ocular surface microbiota of diabetic corneal wounds may be related to delayed healing of the corneal epithelium in diabetic mice, providing a new research target for the investigation of this pathology."

Journal • Preclinical • Infectious Disease • Type 1 Diabetes Mellitus

Preparation of Hybrid Molecularly Imprinted Polymers Based on 3-Triethoxysilylpropyl Methacrylic Amide for Solid-Phase Extraction of Gatifloxacin From Lake Water. (PubMed, J Sep Sci) - "The recovery was 96.52 ± 2.69%. The method exhibits the advantageous features of cost-effectiveness and high sensitivity, rendering it a promising approach for analyzing organic pollutants in water."

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Machine learning-assisted ratiometric fluorescence sensor array for recognition of multiple quinolones antibiotics. (PubMed, Food Chem) - "The addition of quinolone antibiotics (QNs) quench the Eu3+ fluorescence signal through the inner filter effect (IFE) and exhibit characteristic peaks, enabling ratio fluorescence detection of levofloxacin (LVLX), gatifloxacin (GTLX), and moxifloxacin (MXLX). The performance of the DT model is evaluated using accuracy, precision, recall, and F1 score, with stability and generalizability confirmed by stratified ten-fold cross-validation. This approach demonstrates high sensitivity, selectivity and applicability and provides an effective solution for antibiotic residue detection."

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Computational Studies on Recent Congeners of Fluoroquinolones and Nitroimidazoles for Their Use in Periodontal Therapy. (PubMed, J Pharm Bioallied Sci) - "From the results of the study, it can be observed that gatifloxacin and ciprofloxacin have more affinity and interactions with all four targets were analyzed. This study has effectively tested nitroimidazoles and fluoroquinolones comparatively and proposed that fluoroquinolones are more effective for blocking periodontitis."

Journal • Dental Disorders • Infectious Disease • Inflammation • Periodontitis • ER • IL1B

Micellar HPLC and UV Methods with Time Programming for Synchronically Quantifying Gatifloxacin and Its Preservative in Eye Drops: Appraisal of Ecological Impact. (PubMed, ACS Omega) - "Each technique showed respectable accuracy and precision (RSD ≤ 2%) and high linearity r2 > 0.9990. The proposed methodologies provide inexpensive, eco-friendly alternatives to conventional approaches, promoting a less harmful future for quality control and moving analytical chemistry closer to more sustainable methods."

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Historical distribution and multi-dimensional environmental risk assessments of antibiotics in coastal sediments affected by land-based human activities. (PubMed, Mar Pollut Bull) - "We proposed a multi-dimensional risk assessment of antibiotics, encompassing ecological and antimicrobial resistance (AMR) risks, complementing each other. The assessment revealed antibiotics with distinct risks: sulfacetamide (SCM) and clindamycin (CLIN) exhibited high ecological risks, while ERFX, ciprofloxacin (CFX), norfloxacin (NFX), gatifloxacin (GTFX), moxifloxacin (MXFX), and marbofloxacin (MBFX) presented high AMR risks."

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Pathogen Distribution, Drug Resistance, and Postoperative High-Quality Nursing Intervention Effectiveness in Knee Osteoarthritis Patients After Knee Arthroplasty With Postoperative Infection. (PubMed, J Multidiscip Healthc) - "Gram-positive bacteria showed high resistance to penicillin, benzylpenicillin, ampicillin, erythromycin, clindamycin, ciprofloxacin, and gentamicin, but low resistance to gatifloxacin, and no resistance to vancomycin or teicoplanin. Gram-negative bacteria showed high resistance to ciprofloxacin, levofloxacin, gentamicin, and tobramycin, but low resistance to cefepime, imipenem, meropenem, gatifloxacin, and amikacin...Serum levels of inflammatory markers are significantly higher in infection patients compared to non-infection patients. High-quality nursing interventions can effectively alleviate postoperative pain, promote recovery of knee joint function, enhance activities of daily living, and improve patient satisfaction."

Journal • Immunology • Infectious Disease • Oncology • Orthopedics • Osteoarthritis • Pain • Rheumatology • IL6 • TNFA

Effect of a Topical Antibiotic and Povidone-Iodine Versus Povidone Iodine Alone on Conjunctival Flora: A Systematic Review and Meta-Analysis. (PubMed, J Cataract Refract Surg) - "This review found no conclusive benefit of using preoperative topical antibiotics alongside PVI in routine ophthalmic procedures. However, in patients at high-risk of endophthalmitis, levofloxacin may offer additional protection."

Journal • Retrospective data • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Boosting peroxymonosulfate activation for complete removal of gatifloxacin by a bead-chain zeolitic imidazolate framework composite. (PubMed, J Colloid Interface Sci) - "In particular, MnO2@ZIF-2 was well dispersed on a microporous filter membrane to create an immobilized membrane reactor that displayed excellent catalytic performance for the continuous degradation of GAT for 300 min. This work offers an avenue for the design of catalysts with good catalytic activity, particularly for PMS activation in antibiotic wastewater remediation."

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Ultrasensitive Lateral Flow Immunoassay of Fluoroquinolone Antibiotic Gatifloxacin Using Au@Ag Nanoparticles as a Signal-Enhancing Label. (PubMed, Biosensors (Basel)) - "The enhanced LFIA was tested for GAT detection in raw meat samples, and the recoveries from meat were 78.1-114.8%. This method can be recommended as a promising instrument for the sensitive detection of various toxicants."

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Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing imidazothiadiazole moiety. (PubMed, Future Med Chem) - "Furthermore, compound 23 h showed no cytotoxicity to human LO2 cells, and did not show hemolysis even at ultra-high concentration. These results prompted that these compounds are valuable for further development as antimicrobial agents."

Journal • Hematological Disorders