Gatiflox (gatifloxacin) / Orient Europharma - LARVOL DELTA

Feedback-regulated 3D-printed hydrogel micropatch for integrated therapy of fungal keratitis. (PubMed, Theranostics) - "The dual-network hydrogel micropatch comprises an ROS-responsive hydrogel (RRH), voriconazole-loaded F127DA micelles (VCZ-F127DA), and gatifloxacin-loaded cerium metal-organic frameworks (GAT-MOFs). Transcriptomic analysis reveals suppression of NF-κB-mediated inflammatory signaling and upregulation of corneal regenerative pathways after treatment with MFCP. These findings demonstrate that MFCP represents a viable therapeutic option for fungal keratitis."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Development of HPTLC method for simultaneous estimation of Gatifloxacin and Flurbiprofen Sodium using 32 factorial design. (PubMed, Drug Dev Ind Pharm) - "RGB12 multi-colour assessment yielded a Whiteness score of 80.5%. A simple, accurate, robust, and AQbD-based HPTLC method was successfully developed and validated for simultaneous determination of gatifloxacin and flurbiprofen sodium in ophthalmic formulations."

Journal • Ophthalmology

Clofoctol-derived amphiphilic peptidomimetics exhibit broadened antimicrobial activity via multiple contributing mechanisms. (PubMed, J Adv Res) - "These results identify 30 as a promising antimicrobial agent with broadened antibacterial activity, favorable preliminary safety profiles, and multiple contributing antibacterial mechanisms."

Journal • Hematological Disorders • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Association Between Repeated Prophylactic Antimicrobial Eye Drop Use and Reduced Antimicrobial Susceptibility in Conjunctival and Nasal Commensal Bacteria. (PubMed, Antibiotics (Basel)) - "Minimum inhibitory concentration and susceptibility testing were performed on bacteria isolated from the conjunctival sac and nasal cavity using cefmenoxime, ceftazidime, levofloxacin, gatifloxacin, and moxifloxacin. The nasal microbiome α- and β-diversity did not differ significantly between groups, although exploratory LEfSe analysis suggested candidate taxon-level differences. Repeated prophylactic use of antibiotic eye drops was associated with reduced susceptibility in both the conjunctival sac and nasal cavity."

Journal

Natural-biopolymer sodium alginate magnetic multifunctional adsorbent with high capacity for broad-spectrum fluoroquinolone antibiotic removal from water (ACS-Fall 2026) - "Moreover, SA@Fe3O4-SPABS displayed high adsorption capacities for other FQs, namely 693.4 mg g-1 for levofloxacin, 536.1 mg g-1 for moxifloxacin, 366.5 mg g-1 for ofloxacin, and 362.3 mg g-1 for ciprofloxacin. In summary, SA@Fe3O4-SPABS represents a high-capacity, broad-spectrum, and easily recoverable adsorbent for removing fluoroquinolone residues from water. Schematic representation of the mechanisms underlying the adsorption of gatifloxacin antibiotics onto SA@Fe3O4-SPABS Graphical abstract"

Bacteriophage-derived ectolysin: a promising antimicrobial against fluoroquinolone-resistant MRSA. (PubMed, Br J Ophthalmol) - "These results demonstrate the therapeutic potential of P128 for the management of drug-resistant MRSA keratitis and its combination with antimicrobial peptides may expand the antimicrobial armamentarium against biofilm-associated infections."

Journal • Corneal Abrasion • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Pipette-tip micro solid-phase extraction coupled with HPLC-UV using a zwitterionic cyclodextrin-based copolymer for the determination of fluoroquinolones in food. (PubMed, J Chromatogr A) - "Under the optimized conditions, the method exhibited good linearity over the range of 1.0 to 500 μg L⁻¹, limits of detection of 0.07 and 0.24 μg L⁻¹, and limits of quantification of 0.23 and 0.72 μg L⁻¹ for lomefloxacin and gatifloxacin, respectively. Recoveries in spiked milk and honey ranged from 74.8% to 110.3%, and norfloxacin and enrofloxacin were also effectively enriched. The proposed miniaturized method provides a simple, economical, and practical approach for FQs enrichment and screening in complex food matrices."

Journal

Microbial contamination of donor corneoscleral rims and storage medium in keratoplasty. (PubMed, Jpn J Ophthalmol) - "Adding storage medium to the rim culture improved the detection of donor-associated microorganisms. When donor-derived C. albicans keratitis developed, susceptibility data from contemporaneous cultures enabled prompt targeted antifungal therapy and globe preservation, although repeated penetrating keratoplasty was ultimately required."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Bilateral Encephalitozoon hellem Keratoconjunctivitis With Microsporidial Spores in Parrot Feces. (PubMed, Cureus) - "She presented with a three-week history of bilateral ocular redness, itching, foreign-body sensation, and blurred vision that had not improved with topical fluorometholone, lubricants, and levofloxacin prescribed for presumed dry eye disease...The symptoms and corneal lesions resolved over six weeks during treatment with topical 0.02% polyhexamethylene biguanide, topical 0.5% gatifloxacin administered as post-scraping antibacterial prophylaxis, and a short course of oral albendazole, with no recurrence during four months of follow-up. This case highlights the diagnostic value of combining corneal-scraping microscopy with mNGS in treatment-refractory keratoconjunctivitis and the importance of obtaining a detailed avian-exposure history. It also illustrates that microscopic findings in avian feces alone cannot establish zoonotic transmission."

Journal • CNS Disorders • Conjunctivitis • Dry Eye Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Quinolones as anti-Toxoplasma agents: a comprehensive scoping review of in vitro and in vivo efficacy. (PubMed, Parasitol Res) - "In vitro analysis revealed a stark dichotomy: while clinical fluoroquinolones such as ciprofloxacin (IC50 = 3.44-20 µM) possessed weak-to-moderate activity, experimental scaffolds, particularly Hydroxyquinolone derivatives (e.g., Compound A, IC50 = 0.0004 μM) and endochin-like quinolones (ELQs) (e.g., ELQ-316, IC50 = 0.000007 μM) achieved sub-nanomolar potency by inhibiting the mitochondrial electron transport chain...Combination regimens (e.g., gatifloxacin-pyrimethamine) maximized efficacy while also lowering resistance risks...Efficacy is determined by precise structure activity relationships (particularly at the C-7 position) and advanced drug delivery systems. Despite ongoing translational challenges such as bioavailability optimization, tissue penetration barriers, and resistance management new quinolone compounds and combination regimens hold great promise as anti-Toxoplasma drugs."

Journal • Preclinical • Infectious Disease

Bacterial species distribution and antimicrobial susceptibility of canine ocular isolates in Japan: retrospective analysis of a diagnostic laboratory database. (PubMed, J Vet Med Sci) - "Cefotaxime demonstrated high activity against major Gram-positive pathogens, except for methicillin-resistant S. pseudintermedius, and Escherichia coli. In contrast, susceptibility to gatifloxacin varied markedly among the species, whereas the spectrum of gentamicin and polymyxin B was limited due to intrinsic resistance among common Gram-positive pathogens. These findings provide useful information for empirical antimicrobial selection in canine ocular infections in Japan."

Journal • Retrospective data • Infectious Disease • Ocular Infections • Ophthalmology

Exploration of 1,3,4-Thiadiazole Bearing Quinolin-2(1H)-One Hybrids as Potent Antimycobacterial Agents: Design, Synthesis, and In Silico Docking Techniques. (PubMed, Curr Org Synth) - "This study led to the successful synthesis of novel quinolin-2(1H)-one-fused 1,3,4- thiadiazoles."

Journal

Isolation, prevalence, and antimicrobial resistance profiles of Ureaplasma spp. and Mycoplasma hominis in cervical secretions from pregnant and postpartum women in Hangzhou, China. (PubMed, BMC Pregnancy Childbirth) - "Ureaplasma spp. was the predominant genital mycoplasma colonizing pregnant and postpartum women in Hangzhou, with the highest rate observed among those under 20 years of age. There was high in vitro resistance to commonly used antibiotics such as ciprofloxacin and roxithromycin among the isolates. These findings provide local epidemiologic and antimicrobial susceptibility data for pregnant and postpartum women and highlight the need for further multi-center studies to confirm regional resistance patterns and clarify their clinical implications, including when genital mycoplasma colonization may warrant intervention."

Journal • Infectious Disease

Transition-metal-free C-H arylation of unactivated arenes with aryl halides enabled by potassium tert-butoxide/gatifloxacin hydrochloride catalyst. (PubMed, Org Biomol Chem) - "Mechanistic investigations support a base-promoted homolytic aromatic substitution (BHAS) pathway involving single-electron transfer. Overall, this work provides an attractive and practical alternative to conventional cross-coupling strategies for accessing structurally diverse (hetero)biaryl scaffolds."

Journal

A case of microsporidial keratoconjunctivitis (PubMed, Zhonghua Yan Ke Za Zhi) - "Initially diagnosed as bilateral Thygeson superficial punctate keratitis, he was treated with 0.5% loteprednol etabonate suspension eye drops and other medications...The treatment regimen was adjusted to topical application of 1% voriconazole eye drops, 0.3% gatifloxacin ophthalmic gel, and 0.1% tacrolimus eye drops...One month after treatment, his symptoms were basically relieved, with the corneal infiltration and palpebral conjunctival papillae resolved. No recurrence was observed during the one-year follow-up."

Journal • Conjunctivitis • Dry Eye Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Structural Design of PES-CS-MMT Composite Membrane by Layer-by-Layer Self-Assembly for the Removal of Antibiotic Wastewater. (PubMed, Membranes (Basel)) - "In dynamic tests, the membrane displayed concentration-responsive adsorption behavior toward gatifloxacin, ciprofloxacin and ofloxacin, and different pollutants reached equilibrium or quasi-steady states at different rates. These results indicate that pollutant removal was jointly governed by interfacial interactions, gradient-layer diffusion resistance and overall transport behavior rather than by concentration alone. Overall, the layer-by-layer strategy provided a controllable route for constructing gradient functional layers on PES membranes, demonstrating potential for advanced treatment of antibiotic-containing wastewater and related pharmaceutical effluents."

Journal

Homochiral Metal-organic Framework (+)-diacetyl-L-tartaric-NH-MIL-101(Fe) as Stationary Phase for Enantioseparation in Capillary Electrochromatography. (PubMed, J Sep Sci) - "The column's chiral separation ability was assessed by analyzing seven model compounds, comprising four proton pump inhibitors (omeprazole, pantoprazole, lansoprazole, and tenatoprazole) and three fluoroquinolones (ofloxacin, sparfloxacin, and gatifloxacin). The column demonstrated excellent reproducibility, with inter-day, intra-day, and column-to-column relative standard deviations ranging from 1.22% to 4.98%. Additionally, molecular docking simulations were conducted using AutoDock Tools to investigate interactions between the stationary phase and analyte enantiomers, with computational results corroborating experimental CEC data."

Journal

Red mud-based heterojunction photocatalyst with rich oxygen vacancies: driving antibiotics electrons to simultaneously realize in-situ H2O2 production and wastewater purification. (PubMed, J Environ Manage) - "Under the reaction conditions of initial pH 4.5 and Bi4O5Br2-LDH/ARM dosage 0.05 g/L, 99% of GAT (100 mL, 20 mg/L) could be degraded and 127 μM of H2O2 could be produced after 60 min of reaction time. The proposed Bi4O5Br2-LDH/ARM photocatalytic system exhibited a green and sustainable strategy of driving the electrons of antibiotics to simultaneously achieve high-efficient H2O2 production and wastewater purification."

Journal

Dual drug loaded dissolvable annular microneedle patch to treat bacterial conjunctivitis. (PubMed, Int J Pharm) - "In vivo bacterial conjunctivitis model, AMP application led to faster resolution of conjunctival inflammation, improved stromal integrity, and restored corneal clarity relative to commercial formulation. Overall, AMP showed a minimally invasive, vision preserving ocular delivery system offering superior bioavailability and therapeutic efficacy of gatifloxacin and prednisolone in bacterial conjunctivitis model."

Journal • Anterior Segment Eye Disease • Conjunctivitis • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Molecular dynamics simulations to investigate Mycobacterium tuberculosis DNA-gyrase-fluoroquinolone complexes. (PubMed, J Mol Graph Model) - "In this study we performed molecular dynamics (MD) simulations on experimentally derived complexes of wild-type and Ala90Ser mutated Mtb DNA gyrase with three fluoroquinolones - moxifloxacin, gatifloxacin, and levofloxacin. The ranking of fluoroquinolones according to the stability of their DNA-gyrase complexes, binding energies, and key binding site residues, was in accordance with the in vitro reversibility assay data and the clinical effects of the drugs, thus validating the obtained MD results. Overall, our study contributes to a better understanding of the molecular mechanisms underlying fluoroquinolone activity, and demonstrates the potential of the MD simulations to predict the drugs' behavior within Mtb DNA-gyrase complexes."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Evaluation of drug causality in SJS/TEN: The role of the lymphocyte transformation test and conventional/modified IFN-γ ELISpot assays. (PubMed, World Allergy Organ J) - "Drugs tested included carbamazepine, ciprofloxacin, phenytoin, sulphamethoxazole, clozapine, and gatifloxacin. The Modified IFN-γ ELISpot assay outperformed the LTT and Conventional IFN-γ ELISpot in detecting drug-induced immune responses in SJS/TEN patients, particularly for high-risk drugs such as carbamazepine and sulphamethoxazole. Its superior sensitivity and reliability suggest it its role in identifying the culprit drugs in these patients."

Journal • Immunology • Steven-Johnson Syndrome • IFNG • IL2

A natural-biopolymer sodium alginate magnetic multifunctional adsorbent with high capacity for broad-spectrum fluoroquinolone antibiotic removal from water. (PubMed, J Environ Manage) - "Moreover, SA@Fe3O4-SPABS displayed high adsorption capacities for other FQs, namely 693.4 mg g-1 for levofloxacin, 536.1 mg g-1 for moxifloxacin, 366.5 mg g-1 for ofloxacin, and 362.3 mg g-1 for ciprofloxacin. In simulated wastewater, SA@Fe3O4-SPABS achieved a GAT removal efficiency of up to 86.7%. In summary, SA@Fe3O4-SPABS represents a high-capacity, broad-spectrum, and easily recoverable adsorbent for removing fluoroquinolone residues from water."

Journal

Nine-Year Trends in Antibiotic Resistance of Culture-Proven Pseudomonas aeruginosa Keratitis at a Tertiary Eye Center. (PubMed, Cornea) - "Over 9 years, Pseudomonas aeruginosa isolates retained sensitivity to older fluoroquinolones and aminoglycosides, while there was a trend toward increasing resistance to moxifloxacin. Cephalosporin and beta-lactam resistance remained high, except for ceftazidime and piperacillin-tazobactam. Despite the limitations of the study, these findings support a continued role for ciprofloxacin and aminoglycosides as empiric therapy options."

Journal • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Clinical observations on microneedle injection of glucocorticoids for l treatment of blepharocysts (ChiCTR) - P=N/A | N=17 | Not yet recruiting | Sponsor: Zhujiang Hospital of Southern Medical University; Zhujiang Hospital of Southern Medical University

New trial • Ophthalmology

Antibiotic nanozyme hydrogel depot for single-injection MDR bacterial keratitis therapy via localized antibacterial, pro-healing and corneal reinforcement. (PubMed, Mater Today Bio) - "In a murine model, single injection of ANHD into corneal stroma effectively treated multidrug-resistant Staphylococcus epidermidis keratitis, with complete bacterial eradication, significant inflammation reduction, and accelerated epithelial repair. These results demonstrated the potential of ANHD in the treatment of ocular infectious diseases."

Journal • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology