Gatiflox (gatifloxacin) / Orient Europharma - LARVOL DELTA

Lasiodiplodia keratitis: A case series of 27 patients. (PubMed, Indian J Ophthalmol) - "Medical management with natamycin was effective in treating patients with Lasiodiplodia keratitis. However, advanced cases necessitated surgical intervention for complete resolution."

Journal • Infectious Disease • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

Green synthesis of selenium nanoparticles, and its conjugation with antibacterial proteins for enhancing their antibacterial activity. (PubMed, Bioorg Chem) - "The highest percentages of resistance were found for Amikacin (AK; 43 %), Cefuroxime (CXM; 42 %), Gatifloxacin (GAT; 38 %), Clindamycin (DA; 38 %), Ciprofloxacin (CIP; 36 %), Ceftriaxone (CRO; 35 %), Cefoperazone/Sulbactam (CES; 34 %), Nitrofurantoin (F; 31 %), Piperacillin (PRL; 26 %), and Amoxicillin/Clavulanic acid (AMC; 23 %). Results showed that 11S globulin had the highest antibacterial activity of 7S globulin and isolated protein, recording the MIC at 125 μg/mL. Conjugation between Se-NPs with antibacterial proteins (protein isolates, 7S, and 11S) has MBC (125 μg/mL) and MIC (125 μg/mL) values against tested bacteria."

Journal • Infectious Disease • Nephrology • Pneumonia

Screening of dry eye scheme based on cyclosporine, dexamethasone, perfluoroethyloctane eye drops for the treatment of diabetes patients with cataract and interpretation of its internal mechanism (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The First People's Hospital of Zigong City; The First People's Hospital of Zigong City

New trial • Cataract • Diabetes • Dry Eye Disease • Metabolic Disorders • Ophthalmology

Oxygen vacancy-mediated BiVO4/Bi3O4Br S-scheme heterojunction for enhanced photocatalytic degradation of antibiotics. (PubMed, J Colloid Interface Sci) - "A novel S-scheme heterojunction nanocomposite, BiVO4/Bi3O4Br, was designed and successfully synthesized in this work, which exhibits superior performance in degrading fluoroquinolone antibiotics (gatifloxacin hydrochloride (GAT) and lomefloxacin hydrochloride (LOM)) and tetracycline antibiotics (tetracycline hydrochloride (TCH)). Furthermore, the possible degradation routes of GAT were thoroughly explored, and the photocatalytic degradation mechanism of BiVO4/Bi3O4Br was comprehensively elucidated. This study highlights the combined action of S-scheme heterojunctions and OVs in boosting photocatalytic performance, thus providing a fresh perspective for developing OVs-rich S-scheme heterojunction photocatalysts for wastewater treatment."

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Microbiological Profile of Bacterial and Fungal Corneal Ulcers at a National Institute of Ophthalmology in Perú. (PubMed, Arch Soc Esp Oftalmol (Engl Ed)) - "Gram-positive bacteria were the most isolated, with S. epidermidis being the most frequent pathogen, followed by P. aeruginosa. S. epidermidis exhibited alarmingly low susceptibility to commonly used antibiotics."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Epidemiological and Antimicrobial Resistance Trends in Bacterial Keratitis: A Hospital-Based 10-Year Study (2014-2024). (PubMed, Microorganisms) - "The susceptibility to gatifloxacin, moxifloxacin, and ciprofloxacin significantly declined in both Gram-positive cocci and bacilli during the COVID-19 period (all p < 0.01). A similar trend was observed in Streptococcus and Corynebacterium, where resistance rose sharply from 12.0% and 22.2% pre-COVID-19 to 42.9% during COVID-19, and remained elevated at 40.0% and 46.4% post-COVID-19, respectively (p < 0.01). These findings emphasize the rapid rise of fluoroquinolone resistance in several bacterial groups, underscoring the urgent need for continuous surveillance and improved antimicrobial stewardship to enhance treatment outcomes."

Journal • Infectious Disease • Keratitis • Novel Coronavirus Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Deciphering the Transformed Bacterial Ocular Surface Microbiome in Diabetic Mice and Its Consequential Influence on Corneal Wound Healing Restoration. (PubMed, Exp Eye Res) - "The corneal epithelium of diabetic mice healed more rapidly after the application of gatifloxacin eye drops. The changes in the ocular surface microbiota of diabetic corneal wounds may be related to delayed healing of the corneal epithelium in diabetic mice, providing a new research target for the investigation of this pathology."

Journal • Preclinical • Infectious Disease • Type 1 Diabetes Mellitus

Preparation of Hybrid Molecularly Imprinted Polymers Based on 3-Triethoxysilylpropyl Methacrylic Amide for Solid-Phase Extraction of Gatifloxacin From Lake Water. (PubMed, J Sep Sci) - "The recovery was 96.52 ± 2.69%. The method exhibits the advantageous features of cost-effectiveness and high sensitivity, rendering it a promising approach for analyzing organic pollutants in water."

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Machine learning-assisted ratiometric fluorescence sensor array for recognition of multiple quinolones antibiotics. (PubMed, Food Chem) - "The addition of quinolone antibiotics (QNs) quench the Eu3+ fluorescence signal through the inner filter effect (IFE) and exhibit characteristic peaks, enabling ratio fluorescence detection of levofloxacin (LVLX), gatifloxacin (GTLX), and moxifloxacin (MXLX). The performance of the DT model is evaluated using accuracy, precision, recall, and F1 score, with stability and generalizability confirmed by stratified ten-fold cross-validation. This approach demonstrates high sensitivity, selectivity and applicability and provides an effective solution for antibiotic residue detection."

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Computational Studies on Recent Congeners of Fluoroquinolones and Nitroimidazoles for Their Use in Periodontal Therapy. (PubMed, J Pharm Bioallied Sci) - "From the results of the study, it can be observed that gatifloxacin and ciprofloxacin have more affinity and interactions with all four targets were analyzed. This study has effectively tested nitroimidazoles and fluoroquinolones comparatively and proposed that fluoroquinolones are more effective for blocking periodontitis."

Journal • Dental Disorders • Infectious Disease • Inflammation • Periodontitis • ER • IL1B

Micellar HPLC and UV Methods with Time Programming for Synchronically Quantifying Gatifloxacin and Its Preservative in Eye Drops: Appraisal of Ecological Impact. (PubMed, ACS Omega) - "Each technique showed respectable accuracy and precision (RSD ≤ 2%) and high linearity r2 > 0.9990. The proposed methodologies provide inexpensive, eco-friendly alternatives to conventional approaches, promoting a less harmful future for quality control and moving analytical chemistry closer to more sustainable methods."

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Historical distribution and multi-dimensional environmental risk assessments of antibiotics in coastal sediments affected by land-based human activities. (PubMed, Mar Pollut Bull) - "We proposed a multi-dimensional risk assessment of antibiotics, encompassing ecological and antimicrobial resistance (AMR) risks, complementing each other. The assessment revealed antibiotics with distinct risks: sulfacetamide (SCM) and clindamycin (CLIN) exhibited high ecological risks, while ERFX, ciprofloxacin (CFX), norfloxacin (NFX), gatifloxacin (GTFX), moxifloxacin (MXFX), and marbofloxacin (MBFX) presented high AMR risks."

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Pathogen Distribution, Drug Resistance, and Postoperative High-Quality Nursing Intervention Effectiveness in Knee Osteoarthritis Patients After Knee Arthroplasty With Postoperative Infection. (PubMed, J Multidiscip Healthc) - "Gram-positive bacteria showed high resistance to penicillin, benzylpenicillin, ampicillin, erythromycin, clindamycin, ciprofloxacin, and gentamicin, but low resistance to gatifloxacin, and no resistance to vancomycin or teicoplanin. Gram-negative bacteria showed high resistance to ciprofloxacin, levofloxacin, gentamicin, and tobramycin, but low resistance to cefepime, imipenem, meropenem, gatifloxacin, and amikacin...Serum levels of inflammatory markers are significantly higher in infection patients compared to non-infection patients. High-quality nursing interventions can effectively alleviate postoperative pain, promote recovery of knee joint function, enhance activities of daily living, and improve patient satisfaction."

Journal • Immunology • Infectious Disease • Oncology • Orthopedics • Osteoarthritis • Pain • Rheumatology • IL6 • TNFA

Effect of a Topical Antibiotic and Povidone-Iodine Versus Povidone Iodine Alone on Conjunctival Flora: A Systematic Review and Meta-Analysis. (PubMed, J Cataract Refract Surg) - "This review found no conclusive benefit of using preoperative topical antibiotics alongside PVI in routine ophthalmic procedures. However, in patients at high-risk of endophthalmitis, levofloxacin may offer additional protection."

Journal • Retrospective data • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Boosting peroxymonosulfate activation for complete removal of gatifloxacin by a bead-chain zeolitic imidazolate framework composite. (PubMed, J Colloid Interface Sci) - "In particular, MnO2@ZIF-2 was well dispersed on a microporous filter membrane to create an immobilized membrane reactor that displayed excellent catalytic performance for the continuous degradation of GAT for 300 min. This work offers an avenue for the design of catalysts with good catalytic activity, particularly for PMS activation in antibiotic wastewater remediation."

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Ultrasensitive Lateral Flow Immunoassay of Fluoroquinolone Antibiotic Gatifloxacin Using Au@Ag Nanoparticles as a Signal-Enhancing Label. (PubMed, Biosensors (Basel)) - "The enhanced LFIA was tested for GAT detection in raw meat samples, and the recoveries from meat were 78.1-114.8%. This method can be recommended as a promising instrument for the sensitive detection of various toxicants."

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Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing imidazothiadiazole moiety. (PubMed, Future Med Chem) - "Furthermore, compound 23 h showed no cytotoxicity to human LO2 cells, and did not show hemolysis even at ultra-high concentration. These results prompted that these compounds are valuable for further development as antimicrobial agents."

Journal • Hematological Disorders

Molecular characteristics, clonal transmission, and risk factors of Clostridioides difficile among hospitalized patients in a tertiary hospital in Ningbo, China. (PubMed, Front Microbiol) - "ST54 strains showed higher resistance to erythromycin (100%) but lower resistance to moxifloxacin (18.2%) and gatifloxacin (18.2%) (χ 2 = 10.24-16.65, p < 0.05). ST35 strains exhibited higher resistance to ciprofloxacin (66.7%) and tetracycline (33.3%) than other STs (χ 2 = 13.30-20.19, p < 0.05)...Multiple C. difficile genotypes with varied antibiotic resistance patterns circulated in Ningbo, with ST35 causing nosocomial clonal transmission among different floors and buildings within the hospital. These findings and the identified risk factors necessitate enhanced surveillance and infection control in the region."

Journal • Critical care • Infectious Disease

Gatifloxacin hydrochloride confers broad-spectrum antibacterial activity against phytopathogenic bacteria. (PubMed, Front Microbiol) - "Exogenous application of gatifloxacin hydrochloride suppressed disease development caused by R. solanacearum and P. syringae. In summary, our results demonstrate the great potential of microorganism-derived compounds as broad-spectrum antibacterial compounds, providing alternative ways for the efficient control of bacterial plant diseases."

Journal • Infectious Disease

Determination of Nemonoxacin in Small Volumes of Rat Plasma and Bile by a Novel HPLC-Fluorescence Assay and Its Application to Disposition and Biliary Excretion Kinetics. (PubMed, Drug Des Devel Ther) - "A validated method was developed and found to be specific, precise and accurate. The applicability of this proposed method was substantiated in pharmacokinetic studies in rats."

Journal • Preclinical • Infectious Disease • Pneumonia • Respiratory Diseases

Copper(II) aromatic heterocyclic complexes of Gatifloxacin with multi-targeting capabilities for antibacterial therapy and combating antibiotic resistance. (PubMed, Bioorg Chem) - "In vivo experiments using a murine model of S.aureus infection demonstrate the significant antibacterial efficacy of Cu-1, providing robust support for its potential in treating S.aureus infections. This study demonstrates that the coordination complexes formed by copper, Gatifloxacin and suitable aromatic heterocyclic ligands exhibit multi-targeting characteristics against bacteria, offering a new direction for combating antibiotic resistance in antibacterial therapy."

Journal • Infectious Disease

Thelaziasis in an urban woman in Beijing: a case report and literature review. (PubMed, BMC Ophthalmol) - "This case highlights the thelaziasis in urban settings, emphasizing the need for ophthalmologists to consider parasitic infections in differential diagnosis even in well-maintained environments. Then, we provided an overview of human thelaziasis in China by mining publicly available databases from 2014 to 2023, suggesting a difference in regional distribution that warrants further epidemiological studies."

Journal • Review • Conjunctivitis • Dermatology • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Pruritus

Synthesis and Antimicrobial Activity of 3-Alkylidene-2-Indolone Derivatives. (PubMed, Molecules) - "Moreover, the three most active compounds 10f, 10g, and 10h were evaluated for their in vitro cytotoxicity in the HepG2 cancer cell line and L-02; only compound 10h was found to exert some level of cytotoxicity. These findings suggest that the synthesized 3-alkylidene-2-indolone derivatives hold potential for further development as antibacterial agents."

Journal • Infectious Disease • Oncology

Integrated virtual screening and MD simulation study to discover potential inhibitors of mycobacterial electron transfer flavoprotein oxidoreductase. (PubMed, PLoS One) - "This study underscores the efficacy of computational drug repurposing, highlighting bacterial energy metabolism and lipid catabolism as fruitful targets. Further research is necessary to validate the clinical suitability and efficacy of diacerein, levonadifloxacin, and gatifloxacin, potentially enhancing the arsenal against global TB."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Dual Detection of Norfloxacin and Gatifloxacin by Excitation Tuning Strategy Based on Yellow Carbon Dots. (PubMed, J Fluoresc) - "The detection limits of NOR and GAT are 0.0881 µM and 0.0125 µM, respectively. y-CDs prove practical application in the detection of NOR and GAT in milk and egg samples."

Journal • Infectious Disease