GS-1427 / Gilead - LARVOL DELTA

SWIFT: Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis (clinicaltrials.gov) - P2 | N=228 | Recruiting | Sponsor: Gilead Sciences | N=423 ➔ 228 | Trial completion date: Mar 2028 ➔ Feb 2027 | Trial primary completion date: May 2027 ➔ Oct 2025

Enrollment change • Trial completion date • Trial primary completion date • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

PHASE 1 BIOMARKER ANALYSES OF GS-1427 A NOVEL ORAL Α4Β7 INTEGRIN INHIBITOR FOR INFLAMMATORY BOWEL DISEASE DEMONSTRATE Α4Β7 SELECTIVITY AND ONCE DAILY DOSING (UEGW 2024) - "In conclusion, the exploratory biomarker results in this Phase 1 study in healthy subjects demonstrating extended α4β7 RO and α4β7 selectivity together with the pharmacokinetics, safety, and tolerability data (abstract in preparation) support further development of GS-1427 with a once daily dosing regimen in a Phase 2 study in IBD."

Biomarker • P1 data • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CD34

SWIFT: Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis (clinicaltrials.gov) - P2 | N=423 | Recruiting | Sponsor: Gilead Sciences | Not yet recruiting ➔ Recruiting

Enrollment open • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

SWIFT: Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis (clinicaltrials.gov) - P2 | N=423 | Not yet recruiting | Sponsor: Gilead Sciences

Combination therapy • Monotherapy • New P2 trial • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis