SENL103
/ SenlangBio
- LARVOL DELTA
Home
Next
Prev
1 to 8
Of
8
Go to page
1
November 24, 2025
On November 11, 2025, the official website of the Center for Drug Evaluation (CDE) of the National Medical Products Administration showed that the Investigational New Drug (IND) application for "SENL103 Autologous T Cell Injection"...was accepted by the CDE again (Acceptance No.: CXSL2500958), and its indication is systemic light chain (AL) amyloidosis .
New trial • Amyloidosis
August 29, 2025
PKC?-mediated regulation of RIPK4 in keratinocyte differentiation
(ESDR 2025)
- "Phosphomutants were used in NF-κB and IRF6 reporter assays in HEK293T cells, where two sites, S103 and T283, displayed RIPK4 biological function despite lacking hyperphosphorylation on western blot. ATPγS kinase assays confirmed RIPK4 kinase activity is essential, but autophosphorylation is dispensable, suggesting alternative activation mechanisms. Our findings challenge the current model by showing that PKCη negatively regulates RIPK4 and keratinocyte differentiation, and that RIPK4 activation is independent of autophosphorylation, emphasizing the complexity of RIPK4 signaling and warranting further investigation into its upstream regulation."
IRF6
September 03, 2025
S-103: Cardiovascular implications of sleep disruption in women: Emerging evidence and clinical implications
(WSS 2025)
- No abstract available
Clinical • Cardiovascular • CNS Disorders • Sleep Disorder
June 26, 2025
Efficacy and Safety of BCMA Nanobody CAR-T Cell Therapy in Relapsed or Refractory Plasma Cell Myeloma.
(PubMed, Blood Adv)
- P=N/A | "We explored the use of nanobody-based BCMA(S103) CAR-T cell therapy for R/R plasma cell myeloma (NCT04447573). The one-year OS rate was 61.1%, and PFS was 57.2%. BCMA CAR-T therapy, utilizing dual nanobody VHHs targeting BCMA, demonstrates a high overall response rate (ORR) and manageable safety profile in treating patients with R/R plasmacytic myeloma, including those with high-risk features such as extramedullary lesions, high-risk cytogenetic abnormalities, plasma cell leukemia, or anaplastic plasmacytoma."
IO biomarker • Journal • Hematological Malignancies • Leukemia • Multiple Myeloma • Oncology • Plasma Cell Leukemia • Plasmacytoma • TP53
April 08, 2025
s103: Diffuse large B cell lymphoma (DLBCL)
(EHA 2025)
- No abstract available
B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology
April 08, 2025
s103: Workshop: Crisis in Hematology in Ukraine
(EHA 2025)
- No abstract available
Hematological Disorders
May 06, 2025
The Safety and Efficacy of S103 in the Treatment of Refractory Generalized Myasthenia Gravis
(clinicaltrials.gov)
- P1 | N=24 | Not yet recruiting | Sponsor: Ting Chang, MD
New P1 trial • CNS Disorders • Myasthenia Gravis
October 05, 2023
the Safety and Efficacy of SENL103 Autologous T Cell Injection
(clinicaltrials.gov)
- P1 | N=20 | Recruiting | Sponsor: Hebei Senlang Biotechnology Inc., Ltd.
New P1 trial • Hematological Malignancies • Multiple Myeloma • Oncology
1 to 8
Of
8
Go to page
1