cimetropium bromide / Generic mfg. - LARVOL DELTA

Acupuncture vs. antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis. (PubMed, Front Physiol) - "Trimebutine and acupuncture had greater improvements than placebo, but no significant difference was shown between groups. Cimetropium, drotaverine, and acupuncture were all better than placebo in improving abdominal pain. Acupuncture was preferred over pinaverium in relieving global IBS symptoms, and acupuncture had lower adverse events than most antispasmodics."

Retrospective data • Review • Gastrointestinal Disorder • Immunology • Pain

Assessment of Cimetropium Bromide Use for the Detection of Gastric Neoplasms During Esophagogastroduodenoscopy. (PubMed, JAMA Netw Open) - "In this study, the use of cimetropium bromide as premedication was significantly associated with increased gastric neoplasm detection rates during EGD screening, and lesions in the gastric body were detected more frequently among those who received cimetropium bromide compared with those who did not. These findings suggest that cimetropium bromide may be considered as premedication before EGD examination among individuals with no contraindications."

Journal • Esophageal Cancer • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Malignancies • Lymphoma • Oncology • Solid Tumor

Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis. (PubMed, Front Pharmacol) - "Drotaverine, otilonium, cimetropium, pinaverium, and eluxadoline 100 mg had significantly high the relief of global IBS symptomss, for which drotaverine [RR, 2.45 (95% CI, 1.42 to 4.22), P-score = 0.95] was ranked first. But eluxadoline had more reported adverse events. Antispasmodics are still the first choice for the treatment of IBS."

Journal • Retrospective data • Review • Gastrointestinal Disorder • Immunology • Pain

Effectiveness of probiotics in infantile colic: A rapid review. (PubMed, Paediatr Child Health) - "Only two of the six prevention trials showed a significant decrease in crying time compared to placebo, although another two trials showed other benefits of probiotics, including reduced use of medications (simethicone and cimetropium bromide) and physician visits...This rapid review identified limited but favourable evidence of benefit of using probiotics for the treatment of IC in full-term breast-fed infants. While routine use of probiotics for treating or preventing IC cannot yet be recommended, it can be an option to manage IC."

Journal • Review

The Fragility of Randomized Placebo-Controlled Trials for Irritable Bowel Syndrome Management (ACG 2019) - "Only trials comparing Rifaximin, Eluxadoline, fecal microbiota transplant (FMT), probiotics, Ramosetron, Alosetron, physical activity, Cimetropium and Pinaverium to placebo met the inclusion criteria. Thirteen trials meeting the inclusion criteria were analyzed. The impact factor of the journals in which they were published ranged from 3.5-79. The median FI was 6 (range 1-38)."

Clinical