NX-201 / NexGenix - LARVOL DELTA

Coding-complete genome sequence of a bovine viral diarrhea virus subgenotype 1v strain isolated in China. (PubMed, Microbiol Resour Announc) - "It belongs to the 1v subgenotype. This report will increase our understanding of the epidemiology of BVDV in China."

Journal

Randomized, placebo-controlled, multiple ascending dose study of NX210c safety/tolerability and PK/PD in the elderly (EAN 2024) - "NX210c demonstrated a good safety profile following multiple doses in HEV and showed a PD relationship for biomarkers relevant to the BBB, including a reduction of plasma claudin-5. As BBB disruption is a driving feature of NDD, NX210c effect on target biomarkers may represent an important disease-modifying treatment for several neurological disorders and warrants further study in patients with NDD."

Clinical • PK/PD data • CNS Disorders • CLDN5