Zanosar (streptozocin) / Teva - LARVOL DELTA

Physical exercise as a therapeutic strategy in animal models of Alzheimer's disease: Molecular, behavioral, and histopathological evidence. (PubMed, Biochem Biophys Rep) - "The most frequent modeling approach was Aβ injection into the hippocampus of Wistar rats, followed by Streptozocin and other chemicals, and transgenic models...Physical exercise has been linked to lower oxidative stress and neuroinflammation, enhanced cognitive function, and fewer pathological changes in animal models of AD. However, variability in disease models and exercise protocols makes it difficult to identify the best exercise approach."

Journal • Preclinical • Review • Alzheimer's Disease • CNS Disorders • Dementia • Inflammation

Effects of Ozone Therapy on the Bladder of Rats with Streptozocin-Induced Diabetes. (PubMed, Drug Des Devel Ther) - "The thickness of the urothelial basement membrane in the DM+O group was greater than in the DM group. Study findings suggest ozone may limit oxidative stress, inflammation, and structural alterations in the diabetic bladder, indicating a potential supportive role alongside standard diabetes treatment; further studies are needed to confirm its clinical relevance."

Journal • Preclinical • Diabetes • Inflammation • Metabolic Disorders • IL10 • TGFB1 • TNFA

A GLP-1 receptor agonist enhances islet microvascular flow through nitric oxide-dependent mechanisms in a diabetic mouse model: investigation using intravital two-photon imaging. (PubMed, Diabetologia) - "Acute pharmacological activation of the GLP-1R rapidly enhances NO-dependent islet microvascular flow specifically under diabetic conditions. This previously unrecognised in vivo vascular response indicates dynamic regulation of the islet microenvironment by GLP-1R signalling, and suggests that rapid microvascular adaptation may contribute to preservation of beta cell function during metabolic stress."

Journal • Preclinical • Diabetes • Metabolic Disorders

Histone Deacetylase Inhibitor Combined with Rosiglitazone Improves Cognitive Function Via Microglial Polarization and Increased Mature/Pro-BDNF in Alzheimer's Disease. (PubMed, Adv Pharm Bull) - "Forty adult male Wistar rats were randomly assigned into five groups (n=8 per group): (1) Control group receiving saline, (2) AD model group (induced by i.c.v injection of Streptozocin), (3) AD+Rosiglitazone (ROSI) (4) AD+MS-275, and (5) AD+combined ROSI and MS-275 group. Also an increased mature brain-derived neurotrophic factor (BDNF)/pro-BDNF ratio was found in treated groups compared with STZ+saline (P<0.001). These findings suggest that co-administration of Rosiglitazone and MS-275 improves cognitive function in AD rats, potentially through shifting microglial polarization from the M1 to the M2 phenotype and enhancing synaptic strength via an increased mature BDNF/pro-BDNF ratio."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Solid Tumor • BDNF

Integrative Single-Cell RNA Sequencing and Machine Learning Reveals Candidate Plasma Protein-Associated Gene Signatures for Osteoporosis: A Preliminary Exploratory in Silico Study. (PubMed, Int J Gen Med) - "Molecular docking further demonstrated that the biomarkers could bind favorably with streptozocin and bruceantin...In summary, we identified JUN and CTSD as transcriptome-derived plasma protein-associated gene biomarkers in OP. These findings may provide preliminary insights that could inform future diagnostic and therapeutic investigations, although further validation in larger cohorts and direct proteomic studies are warranted."

Gene Signature • Journal • Osteoporosis • Rheumatology • CTSD

Peimisine ameliorates diabetic nephropathy by attenuating inflammation and ferroptosis through inhibition of the JAK/STAT pathway. (PubMed, Exp Cell Res) - "This study aimed to investigate the effect of peimisine on diabetic nephropathy (DN) and explore its potential mechanisms in a mouse model of high-fat diet and streptozocin-induced DN and cell model of high glucose (HG)-treated MPC5 cells...The inhibitory effects of peimisine on inflammation and ferroptosis in HG-treated MPC5 cells were reversed by RO8191. Our findings demonstrated that peimisine could ameliorate DN by attenuating inflammatory responses and ferroptosis through inhibition of the JAK/STAT signaling."

Journal • Diabetes • Diabetic Nephropathy • Inflammation • Metabolic Disorders • Nephrology • Renal Disease

Combined Islet and Kidney Xenotransplantation for Diabetic Nephropathy: Investigation of Pre-Vascularized Composite Grafts versus Sequential Islet-After-Kidney Transplantation in a Pig-to-Nonhuman Primate Model of Xenotransplantation. (PubMed, Xenotransplantation) - "In this limited series, sequential islet-after-kidney xenotransplantation restored metabolic control and represents a promising translational strategy for diabetic nephropathy."

Journal • Preclinical • Diabetes • Diabetic Nephropathy • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Transplantation

Review of Haematological Toxicities in Well-Differentiated Neuroendocrine Tumours: A Case Report and Comprehensive Review of the Literature. (PubMed, J Clin Med) - "First-line treatment with sunitinib plus octreotide achieved temporary disease stabilisation. Upon progression, peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE was initiated, resulting in stable disease but complicated by grade 3 thrombocytopenia...Further treatments with capecitabine and everolimus were limited by progression and significant thrombocytopenia. Therapy was switched to streptozocin plus 5-fluorouracil, which resulted in recovery of platelet counts, absence of haematological toxicity, and a sustained radiologic response until March 2025, when she presented with hepatic progression...Careful patient selection and close monitoring are essential. Streptozocin-based chemotherapy may be an effective and well-tolerated alternative for patients with treatment-limiting toxicity."

Journal • Gastrointestinal Neuroendocrine Tumor • Hematological Disorders • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Solid Tumor • Thrombocytopenia

Nanocomposites of Opuntia ficus-indica mucilage-mediated selenium nanoparticles and nanochitosan as antidiabetic candidates in streptozocin-induced diabetic rats. (PubMed, Front Bioeng Biotechnol) - "Accordingly, rats were divided into six groups, namely, normal control (GI), diabetic control (GII), treatment groups (GIII, GIV, and GV) administered nanocomposite powder (Ch/FM/SeNPs) with concentrations 0.1, 0.2, and 0.3 mg/kg, respectively, and (GVI) received glibenclamide at a dose of 5 mg/kg for 28 days. The results indicated that treatment of diabetic rats with nanocomposite powder (Ch/FM/SeNPs) at a concentration of 0.3 mg/kg resulted in significant increases in body weight, along with significant reductions in blood glucose levels and improvement in biological parameters, lipid profile, and hepatic and renal function. Promisingly, the nanocomposite (Ch/FM/SeNPs) can be used as a hypoglycemic compound; therefore, it could be recommended for the development of antidiabetic drugs."

Journal • Preclinical • Diabetes • Metabolic Disorders

Alkylating agents activate an SLFN11-dependent vulnerability that confers PARP-1 inhibitor sensitivity in kidney cancer. (PubMed, J Exp Clin Cancer Res) - "Our findings reveal an intrinsic SLFN11-dependent vulnerability in ccRCC that synergizes with alkylating agents to induce an acquired PARP-1 dependency, thereby sensitizing BRCA1/2-WT tumors to PARP inhibition. Therefore, this work uncovers a potential therapeutic strategy for targeting SLFN11-high kidney cancers."

Journal • Breast Cancer • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Kidney Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • BRCA1 • BRCA2 • HRD • SLFN11

Integration of network pharmacology, deep learning, and molecular biology reveals the efficacy of Citrus aurantium L. var. amara Engl. blossom extract in ameliorating diabetic osteoporosis. (PubMed, J Ethnopharmacol) - "CAVAE might exert anti-osteoporotic effects on T2DM mice through concurrent activation of PI3K/AKT and Wnt-3a/β-catenin pathways."

Journal • Diabetes • Dyspepsia • Genetic Disorders • Metabolic Disorders • Obesity • Orthopedics • Osteoporosis • Rheumatology • Type 2 Diabetes Mellitus

Changes in interstitial cells of Cajal calcium activity in a diabetic mouse model of delayed gastric emptying. (PubMed, J Physiol) - "Tamoxifen-treated B6.GCaMP5-KitCreERT2 female mice were used as non-diabetic controls (Non-Db), while mice treated with streptozocin to induce diabetes were categorized as having normal (Db-NGE) or delayed (Db-DGE) gastric emptying based on emptying of solids. Ectopic initiation was a key feature associated with delayed GE. The propagation length of ICC Ca2+ activity was inversely correlated to GE times and significantly reduced in stomach preparations from diabetic mice with delayed GE."

Journal • Preclinical • Gastrointestinal Disorder • Metabolic Disorders

The effect(s) of berberine from Berberis vulgaris L. (Berberidaceae) on treating type 1 diabetes mellitus in streptozotocin-induced diabetic rats. (PubMed, Iran J Basic Med Sci) - "Berberine from B. vulgaris effectively stimulates pancreatic β-cell regeneration, as evidenced by restored histoarchitecture, up-regulated Pdx1, and sustained glycemic control despite rapid clearance. This validates its traditional antidiabetic use and positions berberine as a promising disease-modifying agent."

Journal • Preclinical • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus • GAST • PDX1

Biomimetic MCC950-loaded cerium-layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin-induced mice. (PubMed, Br J Pharmacol) - "Findings reveal that pancreas-targeted CLMBM NPs exert potent anti-ROS, anti-inflammatory and antiapoptotic effects, highlighting a promising therapeutic avenue for targeted immunomodulation in type 1 diabetes."

Journal • Preclinical • Diabetes • Immunology • Inflammation • Metabolic Disorders • Pancreatitis • Type 1 Diabetes Mellitus • IL1B • IL6 • NLRP3

Enterococcus faecium colonization and persistence in a model of diabetic wound infection. (PubMed, Infect Immun) - "faecium, particularly vancomycin-resistant strains, is an understudied, clinically important cause of chronic diabetic wound infections. Using a low-dose streptozocin-induced diabetic mouse model, we characterized E. faecium wound infection dynamics and identified differences in colonization and clearance compared to non-diabetic animals...Histological analysis showed epithelial hyper thickening in both groups, indicating that diabetes and E. faecium each contribute to impaired wound healing. This study establishes a diabetic mouse model of E. faecium wound infection and suggests that E. faecium modulates innate immune responses to persist in the wound bed."

Journal • Diabetes • Infectious Disease • Metabolic Disorders

CircRbfox1 Contributes to Colonic Hypersensitivity in Rats With Diabetes by Altering HuC Subcellular Localization to Regulate RBFOX1 Expression. (PubMed, CNS Neurosci Ther) - "We conclude that circRbfox1 serves as pain regulator in diabetic colonic hypersensitivity and provides a potential therapeutic target in clinic."

Journal • Preclinical • Diabetes • Immunology • Metabolic Disorders • Pain • Type 1 Diabetes Mellitus • CACNA1D • CAV1 • RBFOX1

Effects of type 2 diabetes mellitus on fibrosis formation in post-tuberculosis lung disease (IMMUNOLOGY 2026) - "T2DM-mediated mechanisms for fibrosis formation in PTLD have not yet been fully characterized. C3HeB/FeJ mice were used to induce T2DM using a combination of a high fat diet and streptozocin... These results indicate that T2DM affects pro-inflammatory drivers of fibrosis formation, resulting in significant physiological differences. The C3HeB/FeJ mouse shows potential as a translational model to examine the underlying mechanisms of fibrosis formation in PTLD, including as exacerbated by T2DM."

Diabetes • Fibrosis • Immunology • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Tuberculosis • Type 2 Diabetes Mellitus • IL17A • TGFB1

Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity. (PubMed, Sci Adv) - "We observed that AMPK activation substantially reduced tumor formation in both diethylnitrosamine (DEN)-induced and streptozocin-induced (STAM) models of HCC via altered bile acid metabolism and inhibition of hepatic nuclear factor alpha (HNF4α) signaling. These findings provide mechanistic insights into AMPK biology and highlight the potential of AMPK as a therapeutic target, emphasizing the intricate interplay between metabolic dysregulation and cancer development."

Journal • Diabetes • Genetic Disorders • Hepatocellular Cancer • Metabolic Disorders • Obesity • Oncology • Solid Tumor • Type 2 Diabetes Mellitus

Potential gene expression meta-signatures predict neoadjuvant chemotherapy response in invasive breast cancer (AACR 2024) - "Dexamethasone, Vinblastine, and Streptozocin were candidate drugs that interacted with AGTR1, CGA, and S100B, respectively and are associated with progression and metastasis. Detection and evaluation of TME components are essential to predict NAC efficacy and avoid disease relapse. Finally, these findings emphasize the importance of assessing admixed populations to facilitate novel findings and alleviate disparities."

Clinical • Breast Cancer • Oncology • Solid Tumor • APOD • CCL19 • CD4 • CD8 • IL12A • IL17A • IL1B • IL2 • IL21 • IL22 • IL4 • NPY1R • PCSK1 • S100B • TNFSF12

Overexpression of Membrane Metalloendopeptidase Attenuates Oxidative Stress and Inflammation in Diabetic Neuropathy via the Nrf2/HO-1 Pathway. (PubMed, Curr Mol Med) - "Overexpression of MME mitigates oxidative stress and inflammation in painful diabetic neuropathy by activating the Nrf2/HO-1 signaling pathway."

Journal • Diabetic Neuropathy • Inflammation • Neuralgia • Pain • IL1B • IL6 • MME • TNFA

Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes. (PubMed, Kidney Int) - "Our results demonstrate that podocyte-derived PR3 induces caspase-3 cleavage to mediate podocyte apoptosis, thereby potentiating DKD progression, suggesting that pharmacological intervention of podocyte-derived PR3 may represent a promising therapeutic strategy for DKD."

Journal • Preclinical • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • CASP3 • PI3

Study on the Mechanism of Coreopsis tinctoria Nutt. in the Treatment of Diabetic Retinopathy Based on Gut Microbiota. (PubMed, Comb Chem High Throughput Screen) - "Coreopsis tinctoria Nutt. plays a role in the therapy of DR by modifying the composition of the gut microbiota and affecting lipid metabolism."

Journal • Diabetes • Diabetic Retinopathy • Inflammation • Metabolic Disorders • Ophthalmology • Pain • Retinal Disorders

A multi -center retrospective study of temozolomide plus capecitabine in patients with pancreatic neuroendocrine tumors in Japan (ENETS 2026) - "BACKGROUND: For unresectable pancreatic neuroendocrine tu - mors (pNETs), systemic therapies available in Japan include somatostatin analogs, targeted agents, and streptozocin. CAPTEM demonstrated meaningful antitumor acti - vity and well tolerated in Japanese pNETs pts. These real-world outcomes support its recognition as an important therapeutic op - tion for pNETs."

Retrospective data • CNS Disorders • Gastrointestinal Neuroendocrine Tumor • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Infectious Disease • Neuroendocrine Tumor • Oncology • Solid Tumor

Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma. (PubMed, Oral Health Prev Dent) - "ADA, NT5E and TYMS can serve as potential diagnostic markers and therapeutic targets for OSCC. The study has reference value for early diagnosis and the development of individualised treatment strategies."

Biomarker • Journal • Oncology • Oral Cancer • Solid Tumor • Squamous Cell Carcinoma • CD73 • MIR192 • MIR215 • MIR30A • MIR30B • NT5E • TYMS

Synergistic effects of antibiotics and fucoidan on dual-species Staphylococcus aureus and Acinetobacter baumannii biofilm in diabetic rat wound models. (PubMed, PLoS One) - "Fucoidan enhances the efficacy of gentamicin and imipenem against biofilm-associated infections and promotes diabetic wound healing. This combinatorial approach offers a promising strategy for managing chronic, biofilm-infected wounds and combating antibiotic resistance."

Journal • Preclinical • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Type 2 Diabetes Mellitus