Zanosar (streptozocin) / Teva - LARVOL DELTA

Effects of type 2 diabetes mellitus on fibrosis formation in post-tuberculosis lung disease (IMMUNOLOGY 2026) - "T2DM-mediated mechanisms for fibrosis formation in PTLD have not yet been fully characterized. C3HeB/FeJ mice were used to induce T2DM using a combination of a high fat diet and streptozocin... These results indicate that T2DM affects pro-inflammatory drivers of fibrosis formation, resulting in significant physiological differences. The C3HeB/FeJ mouse shows potential as a translational model to examine the underlying mechanisms of fibrosis formation in PTLD, including as exacerbated by T2DM."

Diabetes • Fibrosis • Immunology • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Tuberculosis • Type 2 Diabetes Mellitus • IL17A • TGFB1

Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes. (PubMed, Kidney Int) - "Our results demonstrate that podocyte-derived PR3 induces caspase-3 cleavage to mediate podocyte apoptosis, thereby potentiating DKD progression, suggesting that pharmacological intervention of podocyte-derived PR3 may represent a promising therapeutic strategy for DKD."

Journal • Preclinical • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • CASP3 • PI3

Study on the Mechanism of Coreopsis tinctoria Nutt. in the Treatment of Diabetic Retinopathy Based on Gut Microbiota. (PubMed, Comb Chem High Throughput Screen) - "Coreopsis tinctoria Nutt. plays a role in the therapy of DR by modifying the composition of the gut microbiota and affecting lipid metabolism."

Journal • Diabetes • Diabetic Retinopathy • Inflammation • Metabolic Disorders • Ophthalmology • Pain • Retinal Disorders

A multi -center retrospective study of temozolomide plus capecitabine in patients with pancreatic neuroendocrine tumors in Japan (ENETS 2026) - "BACKGROUND: For unresectable pancreatic neuroendocrine tu - mors (pNETs), systemic therapies available in Japan include somatostatin analogs, targeted agents, and streptozocin. CAPTEM demonstrated meaningful antitumor acti - vity and well tolerated in Japanese pNETs pts. These real-world outcomes support its recognition as an important therapeutic op - tion for pNETs."

Retrospective data • CNS Disorders • Gastrointestinal Neuroendocrine Tumor • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Infectious Disease • Neuroendocrine Tumor • Oncology • Solid Tumor

Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma. (PubMed, Oral Health Prev Dent) - "ADA, NT5E and TYMS can serve as potential diagnostic markers and therapeutic targets for OSCC. The study has reference value for early diagnosis and the development of individualised treatment strategies."

Biomarker • Journal • Oncology • Oral Cancer • Solid Tumor • Squamous Cell Carcinoma • CD73 • MIR192 • MIR215 • MIR30A • MIR30B • NT5E • TYMS

Synergistic effects of antibiotics and fucoidan on dual-species Staphylococcus aureus and Acinetobacter baumannii biofilm in diabetic rat wound models. (PubMed, PLoS One) - "Fucoidan enhances the efficacy of gentamicin and imipenem against biofilm-associated infections and promotes diabetic wound healing. This combinatorial approach offers a promising strategy for managing chronic, biofilm-infected wounds and combating antibiotic resistance."

Journal • Preclinical • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Type 2 Diabetes Mellitus

Responses to medical treatment in patients with metastatic unresectable small intestinal neuroendocrine tumors - A single center study of 378 patients. (PubMed, J Neuroendocrinol) - "Patients treated with everolimus had a median PFS of 5 (95% CI: 0.3-10) months, and chemotherapy with streptozocin and 5-fluorouracil resulted in a median PFS of 8 (95% CI: 5-11) months. Re-introduction of PRRT with 2 additional cycles had reduced efficacy compared with the initial treatment. PFS was short in non-somatostatin receptor-based therapies like everolimus and chemotherapy."

Journal • Retrospective data • Endocrine Cancer • Neuroendocrine Tumor • Oncology • Solid Tumor • SSTR

Pathological effects of diabetic mice with Helicobacter pylori infection. (PubMed, World J Diabetes) - "The STZ-induced diabetic mouse model with H. pylori infection can significantly prolong the colonization time of H. pylori in the stomach and exacerbate the degree of damage to the stomach, liver, and kidney organs."

Journal • Preclinical • Infectious Disease • Inflammation • Metabolic Disorders • Mucositis

Systemic Loss of FKBPL Uncovers Diabetes-Dependent Pathways of Myocardial and Vascular Injury. (PubMed, Arterioscler Thromb Vasc Biol) - "FKBPL-based peptide mimetic, AD-01 (1 nM), in high-glucose conditions, upregulated endothelial vcam1 and glut1 mRNA expression, independent of miR-302b-5p. FKBPL plays an important role in glucose metabolism, endothelial function, angiogenesis, cardiac inflammation and function, and could be explored as a therapeutic target of cardiovascular disease both in nondiabetes and diabetes settings using precision medicine approach."

Journal • Cardiovascular • Diabetes • Hematological Malignancies • Leukemia • Metabolic Disorders • Oncology • CDH5 • COL1A1 • FKBP5 • ICAM1 • IL15 • IL22 • IL7 • LCN2 • LIF • MIR302B • POSTN • SIRT1 • SLC2A1 • VCAM1

aFGF rescues high glucose-induced senescent fibroblasts and improves diabetic wound healing by regulating SIRT1/STAT3 pathway. (PubMed, Sci Rep) - "We injected aFGF locally into the back wound of (Streptozocin) STZ-induced diabetic rats, and subsequently assessed its therapeutic impact on wound healing in vivo by measuring the wound healing rate and the expression of aging markers...Our findings suggested that aFGF ameliorates the dysfunction of senescent fibroblasts by modulating the SIRT1/STAT3 signaling axis, thereby accelerating diabetic wound healing. aFGF is a promising therapeutic candidate for the treatment of diabetic wounds."

Journal • Diabetes • Metabolic Disorders

EP3 promotes macrophage M1-polarization to play a critical role in diabetic renal injury. (PubMed, Biochem Pharmacol) - "In this study, diabetes was induced in mice with global or myeloid cell-selective Ep3 deficiency (Ep3-/-) and their respective controls by a high-fat diet and streptozocin administration...In vitro experiments further revealed that Ep3-/- or EP3 antagonism decreased not only macrophage M1-polarization sensitive to Rho kinase inhibition but also the production of PGE2 in such cells of mice and/or humans. Thus, EP3, whose activation may implicate a self-amplification process, is critically involved in diabetic renal injury via promoting Rho kinase-dependent macrophage M1-polarization to mediate inflammation that may further cause the occurrence of multiple types of RCD, delineating the receptor a promising therapeutic target for diabetic renal injury and diseases with similar mechanisms."

Journal • Diabetes • Diabetic Nephropathy • Inflammation • Metabolic Disorders • Nephrology • Renal Disease

LASP1 mediates ADAM17 upregulation in high glucose to promote fibrosis in diabetic kidneys. (PubMed, Diabetologia) - "LASP1 regulates the synthesis and activation of ADAM17 in mesangial cells and is required for the profibrotic response to high glucose. Its deletion protects against DKD in mice. Targeting LASP1 may have therapeutic value as an indirect method of ADAM17 inhibition to inhibit fibrosis in DKD."

Journal • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Fibrosis • Immunology • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus • ADAM17 • LASP1

A Specific Herbal Mixture of Lavandula, Cloves, Rosa, Astragalus, and Cornus Mas (LCRAC) Improves Cognitive Function in a Rat Model of Streptozotocin-Induced Mild Cognitive Impairment. (PubMed, Adv Biomed Res) - "Importantly, LCRAC administration did not induce any significant changes in serum biochemical markers or histopathological alterations in the kidney, liver, or hippocampus. The study suggests that LCRAC shows promise as a therapeutic agent for enhancing cognitive function and alleviating depressive-like symptoms in MCI without evident toxicity, warranting further clinical investigation."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Psychiatry

Electroacupuncture improves diabetes-associated cognitive impairment in rats: potential involvement of hippocampal insulin receptor substrates 1/phosphatidylinositol 3-kinase/protein kinase B signaling pathway activation. (PubMed, Neuroreport) - "Electroacupuncture's mechanism may be involved in activating the IRS1/PI3K/AKT pathway, promoting the expression of GLUTs and MCTs, and regulating hippocampal energy metabolism."

Journal • Preclinical • Alzheimer's Disease • Cognitive Disorders • Diabetes • Metabolic Disorders • PIK3CG

Phellodendron amurense Rupr. Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota. (PubMed, Nat Prod Bioprospect) - "In this study, a diabetic nephropathy (DN) rat model was established using 2% Streptozocin (STZ) solution, and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mechanism of Phellodendron amurense Rupr...Furthermore, PAP suppressed renal inflammation through gut microbiota reduction, thereby protecting against renal injury in DN rats. This study reveals that PAP alleviates DN symptoms by modulating gut microbiota, enhancing antioxidant and anti-fibrotic capacities, and inhibiting apoptotic pathways, comprehensively elucidating its multifaceted therapeutic mechanisms against DN."

Journal • Diabetic Nephropathy • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease • TGFB1

Marmelosin Protects Against Metabolic Disturbances in High-Fat Diet and Streptozotocin-Induced Diabetes. (PubMed, Diabetes Metab Syndr Obes) - "Marmelosin also reduced apoptosis by downregulating caspase-3 expression. These findings collectively suggest that marmelosin acts as a multifaceted protective effect, including metabolic regulation, anti-inflammatory, antioxidant, and anti-apoptotic activities, highlighting its potential as a promising therapeutic agent for the management of T2DM."

Journal • Diabetes • Dyslipidemia • Inflammation • Metabolic Disorders • Type 2 Diabetes Mellitus • CASP3 • IL1B • IL6 • TNFA

Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy. (PubMed, In Vivo) - "The tested PDEIs, pentoxifylline, sildenafil, and milrinone, exhibit significant anti-inflammatory and anti-apoptotic effects, highlighting their potential in slowing the progression of diabetic nephropathy."

IO biomarker • Journal • B Cell Lymphoma • Diabetes • Diabetic Nephropathy • Lymphoma • Metabolic Disorders • Nephrology • Oncology • Renal Disease • BAX • IL6 • TNFA

Canagliflozin Promotes Structural and Functional Changes in Proximal Tubular Cell Mitochondria of Hypertensive-Diabetic Mice. (PubMed, Int J Mol Sci) - "Four weeks after streptozocin (STZ) induction of type 1 diabetes in genetic hypertensive (Lin) mice, they were fed either CANA-infused chow or a regular diet for 1 week. In conclusion, in vivo CANA treatment positively affects proximal tubular cells' mitochondria in male hypertensive-diabetic mice with a minor impact in females. The improvement in mitochondrial function and structure might be key to the kidney-protective effects of CANA."

Journal • Preclinical • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus

Duodenal myoelectrical hyperactivity drives diabetic remission in rat models of type 2 diabetes. (PubMed, Diabetologia) - "ADES mimics RYGB-induced duodenal hyperactivity, offering comparable glucose-lowering effects. Targeting duodenal myoelectrical activity may provide a minimally invasive alternative to RYGB for diabetes treatment."

Journal • Preclinical • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus • PDX1

YAP1 inhibition protects retinal vascular endothelial cells under high glucose by inhibiting autophagy. (PubMed, Open Life Sci) - "To further evaluate the protective effect of YAP1 inhibition on retinal endothelial cells in vivo, a streptozocin-induced DR mouse model was employed...Additionally, YAP1 knockdown reversed glucose-induced nucleus translocation of NF-κB. This study demonstrated that inhibition of YAP1 exhibits a protective role against HG-induced RVEC injury, representing a novel target for the management and therapy of DR in clinics."

Journal • Diabetes • Diabetic Retinopathy • Inflammation • Metabolic Disorders • Retinal Disorders • YAP1

Aberrant STING signalling promotes endothelial dysfunction and neurovascular injury in diabetic retinopathy. (PubMed, Diabetologia) - "Our findings demonstrate endothelial-intrinsic activation of the cyclic GMP-AMP synthase (cGAS)/STING/IFN pathway as a key driver of retinal inflammation and neurovascular dysfunction in diabetes. Targeting this pathway may offer a potential therapeutic approach for early intervention in diabetic retinopathy."

Journal • Diabetic Retinopathy • Inflammation • Metabolic Disorders • Ocular Inflammation • Retinal Disorders • Type 2 Diabetes Mellitus • CD31 • CGAS • PECAM1 • STING

Real-World Determinants of Olanzapine Prescribing for Antiemetic Prophylaxis in Adults Receiving Highly-Emetogenic Chemotherapy. (PubMed, Hosp Pharm) - "Since 2017, guidelines recommend a four-drug prophylactic antiemetic regimen-5HT3 receptor antagonist (5HT3RA), NK1 receptor antagonist (NK1RA), dexamethasone, and olanzapine-for patients receiving highly emetogenic chemotherapy (HEC)...Adults ≥21 years initiating cisplatin, carmustine, dacarbazine, mechlorethamine, streptozocin, or cyclophosphamide plus anthracycline (AC) in 2022 were included...Despite guideline recommendations, prophylactic olanzapine use in HEC remains suboptimal, influenced by clinical and non-clinical contextual factors. Targeted efforts at information dissemination and updated prescribing systems are needed to promote equitable, evidence-based supportive care."

Journal • Real-world evidence • Chemotherapy-Induced Nausea and Vomiting • Hematological Disorders • Hematological Malignancies • Oncology

Anodic microbiota reassembly via cell-cell interactions confers oxygen resilience in microbial fuel cells. (PubMed, Bioresour Technol) - "Indole-3-acetic acid (IAA) and its precursors from anaerobes, together with streptozocin, phenazine, and rhamnolipid produced sequentially by aerobes, drove the anaerobic-aerobic transition...Subsequent cell-cell signaling guided anodic microbiome succession from Acinetobacter to Stenotrophomonas, and finally to Pseudomonas. These findings elucidate the anode microbiome transformation mechanism and confirm with a reassembled synthetic consortium that iMFCs can operate aerobically, providing key insights for scaling the technology."

Journal

Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in Chrebp Knockout Mice. (PubMed, Int J Mol Sci) - "Therefore, insulin and glucose signals are important for maintaining muscle and bone mass and function. However, further studies are needed to elucidate the mechanisms by which ChREBP deletion and insulin deficiency cause osteosarcopenia."

Journal • Preclinical • Diabetes • Metabolic Disorders • Muscular Atrophy • Osteoporosis • Rheumatology • Sarcopenia • Type 1 Diabetes Mellitus • IGF1

CD38 knockout attenuates type 2 diabetic renal injury by downregulating p53 and Bax via the ERK/JNK signaling pathway. (PubMed, Mol Immunol) - "CD38 deletion regulated body weight and fasting blood glucose, improved renal histopathological injury and apoptosis by inhibiting MAPK signaling pathway; CD38 deficiency alleviates diabetic nephropathy by inhibiting MAPK/p53-mediated apoptosis, highlighting its role as a potential therapeutic target."

IO biomarker • Journal • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Glomerulonephritis • Metabolic Disorders • Nephrology • Renal Calculi • Renal Disease • Type 2 Diabetes Mellitus • BAX • BCL2