metronidazole topical / Generic mfg. - LARVOL DELTA

Topical versus oral metronidazole for post-haemorrhoidectomy pain: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Colorectal Dis) - "Topical and oral metronidazole showed similar short-term analgesic efficacy after haemorrhoidectomy."

Clinical • Journal • Retrospective data • Review • Pain

The efficacy of metronidazole rinses in reducing surgical site infections and improving wound healing in patients with purulent appendicitis: a systematic review and meta-analysis. (PubMed, BMC Infect Dis) - "Larger multicenter trials are needed to validate the efficacy of metronidazole irrigation across diverse patient populations."

Journal • Retrospective data • Review • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Male Partner Treatment and the Potential Sexual Transmission of Bacterial Vaginosis: Considerations for Patient Counseling and Clinical Application in the United States. (PubMed, Am J Obstet Gynecol) - "However, for the first time, an open-label, randomized controlled trial in Australia showed a decrease in BV recurrences in women whose male partners were treated with a combination of oral metronidazole and topical clindamycin cream over 12 weeks. This has resulted in increasing questions from patients regarding both MPT and the sexual transmissibility of BV. Here, we review evidence regarding the sexual transmission of BV, discuss complexities with potential implementation of MPT, and provide a framework from which to counsel patients."

Journal • Gynecology • Vaginitis

A case of delayed cutaneous S. marcescens after rhinoplasty . (PubMed, Dermatol Online J) - "Initial treatments, including intralesional corticosteroids, oral doxycycline, and topical metronidazole, failed to resolve the infection...The patient's abscess resolved following a course of levofloxacin but surgery was required to remove remnant scar tissue. This case underscores the importance of considering atypical pathogens in chronic cutaneous infections following cosmetic procedures, even in immunocompetent patients. Increased awareness among clinicians can aid in prompt diagnosis and targeted therapy."

Journal • Aesthetic Medicine • Infectious Disease

Curcumin-loaded Nanofibers versus Metronidazole Gel in the Treatment of Chronic Periodontitis: A Double-blind, Randomized Controlled Trial. (PubMed, J Pharm Bioallied Sci) - "Notably, the curcumin-loaded nanofiber group demonstrated statistically significant greater reductions in PD and CAL at three months compared to the metronidazole gel group (P < 0.05). Curcumin-loaded metronidazole was used in nanofibers technology on chronic periodontitis patients, showing the possibility of improving therapeutic results, especially in posteriori periods, compared to the conventional metronidazole gel."

Journal • Dental Disorders • Inflammation • Periodontitis

Metronidazole-Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis. (PubMed, Adv Healthc Mater) - "In animal studies, the topical application of nGel/MNZ significantly attenuates the inflammatory response in periodontitis, reduces the expression of key inflammatory factors interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α), and improves the balance of the microbial composition of gingival crevicular fluid (GCF). The study demonstrates that cyclodextrin nanogel (nGel) loaded with metronidazole not only provides an efficient drug delivery route but also has potential clinical applications and offers a novel strategy for the local treatment of periodontitis."

Journal • Dental Disorders • Oncology • Periodontitis • IL1B • TNFA

Efficacy and safety of 0.75% metronidazole gel in patients with mild chronic paronychia: a randomized, double-blind, placebo-controlled trial (EADV 2025) - "The 0.75% metronidazole gel is well tolerated and contributes to clinical improvement in subjects with chronic mild paronychia and health education combined with waterproof measures are also beneficial. Table 1. Patient Baseline Characteristics Patients, N Age, mean (SD), year Gender Male, No."

Clinical • Dermatitis • Dermatology • Immunology • Inflammation

Facial demodicosis with sharply demarcated islands of sparing: A case series (EADV 2025) - "Common treatments included topical or oral ivermectin, topical permethrin cream, oral metronidazole, topical azelaic acid, tea tree oil wash, systemic low-dose isotretinoin, and broadband light (BBL) laser (Table I). Island-sparing facial demodicosis is a distinct clinical variant that can mimic other dermatoses. Awareness of this pattern, together with dermoscopy, facilitates prompt diagnosis and appropriate therapy. The sharply demarcated sparing suggests regional differences in pilosebaceous anatomy or cutaneous microbiota that constrain mite proliferation—an observation warranting further investigation."

Clinical • Dermatitis • Dermatology • Inflammation

When the Skin Sees Double: Cutaneous Lupus and Rosacea, a Confusing Duo (EADV 2025) - "He was treated with topical metronidazole and oral azithromycin...Metronidazole and azithromycin are effective treatments; the latter is preferred due to reduced photosensitivity compared to tetracyclines... Diagnosing facial erythema remains complex due to overlapping causes. Long-term follow-up and careful differential diagnosis are vital, especially when autoimmune comorbidities are present. A multidisciplinary approach improves outcomes in such challenging clinical scenarios."

Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Dry Eye Disease • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Ocular Inflammation • Ophthalmology • Polycythemia Vera • Rosacea • Systemic Lupus Erythematosus

Childhood granulomatous periorificial dermatitis – a case report with dermoscopic and reflectance confocal microscopy clues (EADV 2025) - "According to the patient's mother, prior empirical treatment with topical tacrolimus did not result in a clinical improvement...The patient experienced marked clinical improvement following an 8-week course of systemic and topical erythromycin in association with topical metronidazole and adapalene... This case demonstrates diagnostic difficulties associated with CGPD. While none of the non-invasive imaging modalities provides specific findings for CGPD, combined use of dermoscopy and RCM may help to narrow the differential diagnosis by indicating a granulomatous process. Treatment of CGPD is challenging."

Case report • Clinical • Dermatitis • Dermatology • Immunology

Nodular Rosacea: A Case Series of Three Patients with Clinical, Histopathologic, and Differential Diagnostic Insights (EADV 2025) - "Prior treatment with clobetasol and high-dose prednisone was ineffective... All patients were treated with oral methylprednisolone (16 mg/day tapered after 1 week), azithromycin (500 mg three times weekly for 6 weeks), topical metronidazole (0.75% cream in the morning), and ivermectin (1% cream at night)... Nodular rosacea may mimic various dermatoses including seborrheic dermatitis, pseudolymphoma and histoid leprosy, complicating diagnosis. This case series emphasizes the importance of using immunohistochemistry and special staining techniques to differentiate nodular rosacea from these conditions. A combined treatment approach, including oral anti-inflammatory agents, topical antimicrobials, and isotretinoin, proved to be highly effective in achieving long-term remission in all cases."

Clinical • Acne Vulgaris • B Cell Lymphoma • Dermatitis • Dermatology • Fibrosis • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Pruritus • Rosacea • Seborrheic Dermatitis • CD20

osacea Fulminans in Early Pregnancy: Therapeutic Challenges and Case-Based Approach at 11 Weeks' Gestation (EADV 2025) - "Prednisone 20 mg/day was initiated, combined with a 3-day course of azithromycin 500 mg— both considered relatively safe in pregnancy...Due to partial response and the need to avoid teratogenic agents like tetracyclines or isotretinoin, oral dapsone 50 mg daily—used with caution in pregnancy— was introduced at 20 weeks... Management of rosacea fulminans in pregnancy requires balancing efficacy with fetal safety. Systemic corticosteroids and macrolides are first-line options. Topical metronidazole is safe and effective, while dapsone may be considered in refractory cases with hematologic monitoring."

Clinical • Dermatology • Hematological Disorders • Immunology • Inflammation • Rosacea

Chronic Nipple Sinus Secondary to Demodex folliculorum Infestation: A Case Report. (PubMed, Cureus) - "Histopathology of the excised tissue unexpectedly demonstrated heavy infestation of pilosebaceous units with D. folliculorum mites within chronic granulation tissue. Following surgery, the patient was treated with oral metronidazole and topical agents (tea tree oil wash and sulfur soap)."

Journal • Infectious Disease • Novel Coronavirus Disease

Topical drug treatment of rosacea in Switzerland: A descriptive study using Swiss claims data. (PubMed, Dermatology) - "The discrepancy between annual and overall prevalence suggests that many patients treated with TRM receive intermittent therapy. Despite the decline in use, metronidazole remains the most frequently used TRM in Switzerland, but use of ivermectin increased continuously. The slight decrease in tetracycline-antibiotics among patients treated with TRM after 2017 might reflect efficacy of ivermectin."

Journal • Dermatology • Rosacea

3D-printed hydrogel patch for controlled topical release: Gelatin/tannic acid formulation meets additive manufacturing. (PubMed, Eur J Pharm Biopharm) - "The gelatin/tannic acid and gelatin/tannic acid-metronidazole hydrogels had similar gelation temperatures, while the salicylic acid hydrogel gelled at a lower temperature...In vitro permeation tests revealed salicylic acid penetrated the epidermal barrier and accumulated within the skin, despite low overall retention of both active ingredients. These findings highlight the potential of personalized 3D-printed patches for treating mask-related skin conditions."

Journal • Dermatology • Rosacea

Development of 3D-Printed Hydrogel Disks as Standardized Platform for Evaluating Excipient Impact on Metronidazole's Antimicrobial Activity. (PubMed, Pharmaceutics) - "The tested plasticizers were compatible with MET. This platform aids rational formulation design and screening for optimal excipients in designed formulations and for various pharmaceutical applications."

Journal • Infectious Disease

Sequential combination treatment with doxycycline and isotretinoin in association with topical calcineurin inhibitors and metronidazole cream for the treatment of rosacea fulminans. (PubMed, Ital J Dermatol Venerol) - No abstract available

Journal • Dermatology • Rosacea

A Single-Center Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of Sarecycline for Treating Periorificial Dermatitis. (PubMed, J Drugs Dermatol) - "Sarecycline may be an appropriate novel treatment option for POD and should be explored further in a larger population study capturing this data. Furthermore, there is a need for more large-scale clinical studies evaluating treatment options for POD, with a focus on the impacts of antibiotic resistance and its implications on public health."

Journal • Dermatitis • Dermatology • Immunology

Box-Behnken Design Assisted Optimization and Characterization of Chitosan Film for Simultaneous Topical Delivery of Ascorbic Acid and Metronidazole. (PubMed, Pharmaceutics) - "Moreover, in vitro release studies revealed a co-release pattern, delivering both bioactive compounds simultaneously. These findings suggest that the prepared chitosan-based film could serve as a promising platform for topical delivery."

Journal

Evaluation of antibiotic therapy in the treatment of hidradenitis suppurativa (SID 2025) - "To evaluate this, eleven cohorts were created within TriNetX using International Classification of Disease (ICD)-10 codes, each composed of patients prescribed either oral doxycycline, oral minocycline, oral and topical clindamycin, oral amoxicillin, oral and topical metronidazole, oral moxifloxacin, oral rifampin, or oral and topical dapsone within three years of HS diagnosis. Each cohort was excluded from usage of the other measured medications, adalimumab, secukinumab, or bimekizumab, and excluded from a history of deroofing procedures...These results question the efficacy of doxycycline monotherapy as a first-line therapy in the treatment of HS. Additional studies should be conducted to further analyze the efficacy of both oral and topical antibiotic monotherapies in the treatment of HS."

Late-breaking abstract • Dermatology • Hidradenitis Suppurativa • Immunology

Late ulcerating infantile hemangioma responsive to propranolol (SID 2025) - "The patient had been previously treated with topical timolol solution (0.5%) for eight months and metronidazole cream (0.75%) and mupirocin ointment (2%) for one month, all without resolution...The patient's topical regimen was changed to gentamicin ointment (0.1%) with Duoderm dressings, but the ulceration and drainage persisted for another two weeks...Ulceration of IHs most commonly occurs while they are proliferating in the first 3-6 months of life, when propranolol therapy is thought to be most beneficial. This case highlights the rare occurrence of late ulceration and demonstrates that propranolol remains effective even when initiated later in the disease course."

Pain

Complete Resolution of Granulomatous Rosacea With Topical Ruxolitinib. (PubMed, Cureus) - "After failing multiple established treatments, the patient achieved near-complete resolution of her condition following 10 months of combination therapy with topical ruxolitinib and metronidazole cream. This case highlights the potential efficacy of topical JAK inhibitors as a novel therapeutic approach for recalcitrant GR."

Journal • Dermatology • Inflammation • Rosacea

The Effectiveness of Metronidazole as a Localized Drug Delivery System in the Treatment of Periodontal Diseases: A Narrative Review. (PubMed, Cureus) - "Commonly utilized local drug delivery agents for patients suffering from periodontitis include tetracycline, metronidazole, minocycline, doxycycline, and chlorhexidine...A 25% metronidazole gel is used widely in periodontitis patients...To achieve favorable clinical outcomes, the non-surgical treatment of peri-implantitis should involve the systemic or local administration of metronidazole. Thus, the role of metronidazole in the emergence of periodontal diseases and its therapeutic uses are investigated in this narrative review."

Journal • Review • Dental Disorders • Infectious Disease • Periodontitis

Lotilaner for Demodex Blepharitis: The Journey from Veterinary Use to Human Medicine. (PubMed, J Ocul Pharmacol Ther) - "In 2023, Xdemvy® (0.25% lotilaner ophthalmic solution) was approved by the U.S. FDA for treating Demodex blepharitis in humans...Other products evaluated for treating Demodex blepharitis include ivermectin eye ointment, ivermectin-metronidazole gel, permethrin cream, terpinen-4-ol wipes, and hypochlorous acid spray. Along with these, azithromycin eye drop, azithromycin/loteprednol eye drop, and other treatments are being evaluated for treating blepharitis. Other drugs from the isoxazoline drug class including afoxolaner, sarolaner, and fluralaner, could also be potentially explored for human use."

Journal • Review • Dry Eye Disease • Infectious Disease • Inflammatory Arthritis • Lyme Disease • Ocular Inflammation • Ophthalmology

Emulgel Containing Metronidazole and Clindamycin for the Treatment of Rosacea. (PubMed, Pharmaceutics) - "Also, there is no antagonism between the two antibiotics and the MD-CM-gel shows better results when compared to the formulations with the antibiotics separately and to commercial formulations. It is suggested that, following detailed preclinical and clinical studies, MD-CM-gel could be considered as an alternative for treating rosacea."

Journal • Dermatology • Developmental Disorders • Infectious Disease • Inflammation • Rosacea