metronidazole topical / Generic mfg. - LARVOL DELTA

Clinician Treatment Patterns of Perioral Dermatitis: A Retrospective Chart Review (AAD 2026) - "Topical metronidazole (45.5%) and doxycycline (23.3%) were most often prescribed first-line. POD prescribing patterns differ among providers. This and high rates of treatment discontinuation highlight the need for guidelines for POD and continued education on best practices across providers."

Retrospective data • Review • Dermatitis • Dermatology • Immunology

Insurance Coverage of Rosacea Topicals: A Cross-Sectional Review (AAD 2026) - " Azelaic acid gel, oxymetazoline hydrochloride cream, ivermectin cream, sulfacetamide sodium–sulfur cleanser, metronidazole gel, minocycline foam, brimonidine gel, and Epsolay benzoyl peroxide (BPO) cream were reviewed across UnitedHealth Group, Elevance (Anthem), CVS Health (Aetna), Cigna, Health Care Service Corporation Blue Cross Blue Shield (BCBS), Kaiser Permanente, BCBS Florida, BCBS Michigan, Centene, and Blue Shield of California. Only two rosacea topicals were consistently covered by major commercial insurers, and many plans imposed quantity limits and step therapy barriers. Interestingly, metronidazole, identified as less effective than the uncovered topicals, was the most covered agent. [5] This disconnect between evidence-based rosacea treatments and insurer restrictions underscores the need for reform and improved access."

Reimbursement • Review • US reimbursement • Dermatology • Inflammation • Rosacea

Eosinophilic-Rich Linear Immunoglobulin A Bullous Dermatosis (AAD 2026) - "The drug-induced variant is most commonly linked to vancomycin, though other implicated agents include trimethoprim-sulfamethoxazole, amoxicillin, nonsteroidal anti-inflammatory drugs, simvastatin, cyclosporine, furosemide, lithium, and various additional medications...Treatments—including metronidazole gel, prednisone, triamcinolone, mupirocin, and doxycycline—provided minimal relief...Eosinophil-rich LABD has been infrequently reported in both adult and pediatric patients. Known associations include COVID-19 vaccination, parvovirus B19 infection, hematologic malignancies, and certain medications."

Alopecia • Cough • Dermatology • Hematological Malignancies • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Novel Coronavirus Disease • Orthopedics • Pruritus • Respiratory Diseases

Pharmacokinetics of Transdermal Metronidazole (clinicaltrials.gov) - P4 | N=24 | Active, not recruiting | Sponsor: University of Iowa | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Jul 2026

Trial completion date • Trial primary completion date

Dermoscopic Response Predictors in Papulopustular Rosacea Treated with Topical Ivermectin and Metronidazole: A Prospective Observational Comparative Study. (PubMed, Clin Cosmet Investig Dermatol) - "Ten patients received ivermectin 10 mg/g cream and 13 received metronidazole 1% gel (non-randomized, based on physician preference), applied once daily for 8 weeks. PFPs in dermoscopy of moderate-to-severe PPR serve as positive predictors for optimal response to topical ivermectin, but not metronidazole. This observation warrants validation in larger controlled trials."

Journal • Observational data • Dermatology • Rosacea

Tunnel vision: Rethinking local therapy for perianal fistulas in Crohn's disease. (PubMed, J Crohns Colitis) - "There is an unmet need to generate novel local therapies that achieve long-lasting fistula closure. To facilitate their development, the delineation of host and microbial pathways contributing to PFCD pathogenesis and research in drug delivery systems are needed."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Efficacy and safety of 0.75% metronidazole gel in patients with mild chronic paronychia: a randomized, double-blind, placebo-controlled trial. (PubMed, J Am Acad Dermatol) - No abstract available

Clinical • Journal

METROCLIN: Metronidazole 2% Gel Versus Clindamycin 1% Gel for Moderate Acne Vulgaris (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: Jinnah Postgraduate Medical Centre

New P4 trial • Acne Vulgaris • Dermatology

Metronidazole SC Penetrance With Moisturizers (clinicaltrials.gov) - P=N/A | N=21 | Completed | Sponsor: Duke University | Recruiting ➔ Completed

Trial completion • Dermatology • Rosacea

Metronidazole is an effective method of analgesia following haemorrhoidectomy: a systematic review and meta-analysis. (PubMed, Int J Colorectal Dis) - "This review synthesises the best available evidence to support the use of metronidazole to reduce pain after excisional haemorrhoidectomy. While both oral and topical forms appear to be beneficial, topical administration appears to have a more effective analgesic effect from post-operative day 3."

Journal • Retrospective data • Review • Pain

Disseminated miliary lupus on the face: successful treatment with oral dapsone and topical metronidazole. (PubMed, An Bras Dermatol) - No abstract available

Journal • Immunology • Inflammatory Arthritis • Lupus

Evaluating the antimicrobial efficacy, growth factor release drug kinetics of titanium platelet-rich fibrin loaded with amoxiclav, metronidazole and neem gel: an in vitro study. (PubMed, J Korean Assoc Oral Maxillofac Surg) - "Hence present study aimed to evaluate the antimicrobial efficacy, drug kinetics and growth factor release of T-PRF injected with amoxicillin+clavulanic acid (amoxiclav gel), metronidazole (MTZ) and neem (NE) gels separately. Growth factor release was not compromised, aiding in the preservation of regenerative capacity. Therefore, T-PRF can be used as a SDDS."

Journal • Preclinical • Dental Disorders • Periodontitis

Dermal disposition characterization and development of a retrospective level A in vitro-in vivo relationship for topical metronidazole products. (PubMed, J Pharm Sci) - "These results suggest that the dermal infusion approach can be used to study dermal API disposition, which can aid in the comprehension of in vivo cutaneous pharmacokinetic (cPK) data. Furthermore, a mechanistic cPK understanding is essential for the successful development of new topical therapeutics and assessment of bioequivalence of TDPs, alike."

Journal • Preclinical • Retrospective data

Topical versus oral metronidazole for post-haemorrhoidectomy pain: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Colorectal Dis) - "Topical and oral metronidazole showed similar short-term analgesic efficacy after haemorrhoidectomy."

Clinical • Journal • Retrospective data • Review • Pain

The efficacy of metronidazole rinses in reducing surgical site infections and improving wound healing in patients with purulent appendicitis: a systematic review and meta-analysis. (PubMed, BMC Infect Dis) - "Larger multicenter trials are needed to validate the efficacy of metronidazole irrigation across diverse patient populations."

Journal • Retrospective data • Review • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Male Partner Treatment and the Potential Sexual Transmission of Bacterial Vaginosis: Considerations for Patient Counseling and Clinical Application in the United States. (PubMed, Am J Obstet Gynecol) - "However, for the first time, an open-label, randomized controlled trial in Australia showed a decrease in BV recurrences in women whose male partners were treated with a combination of oral metronidazole and topical clindamycin cream over 12 weeks. This has resulted in increasing questions from patients regarding both MPT and the sexual transmissibility of BV. Here, we review evidence regarding the sexual transmission of BV, discuss complexities with potential implementation of MPT, and provide a framework from which to counsel patients."

Journal • Gynecology • Vaginitis

A case of delayed cutaneous S. marcescens after rhinoplasty . (PubMed, Dermatol Online J) - "Initial treatments, including intralesional corticosteroids, oral doxycycline, and topical metronidazole, failed to resolve the infection...The patient's abscess resolved following a course of levofloxacin but surgery was required to remove remnant scar tissue. This case underscores the importance of considering atypical pathogens in chronic cutaneous infections following cosmetic procedures, even in immunocompetent patients. Increased awareness among clinicians can aid in prompt diagnosis and targeted therapy."

Journal • Aesthetic Medicine • Infectious Disease

Curcumin-loaded Nanofibers versus Metronidazole Gel in the Treatment of Chronic Periodontitis: A Double-blind, Randomized Controlled Trial. (PubMed, J Pharm Bioallied Sci) - "Notably, the curcumin-loaded nanofiber group demonstrated statistically significant greater reductions in PD and CAL at three months compared to the metronidazole gel group (P < 0.05). Curcumin-loaded metronidazole was used in nanofibers technology on chronic periodontitis patients, showing the possibility of improving therapeutic results, especially in posteriori periods, compared to the conventional metronidazole gel."

Journal • Dental Disorders • Inflammation • Periodontitis

Metronidazole-Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis. (PubMed, Adv Healthc Mater) - "In animal studies, the topical application of nGel/MNZ significantly attenuates the inflammatory response in periodontitis, reduces the expression of key inflammatory factors interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α), and improves the balance of the microbial composition of gingival crevicular fluid (GCF). The study demonstrates that cyclodextrin nanogel (nGel) loaded with metronidazole not only provides an efficient drug delivery route but also has potential clinical applications and offers a novel strategy for the local treatment of periodontitis."

Journal • Dental Disorders • Oncology • Periodontitis • IL1B • TNFA

Efficacy and safety of 0.75% metronidazole gel in patients with mild chronic paronychia: a randomized, double-blind, placebo-controlled trial (EADV 2025) - "The 0.75% metronidazole gel is well tolerated and contributes to clinical improvement in subjects with chronic mild paronychia and health education combined with waterproof measures are also beneficial. Table 1. Patient Baseline Characteristics Patients, N Age, mean (SD), year Gender Male, No."

Clinical • Dermatitis • Dermatology • Immunology • Inflammation

Facial demodicosis with sharply demarcated islands of sparing: A case series (EADV 2025) - "Common treatments included topical or oral ivermectin, topical permethrin cream, oral metronidazole, topical azelaic acid, tea tree oil wash, systemic low-dose isotretinoin, and broadband light (BBL) laser (Table I). Island-sparing facial demodicosis is a distinct clinical variant that can mimic other dermatoses. Awareness of this pattern, together with dermoscopy, facilitates prompt diagnosis and appropriate therapy. The sharply demarcated sparing suggests regional differences in pilosebaceous anatomy or cutaneous microbiota that constrain mite proliferation—an observation warranting further investigation."

Clinical • Dermatitis • Dermatology • Inflammation

When the Skin Sees Double: Cutaneous Lupus and Rosacea, a Confusing Duo (EADV 2025) - "He was treated with topical metronidazole and oral azithromycin...Metronidazole and azithromycin are effective treatments; the latter is preferred due to reduced photosensitivity compared to tetracyclines... Diagnosing facial erythema remains complex due to overlapping causes. Long-term follow-up and careful differential diagnosis are vital, especially when autoimmune comorbidities are present. A multidisciplinary approach improves outcomes in such challenging clinical scenarios."

Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Dry Eye Disease • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Ocular Inflammation • Ophthalmology • Polycythemia Vera • Rosacea • Systemic Lupus Erythematosus

Childhood granulomatous periorificial dermatitis – a case report with dermoscopic and reflectance confocal microscopy clues (EADV 2025) - "According to the patient's mother, prior empirical treatment with topical tacrolimus did not result in a clinical improvement...The patient experienced marked clinical improvement following an 8-week course of systemic and topical erythromycin in association with topical metronidazole and adapalene... This case demonstrates diagnostic difficulties associated with CGPD. While none of the non-invasive imaging modalities provides specific findings for CGPD, combined use of dermoscopy and RCM may help to narrow the differential diagnosis by indicating a granulomatous process. Treatment of CGPD is challenging."

Case report • Clinical • Dermatitis • Dermatology • Immunology

Nodular Rosacea: A Case Series of Three Patients with Clinical, Histopathologic, and Differential Diagnostic Insights (EADV 2025) - "Prior treatment with clobetasol and high-dose prednisone was ineffective... All patients were treated with oral methylprednisolone (16 mg/day tapered after 1 week), azithromycin (500 mg three times weekly for 6 weeks), topical metronidazole (0.75% cream in the morning), and ivermectin (1% cream at night)... Nodular rosacea may mimic various dermatoses including seborrheic dermatitis, pseudolymphoma and histoid leprosy, complicating diagnosis. This case series emphasizes the importance of using immunohistochemistry and special staining techniques to differentiate nodular rosacea from these conditions. A combined treatment approach, including oral anti-inflammatory agents, topical antimicrobials, and isotretinoin, proved to be highly effective in achieving long-term remission in all cases."

Clinical • Acne Vulgaris • B Cell Lymphoma • Dermatitis • Dermatology • Fibrosis • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Pruritus • Rosacea • Seborrheic Dermatitis • CD20

osacea Fulminans in Early Pregnancy: Therapeutic Challenges and Case-Based Approach at 11 Weeks' Gestation (EADV 2025) - "Prednisone 20 mg/day was initiated, combined with a 3-day course of azithromycin 500 mg— both considered relatively safe in pregnancy...Due to partial response and the need to avoid teratogenic agents like tetracyclines or isotretinoin, oral dapsone 50 mg daily—used with caution in pregnancy— was introduced at 20 weeks... Management of rosacea fulminans in pregnancy requires balancing efficacy with fetal safety. Systemic corticosteroids and macrolides are first-line options. Topical metronidazole is safe and effective, while dapsone may be considered in refractory cases with hematologic monitoring."

Clinical • Dermatology • Hematological Disorders • Immunology • Inflammation • Rosacea