metronidazole topical / Generic mfg. - LARVOL DELTA

Parenteral Ozone Therapy Combined with Topical Antimicrobials Enhances Tissue Repair in Mandibular Osteonecrosis of Elderly Female Rats. (PubMed, J Funct Biomater) - "Topical metronidazole and chlorhexidine were associated with favorable tissue repair findings, while combined therapies showed more favorable outcomes than zoledronate treatment alone. These findings suggest that systemic ozone therapy, particularly when associated with topical antimicrobial treatments, improves alveolar repair and represents a promising adjunctive strategy for preventing MRONJ."

Journal • Preclinical • Osteoporosis • Rheumatology

Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation (clinicaltrials.gov) - P=N/A | N=120 | Completed | Sponsor: H.P. Government Dental College and Hospital Shimla

New trial • Dental Disorders • Inflammation

An Unusual Perioral Presentation of Pityriasis Folliculorum Mimicking Periorificial Dermatitis. (PubMed, Cureus) - "The condition persisted despite treatment with topical metronidazole, topical tretinoin, and topical antifungal therapy. Given the lack of response to topical therapies, a potassium hydroxide (KOH) skin scraping was performed and demonstrated numerous Demodex mites, with rapid resolution following the initiation of topical ivermectin. This case highlights the importance of considering Demodex‑related disease in the evaluation of perioral papulopustular eruptions when standard therapies are ineffective. Early recognition can help guide appropriate management and prevent prolonged symptoms."

Journal • Dermatitis • Dermatology • Immunology

Use of Benzene-Free Carbomer 980 in the Formulation of Metronidazole Gel 0.75% and Demonstration of Equivalence with Carbomer 940. (PubMed, AAPS PharmSciTech) - "The in vitro release and permeation study also demonstrates that the formulations prepared with C940 and C980 exhibit performance equivalence to the innovator formulation under the tested conditions. Hence, replacing the benzene-grade carbomer with the corresponding non-benzene-grade carbomer does not significantly affect product performance relative to the reference product."

Journal

Differences in Rheological Properties between Brand and Generic Metronidazole Gels and Their Potential Impact on Malodor Management in Cancer Survivors. (PubMed, JMA J) - "Although containing identical active ingredients, the two formulations exhibit distinct rheological profiles that may affect clinical handling and usability in malodor management. Q3 attributes should be considered when selecting topical products for cancer survivors with fungating wounds."

Journal • Oncology

A new care option for breast cancer rupture wounds : A case showing positive results with Aqua Create Skin Solution® . (JBCS 2026) - "Traditionally, povidone-iodine preparations and metronidazole gel have been used to manage spontaneous ulcers, but the complexity of treatment and the difficulty of self-management remain challenges when the lesion is extensive...In this case, the use of Aqua Create Skin Solution® simplified the treatment, improved both the odor and exudate, and reduced the patient's burden during treatment. The care of self-inflicted wounds using Aqua Create Skin Solution® suggests that it may be a useful option for symptom relief and QOL improvement."

Clinical • Breast Cancer • Oncology • Solid Tumor

A Case of Lupus Miliaris Disseminatus Faciei Successfully Treated With Topical Metronidazole. (PubMed, J Dermatol) - No abstract available

Journal • Dermatology • Immunology • Inflammatory Arthritis • Lupus • Rosacea

Role of saturation dynamics in driving skin permeation from topical gel formulations. (PubMed, J Pharm Sci) - "Diclofenac sodium and lidocaine gels formulated with 1% PEG-200 showed progressively increasing DS over time and correspondingly higher permeation fluxes in in vitro permeation studies. In contrast, metronidazole gels showed little discrimination in DS and flux across PEG-200 concentrations, consistent with their hydrophilic nature and distinct solubility dynamics...Overall, the findings highlight that thermodynamic activity, modulated by solvent evaporation and shifts in solubility, governs the performance of topical formulations. These results underscore the value of monitoring DS profiles as predictive markers of drug delivery efficiency in topical product design."

Journal

Efficacy, Tolerance, and Safety of a Novel Botanical Anti-Inflammatory Moisturizer in Rosacea: Results From a Double-Blinded, Randomized Controlled Trial. (PubMed, J Cosmet Dermatol) - "The oat and aloe anti-inflammatory moisturizer was superior and outperformed 0.75% metronidazole cream in both erythema and lesion reduction in rosacea subjects after 8 and 12 weeks of treatment."

Clinical • Journal • Dermatology • Rosacea

Comparative Efficacy of 10% Azelaic Acid Versus 1% Metronidazole in the Treatment of Mild to Moderate Rosacea: A Randomized Controlled Study in Vietnamese Patients (EADV-Sp 2026) - "Materials and Methods In this randomized controlled trial, 60 patients with mild to moderate rosacea were allocated 1:1 to receive either 10% Azelaic Acid gel or 1% Metronidazole gel, applied twice daily, in conjunction with oral Doxycycline 100mg once daily for 12 weeks. Mild local adverse effects were more frequent with azelaic acid, with itching reported in 81.2% versus 57.1% and stinging in 60% versus 55.6% of patients, respectively Conclusions Both 10% azelaic acid and 1% metronidazole, in combination with doxycycline 100 mg, are effective for mild to moderate rosacea. Azelaic acid demonstrates slightly superior clinical efficacy but is associated with a higher incidence of mild, transient local irritation."

Clinical • Dermatitis • Dermatology • Immunology • Pruritus • Rosacea

Cutaneous Leishmaniasis in Central Sri Lanka: Epidemiology, Clinical Spectrum, Diagnosis and Management at a Tertiary Care Hospital (EADV-Sp 2026) - "Treatment modalities included intralesional sodium stibogluconate (45%), topical metronidazole (16%), intralesional metronidazole (8%), cryotherapy (4%), and combination regimens incorporating sodium stibogluconate or itraconazole. Intralesional therapies, especially sodium stibogluconate and metronidazole, were effective and well tolerated. Strengthening regional surveillance, improving access to early diagnosis, and promoting timely local treatment may reduce disease morbidity and transmission."

Clinical • Dermatology • Infectious Disease • Inflammation

Granulomatous Demodicosis Presenting as a Large Indurated Plaque of the Forehead: An Unusual Clinical Presentation (EADV-Sp 2026) - "Following discontinuation of corticosteroids, treatment with oral and topical metronidazole combined with topical permethrin was initiated...Conclusions Granulomatous demodicosis may present as an atypical plaque-forming lesion closely resembling other facial granulomatous dermatoses. Recognition of this uncommon presentation and its characteristic histopathological features is essential for accurate diagnosis and appropriate management."

Clinical • Immunology • Infectious Disease • Inflammation • Rosacea • Sarcoidosis

Unilateral Granulomatous Rosacea-like Eruption: A Diagnostic Challenge Unmasking Nickel Hypersensitivity from a Dental Implant (EADV-Sp 2026) - "Based on clinical findings, the patient was initially diagnosed with rosacea and treated with doxycycline 100 mg daily for 6 weeks without improvement. Subsequent therapy with pimecrolimus cream was also ineffective...A combination of topical metronidazole gel 2 times daily and ivermectin cream was prescribed for 12 weeks; however, the skin condition remained unchanged. Due to the failure of multiple topical agents and systemic antibiotics, treatment with low-dose systemic isotretinoin 10mg daily for 30 days was initiated...This case highlights the diagnostic challenge of implant-related metal hypersensitivity, which may clinically and histologically mimic more common inflammatory dermatoses like rosacea. Clinicians should suspect dental alloy allergies in asymmetrical or refractory facial dermatoses, as resolution may require removing the stimulus."

Dermatitis • Dermatology • Immunology • Rosacea

Malignant Fungating Wounds in Advanced Cancer: Pathophysiology, Odor Control, and Dignity-Centered Management. (PubMed, Curr Oncol Rep) - "Topical metronidazole remains the most robustly supported intervention for odor control, with emerging evidence for cadexomer iodine and Manuka honey as biofilm-disrupting adjuncts...Malignant fungating wounds demand a comprehensive, dignity-centered clinical response that is simultaneously evidence-based, culturally sensitive, and globally implementable. This review synthesizes the pathophysiology, evidence base, and ethical imperatives of MFW care into a unified clinical framework, providing oncologists and palliative care teams with practical algorithms for odor management and myiasis control, and reinforcing the imperative for equitable access to palliative wound care worldwide."

Journal • Review • Oncology • Palliative care • Solid Tumor

Effectiveness and Safety of Topical Tofacitinib 2% Ointment versus Metronidazole 0.75% Cream in Erythematotelangiectatic Rosacea: A Randomized Controlled Trial. (ChiCTR) - P=N/A | N=60 | Sponsor: University of Mosul; University of Mosul

New trial • Dermatology • Rosacea

Disseminated Ureaplasma infection: a case report of a patient with rheumatoid arthritis on rituximab therapy with multiple abscesses and arthritis. (PubMed, Ups J Med Sci) - "A 51-year-old woman with rheumatoid arthritis treated with rituximab and leflunomide presented with a 5-month history of malodorous vaginal discharge. Initial examination revealed vulvovaginitis and cervicitis, and she was treated with metronidazole and topical corticosteroids...Treatment with oral doxycycline led to rapid clinical and laboratory test improvement, and moxifloxacin was added for bactericidal coverage...Ureaplasma parvum should therefore be considered in patients presenting with sterile abscesses, systemic inflammation, and urogenital symptoms. Early recognition through molecular testing and targeted antimicrobial treatment can prevent prolonged morbidity and unnecessary surgical interventions."

Journal • Immunology • Infectious Disease • Inflammatory Arthritis • Oncology • Ovarian Cancer • Pain • Rheumatoid Arthritis • Rheumatology • Vaginitis • CRP

Clinician Treatment Patterns of Perioral Dermatitis: A Retrospective Chart Review (AAD 2026) - "Topical metronidazole (45.5%) and doxycycline (23.3%) were most often prescribed first-line. POD prescribing patterns differ among providers. This and high rates of treatment discontinuation highlight the need for guidelines for POD and continued education on best practices across providers."

Retrospective data • Review • Dermatitis • Dermatology • Immunology

Insurance Coverage of Rosacea Topicals: A Cross-Sectional Review (AAD 2026) - " Azelaic acid gel, oxymetazoline hydrochloride cream, ivermectin cream, sulfacetamide sodium–sulfur cleanser, metronidazole gel, minocycline foam, brimonidine gel, and Epsolay benzoyl peroxide (BPO) cream were reviewed across UnitedHealth Group, Elevance (Anthem), CVS Health (Aetna), Cigna, Health Care Service Corporation Blue Cross Blue Shield (BCBS), Kaiser Permanente, BCBS Florida, BCBS Michigan, Centene, and Blue Shield of California. Only two rosacea topicals were consistently covered by major commercial insurers, and many plans imposed quantity limits and step therapy barriers. Interestingly, metronidazole, identified as less effective than the uncovered topicals, was the most covered agent. [5] This disconnect between evidence-based rosacea treatments and insurer restrictions underscores the need for reform and improved access."

Reimbursement • Review • US reimbursement • Dermatology • Inflammation • Rosacea

Eosinophilic-Rich Linear Immunoglobulin A Bullous Dermatosis (AAD 2026) - "The drug-induced variant is most commonly linked to vancomycin, though other implicated agents include trimethoprim-sulfamethoxazole, amoxicillin, nonsteroidal anti-inflammatory drugs, simvastatin, cyclosporine, furosemide, lithium, and various additional medications...Treatments—including metronidazole gel, prednisone, triamcinolone, mupirocin, and doxycycline—provided minimal relief...Eosinophil-rich LABD has been infrequently reported in both adult and pediatric patients. Known associations include COVID-19 vaccination, parvovirus B19 infection, hematologic malignancies, and certain medications."

Alopecia • Cough • Dermatology • Hematological Malignancies • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Novel Coronavirus Disease • Orthopedics • Pruritus • Respiratory Diseases

Assessment of Treatment Effectiveness in Acute and Chronic Anal Fissures. (PubMed, Medicina (Kaunas)) - "Previous treatments, including 0.4% glyceryl trinitrate and 5% lidocaine, were recorded. However, the observed benefit does not appear to be uniform across all patients, and, in the absence of microbiological data, the extent of microbial involvement remains uncertain. Accordingly, topical metronidazole may be considered for carefully selected cases of acute anal fissure based on clinical judgement, while avoiding routine or indiscriminate antibiotic use."

Journal • Retrospective data • Gastrointestinal Disorder • Infectious Disease • Inflammation

Pharmacokinetics of Transdermal Metronidazole (clinicaltrials.gov) - P4 | N=24 | Active, not recruiting | Sponsor: University of Iowa | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Jul 2026

Trial completion date • Trial primary completion date

Dermoscopic Response Predictors in Papulopustular Rosacea Treated with Topical Ivermectin and Metronidazole: A Prospective Observational Comparative Study. (PubMed, Clin Cosmet Investig Dermatol) - "Ten patients received ivermectin 10 mg/g cream and 13 received metronidazole 1% gel (non-randomized, based on physician preference), applied once daily for 8 weeks. PFPs in dermoscopy of moderate-to-severe PPR serve as positive predictors for optimal response to topical ivermectin, but not metronidazole. This observation warrants validation in larger controlled trials."

Journal • Observational data • Dermatology • Rosacea

Tunnel vision: Rethinking local therapy for perianal fistulas in Crohn's disease. (PubMed, J Crohns Colitis) - "There is an unmet need to generate novel local therapies that achieve long-lasting fistula closure. To facilitate their development, the delineation of host and microbial pathways contributing to PFCD pathogenesis and research in drug delivery systems are needed."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Efficacy and safety of 0.75% metronidazole gel in patients with mild chronic paronychia: a randomized, double-blind, placebo-controlled trial. (PubMed, J Am Acad Dermatol) - No abstract available

Clinical • Journal

METROCLIN: Metronidazole 2% Gel Versus Clindamycin 1% Gel for Moderate Acne Vulgaris (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: Jinnah Postgraduate Medical Centre

New P4 trial • Acne Vulgaris • Dermatology