dendritic cell activation therapy / SBI Biotech - LARVOL DELTA

[VIRTUAL] Exposure to Topical Antimicrobials Reduces Inflammatory Gene Expression in Cutaneous Lupus Lesional Skin (ACR-ARHP 2020) - "Inflammatory signaling can be reduced in lupus lesional skin by reducing Gram-positive bacterial load by topical antibiotic treatment. CCL19 is an interferon regulated gene that mediates ectopic lymphoid aggregates in non-lymphoid tissues. CCL2, a chemokine highly expressed in CLE, and CXCL10 are known to recruit monocytes, memory T cells and dendritic cells to sites of inflammation, resulting in Th1 oriented inflammation in CLE."

Cutaneous Lupus Erythematosus • Dermatitis • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus • CCL19 • CCL2 • CXCL10 • ICAM1 • IL6 • PTGS2

Bioinformatic analysis of key biomarkers and immune filtration of skin biopsy in discoid lupus erythematosus. (PubMed, Lupus) - "This bioinformatic study selected key biomarkers from the contrast between DLE and NC skin samples and is the first research to analyze immune cell filtration in DLE."

Biomarker • Journal • Cutaneous Lupus Erythematosus • Discoid Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus • CD4 • CD8

Identification of key genes and immune profile in limited cutaneous systemic sclerosis-associated pulmonary arterial hypertension by bioinformatics analysis. (PubMed, Life Sci) - "Pathogen infection, changes in the number and function of immune cells, and interactions among immune cells may preliminarily reveal the pathological mechanism of lcSSc-PAH. The hub genes, pathways and immune characteristics identified in this research remains to be further studied."

Journal • Fibrosis • Hypertension • Immunology • Pulmonary Arterial Hypertension • Respiratory Diseases • Scleroderma • Systemic Sclerosis • ZAP70

Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. (PubMed, Gut Microbes) - "Thus, the present work identifies GroEL/Hsp60 as a major Hh-antigen and its role in disease onset, progression, and outcome in this colitis model. Our results highlight the importance of CD103 DC- and iTreg-mediated immune tolerance to specific pathobionts to maintain healthy intestinal balance."

Journal • Gastroenterology • Gastrointestinal Disorder • Immune Modulation • Immunology • Inflammation • Inflammatory Bowel Disease • CD40LG • IFNG

An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. (PubMed, mBio) - "This Treg deficiency cannot be corrected by cohousing with normal mice later and is recapitulated by reconstitution of germfree mice with microbiota harvested from antibiotic-exposed donors. As a consequence of their dysbiosis, and possibly of their Treg deficiency, antibiotic-impacted offspring generate dysregulated Th1 responses to bacterial challenge infection and develop more severe symptoms of ovalbumin-induced anaphylaxis."

Journal • Allergy • Asthma • Genetic Disorders • Immunology • Metabolic Disorders • Obesity • Respiratory Diseases • CD4 • FOXP3

Citrobacter koseri stimulates dendritic cells to induce IL-33 expression via abundant ATP production. (PubMed, J Med Microbiol) - "koseri JCM1658 was observed to proliferate more vigorously and produce more ATP than other enterobacteria.Conclusion.C. koseri acts as an allergenic bacterium through ATP production, stimulating dendritic cells to induce IL-33 expression, while LPS released from inactivated C. koseri JCM1658 attenuates this allergenicity."

IO biomarker • Journal • Allergy • Food Hypersensitivity • Immunology • TLR4

Interferon-inducible protein 16 may be a biomarker and prognostic factor in renal cell carcinoma by bioinformatics analysis. (PubMed, Medicine (Baltimore)) - "IFI16 is overexpressed in RCC and may be an important oncogene in the progression of kidney. In addition, IFI16 may a marker for RCC diagnosis and prognosis, which may be related to immune infiltration."

Biomarker • Journal • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Infectious Disease • Oncology • Renal Cell Carcinoma • Respiratory Diseases • Solid Tumor • Tuberculosis • IFI16

Development of a prognostic model of glioma based on immune-related genes. (PubMed, Oncol Lett) - "The infiltration of B cells, CD8 T cells, dendritic cells, macrophages and neutrophils was positively associated with the prognostic risk score. In the present study, several clinically significant survival-associated IRGs were identified, and a prognosis evaluation model of glioma was established."

IO biomarker • Journal • Glioblastoma • Glioma • Oncology • Solid Tumor • BIRC5 • CD8 • CDK4 • FCER1G • IDH1 • SOCS1

Phosphatase and Tensin Homolog Mutation in Immune Cell Infiltration and Clinicopathological Features of Low-Grade Gliomas. (PubMed, Front Mol Biosci) - "In this study, we outlined an approach to assess the influence of PTEN mutations on prognosis, overall survival, and messenger RNA (mRNA) expression. Our results provided alternative strategies for the personalized treatment of patients with LGGs harboring the PTEN mutation."

Clinical • Journal • Oncology • Solid Tumor • CD8 • PTEN

AUNIP Expression Is Correlated With Immune Infiltration and Is a Candidate Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma and Lung Adenocarcinoma. (PubMed, Front Oncol) - "In addition, AUNIP expression was correlated with immune infiltration in various other tumors. In conclusion, AUNIP, which is associated with tumor immune infiltration, is a candidate diagnostic and prognostic biomarker for HCC and LUAD."

Biomarker • Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Oral Cancer • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD8

FCGR1A Serves as a Novel Biomarker and Correlates With Immune Infiltration in Four Cancer Types. (PubMed, Front Mol Biosci) - "FCGR1A may be a potential prognostic biomarker and related to immune infiltration levels in diverse cancers, especially in CESC, CHOL, KIRC, and SKCM. Besides, FCGR1A may be involved in the activation, regulation, or induction of immune cells and diverse physiological and pathological processes."

Biomarker • Journal • Biliary Cancer • Cervical Cancer • Cholangiocarcinoma • Clear Cell Renal Cell Carcinoma • Cutaneous Melanoma • Gastrointestinal Cancer • Melanoma • Oncology • Renal Cell Carcinoma • Solid Tumor • CD8 • FCGR3A

RNF183 Is a Prognostic Biomarker and Correlates With Tumor Purity, Immune Infiltrates in Uterine Corpus Endometrial Carcinoma. (PubMed, Front Genet) - "Besides, the expression of RNF183 in UCEC is significantly correlated with the expression of several immune cell markers, including B cell, M1 macrophage marker, M2 Macrophage, Dendritic cell, Th1 markers, Th2 markers, Treg markers, and T cell exhaustion markers, indicating its role in regulating tumor immunity. These results suggested that RNF183 may be considered as a novel prognostic factor in endometrial cancer and an early diagnostic indicator for patients with UCEC."

Biomarker • Journal • Endometrial Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • Uterine Cancer • TP53 • TRAF4

Immunocyte infiltration characteristics of gene expression profile in nasopharyngeal carcinoma and clinical significance (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi) - "CCDC39 was a key gene in NPC, which was highly expressed in NPC and beneficial to the prognosis of patients, but the low expression of memory B cells was not conducive to the prognosis of patients. Conclusion A large number of immune cells are distributed in the microenvironment of NPC, and the expression of different types of immune cells is different, but memory B cells have the most obvious effect on the prognosis of patients."

Clinical • Journal • Nasopharyngeal Carcinoma • Oncology • Solid Tumor

Analysis of differential expression of long non‑coding RNAs in exosomes derived from mature and immature dendritic cells. (PubMed, Mol Med Rep) - "The results of gene set enrichment analysis identified that three lncRNA‑associated transcripts (Procr‑203, Clec4e‑202 and Traf1‑203) were highly associated with immunoregulatory functions including T helper cell differentiation and Janus kinase‑STAT signaling pathway. The results indicated the involvement of candidate lncRNAs in immunoregulation and suggested a new perspective on the modulation of lncRNAs in Dex."

Journal

Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment. (PubMed, J Transl Med) - "Taken together, IL-33 may be a key tumour promoter of HCC proliferation and tumourigenicity, an important mediator, and a potential therapeutic target for regulating HCC progression."

Journal • Tumor microenvironment • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Immunology • Inflammation • Oncology • Solid Tumor • CD8

[VIRTUAL] Gut Microbiota-Induced Regulatory T Cells in Patients with Hematological Malignancies Receiving Allogeneic Hematopoietic Stem Cell Transplantation: Towards Deciphering a Role for These Tregs in aGVHD (ASH 2020) - "Moreover, administration of DP8α target antigens (F. prausnitzii-derived), in the form of peptides, proteins, or even bacterial lysates, such as probiotics, could also be foreseen to either directly in vivo expand these Tregs or indirectly through the induction of tolerogenic dendritic cells (Alameddine et al., 2019, Front Immunol) and subsequent Treg differentiation/priming to limit GvHD-related inflammation."

Clinical • Gastroenterology • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Inflammation • Oncology • Transplantation • CD73 • FOXP3 • IL10

Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by Porphyromonas gingivalis. (PubMed, Front Immunol) - "Use of allosteric panAkt inhibitor MK2206 and mTOR inhibitor rapamycin confirmed the role of Akt/mTOR signaling in autophagy inhibition by P. gingivalis in DCs. Addition of ABT-199 peptide to disrupt the interaction of antiapoptotic Bcl2 and its proapoptotic partners BAK/BAX restored apoptotic death to P. gingivalis-infected DC cells. In summary, we have identified the underlying mechanism by which P. gingivalis promotes its own survival and that of its host DCs."

IO Biomarker • Journal • Dental Disorders • Immunology • Inflammation • Periodontitis

Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment. (PubMed, Front Endocrinol (Lausanne)) - "During the occurrence and development of PTC, the overall immune level was increased, and the abundance and proportion of tumor-promoting immune cells were significantly increased, indicating that immune escape had been aggravated. Finally, we speculate that EBV may play an important role in changing the immune microenvironment of PTC tumors."

Journal • Epstein-Barr Virus Infection • Immunology • Infectious Disease • Inflammation • Oncology • Solid Tumor • Thyroid Gland Anaplastic Carcinoma • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • BRAF • CD8

Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice. (PubMed, Crit Care) - "These results show that gut dysbiosis strongly impairs monocyte/dendritic progenitors and lung immunity, worsening outcomes of P. aeruginosa lung infection. Treatment with a fecal microbial transplant or immune stimulation by Flt3-Ligand both restore lung cellular responses to and outcomes of P. aeruginosa following antibiotic-induced gut dysbiosis."

Journal • Preclinical • CNS Disorders • Depression • Mood Disorders • Psychiatry • Transplantation • FLT3

Identification of DRP1 as a prognostic factor correlated with immune infiltration in breast cancer. (PubMed, Int Immunopharmacol) - "Our results suggest that DRP1 is a marker of poor prognosis in patients with BC and plays an important role in tumor-related immune infiltration."

Biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • CD8

Identification of a Prognostic Model Based on Immune-Related Genes of Lung Squamous Cell Carcinoma. (PubMed, Front Oncol) - "Our study identifies a prognostic model based on IRGs, which is then used to predict LUSC prognosis and analyze immunocyte infiltration. This may provide a novel insight for exploring the potential IRGs in the IME of LUSC."

Journal • Non Small Cell Lung Cancer • Oncology • Squamous Cell Carcinoma • NR4A1

Mining Database for the Clinical Significance and Prognostic Value of ESRP1 in Cutaneous Malignant Melanoma. (PubMed, Biomed Res Int) - "Furthermore, our results suggested that ESRP1 played an important role in regulating tumor-associated macrophage polarization, dendritic cell infiltration, Treg cells, and T cell exhaustion. Our study demonstrates ESRP1 expression, prognostic value, and potential regulatory networks in CMM, thereby shedding light on the clinical significance of ESRP1, and provides a novel biomarker for determining prognosis and immune infiltration in CMM."

Clinical • Journal • Melanoma • Oncology • Solid Tumor • ESRP1

[VIRTUAL] Immune Signatures Correlate with Clinical Outcome After Trauma Injury (AAST 2020) - "Computational analyses of deep immune profiling of trauma recovery demonstrate an association with specific immune populations and patient outcomes early after injury. Our results suggest that alterations in myeloid-origin cell types, namely neutrophils and other granulocytic subsets, likely contribute to immune dysfunction after injury. Preservation of effector-T cell functions correspond with decreased hospital LOS and less organ dysfunction."

Clinical • Clinical data • Infectious Disease • Mood Disorders • Pneumonia • Respiratory Diseases

Regulatory T Cells and Plasmacytoid Dendritic Cells Within the Tumor Microenvironment in Gastric Cancer Are Correlated With Gastric Microbiota Dysbiosis: A Preliminary Study. (PubMed, Front Immunol) - "With pearson's correlation analysis, we found that several non-abundant genera such as Stenotrophomonas and Selenomonas were positively correlated with BDCA2pDCs and Foxp3Tregs, respectively, while Comamonas and Gaiella were negatively correlated with BDCA2pDCs and Foxp3 Tregs, respectively. The increased BDCA2pDCs and Foxp3Tregs might be modulated by gastric mucosal microbiota, both participated in the immunosuppression microenvironment of GC, which might provide evidence to establish new strategies in antitumor therapy targeting on gastric microbiota."

Biomarker • Journal • Tumor microenvironment • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Gut microbiome alterations in type 1 autoimmune pancreatitis after induction of remission by prednisolone. (PubMed, Clin Exp Immunol) - "Pancreatic accumulation of pDCs capable of producing large amounts of IFN-α and IL-33 was also significantly higher in mice that received both treatments. These data suggest that intestinal colonization by K. pneumoniae may play an intensifying role in the development of type 1 AIP."

Clinical • Journal • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Immunology • Infectious Disease • Oncology • Pancreatic Cancer • Pancreatitis • Pneumonia • Respiratory Diseases • Solid Tumor