ACP-01 / Hemostemix, Aspire Health Science - LARVOL DELTA

Signature motif identification and enzymatic characterization of a protein tyrosine phosphatase in Metarhizium anisopliae (PubMed, Sheng Wu Gong Cheng Xue Bao) - "Functional analysis confirmed that the L-protein retained the PTP activity despite the absence of arginine in its signature motif, while AcP101 functioned as an acid phosphatase. This study provides the first functional validation of an arginine-deficient PTP motif, expanding the definition of PTP signature motifs and offering new insights for phosphatase classification."

Journal

ACP-CLI: ACP-01 in Patients With Critical Limb Ischemia (clinicaltrials.gov) - P2 | N=67 | Completed | Sponsor: Hemostemix | N=107 ➔ 67

Enrollment change • Cardiovascular • Peripheral Arterial Disease

ACP-CLI: ACP-01 in Patients With Critical Limb Ischemia (clinicaltrials.gov) - P2 | N=107 | Completed | Sponsor: Hemostemix | Unknown status ➔ Completed

Trial completion • Cardiovascular • Peripheral Arterial Disease

Safety and outcomes analysis: transcatheter implantation of autologous angiogenic cell precursors for the treatment of cardiomyopathy. (PubMed, Stem Cell Res Ther) - "Transcatheter implantation of ACP-01 for cardiomyopathy is safe and improves LVEF in the setting of ischemic and non-ischemic cardiomyopathy. The results warrant further investigation in a prospective, blinded, and controlled clinical study."

Journal • Retrospective data • Bone Marrow Transplantation • Cardiomyopathy • Cardiovascular • Infectious Disease • Respiratory Diseases • Transplantation • Ventricular Tachycardia • CD31 • CD34 • PECAM1

Relative gene expression, micronuclei formation, and ultrastructure alterations induced by heavy metal contamination in Pimelia latreillei (Coleoptera: Tenebrionidae) in an urban-industrial area of Alexandria, Egypt. (PubMed, PLoS One) - "To analyze/monitor genotoxicity in P. latreillei sampled from the polluted site, the transcription levels of levels of heat shock proteins (Hsps) and accessory gland seminal fluid protein (AcPC01) in testicular tissues were recorded...Ultrastructure anomalies (nuclear and cytoplasmic disruption) were also observed in the testicular cells of the beetles sampled from the polluted site compared to those sampled from the unpolluted site. Our results, therefore, advocate a need for adequate measures to reduce increasing environmental pollution in the urban-industrial areas."

Journal • HSP90AA1

Nickel oxide nanoparticles induce genotoxicity and cellular alterations in the ground beetle Blaps polycresta (Coleoptera: Tenebrionidae). (PubMed, Toxicol Ind Health) - "Decreased gene expression of AcPC01, AcPC02, and AcPC04 (≤1.5-, ≤2-, and < 2.5-fold, respectively, vs. controls) also were reported in the treated group...Ultrastructure observations using scanning and transmission electron microscopy showed severe damage to the subcellular organelles as well as deformities of the heads and flagella of the spermatozoa. Therefore, the present study postulated the impact of NiO-NPs in an ecological model."

Journal • HSP90AA1