BNT165
/ BioNTech
- LARVOL DELTA
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October 10, 2025
Immunogenicity and Protective Efficacy Induced by PfCSP-encoding RNA-LNP Malaria Vaccines BNT165b1 and BNT165c in Mice
(ASTMH 2025)
- P1, P1/2 | "Despite their positive public health impact, the efficacy of the approved malaria vaccines (RTS,S/AS01 and R21/Matrix-M) is limited and short lived...Finally, immunization with BNT165b1 or BNT165c partially protects mice against infection with PfCSP-expressing P. berghei sporozoites. These pre-clinical results support the ongoing evaluation of BNT165b1 and BNT165c in early phase clinical trials (NCT05581641 and NCT06069544)."
Preclinical • Infectious Disease • Malaria • IFNG • TNFA
October 01, 2024
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
(clinicaltrials.gov)
- P1 | N=60 | Completed | Sponsor: BioNTech SE | Active, not recruiting ➔ Completed
Trial completion • Infectious Disease • Malaria
January 01, 2024
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
(clinicaltrials.gov)
- P1 | N=60 | Active, not recruiting | Sponsor: BioNTech SE
Trial completion date • Trial primary completion date • Infectious Disease • Malaria
April 10, 2023
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
(clinicaltrials.gov)
- P1 | N=60 | Active, not recruiting | Sponsor: BioNTech SE | Recruiting ➔ Active, not recruiting
Enrollment closed • Infectious Disease • Malaria
January 13, 2023
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
(clinicaltrials.gov)
- P1 | N=60 | Recruiting | Sponsor: BioNTech SE | Not yet recruiting ➔ Recruiting
Enrollment open • Infectious Disease • Malaria
October 14, 2022
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
(clinicaltrials.gov)
- P1 | N=60 | Not yet recruiting | Sponsor: BioNTech SE
New P1 trial • Infectious Disease • Malaria
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