SB-001 / Solid BioSci, Northwestern University - LARVOL DELTA

High-level production of poly-γ-glutamic acid from untreated molasses by Bacillus siamensis IR10. (PubMed, Microb Cell Fact) - "These results suggest that untreated molasses can be used for economical and industrial-scale production of γ-PGA by B. siamensis IR10."

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Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage. (PubMed, Org Biomol Chem) - "The subsequent mechanistic study revealed that SB2001 induced apoptotic cell death through restoring p53 function and suppressed the human papillomavirus (HPV)-mediated oncoprotein signaling pathway via oxidative damage in HeLa cells. SB2001 also selectively induced HeLa-specific tumor regression without any adverse effects in an in vivo tumor xenograft model, demonstrating its potential as a promising chemical probe."

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Variability in the immunogenic preS region of Pakistani hepatitis B virus isolates. (PubMed, Virusdisease) - "Sequencing results showed that eight samples (SBS002-SBS008) have a deletion of 33 nucleotides at N-terminal that is characteristics of genotype D while SBS001 belongs to genotype C. Silent mutations and amino acid changes were also searched in this highly variable region of genome. Based upon this study it was concluded that genotype D is the most common genotype in Pakistan."

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Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent. (PubMed, Chem Sci) - "MTH1 was identified by both TS-FITGE and TPP, and SB2001 inhibited the function of MTH1 in hydrolyzing oxidized nucleotides. Compared to CaSki cells, HeLa cells displayed downregulated DNA mismatch repair pathways, which made HeLa cells more susceptible to the oxidative stress caused by SB2001, resulting in increased 8-oxoG concentrations, DNA damage, and subsequent cell death."

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