DB003
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- LARVOL DELTA
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February 08, 2025
Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence.
(PubMed, ACS Chem Biol)
- "Achieving strong, selective minor groove binding at -TTAA- sequences has been challenging, but DB1003, a benzimidazole-furan-furan diamidine, has demonstrated cooperative dimeric binding activity at -TTAA-...This distinctive binding arrangement and the properties of diamidines at the -TTAA- minor groove demonstrate that benzimidazole-furan-thiophene is a unique DNA binding pharmacophore. Competition mass spectroscopy and circular dichroism studies confirmed the binding stoichiometry and selectivity preference of the compounds for the -TTAA- sequence."
Journal
January 25, 2023
"I already have @elsanchez09 @DBM003 @frolivr @KizzyPhD"
(@traciedelgado)
July 19, 2022
"Virologist decompression exercise. Missing the rest of #tenOever lab @ASV2022 though. Lots of love to @DBM003 @Viral_Xavier @skyleruhl @tinagoneviral @Justin_Frere @afajardo32"
(@virusninja)
September 25, 2021
"Where do you stand? @VaziriLab @genomewarriors @DBM003 @rothmaa @NicoleCruzMD @Abderhman1994 @jordanmarrocco @kritvenks @evolvingORs @pinarayata @lizzyzhao @KevinPORourke @NavinPokala @cpnoct @JeanneGarb @AndrewIWong @caitlinsgilbert @davidr_requena @RockLabTB @its__electric"
(@progressiveMDs)
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