DB003 / DotBio - LARVOL DELTA

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence. (PubMed, ACS Chem Biol) - "Achieving strong, selective minor groove binding at -TTAA- sequences has been challenging, but DB1003, a benzimidazole-furan-furan diamidine, has demonstrated cooperative dimeric binding activity at -TTAA-...This distinctive binding arrangement and the properties of diamidines at the -TTAA- minor groove demonstrate that benzimidazole-furan-thiophene is a unique DNA binding pharmacophore. Competition mass spectroscopy and circular dichroism studies confirmed the binding stoichiometry and selectivity preference of the compounds for the -TTAA- sequence."

Journal

"I already have @elsanchez09 @DBM003 @frolivr @KizzyPhD" (@traciedelgado)

"Virologist decompression exercise. Missing the rest of #tenOever lab @ASV2022 though. Lots of love to ⁦@DBM003⁩ ⁦@Viral_Xavier⁩ ⁦@skyleruhl⁩ ⁦@tinagoneviral⁩ ⁦@Justin_Frere⁩ @afajardo32" (@virusninja)

"Where do you stand? @VaziriLab @genomewarriors @DBM003 @rothmaa @NicoleCruzMD @Abderhman1994 @jordanmarrocco @kritvenks @evolvingORs @pinarayata @lizzyzhao @KevinPORourke @NavinPokala @cpnoct @JeanneGarb @AndrewIWong @caitlinsgilbert @davidr_requena @RockLabTB @its__electric" (@progressiveMDs)