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The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth. (PubMed, Nat Plants) - "Although most of the secondary tissues are made up of parenchyma cells, which are also produced by both cambia, their diversity and function are poorly understood...Furthermore, we show that mature phloem parenchyma gradually obtains periderm identity, and this transformation can be accelerated by jasmonate treatment or wounding. Our study thus reveals the diversity of parenchyma cells and their capacity to undergo considerable identity changes during secondary growth."

Journal

Diclofenac for the Treatment of Patients with Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy (clinicaltrials.gov) - P2 | N=20 | Not yet recruiting | Sponsor: Emory University

Metastases • New P2 trial • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • PD-L1

The AaERF64-AaTPPA module participates in cold acclimatization of Actinidia arguta (Sieb. et Zucc.) Planch ex Miq. (PubMed, Mol Breed) - "AaTPPA expression levels were much higher in lateral buds, roots, and stem cambia than in leaves in autumn...In summary, the temperature decrease in autumn is likely to induce AaERF64 expression through an ethylene-dependent pathway, which consequently upregulates AaTPPA expression, leading to the accumulation of osmotic protectants such as soluble sugars and proline in the overwintering tissues of A. arguta. The online version contains supplementary material available at 10.1007/s11032-024-01475-8."

Journal

Medullary bundles in Caryophyllales: form, function, and evolution. (PubMed, New Phytol) - "Additionally, correlated evolution between medullary bundles and successive cambia was tested...Disparate developmental pathways were found leading to rampant convergent evolution of CVTP in Caryophyllales. These findings indicate the diversification of medullary bundles and vascular tissues as another central theme for functional and comparative molecular studies in Caryophyllales."

Journal

Form and contour: breeding and genetics of organ shape from wild relatives to modern vegetable crops. (PubMed, Front Plant Sci) - "Selection for visually-pleasing shapes in vegetable crops resulted from a number of opportunistic factors, including modification of supernumerary cambia, allelic variation at loci that control fundamental processes such as cell division, cell elongation, transposon-mediated variation, and partitioning of photosynthate...Crop wild relatives are often considered less relevant for modern breeding efforts when it comes to characteristics such as shape, however this view may be unnecessarily limiting. Useful allelic variation in wild species may not have been examined or exploited with respect to shape modifications, and newly emergent information on key genes and proteins may provide additional opportunities to regulate the form and contour of vegetable crops."

Journal • Review

"Ectopic Cambia: Connections Between Natural and Experimental Vascular Mutants". (PubMed, Am J Bot) - "The textbook illustration of secondary growth--a core of secondary xylem surrounded by a sheath of secondary phloem--is generated through a cylindrical meristem called the vascular cambium (Fig. 1A)."

Journal

Vascular variants in seed plants-a developmental perspective. (PubMed, AoB Plants) - "In this framework, vascular variants are defined by their developmental origin (instead of anatomical patterns), allowing the classification of alternative vascular ontogenies into three categories: (i) procambial variants, (ii) cambial variants and (iii) ectopic cambia...An overview of the developmental diversity and phylogenetic distribution of vascular variants across selected seed plants is provided. Finally, this viewpoint discusses the evolutionary implications of vascular variants."

Journal • Review

Molecular phylogeny of Urvillea (Paullinieae, Sapindaceae) and its implications in stem vascular diversity. (PubMed, Ann Bot) - "Urvillea stands out as the third most diverse genus in number of vascular variants within Paullinieae, but only one ontogeny (fissured stems) is exclusive for the genus. Differential cambial activity and ectopic cambia are the main ontogenetic processes generating stem diversity. The evolutionary history of vascular variants demonstrates the large developmental plasticity of the cambium in such a small genus and corroborates a scenario of repeated evolution of complex anatomies within Paullinieae lianas."

Journal

From procambium patterning to cambium activation and maintenance in the Arabidopsis root. (PubMed, Curr Opin Plant Biol) - "These two cambia are the lateral meristems providing secondary growth...Cork cambium produces a protective layer called cork. In this review, we focus on recent advances in understanding the formation of procambium and its gradual maturation to active cambium in the Arabidopsis thaliana root."

Journal • Review

Drugs for migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Differential benefit of intra-operative administration of ketorolac on breast cancer disease recurrence according to baseline body mass index (SABCS 2017) - "The fact that only ketorolac but not diclofenac was associated with a significant reduction of distant recurrences in BC patients with elevated BMI could be explained by the specific Rho GTPase inhibitory effect of the R-enantiomer of ketorolac, absent in diclofenac. While this study is limited by its retrospective nature, it suggests a potentially important repositioning of ketorolac in the intra-operative treatment of BC patients with elevated BMI. A prospective study is on its way."

Retrospective data • Hormone Receptor Breast Cancer

Evaluating clinically relevant pharmacological agents in a rat ambulation model to ameliorate PEGylated recombinant hyaluronidase PH20 (PEGPH20)-mediated musculoskeletal adverse events (AACR 2017) - P3; "...The most advanced clinical trial (Phase 3) is evaluating PEGPH20 plus Abraxane® (nab-paclitaxel)/gemcitabine (AG) in patients with stage IV untreated pancreatic ductal adenocarcinoma (PDA)(NCT02715804)...The steroid dexamethasone, currently being used in the Phase 2 and Phase 3 PDA clinical trials to manage MSEs, was the positive control. As a class, nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, ketoprofen, diclofenac, and piroxicam, increased rat ambulation by ~40% on the first night following PEGPH20 treatment compared to PEGPH20 alone...No other drug classes increased rodent ambulation. These data suggest that NSAIDs may be useful in partially alleviating the MSEs experienced by patients receiving PEGPH20."

Adverse events • Biosimilar • Demo Pain • Gastrointestinal Cancer • Oncology • Pain • Pancreatic Cancer • Venous Thromboembolism

Measuring pediatric palliative care quality: Challenges and opportunities. (PubMed, J Pain Symptom Manage) - "While important strides toward addressing quality measurement challenges in PPC have been made, including ongoing quality measurement initiatives like the Cambia Metrics Project, the PPC What Matters Most study, and collaborative learning networks, more work remains. Providing high-quality PPC to all children and families will require a multi-pronged approach. In this paper, we suggest several strategies for advancing high-quality PPC, which includes 1) considering how and by whom success is defined; 2) evaluating, adapting, and developing PPC measures, including those that address care disparities within PPC for historically marginalized and excluded communities; 3) improving the infrastructure with which to routinely and prospectively measure, monitor, and report clinical and administrative quality measures; 4) increasing endorsement of PPC quality measures by prominent quality organizations to facilitate accountability and possible reimbursement; and 5) integrating..."

Journal • Palliative care • Pediatrics

Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis. (PubMed, Int J Pharm) - "BioGIT experiments were performed with four APIs: Compound Α (tablet, three dose levels), Compound E (capsule PiC1, capsule PiC2 and tablet), fenofibrate (Lipidil® capsule and Lipidil 145 ONE® tablet) and Compound F (HP-β-CD aqueous solution and tablet)...The log-transformed ratios of mean BioGIT AUC values for two doses and/or two formulations estimated in this study and in a recent study for two diclofenac potassium products (Cataflam® tablet and Voltfast® sachet, same dose) vs. the corresponding log-transformed ratios of mean plasma AUC values (n=7 pairs of ratios), were included in a previously established correlation between log-transformed ratios of mean BioGIT AUC values and log-transformed ratios of plasma AUC values (n=9 pairs of ratios).The correlation between log-transformed plasma AUC ratios vs. log-transformed BioGIT AUC ratios was confirmed (n=16 pairs of ratios, R=0.90). Compared with the previously established correlation the..."

Journal

Apoyo organizacional percibido y comportamientos de empoderamiento en mujeres supervivientes de cáncer de mama reincorporadas laboralmente. (PubMed, Glob Health Promot) - "La mayoría de las mujeres participantes percibieron bajo apoyo organizacional, y este cambia según la presencia de algunas secuelas del tratamiento. El 49.6% de las participantes había adoptado totalmente comportamientos de empoderamiento que varían significativamente de acuerdo con la edad, la presencia de secuelas, el apoyo organizacional percibido y el tiempo de retorno al trabajo. Las secuelas del tratamiento tienen influencia sobre el apoyo organizacional percibido y la adopción de comportamientos de empoderamiento."

Journal

Miravo Healthcare Enters into Definitive Agreement to be Acquired by Searchlight Pharma Inc. (Businesswire) - "Nuvo Pharmaceuticals Inc. d/b/a Miravo Healthcare...and Searchlight Pharma Inc., a private Canadian-based specialty healthcare company...are pleased to announce that they have entered into a definitive agreement (the 'Arrangement Agreement') pursuant to which the Purchaser has agreed to acquire all of the issued and outstanding common shares of the Company (the 'Company Shares') in exchange for cash consideration of $1.35 per Company Share, representing a 79.8% premium to the 90-day volume-weighted average trading price of the Company Shares on the Toronto Stock Exchange for the period ended December 22, 2022....'Not only does an all-cash transaction provide immediate and certain value to shareholders, it also allows important healthcare products like...Cambia® and Suvexx® to remain available to healthcare providers and patients through the enhanced scale of the Searchlight business.'"

M&A • CNS Disorders • Migraine • Pain

Miravo Healthcare Announces Third Quarter 2022 Results (Businesswire) - "Revenue related to the...Cambia® and Suvexx® was $10.7 million, an increase of 32% compared to revenue of $8.1 million for the three months ended September 30, 2021. Total Canadian prescriptions of...Cambia and Suvexx increased by 27%, 7% and 86%, respectively compared to the three months ended September 30, 2021."

Commercial • CNS Disorders • Migraine • Pain

ATOM: Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine (clinicaltrials.gov) - P4 | N=645 | Recruiting | Sponsor: Danish Headache Center | Not yet recruiting ➔ Recruiting | Initiation date: Feb 2022 ➔ May 2022

Enrollment open • Trial initiation date • CNS Disorders • Migraine

Stem cambial variants of Taiwan lianas. (PubMed, Bot Stud) - "Our study documented regular secondary growth with a single cambium in 36 species and cambial variants present in 16 species of Taiwanese lianas. Furthermore, we provide crucial baseline data on liana cambial variations, thereby improving our understanding of their morphology and identification."

Journal

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Linking the evolution of development of stem vascular system in Nyctaginaceae and its correlation to habit and species diversification. (PubMed, Evodevo) - "Our findings suggest that multiple developmental mechanisms, such as heterochrony and heterotopy, generate the transitions between interxylary phloem and successive cambia. Intermediate between these two extremes are present in Nyctaginaceae, suggesting a continuum morphology across the family as a generator of anatomical diversity."

Journal

ATOM: Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine (clinicaltrials.gov) - P4 | N=645 | Not yet recruiting | Sponsor: Danish Headache Center

New P4 trial • CNS Disorders • Migraine

Assertio Reports Third Quarter 2021 Financial Results (GlobeNewswire) - "Assertio Holdings, Inc...today reported financial results for the third quarter ended September 30, 2021....Our partnership with the leading migraine telemedicine platform, Cove, has had a strong initial launch with a 77% increase in CAMBIA® prescriptions through Cove in the third quarter of 2021 compared to the third quarter of 2020. Our SPRIX® program with Cove was also recently launched."

Commercial • CNS Disorders • Migraine • Pain

"Thanks God for the presence of painkillers🙏 Thx @Novartis for Catafast ⚡⚡ Thx @GSK for Panadol migraine 💯" (@1MostafaBarakat)

CNS Disorders • Migraine • Pain

Evolution of Root Morphology in Table Beet: Historical and Iconographic. (PubMed, Front Plant Sci) - "Beta maritima possesses supernumerary root cambia, which facilitated selection of swollen rooted forms...Modern, spherical beet roots were depicted in 1936 by the Russian painter Zinaida Serebriankov, 1936. Artistic and historical representations of table beet suggest that swollen rooted forms have existed during the past five centuries, but conically shaped roots were gradually replaced by spherically shaped roots during this period."

Journal • Review