Naphcon-A (naphazoline HCl) / Novartis - LARVOL DELTA

Naphazoline abuse: a rare case of myocardial infarction with nonobstructive coronary arteries. (PubMed, J Cardiovasc Med (Hagerstown)) - No abstract available

Journal • Cardiovascular • Myocardial Infarction

Naphazoline abuse: a rare case of myocardial infarction with nonobstructive coronary arteries. (PubMed, J Cardiovasc Med (Hagerstown)) - "We describe the case of a previously healthy man who experienced a MINOCA (myocardial infarction with nonobstructive coronary arteries) after abuse of recommended dose of naphazoline. To our knowledge, this is the first time that a strict temporal relation between the occurrence of MINOCA and topical naphazoline abuse is being described."

Journal • Atrial Fibrillation • Cardiovascular • Hypertension • Myocardial Infarction

Rapid determination of 87 prohibited ingredients in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry (PubMed, Se Pu) - "The positive components included trimethoprim, terbinafine, naphazoline, 7-methoxycoumarin, and 7-methylcoumarin. The established method displays the advantages of simple operation and rapidness and a high sensitivity and good recovery. And, this method provides technical support for rapid risk screening and the revision of national standards for cosmetics."

Journal • Pain

Safety and Tolerability of PRO-185 (clinicaltrials.gov) - P1 | N=22 | Completed | Sponsor: Laboratorios Sophia S.A de C.V. | Not yet recruiting ➔ Completed

Trial completion • Ophthalmology

Application of multivariate chemometrics tools for spectrophotometric determination of naphazoline HCl, pheniramine maleate and three official impurities in their eye drops. (PubMed, Sci Rep) - "The proposed models could determine NZ and PN with respective detection limits of 0.447 and 1.750 μg mL for PLS, and 0.494 and 2.093 μg mL for ANN. The two established models were compared favorably with official methods where no significant difference observed."

Journal

Rapid Resolution Of Botulinum Toxin-Induced Upper Eyelid Ptosis After Treatment With A Combination Of Anticholinesterase And Alpha-2-Adrenergic Agonist (WCD 2023) - "The eyelid immediately began to rise after administering 60 mg of oral pyridostigmine (anticholinesterase) and naphazoline HCl 0.012% eye drops (alpha-2-adrenergic agonist), achieving symmetrical eye anthropometrical measurement without feeling heaviness or fatigue in two hours...Treatments were discontinued, and there was no recurrence after another one-month evaluation while retaining the botulinum toxin cosmetic outcome. KEY MESSAGE: The combination of anticholinesterase and alpha-2-adrenergic agonists might provide a rapid resolution of botulinum toxin-induced ptosis with the consideration of any possible side effects"

Aesthetic Medicine • Dermatology • Fatigue

Green easily implemented spectrophotometric methods for concurrent determination of ephedrine hydrochloride and naphazoline nitrate in nasal preparations containing methylparaben. (PubMed, J AOAC Int) - "The three components of a decongestant nasal preparation were determined using cheap green versatile spectrophotometric methods that keep the advantages of chromatographic techniques including accuracy, reproducibility and selectivity."

Journal

Effects of thiram exposure on liver metabolism of chickens. (PubMed, Front Vet Sci) - "Metabolomics analysis shows that 62 metabolites were down-regulated (ginsenoside F5, arbekacin, coproporphyrinogen III, 3-keto Fusidic acid, marmesin, isofumonisin B1, 3-Hydroxyquinine, melleolide B, naphazoline, marmesin, dibenzyl ether, etc.) and 35 metabolites were up-regulated (tetrabromodiphenyl ethers, deoxycholic acid glycine conjugate, L-Palmitoylcarnitine, austalide K, hericene B, pentadecanoylcarnitine, glyceryl palmitostearate, quinestrol, 7-Ketocholesterol, tetrabromodiphenyl ethers, etc.) in thiram-induced chickens, mainly involved in the metabolic pathways including glycosylphosphatidylinositol (GPI)-anchor biosynthesis, porphyrin and chlorophyll metabolism, glycerophospholipid metabolism, primary bile acid biosynthesis and steroid hormone biosynthesis. Taken together, this research showed that thiram exposure significantly altered hepatic metabolism in chickens. Moreover, this study also provided a basis for regulating the use and disposal of thiram to..."

Journal • Metabolic Disorders

A dexamethasone ophthalmic insert (Dextenza) for allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

About the pathways to deliver brimonidine to the Muller's muscle. (PubMed, JAAD Case Rep) - No abstract available

Journal • Ophthalmology

Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors (clinicaltrials.gov) - P1 | N=34 | Completed | Sponsor: Sanofi | Active, not recruiting ➔ Completed | Trial completion date: Mar 2023 ➔ Dec 2022

Metastases • Monotherapy • Trial completion • Trial completion date • Oncology • Solid Tumor • CEACAM5

Safety and Tolerability of PRO-185 (clinicaltrials.gov) - P1 | N=22 | Not yet recruiting | Sponsor: Laboratorios Sophia S.A de C.V. | Trial completion date: Aug 2022 ➔ Mar 2023 | Initiation date: Aug 2022 ➔ Feb 2023 | Trial primary completion date: Aug 2022 ➔ Mar 2023

Trial completion date • Trial initiation date • Trial primary completion date • Ophthalmology

Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors (clinicaltrials.gov) - P1 | N=34 | Active, not recruiting | Sponsor: Sanofi | Recruiting ➔ Active, not recruiting | N=81 ➔ 34

Enrollment change • Enrollment closed • Metastases • Monotherapy • Oncology • Solid Tumor • CEACAM5

Naphazoline and oxymetazoline are superior to epinephrine in enhancing the cutaneous analgesia of lidocaine in rats. (PubMed, Fundam Clin Pharmacol) - "We observed that 4 adrenergic agonists and epinephrine induce analgesia by themselves, and such an effect has a longer duration than local anesthetics. Co-administration of lidocaine with the adrenergic agonist enhances the analgesic effect, and the cutaneous analgesic effect of lidocaine plus naphazoline (or oxymetazoline) is greater than that of lidocaine plus epinephrine."

Journal • Preclinical • Anesthesia • Pain

The signaling and selectivity of α-adrenoceptor agonists for the human α2A, α2B and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors. (PubMed, Pharmacol Res Perspect) - "Ligands with high intrinsic efficacy (e.g., brimonidine and moxonidine at α2A) stimulated biphasic (Gi-Gs) concentration responses, however for ligands with low intrinsic efficacy (e.g., naphazoline), responses were monophasic (Gi-only)...Comparison with α1 and β1/β2-adrenoceptors demonstrated subclass affinity selectivity for some compounds (e.g., α2:dexmedetomidine, α1:A61603) whilst e.g., oxymetazoline had high affinity for both α2A and α1A-subtypes, compared to all others. Some compounds had subclass selectivity due to selective intrinsic efficacy (e.g., α2:brimonidine, α1:methoxamine/etilefrine). A detailed knowledge of these agonist characteristics is vital for improving computer-based deep-learning and drug design."

Journal • ADHD (Impulsive Aggression) • Anesthesia • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Hypertension • Psychiatry

Pharmacological Properties and Function of the PxOctβ3 Octopamine Receptor in Plutella xylostella (L.). (PubMed, Insects) - "Furthermore, the agonists naphazoline, clonidine, 2-phenethylamine, and amitraz activated the PxOctβ3 receptor, and naphazoline was the most effective. Only metoclopramide and mianserin had significant antagonistic effects on PxOctβ3, whereas yohimbine, phentolamine, and chlorpromazine lacked obvious antagonistic effects. The injection of double-stranded RNA in an RNA interference assay indicated that PxOctβ3 regulates development in P. xylostella. This study demonstrated the pharmacological properties and functions of PxOctβ3 in P. xylostella, thus, providing a theoretical basis for the design of pesticides that target octopamine receptors."

Journal

Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors (clinicaltrials.gov) - P1 | N=81 | Recruiting | Sponsor: Sanofi | Active, not recruiting ➔ Recruiting | Trial completion date: Oct 2022 ➔ Mar 2023 | Trial primary completion date: Aug 2022 ➔ Nov 2022

Enrollment open • Monotherapy • Trial completion date • Trial primary completion date • Oncology • Solid Tumor • CEACAM5

Safety and Tolerability of PRO-185 (clinicaltrials.gov) - P1 | N=22 | Not yet recruiting | Sponsor: Laboratorios Sophia S.A de C.V.

New P1 trial • Ophthalmology

Understanding ocular comfort differences between 0.7% olopatadine and 0.3% pheniramine maleate/0.025% naphazoline hydrochloride eye drops. (PubMed, Clin Exp Optom) - "There were no between drop differences in visual acuity, though eyes treated with VISINE were less red than eyes treated with Pataday. Topically applied Pataday drops were more comfortable than VISINE drops."

Journal • Allergy • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology

In brief: OTC alcaftadine (Lastacaft Once Daily Relief) for allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Patient-Reported Symptoms Associated with Over-the-Counter Allergy Eye Drops (ASCRS-ASOA 2022) - "The Purpose of this work was to evaluate a patient’s perceived ocular comfort after application of topical 0.7% olopatadine compared to 0.035% ketotifen fumarate or 0.3% pheniramine maleate/0.025% naphazoline hydrochloride. Both studies found that participants were numerically more likely to report that they strongly preferred or preferred 0.7% olopatadine over the comparison drops for all Likert symptoms evaluated except for vision fluctuation/blur, which was similar between 0.7% olopatadine and 0.3% pheniramine maleate. Conclusion Topical 0.7% olopatadine appears to be more comfortable and result in less ocular symptoms than 0.035% ketotifen fumarate or 0.3% pheniramine maleate, which suggests that patients may be more likely to comply with topical 0.7% olopatadine than its common market competitors."

Clinical • Allergy • Immunology

A drug-eluting contact lens for allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities. (PubMed, BMC Chem) - "Method greenness was evaluated and compared to the reported HPLC one via environmental, health and safety tool. The developed method has much potential over the reported one of being simple, selective, economic and time saving for the analysis of the five cited compounds."

Journal

Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma. (PubMed, Comput Biol Med) - "This bioinformatics analysis brings a new insight into the role of circRNA/miRNA/mRNA interactions in ccRCC pathogenesis, prognosis, and possible drug treatment or immunotherapy."

Clinical • IO biomarker • Journal • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Kidney Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • CTSS • IKZF1 • MIR1205 • MIR122 • MIR1231 • P2RY8 • VCAM1

Real-Life Active Surveillance of a Naphazoline/ Hypromellose Fixed Combination's Safety Profile in Peruvian Population. (PubMed, Integr Pharm Res Pract) - "No risk factors related to the clinical and demographic characteristics of the patients were identified. The low incidence of ADRs, their short recovery time, and their categorization as "mild" and "not serious" demonstrates the high tolerability in the studied population; therefore, according to the study, the safety profile for NAPH seems to be adequate, with a suitable tolerability."

Clinical • Journal • Dermatology • Ophthalmology • Pain • Pruritus