IC-200 / Astellas - LARVOL DELTA

Comparision of intraocular pressure measured using the new icare 200™ rebound tonometer and the Perkins™ applanation tonometer in healthy subjects and in patients with primary congenital glaucoma. (PubMed, Arch Soc Esp Oftalmol) - "There was excellent agreement between the IC200 and GAT tonometers, both in healthy subjects and PCG, with a trend to overestimate IOP when measured with IC200. There was no influence by CCT on IOP measurements in patients with PGC."

Clinical • Journal • Glaucoma • Ophthalmology

A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids. (PubMed, Molecules) - "The best compound, a steroidal thiosemicarbazone compound 8 (ID_1260) was active in vitro (IC 200 nM) and in vivo (60% infection reduction at 50 mg/kg) in Leishmania and T. cruzi. It also has low toxicity in vitro and in vivo (LD >2000 mg/kg) and no genotoxic effects, being a promising compound for anti-trypanosomatid drug development."

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