Undisclosed Fzd4 Wnt antibody / Surrozen - LARVOL DELTA

Surrozen Publishes Study in Nature Communications Demonstrating the Promise of a Fzd4 Wnt Antibody in Treating Ischemic Stroke (GlobeNewswire) - "Surrozen, Inc...announced today they co-authored a publication with Stanford Medicine and Columbia University scientists in Nature Communications. The results observed with systemic administration of Surrozen’s Frizzled-4 (Fzd4) selective Wnt mimetic antibody in a disease model of ischemic stroke reveal the potential for this novel mechanism of action to reverse blood-brain-barrier (BBB) dysfunctions such as leakage in the surrounding brain tissue, death of surrounding tissue, and tissue swelling while improving neurologic function....This publication describes 1) overcoming the challenges of systemic pharmacologic Fzd4 stimulation to develop an optimized, Fzd4 selective –Wnt mimetic antibody, and 2) results from administering this Fzd4 Wnt surrogate (L6-F4-2) in preclinical models of ischemic stroke."

Preclinical • CNS Disorders • Ischemic stroke