CK-102 / Fortress, Teva - LARVOL DELTA

The combination therapy of isomucronulatol 7-O-beta-glucoside (IMG) and CEP-9722 targeting ferroptosis-related biomarkers in non-small cell lung cancer (NSCLC). (PubMed, BMC Pulm Med) - "We identified an effective ferroptosis-related prognostic model based on single-cell sequencing. The potential prediction model is devoted to exploring clinical therapeutic targets for NSCLC."

Biomarker • Combination therapy • Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Phase I dose-escalation study to evaluate the safety, pharmacokinetics, and pharmacodynamics of CEP-9722 (a PARP1-2 inhibitor) as single agent and in combination with temozolomide in patients with advanced solid tumors (NCT00920595) (ASCO 2012) - Presentation time: Mon, Jun 4, 8:00 AM - 12:00 PM; Anticipated presentation at ASCO 2012

Anticipated P1 data presentation • Oncology

Phase I dose-escalation study to evaluate the safety, pharmacokinetics, and pharmacodynamics of CEP-9722 (a PARP1-2 inhibitor) as single agent and in combination with temozolomide in patients with advanced solid tumors (NCT00920595) (ASCO 2012) - Presentation time: Monday June 4, 8:00 AM to 12:00 PM; P1, N=26; The MTD of CEP-9722 in combination with TMZ (150 mg/m2) was reached at 1000 mg/day; Pharmacodynamic analysis demonstrated PARP inhibition at all doses

P1 data • Oncology

Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer. (PubMed, Curr Treat Options Oncol) - "Olaparib, rucaparib, and niraparib all have indications for maintenance therapy in recurrent platinum-sensitive ovarian cancer after response to platinum-based therapy. Other newer agents such as talazoparib, veliparib, 2X-121, and CEP-9722 are in earlier stages of development. As more FDA-approved indications for PARP inhibitor therapy in ovarian cancer become available, we anticipate the decision of which PARP inhibitor to use will become increasingly complex."

Biomarker • BRCA Biomarker • Clinical • Journal • PARP Biomarker • Review