olumacostat glasaretil (DRM01) / Eli Lilly - LARVOL DELTA

Combined Immediate-Release and Extended-Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation. (PubMed, Clin Pharmacol Drug Dev) - "A modified controlled-release sodium valproate formulation (VAL001, test) was compared with an approved enteric-coated tablet formulation (Absenor, reference). No serious or severe adverse events were observed. The novel capsule formulation of valproate, containing a combination of immediate-release granules and extended-release pellets, appears to have suitable pharmacokinetic properties for cancer treatments aiming for histone deacetylase inhibition."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

"Thank you to Maria’s expert thesis committee, many insights shared! @CathyEngMD @Duvall_Lab_VU @creinhartking @marjanrafat @TheRealJVal2001 🧠🎓" (@profmikeking)

"Positiva resultat från PK-studie av VAL001 https://t.co/WCgekBuR0X" (@CisionNews)

"BioStock: Sista personen doserad i Respiratorius PK-studie med VAL001 https://t.co/QZ3bokV4Dx" (@CisionNews)

"Dosering av sista försökspersonerna i PK-studie av VAL001 https://t.co/nVPXHpeY6c" (@CisionNews)

"Further positive results for VAL001 https://t.co/Te7IFtoyOn" (@CisionNews)

"Ytterligare positiva resultat för VAL001 https://t.co/s5qO4P0VI0" (@CisionNews)

"Dosering av de första försökspersonerna i PK-studie av VAL001 https://t.co/TGkNBJtSuX" (@CisionNews)

"Dosing of First Study Subjects in PK Study of VAL001 https://t.co/55Ao1k6gh3" (@CisionNews)

"PK study approval for VAL001 https://t.co/LpuoJ0TdDc" (@CisionNews)

"BioStock: Respiratorius begins production of VAL001 https://t.co/2VeJkx6cjz" (@CisionNews)

"BioStock: Respiratorius inleder produktion av VAL001 https://t.co/bNtg0TNtH9" (@CisionNews)

"Produktionsstart för VAL001 https://t.co/qTfFeYGbEC" (@CisionNews)

"Production Initiated for VAL001 https://t.co/IYQERSI64L" (@CisionNews)

"BioStock: Respiratorius gets patent approval in Brazil for VAL001 https://t.co/Pkmclrr4SO" (@CisionNews)

"Brazil grants patent for VAL001 https://t.co/Q7i0bmsHqD" (@CisionNews)

"Brasiliens patentverk beviljar patent för VAL001 https://t.co/sHRHGg9ib8" (@CisionNews)

Identification of serum biomarkers for Systemic Lupus Erythematosus using a library of phage displayed random peptides and deep sequencing. (PubMed, Mol Cell Proteomics) - "Among them, two peptides, i.e., SLE2018Val001 and SLE2018Val002 were confirmed between SLE with other autoimmune patients. The procedure we established could be easily adopted for the identification of autoantibodies as biomarkers for many other diseases."

Biomarker • Journal • Immunology • Lupus • Systemic Lupus Erythematosus

From pathogenesis of acne vulgaris to anti-acne agents. (PubMed, Arch Dermatol Res) - "Commonly used anti-acne agents include retinoids, benzoyl peroxide, antibiotics and hormonal agents (e.g. spironolactone, combination oral contraceptive and flutamide). New approaches including peroxisome proliferator-activated receptor γ modifier, melanocortin receptor antagonists, epigallocatechin-3-gallate, metformin, olumacostat glasaretil, stearoyl-CoA desaturase inhibitor omiganan pentahydrochloride, KPT, afamelanotide, apremilast and biologics have been developed as promising treatments for acne vulgaris. Although these anti-acne agents have various pharmacological effects against the diverse pathogenesis of acne, all of them have a synergistic mode of action, the attenuation of Akt/mTORC1 signaling and enhancement of p53 signal transduction. In addition to drug therapy, diet with no hyperglycemic carbohydrates, no milk and dairy products is also beneficial for treatment of acne."

Journal • Review