Sediel (tandospirone) / Sumitomo Pharma, Pfizer - LARVOL DELTA

Treatments for vascular depression in older adults: A systematic review. (PubMed, Int Psychogeriatr) - "Evidence on treatment for VaD remains limited, highlighting the need for large, well-designed RCTs and integrated approaches combining vascular risk management with targeted therapies."

Journal • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Depression • Mood Disorders • Psychiatry • Vascular Neurology

Descriptive analysis of prescription interception patterns: characterizing medication safety risks in an outpatient setting. (PubMed, Front Pharmacol) - "The top three intercepted medications were Duloxetine Hydrochloride Enteric Capsules (3.63%), Atorvastatin Calcium Tablets (3.11%), and Tandospirone Citrate Capsules (2.81%). The study suggests that targeted interventions, including upgrading electronic prescribing systems, department-specific training, and forming special review panels, are necessary to reduce prescription errors and improve medication safety. Future work should focus on multicenter studies and, as a longer-term direction, explore the potential of artificial intelligence for dynamic risk prediction to enhance the continuous optimization of medical quality."

Journal • Cardiovascular • Dyslipidemia

Clinical Characteristics Associated With Nightmares During Lemborexant Treatment in Psychiatric Patients: A Retrospective Study. (PubMed, J Clin Psychopharmacol) - "This study revealed that patients aged 50 years or older who were prescribed LEM experienced a lower incidence of nightmares than younger patients. When prescribing LEM-particularly in younger patients, in combination with tandospirone, or following benzodiazepines discontinuation-clinicians should consider potential nightmares associated with LEM. These findings offer clinically meaningful insights for optimizing insomnia treatment while minimizing LEM-associated risks."

Journal • Retrospective data • CNS Disorders • Insomnia • Mental Retardation • Psychiatry • Sleep Disorder

Aggravation of stiff-person syndrome with ophthalmoplegia after tandospirone initiation: a case report. (PubMed, Front Immunol) - "Treatment with baclofen and lorazepam showed poor efficacy, and she was once misdiagnosed with anxiety and depression as well as oculomotor nerve palsy...As the patient could not tolerate hormone pulse therapy, she was administered rituximab and two sessions of intravenous immunoglobulin (IVIG)...SPS is relatively uncommon and prone to misdiagnosis. Therefore, we need to understand the various clinical manifestations of SPS, achieve early intervention, and thereby improve the prognosis and quality of life of patients."

Journal • CNS Disorders • Depression • Mood Disorders • Ophthalmology • Psychiatry

Acute apocynin-tandospirone derivatives (ATDs) exacerbate methamphetamine-induced hyperlocomotion in rats. (PubMed, Psychopharmacology (Berl)) - "The results demonstrate that acute ATD administration neither suppressed MAP-induced behavioral abnormalities nor produced marked neurochemical changes, but instead enhanced MAP-induced locomotor activity, indicating a clear dissociation from their previously reported chronic effects."

Journal • Preclinical • CNS Disorders • Psychiatry • Schizophrenia

Assessment of Off-Label Psychotropic Drug Use in Children and Adolescents: A Multi-Center Cross-Sectional Study in China. (PubMed, Pharmacoepidemiol Drug Saf) - "Off-label use of psychotropic drugs is highly prevalent in children and adolescents. The use of psychotropic drugs should be based on instructions and evidence-based medical evidence to ensure their rational use in these patient populations. The drug administration should standardize the practice of pediatric prescription in the future."

Journal • Observational data • Retrospective data • CNS Disorders • Mood Disorders • Pediatrics • Psychiatry

Efficacy of escitalopram plus tandospirone in treating vascular depressive mood disorder: A 12-week single-center randomized controlled trial. (PubMed, J Affect Disord) - "Combination treatment significantly improves anxiety, depression, and somatization symptoms in patients with VaDep in which platelet 5-HT1AR and platelet 5-HT1BR are potential objective indicators. These findings may provide clinical insights for the treatment of VaDep."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Psychotic major depressive disorder and rapid eye movement sleep behavior disorder cooccurring with a pineal cyst: a case report with neuroimaging insights in a 15-year-old female. (PubMed, BMC Psychiatry) - "This case highlights the value of structural neuroimaging in adolescents with psychotic major depressive disorder and underscores the importance of individualized, multimodal treatment planning. Further research is warranted to clarify the clinical significance of pineal abnormalities and their association with mood and sleep disorders."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • REM Sleep Behavior Disorder • Sleep Disorder

Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients. (PubMed, NPJ Digit Med) - "Importantly, tandospirone not only alleviates ED but also enhances the therapeutic efficacy of cisplatin. These findings highlight the clinical importance of systematic ED management in lung cancer care and suggest tandospirone as a promising candidate that may simultaneously support psychological well-being and improve chemotherapy response, offering a more comprehensive treatment strategy for NSCLC patients."

Journal • CNS Disorders • Depression • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Psychiatry • Solid Tumor

Case Report: Generalized anxiety disorder and hypertension: a bidirectional loop unraveled by integrated management. (PubMed, Front Psychiatry) - "Despite triple antihypertensive therapy (nifedipine, arotinolol, sacubitril/valsartan), blood pressure (BP) remained uncontrolled (176/105 mmHg) with severe anxiety (HAMA = 36)...Multimodal management combining pharmacotherapy (escitalopram, tandospirone), transcranial magnetic stimulation (9 sessions), biofeedback (14 sessions), psychotherapy, and lifestyle interventions achieve: mean BP decreased significantly from 176/105 mmHg to 125/72 mmHg during hospitalization; significant anxiety reduction (HAMA = 3), mean BP stabilized at 131/77 mmHg with 50% reduction in antihypertensive dosages, normalization of elevated ACTH (99.9→normal pg/mL) and cortisol (18.7→normal μg/dL) and sustained improvement at 6-month follow-up. This case demonstrates thyroidectomy-induced endocrine disruption as a novel trigger in the GAD-HT bidirectional loop. Multimodal therapy targeting shared neurobiological pathways (HPA axis, autonomic regulation, serotonin signaling)..."

Journal • Cardiovascular • CNS Disorders • General Anxiety Disorder • Hypertension • Mood Disorders • Psychiatry

Psychosis induced by invocation presenting as possession state: A case of Kitousei-Seishinbyo still emerging in modern Japan. (PubMed, PCN Rep) - "Management involved family psychoeducation, occupational therapy, and low-dose psychotropics (tandospirone and zolpidem)...This case illustrates a present-day example of Kitousei-Seishinbyo triggered by encountering a fortune-teller. Improvement was achieved through combined psychosocial interventions and low-dose pharmacotherapy."

Journal • CNS Disorders • Psychiatry

Emotional Distress Following Lung Cancer Surgery and Tandospirones Dual Benefits for Chemotherapy (IASLC-WCLC 2025) - "Among the tested anti-ED drugs, tandospirone exhibited no tumor-promoting effects and unexpectedly enhanced cisplatin's cytotoxicity. Conclusions : Our findings highlight the dual role of tandospirone in alleviating ED and enhancing chemotherapy efficacy through cholesterol metabolism modulation. Furthermore, our study provides a scientific basis for integrating psychological support with metabolic interventions in lung cancer treatment, offering a novel strategy to improve patient outcomes."

Surgery • CNS Disorders • Depression • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Psychiatry • Solid Tumor

Problematic Use of Buspirone and Tandospirone: A Scoping Review. (PubMed, J Addict Med) - "Findings highlight a discrepancy in the primary literature. Specifically, experimental studies conclude that so far, buspirone and tandospirone have a low potential for problematic use. However, more recent case reports document instances of nonprescribed buspirone misuse, particularly among individuals with a history of incarceration or SUD, possibly stemming from a complex interplay of biopsychosocial-behavioral rather than purely pharmacological factors. Further research is needed to guide strategies for preventing problematic azapirone use while ensuring effective anxiety treatment in high-risk populations."

Journal • CNS Disorders • Mood Disorders • Psychiatry

Augmentation Therapy With Serotonin 5-HT1A Receptor Partial Agonists on Cognitive Function in Depressive Disorders: A Systematic Review of Randomized Controlled Studies. (PubMed, Neuropsychopharmacol Rep) - "Further studies with novel 5-HT1A receptor agonists are warranted to examine their potentially more robust benefits on cognitive performance in subjects suffering from mood deficits."

Journal • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

Efficacy and Safety of Escitalopram Combined with Tandospirone Citrate in Treating Patients with Vascular Depression and Chronic Insomnia: A Randomized Controlled Trial. (PubMed, CNS Drugs) - P4 | "The statistically significant changes in PSG, PSQI, and AIS may indicate that the combination of escitalopram and tandospirone may improve, with a reasonable safety profile, the sleep quality of patients with VaDe. The clinical results observed were associated with changes in measures of plasma 5-HT and platelet 5HT7R; these findings suggest that a possible role of central serotonergic function in the mechanism of action of the drug combination in this trial could be a relevant subject of future studies."

Journal • CNS Disorders • Depression • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder

Severe bradycardia triggered by repetitive transcranial magnetic stimulation in a patient with major depressive disorder and premature ventricular contractions: a case report. (PubMed, BMC Psychiatry) - "The influence of rTMS on heart rate (HR) is likely mediated through the autonomic nervous system (ANS). Currently, severe arrhythmias are not widely recognized as adverse effects of rTMS. While the exact mechanisms by which rTMS affects the cardiovascular system remain unclear, this case underscores the necessity for caution when using rTMS to treat psychiatric patients with arrhythmias."

Journal • Cardiovascular • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

A Real-world Study on the Effectiveness and Safety of Tandospirone in Treating Patients with Anxiety. (ChiCTR) - P4 | N=2000 | Recruiting | Sponsor: Shanghai Tongji Hospital; Shanghai Tongji Hospital

New P4 trial • Mood Disorders • Psychiatry

Deep eutectic solvent combined with permeation enhancer strategy to convert tandospirone from oral to transdermal formulations improving drug bioavailability. (PubMed, Eur J Pharm Biopharm) - "The results of the mechanistic study showed that levulinic acid(LeA) acted as a bridge to increase the interaction between the Tan and the matrix and inhibited the crystallization of the drug in the patch, and THEDES together with CPE improved the matrix fluidity and skin permeability. This study provides a reference for the joint application of THEDES and CPEs in patch development."

Journal • Mood Disorders • Psychiatry

Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid. (PubMed, Neuropsychopharmacology) - "Treatment with a low-affinity NMDA receptor antagonist (memantine), a selective 5-HT reuptake inhibitor (fluoxetine), and a 5-HT1A receptor agonist (tandospirone) attenuated both the increase in CaMKII phosphorylation and ASD-like behavior of prenatal VPA mice. WAY-100635-a 5-HT1A receptor antagonist-antagonized the effect of fluoxetine on impaired social behavior and object recognition memory. These results suggest that E/I imbalance and ASD-like behavior are associated with hypo-serotonergic receptor signaling through 5-HT1A receptors in prenatal VPA mice."

Journal • Preclinical • Alzheimer's Disease • Autism Spectrum Disorder • CNS Disorders • Cognitive Disorders • Developmental Disorders • Genetic Disorders • Psychiatry

Ameliorating effect of chotosan and its active component, Uncaria hook, on lipopolysaccharide-induced anxiety-like behavior in mice. (PubMed, Front Pharmacol) - "Furthermore, treatment with tandospirone, a 5-HT1A receptor agonist, alleviated anxiety-like behavior in mice, whereas treatment with DOI, a 5-HT2A receptor agonist, enhanced anxiety-like behavior in mice...These findings indicate that chotosan exerts anxiolytic-like effects in the context of inflammation-induced anxiety, potentially mediated by the inhibition of 5-HT2A receptor hyperfunction in LPS-treated mice. Consequently, we postulate that chotosan may be effective in managing inflammation-induced anxiety-like behaviors."

Journal • Preclinical • Inflammation • Mood Disorders • Psychiatry

Unexplained recurrent high fever observed in a depressed adolescent. (PubMed, BMC Psychiatry) - "Depression should be considered a potential cause of unexplained recurrent fevers in adolescents, even when the temperature is significantly outside the normal range."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Efficacy and safety of venlafaxine hydrochloride combined with tandospirone citrate for patients with vascular depression accompanied by somatic symptoms: An open-labeled randomized control trial. (PubMed, CNS Neurosci Ther) - "The combined therapy rapidly acts on VaDep comorbid with anxiety and somatic symptoms and significantly alleviates the anxiety and somatic symptoms. The plasma levels of 5-HT may serve as potential objective candidates in evaluating VaDep severity and the efficacy of the undertaken treatment regimen."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. (PubMed, Neurobiol Dis) - "Finally, chronic treatment of adult MPA mice with fluoxetine, an inhibitor of 5-HT reuptake transporter, or the 5-HT1A receptor agonist tandospirone rescues cognitive flexibility and memory impairments. All together, these data demonstrate that the development of 5-HT system function is vulnerable to moderate perinatal asphyxia. 5-HT hypofunction might in turn contribute to long-term cognitive impairment in adulthood, indicating a potential target for pharmacological therapies."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Developmental Disorders • Epilepsy

Pharmacokinetics and absorption mechanism of tandospirone citrate. (PubMed, Front Pharmacol) - "The low absolute bioavailability of TDS may be attributed to its rapid metabolism. The pharmacokinetic data and absorption characteristics obtained in this study provide fundamental information for the further development and utilization of TDS."

Journal • PK/PD data • CNS Disorders • General Anxiety Disorder • Mood Disorders • Psychiatry

Comparison of tandospirone and escitalopram as a symptomatic treatment in Multiple System Atrophy-cerebellar ataxia: An open-label, non-controlled, 4 weeks observational study. (PubMed, J Psychiatr Res) - "Tandospirone citrate was more effective in improving depression/anxiety and some cerebellar ataxia symptoms, whereas escitalopram was more effective in improving some autonomic symptoms in MSA-C patients over a short-term period in an open-label observational study without a control group. Further research is needed to evaluate the long-term effects of tandospirone and escitalopram in MSA-C in long-term placebo controlled trials."

Journal • Observational data • Ataxia • CNS Disorders • Depression • Dermatology • Mood Disorders • Movement Disorders • Multiple System Atrophy • Parkinson's Disease • Psychiatry