iC9.GD2.CAR.IL-15 T-cells / UNC Lineberger Comprehensive Cancer Center - LARVOL DELTA

Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma (clinicaltrials.gov) - P1 | N=18 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Trial completion date: Jun 2039 ➔ Jun 2044 | Trial primary completion date: May 2025 ➔ May 2030

Trial completion date • Trial primary completion date • Neuroblastoma • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • IL15

Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Trial completion date: Feb 2027 ➔ Oct 2029 | Trial primary completion date: Feb 2025 ➔ Nov 2027

Trial completion date • Trial primary completion date • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor

Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma (clinicaltrials.gov) - P1 | N=18 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Trial primary completion date: Jun 2024 ➔ May 2025

CAR T-Cell Therapy • Trial primary completion date • CNS Tumor • Neuroblastoma • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • IL15

Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Not yet recruiting ➔ Recruiting

CAR T-Cell Therapy • Enrollment open • Lung Cancer • Neuroendocrine Tumor • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • IL15

Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer (clinicaltrials.gov) - P1 | N=24 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center

CAR T-Cell Therapy • New P1 trial • Lung Cancer • Neuroendocrine Tumor • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • IL15