Trimera / Dystrogen - LARVOL DELTA

The essential oil from Baccharis trimera (Less.) DC improves gastric ulcer healing in rats through modulation of VEGF and MMP-2 activity. (PubMed, J Ethnopharmacol) - "These findings indicated that EOBT was effective in preventing and accelerating ulcer healing by decreasing MPO activity, increasing VEGF expression, and decreasing MMP-2 activity. These actions collectively contribute to the rapid recovery of gastric mucosa following treatment with EOBT, without any observed toxicity."

Journal • Gastroenterology • Gastrointestinal Disorder • Pain • Peptic Ulcer • CASP9 • MMP2 • MMP9 • MPO • VEGFA

Paratrimerins J-Y, Dimeric Coumarins Isolated from the Stems of Paramignya trimera. (PubMed, J Nat Prod) - "With regard to P. trimera being a recently emerging medicinal resource for liver cancer, the dimers 1-18 were evaluated for cytotoxicity against a wide panel of human cancer cell lines. Paratrimerin W (16) was cytotoxic toward Huh7 hepatocellular carcinoma, HT1080 fibrosarcoma, and HT29 colorectal cancer cells with IC values of 14.9, 18.4, and 22.5 μM, respectively."

Journal • Colorectal Cancer • Fibrosarcoma • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Liver Cancer • Oncology • Sarcoma • Solid Tumor

New species of Duplominona Karling, 1966 (Platyhelminthes, Proseriata) from the Pacific coast of Panama. (PubMed, Zootaxa) - "Both D. trimera n. sp...The presence of species with a tripartite tail on both sides of the Isthmus of Panama suggests the possibility of further geminate species pairs; however, no support could be obtained on the basis of the morphology of their hard structures. Five of the eight new species of Duplominona have been found in a single locality, and the diversity of genus along the Pacific coast of Panama may be far higher than present contribution suggests."

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Phylogenetic relationship of Paramignya trimera and its relatives: an evidence for the wide sexual compatibility. (PubMed, Sci Rep) - "Analysis of genetic variation, interspecific and intraspecific distances using ITS, matK and rbcL sequences shown that P. trimera was closely related to A. buxifolia, Severinia monophylla and Luvunga scandens. In addition, matK sequences represented as the effective candidate DNA barcode to identify and distinguish Paramignya species from others of the family Rutaceae."

Journal • Hepatology • Oncology

Effects of Gender and Geographical Origin on the Chemical Composition and Antiradical Activity of Baccharis myriocephala and Baccharis trimera. (PubMed, Foods) - "The obtained results clearly demonstrated that the geographical region of plant collection influenced the chemical composition of essential oils from the studied Baccharis species. Moreover, the obtained fractions were constituted by several antiradical compounds, which reinforced the usage of these species in folk medicine."

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Chemical characterization of polysaccharides from Baccharis trimera (Less.) DC. infusion and its hepatoprotective effects. (PubMed, Food Res Int) - "No signs of toxicity were observed. Thus, inulin present in B. trimera infusion protects the liver from the oxidative stress caused by CCl administration and can corroborate with the hepatoprotective effects presented by the species infusion."

Journal • Hepatology • CAT

Paratrimerin I, cytotoxic acridone alkaloid from the roots of Paramignya trimera. (PubMed, Nat Prod Res) - "Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC values of 0.43 and 0.26 µM, respectively. The N-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity."

Journal • Breast Cancer • Oncology • Solid Tumor

Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle. (PubMed, Antibiotics (Basel)) - "The oils were completely ineffective against ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (RSV, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses. This is the first report describing the cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas activities of the essential oils of P. trimera and L. littoralis."

Journal • Immunology • Infectious Disease

Promising therapeutic use of Baccharis trimera (less.) DC. as a natural hepatoprotective agent against hepatic lesions that are caused by multiple risk factors. (PubMed, J Ethnopharmacol) - "B. trimera may be promising as a hepatoprotective agent against hepatic lesions that are caused by multiple risk factors."

Clinical • Journal

H HR-MAS NMR and chemometric methods for discrimination and classification of Baccharis (Asteraceae): A proposal for quality control of Baccharis trimera. (PubMed, J Pharm Biomed Anal) - "However, PLS-DA and SIMCA applied to commercial samples showed that none of the commercial samples were classified as B. trimera, which suggested the lack of strict quality control regarding these products. The methodology developed in the present work might contribute to chemotaxonomy of the genus Baccharis."

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