225Ac-DOTA-girentuximab (TLX252) / Telix - LARVOL DELTA

Synergistic Anti-Tumour Effects of 225 Ac-DOTA-Girentuximab Combined with DNA Damage Response Inhibitors in CAIX-Positive Renal Cancer (EANM 2025) - No abstract available

Kidney Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • CA9

Telix Announces Record-Breaking Presence at EANM 2025 (PRNewswire) - "'Telix presentation highlights include the Phase 3 ProstACT Global trial of TLX591 in mCRPC, the IPAX-Linz and IPAX-2 therapeutic trials of TLX101 in glioma, and real-world experience with TLX250-CDx in ccRCC. Telix will host a sponsored symposium on CAIX and FAP targeting theranostics, and abstracts will also be presented from Telix's pan-tumor programs and its Rhine Pharma subsidiary, whose mission is to expand global access to innovative cancer imaging and therapy.'"

Clinical data • Preclinical • Trial status • Castration-Resistant Prostate Cancer • Glioblastoma • Ovarian Cancer • Renal Cell Carcinoma • Triple Negative Breast Cancer

Enhanced Antitumor Efficacy of DNA Damage Response Inhibitors Combined with 225Ac-DOTA-girentuximab (SNMMI 2025) - "Lartesertib and peposertib exhibited IC50 values of 3.543 µM and 0.7712 µM, respectively, in SK-RC-52 cells. The IC50 value for 225Ac-DOTA-girentxuimab in SK-RC-52 cells was 0.1505 kBq/mL. Synergy mapping analysis revealed an additive effect between 225Ac-DOTA-girentuximab and lartesertib."

Clinical • Ataxia • Immunology • Movement Disorders • Oncology • Primary Immunodeficiency • CA9

Telix Theranostic Programs and Satellite Symposia on Innovation in PSMA and CAIX Imaging Featured at SNMMI 2025 (Telix Press Release) - "Presentation highlights include the ProstACT Global Phase 3 study of TLX591 in advanced prostate cancer, preclinical data on Telix’s TLX252 alpha therapy candidate in CAIX expressing tumors in combination with DDRIs, and clinical study data on Illuccix impact on decision-making. Two sponsored symposia will highlight innovation in precision diagnostics, the first on CAIX-PET imaging in renal cancer, and the second on Illuccix PSMA-PET imaging in prostate cancer, including Telix’s new PSMA biopsy trial."

Clinical data • Preclinical • Bladder Cancer • Castration-Resistant Prostate Cancer • Kidney Cancer

Telix at ANZSNM Annual Scientific Meeting 2025 (PRNewswire) - "Telix Pharmaceuticals Limited...announces a strong presence at the 55th Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine (ANZSNM ASM 2025), to be held in Melbourne, Australia from 23–25 May 2025....Demonstrating its commitment to development and education in theranostics, Telix presentations include: ProstACT Global Phase 3 study of TLX591 (177Lu-rosopatamab tetraxetan), Telix's first-in-class PSMA targeting radio antibody-drug conjugate (rADC) therapy candidate; STARSTRUCK study of TLX250 (177Lu-girentuximab) in combination with peposertib in patients with carbonic anhydrase IX (CAIX)-expressing solid tumors, and a preclinical evaluation of 225Ac-girentuximab in combination with DNA damage response inhibition..."

Clinical data • Preclinical • Castration-Resistant Prostate Cancer

Telix Featured in 13 Abstracts at the Annual Congress of the European Association of Nuclear Medicine (EANM) (PRNewswire) - "Telix's extensive theranostic pipeline will be showcased in presentations covering...TLX101 (131I-iodofalan or 131I-IPA) glioblastoma therapy; TLX66 (90Y-besilesomab) bone marrow conditioning therapy; TLX252 (225Ac-girentuximab) carbonic anhydrase IX (CAIX)-targeted alpha therapy..."

Clinical data • Glioma