oxandrolone / Generic mfg. - LARVOL DELTA

Manhole Sampling at Gyms and Sports Centers in Denmark: A Pilot Study Using Wastewater Analysis as a Tool for Monitoring the Use of Performance-Enhancing Drugs. (PubMed, Drug Test Anal) - "The study showed the presence of anabolic agents such as oxandrolone, stanozolol, and ostarine in wastewater sampled from the gyms. Wastewater analysis may be used as an easy and cost-effective tool to complement both preventive and control measures, such as information campaigns, surveys, or personal testing. However, not all locations are suitable for manhole sampling, and it is necessary to consider the legal, ethical, and practical aspects before using wastewater analysis to monitor communities or specific populations."

Journal

Post-COVID-19 subacute painless thyroiditis: a case report in an anabolic androgenic steroid user. (PubMed, BMC Infect Dis) - "This case highlights the need to consider subacute thyroiditis in patients with unexplained thyrotoxicosis after COVID-19, especially when confounding factors, such as anabolic steroid use, are present."

Journal • Developmental Disorders • Endocrine Disorders • Immunology • Infectious Disease • Musculoskeletal Pain • Novel Coronavirus Disease • Pain • Respiratory Diseases

Comparative effects of respiratory stimulants in mechanically ventilated patients: a network meta-analysis of randomized controlled trials. (PubMed, Sci Rep) - "A systematic search of PubMed, Web of Science, and Scopus (up to November 10, 2023) identified 15 randomized controlled trials (1,528 participants) evaluating ten respiratory stimulants in mechanically ventilated critically ill adults: Almitrine Bismesylate (AB), Doxofylline (DX), Progesterone (PRG), Acetazolamide (ACZT), Growth Hormone (GH), Oxandrolone (OXA), Nandrolone (NA), Caffeine (CAF), Donepezil (DPZ), and a multi-agent adjuvant therapeutic (AT) regimen containing anisodamine. However, agents such as NA, GH, and DPZ may help shorten ICU stay, reduce duration of mechanical ventilation, or improve weaning efficiency. These findings underscore the potential value of multi-agent adjuvant approaches and highlight the need for larger, high-quality trials to confirm their clinical benefits.Trial registration: CRD42023454122 (18/10/2023)."

Journal • Retrospective data • Critical care

Evidence-Based Management of Burns: A Narrative Review of Evolving Practices. (PubMed, Eur Burn J) - " Key advances include the integration of propranolol and oxandrolone for metabolic modulation; enzymatic debridement agents such as NexoBrid®; regenerative approaches like epidermal cell sprays (e.g., RECELL®) and dermal substitutes (e.g., Integra®, MatriDerm®, NovoSorb® BTM); and innovations in scar modulation, notably fractional CO2 laser therapy. The integration of systemic, local, and rehabilitative strategies is improving outcomes in survival, function, and quality of life. Ongoing challenges include cost, access, and translation of novel therapies into widespread clinical practice."

Journal • Review • Thermal Injury

Comparative Efficacy of GnRHa Monotherapy vs. Combination Therapy for Central Precocious Puberty: A Systematic Review and Meta-Analysis. (PubMed, J Clin Endocrinol Metab) - "GH combination therapy enhances growth outcomes in children with CPP compared to GnRHa alone. Stanozolol, oxandrolone, and estrogen show promise but require further research. Personalized combination regimens and additional long-term RCTs are needed, particularly involving male patients and non-GH adjunctive therapies."

Journal • Monotherapy • Retrospective data • Endocrine Disorders

Oxandrolone treatment prevents muscle atrophy and retraction after rotator cuff injury: an experimental study in rats. (PubMed, JSES Rev Rep Tech) - "There was no statistical difference in muscle retraction in the oxandrolone treatment group before and after treatment (P = .098), but muscle retraction increased in the placebo treatment group (P = .005). Two-week oxandrolone treatment prevents muscle retraction and muscle atrophy by reducing fibrosis and increasing muscle fiber cross-sectional area after RC tears."

Journal • Preclinical • Fibrosis • Immunology • Muscular Atrophy

Effects of growth hormone and anabolic steroids, in critically ill patients admitted to the intensive care unit: a systematic review and meta-analysis. (PubMed, Sci Rep) - "Only studies using growth hormone, nandrolone, and oxandrolone were found...A possible subgroup that could benefit from growth hormone or anabolic steroids are critically ill patients who have surpassed the acute inflammatory phase of critical illness. Further research into various aspects of PEDs is needed within the context of current clinical practices."

Clinical • Journal • Retrospective data • Review • Critical care

Oxandrolone for burn patients: a systematic review and updated meta-analysis of randomized controlled trials from 2005 to 2025. (PubMed, World J Emerg Surg) - "Oxandrolone demonstrates clinical utility in burn management by significantly reducing surgical burden (SMD = - 1.25; p = 0.04), shortening hospitalization (LOS/TBSA SMD = - 1.07; p = 0.007), and enhancing anabolic recovery (weight gain SMD = 0.58; lean mass SMD = 1.30; both p < 0.001). However, extreme heterogeneity (I2 ≥ 95.0%) and temporal limitations necessitate cautious interpretation. Critically, it confers no mortality benefit (RR = 1.04; p = 0.913), fails to reduce infections (RR = 0.83; p = 0.639), and elevates hepatotoxicity risk in adults (19% vs. 5%; p = 0.002). These findings support its adjunctive role in metabolic rehabilitation but mandate risk-stratified implementation."

Clinical • Journal • Retrospective data • Review • Hepatology • Infectious Disease • Liver Failure • Metabolic Disorders • Pediatrics

Comparative effects of growth hormone, testosterone, and aromatase inhibitors on height gain in children and adolescents with idiopathic short statures: a network meta-analysis. (PubMed, Ann Hum Biol) - "All the treatment groups (GH, anastrozole, letrozole, AI+GH) demonstrated significantly greater height gains than did the placebo group. Oxandrolone did not significantly differ from the placebo (SMD = 0.52, 95% CI = -0.03-1.07). GH, AIs, and combination therapies improve height in children and adolescents with ISS, with letrozole showing a modest advantage but no clear superiority, highlighting the need for individualised treatment."

Clinical • Journal • Retrospective data • Review • Idiopathic Short Stature

The efficacy and safety of androgen analog oxandrolone in improving clinical outcomes in burn patients: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Front Med (Lausanne)) - "Our meta-analysis showed that oxandrolone supplements are beneficial for burn patients as they significantly reduce the weight loss in catabolic phase, operation times, LOS/TBSA%, LOS, mortality and increase weight gain and lean body mass in recovery phase. However, this intervention has minimal impact on healing time of donor area, side effects and infection."

Clinical data • Journal • Retrospective data • Review • Infectious Disease

A Preliminary Analysis of the Incidence of Transaminitis Observed in Oxandrolone Versus Testosterone Therapy in Major Burn Injury. (PubMed, J Burn Care Res) - "The median length of stay was 28 and 36 days, respectively, with a mortality rate of 21% and 6% in each group. Preliminary data from this study demonstrate a trend to higher incidence of oxandrolone transaminitis in comparison to testosterone, without statistical significance."

Journal • Thermal Injury

Oxandrolone Multiligament Knee (clinicaltrials.gov) - P4 | N=60 | Suspended | Sponsor: George F. Hatch | Active, not recruiting ➔ Suspended

Trial suspension • Musculoskeletal Diseases • Orthopedics

IMOX: Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction (clinicaltrials.gov) - P2 | N=96 | Not yet recruiting | Sponsor: Science Valley Research Institute

New P2 trial

MiRAGE-DTI: A novel approach for drug-target interaction prediction by integrating drug and target similarity metrics. (PubMed, Comput Biol Med) - "MiRAGE-DTI represents a versatile and powerful tool for advancing drug discovery and development. Its ability to identify novel therapeutic opportunities, repurpose existing drugs, and enable precision medicine highlights its transformative potential in tackling unmet medical needs. The framework's robust performance, validated predictions, and wide-ranging practical applications position MiRAGE-DTI as a critical resource for modern drug discovery."

Journal • CYP2E1

The Impact of Turner Syndrome and Hypogonadism on Brain and Hypothalamic-Pituitary Structure: Effects of Treatment with Sex Steroids and Growth Hormone (ESPE-ESE 2025) - "Cognitive Outcomes: Working memory shows improvement with combined GH and oxandrolone therapy but no significant change with GH alone (Soliman et al., 2024)... GH and sex steroid therapies are pivotal in addressing the neurodevelopmental and hypothalamic- pituitary deficits in TS. Early and comprehensive treatment strategies significantly enhance structural and functional outcomes, underscoring the importance of individualized approaches."

Cardiovascular • CNS Disorders • Cognitive Disorders • Endocrine Disorders • Genetic Disorders • Turners Syndrome

Effects of Growth Hormone (GH) and Sex Steroid Therapy on Brain Structure and Pituitary Function in Turner Syndrome (TS) (ESPE-ESE 2025) - "Cognitive Outcomes: Oxandrolone, a common adjunct with GH, improves working memory but GH alone does not significantly affect cognitive performance [(Ross et al., 1997)](https://consensus.app; (Ross et al., 2003)... GH and sex steroid therapies positively impact brain structure and pituitary function in TS, with combination therapy yielding the most substantial benefits. Tailored interventions and rigorous monitoring are essential to optimize clinical and neurodevelopmental outcomes in TS patients."

Genetic Disorders • Turners Syndrome

Hemoptysis and Anabolic Steroids: A Case Report of Oxandrolone-Induced Bleeding. (PubMed, Am J Case Rep) - "AAS might not appear on standard medication reconciliation sections in electronic medical records or on basic toxicology screen results. Further research is needed to elucidate factors that can influence bleeding versus thrombotic manifestations."

Journal • CNS Disorders • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease

COMBINED EFFECTS OF OXANDROLONE AND EXERCISE ON MUSCLE RECOVERY IN RATS WITH SEVERE BURN AND HINDLIMB UNLOADING. (PubMed, Shock) - "Oxandrolone and resistance exercise have independent positive effects on muscle function recovery in this clinically relevant rodent model of severe burn. Both treatments combined increased signaling pathways by increasing protein synthesis."

Journal • Preclinical • Fatigue • Muscular Atrophy • Thermal Injury • PPARGC1A

Development, dissemination and community response towards the first community notice regarding misrepresented illicit anabolic-androgenic steroids in circulation in Australia. (PubMed, Drug Alcohol Rev) - "This study, the first to describe a community notice for illicit market AAS, reveals a strong demand for harm reduction interventions. We call for the urgent expansion of drug-checking services to provision for AAS and, thus, provide equitable health support to address systemic gaps for this group."

Journal • Developmental Disorders

Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review. (PubMed, RMD Open) - "Drug interventions for IBM were not effective for most of the outcomes of interest. We observed inconsistency of outcome measures across trials. More RCTs are needed, of adequate size and duration, and using a standardised set of outcome measures."

Clinical • Journal • Review • CNS Disorders • Immunology • Myositis

Metabolic response to burn injury: a comprehensive bibliometric study. (PubMed, Front Med (Lausanne)) - "The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research."

Journal • Infectious Disease • Inflammation • Oncology • Septic Shock • Solid Tumor • Thermal Injury

Oxandrolone Rotator Cuff Trial (clinicaltrials.gov) - P=N/A | N=116 | Active, not recruiting | Sponsor: University of Southern California | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: May 2024 ➔ Jul 2025

Trial completion date • Trial primary completion date

Oxandrolone Multiligament Knee (clinicaltrials.gov) - P4 | N=60 | Active, not recruiting | Sponsor: George F. Hatch | Recruiting ➔ Active, not recruiting

Enrollment closed • Musculoskeletal Diseases • Orthopedics

Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone. (PubMed, J Pediatr (Rio J)) - "These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth."

Journal • Genetic Disorders • Turners Syndrome

Changing trends in anabolic-androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation. (PubMed, Drug Test Anal) - "Oxymetholone was the most prevalent AAS, followed by metandienone (methandrostenolone, methandienone), methyltestosterone, oxandrolone, mestanolone (methylandrostanolone), stanozolol, and androstenedione. Multiple AASs were found in 21 samples and 10 samples contained other drugs, including amitriptyline, sertraline, zopiclone, mirtazapine, sildenafil, etizolam, Δ9-tetrahydrocannabinol, and the synthetic cannabinoid MDMB-INACA. Most AAS samples were tablets (77.0%), although they were also detected in powders, herbal material, e-cigarettes, and a fragmented soap bar-type sample. There was a large variation in the concentration of AASs in the tablets and powders seized from the Scottish prisons, demonstrating AASs are another highly variable component of the polydrug use situation in prisons, the effects of which need to be examined further."

Journal