oxandrolone / Generic mfg. - LARVOL DELTA

Multicenter Analysis of Standard of Care versus Oxandrolone versus Testosterone in burn hypermetaboliSm (MASCOTS). (PubMed, J Burn Care Res) - "Anabolic therapy was associated with higher rates of venous thromboembolic events (p = 0.019). These findings underscore that optimizing anabolic therapy will require balancing efficacy, safety, and economic considerations, with a focus on long-term functional outcomes beyond initial hospital stay."

Clinical • Journal • Cardiovascular • Critical care

A Novel BRCA2-Associated Form of FGF23-Mediated Hypophosphatemic Rickets: Clinical, Biochemical, and Genetic Evidence (ENDO 2026) - "Intervention and Outcome: Treatment with burosumab (40 mg s.c. every 2 weeks) normalized phosphaturia and PTH and improved mineral metabolism. Due to initial worsening of bone density (DEXA Z-score −2.5 SDS at 6 months), adjunctive therapy with calcium, cholecalciferol, oxandrolone, and alendronate was introduced, resulting in dramatic improvement in bone mineral density (final Z-score −1.1 SDS), growth velocity, and near-complete radiographic resolution of osteopenia, although cortical thickness indices remained low... This case supports the existence of a novel form of FGF23-mediated hypophosphatemic rickets potentially linked to BRCA2 pathway dysfunction. Given emerging evidence that BRCA2 signaling intersects with Klotho–FGF23 regulation and reports of elevated FGF23 in BRCA2 carriers, BRCA2 may act as a disease modifier or causative factor in rare, genetically complex HR. Functional studies are warranted to elucidate this newly proposed link between cancer..."

Clinical • Musculoskeletal Diseases • AXIN1 • BRCA2 • ENPP1 • FGF23 • PHACTR1

Oxandrolone Rotator Cuff Trial (clinicaltrials.gov) - P=N/A | N=4 | Terminated | Sponsor: University of Southern California | N=116 ➔ 4 | Active, not recruiting ➔ Terminated | Trial primary completion date: Jul 2025 ➔ Jan 2026; Recruitment difficulties

Enrollment change • Trial primary completion date • Trial termination

Treatment Effects of Bisphosphonates Compared to Oxandrolone on Burn-Induced Bone Loss and Recovery in Mice. (PubMed, J Orthop Trauma) - "Alendronate was the superior protective treatment for preventing burn-induced bone loss and enhancing recovery in a murine model of post-burn systemic bone loss compared with oxandrolone, Vitamin D/ Calcium supplementation, and no treatment. These findings suggest that early administration of bisphosphonates in burn patients may be a promising method for mitigating post-traumatic bone loss."

Journal • Preclinical • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Thermal Injury

A Comparison of Three Analytical Procedures for Oxandrolone Long-Term Metabolite Determination in Urine Samples. (PubMed, Drug Test Anal) - "The first two approaches are reported here for the first time in the context of LTM analysis in antidoping applications. These methodologies represent innovative analytical strategies that may be transferable to other target analytes and thereby contribute to further improvements in sports drug testing."

Journal

Metformin reverses oxandrolone-induced anxiety-like behavior and amygdalar neurochemical dysregulation in male rats. (PubMed, Psychopharmacology (Berl)) - "The study provides mechanistic insight into the neuropsychiatric risks of anabolic steroid exposure and highlights potential therapeutic targets."

Journal • Preclinical • CNS Disorders • Mood Disorders • Psychiatry

Testosterone and anabolic therapy to recover strength, function, and quality of life after critical illness. (PubMed, Curr Opin Crit Care) - "Anabolic therapies appear most effective when integrated into multimodal recovery strategies combining personalized nutrition, progressive rehabilitation, and targeted pharmacologic support. Multidisciplinary prehabilitation/rehabilitation services/clinics may help accelerate recovery and reduce long-term disability in ICU survivors, though further multicomponent trials, including anabolic agents are urgently needed."

HEOR • Journal • Critical care • Sarcopenia

Effects of androgen therapy on final adult height in boys with constitutional delay of growth and puberty: a meta-analysis of retrospective cohort studies. (PubMed, BMC Endocr Disord) - "Short-term androgen therapy can improve final adult height in boys with CDGP, with low-dose, short-course testosterone regimens appearing to be the most favorable option. Given the limited number and retrospective nature of the included studies, these findings require further confirmation through high-quality comparative studies."

Journal • Retrospective data • Review

Oxandrolone Multiligament Knee (clinicaltrials.gov) - P4 | N=60 | Suspended | Sponsor: George F. Hatch | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics

Retrospective Safety Evaluation of Intramuscular Testosterone Cypionate in Male Burn Patients (SCCM 2026) - "Following the 2023 market withdrawal of oxandrolone, our burn center implemented intramuscular (IM) testosterone cypionate as an alternative anabolic agent... IM testosterone cypionate appears to be a safe and feasible anabolic strategy for male burn patients when appropriately monitored. The observed rise in testosterone was consistent with the intended dosing effect, and no major safety concerns emerged. Mild liver enzyme elevations were common but not clearly attributable to testosterone."

Retrospective data • Cardiovascular • Diabetes

IMOX: Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction (clinicaltrials.gov) - P2 | N=96 | Recruiting | Sponsor: Science Valley Research Institute | Trial completion date: Sep 2026 ➔ Apr 2027 | Trial primary completion date: Sep 2026 ➔ Apr 2027

Trial completion date • Trial primary completion date

EFFECTS OF REPEATED ADMINISTRATION OF OXANDROLONE IN FEMALE WISTAR RATS UNDERGOING STRENGTH TRAINING. (PubMed, J Steroid Biochem Mol Biol) - "Histopathological analysis revealed oxandrolone-induced damage to cardiac and skeletal muscle, along with structural alterations in the spleen and adrenal gland. Given its limited effect on muscle strength, along with histopathological changes and increased liver lipoperoxidation, these findings raise concerns about oxandrolone use in healthy individuals seeking aesthetic or athletic benefits."

Journal • Preclinical

Androgen Use Among Female Amateur Athletes: A Retrospective Analysis. (PubMed, Scand J Med Sci Sports) - "Most reported intermittent oral cycles with oxandrolone...While these patterns may reduce some dose-dependent risks such as heart failure, reliance on oral androgens increases the risk of hepatotoxicity and adverse lipid effects. A prospective study with a systematic approach is required to provide more reliable data on the health risk of androgen use in women."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

IMOX: Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction (clinicaltrials.gov) - P2 | N=96 | Recruiting | Sponsor: Science Valley Research Institute | Not yet recruiting ➔ Recruiting | Trial completion date: May 2026 ➔ Sep 2026 | Initiation date: Jun 2025 ➔ Oct 2025 | Trial primary completion date: May 2026 ➔ Sep 2026

Enrollment open • Trial completion date • Trial initiation date • Trial primary completion date

Manhole Sampling at Gyms and Sports Centers in Denmark: A Pilot Study Using Wastewater Analysis as a Tool for Monitoring the Use of Performance-Enhancing Drugs. (PubMed, Drug Test Anal) - "The study showed the presence of anabolic agents such as oxandrolone, stanozolol, and ostarine in wastewater sampled from the gyms. Wastewater analysis may be used as an easy and cost-effective tool to complement both preventive and control measures, such as information campaigns, surveys, or personal testing. However, not all locations are suitable for manhole sampling, and it is necessary to consider the legal, ethical, and practical aspects before using wastewater analysis to monitor communities or specific populations."

Journal

Post-COVID-19 subacute painless thyroiditis: a case report in an anabolic androgenic steroid user. (PubMed, BMC Infect Dis) - "This case highlights the need to consider subacute thyroiditis in patients with unexplained thyrotoxicosis after COVID-19, especially when confounding factors, such as anabolic steroid use, are present."

Journal • Developmental Disorders • Endocrine Disorders • Immunology • Infectious Disease • Musculoskeletal Pain • Novel Coronavirus Disease • Pain • Respiratory Diseases

Comparative effects of respiratory stimulants in mechanically ventilated patients: a network meta-analysis of randomized controlled trials. (PubMed, Sci Rep) - "A systematic search of PubMed, Web of Science, and Scopus (up to November 10, 2023) identified 15 randomized controlled trials (1,528 participants) evaluating ten respiratory stimulants in mechanically ventilated critically ill adults: Almitrine Bismesylate (AB), Doxofylline (DX), Progesterone (PRG), Acetazolamide (ACZT), Growth Hormone (GH), Oxandrolone (OXA), Nandrolone (NA), Caffeine (CAF), Donepezil (DPZ), and a multi-agent adjuvant therapeutic (AT) regimen containing anisodamine. However, agents such as NA, GH, and DPZ may help shorten ICU stay, reduce duration of mechanical ventilation, or improve weaning efficiency. These findings underscore the potential value of multi-agent adjuvant approaches and highlight the need for larger, high-quality trials to confirm their clinical benefits.Trial registration: CRD42023454122 (18/10/2023)."

Journal • Retrospective data • Critical care

Evidence-Based Management of Burns: A Narrative Review of Evolving Practices. (PubMed, Eur Burn J) - " Key advances include the integration of propranolol and oxandrolone for metabolic modulation; enzymatic debridement agents such as NexoBrid®; regenerative approaches like epidermal cell sprays (e.g., RECELL®) and dermal substitutes (e.g., Integra®, MatriDerm®, NovoSorb® BTM); and innovations in scar modulation, notably fractional CO2 laser therapy. The integration of systemic, local, and rehabilitative strategies is improving outcomes in survival, function, and quality of life. Ongoing challenges include cost, access, and translation of novel therapies into widespread clinical practice."

Journal • Review • Thermal Injury

Comparative Efficacy of GnRHa Monotherapy vs. Combination Therapy for Central Precocious Puberty: A Systematic Review and Meta-Analysis. (PubMed, J Clin Endocrinol Metab) - "GH combination therapy enhances growth outcomes in children with CPP compared to GnRHa alone. Stanozolol, oxandrolone, and estrogen show promise but require further research. Personalized combination regimens and additional long-term RCTs are needed, particularly involving male patients and non-GH adjunctive therapies."

Journal • Monotherapy • Retrospective data • Endocrine Disorders

Oxandrolone treatment prevents muscle atrophy and retraction after rotator cuff injury: an experimental study in rats. (PubMed, JSES Rev Rep Tech) - "There was no statistical difference in muscle retraction in the oxandrolone treatment group before and after treatment (P = .098), but muscle retraction increased in the placebo treatment group (P = .005). Two-week oxandrolone treatment prevents muscle retraction and muscle atrophy by reducing fibrosis and increasing muscle fiber cross-sectional area after RC tears."

Journal • Preclinical • Fibrosis • Immunology • Muscular Atrophy

Effects of growth hormone and anabolic steroids, in critically ill patients admitted to the intensive care unit: a systematic review and meta-analysis. (PubMed, Sci Rep) - "Only studies using growth hormone, nandrolone, and oxandrolone were found...A possible subgroup that could benefit from growth hormone or anabolic steroids are critically ill patients who have surpassed the acute inflammatory phase of critical illness. Further research into various aspects of PEDs is needed within the context of current clinical practices."

Clinical • Journal • Retrospective data • Review • Critical care

Oxandrolone for burn patients: a systematic review and updated meta-analysis of randomized controlled trials from 2005 to 2025. (PubMed, World J Emerg Surg) - "Oxandrolone demonstrates clinical utility in burn management by significantly reducing surgical burden (SMD = - 1.25; p = 0.04), shortening hospitalization (LOS/TBSA SMD = - 1.07; p = 0.007), and enhancing anabolic recovery (weight gain SMD = 0.58; lean mass SMD = 1.30; both p < 0.001). However, extreme heterogeneity (I2 ≥ 95.0%) and temporal limitations necessitate cautious interpretation. Critically, it confers no mortality benefit (RR = 1.04; p = 0.913), fails to reduce infections (RR = 0.83; p = 0.639), and elevates hepatotoxicity risk in adults (19% vs. 5%; p = 0.002). These findings support its adjunctive role in metabolic rehabilitation but mandate risk-stratified implementation."

Clinical • Journal • Retrospective data • Review • Hepatology • Infectious Disease • Liver Failure • Metabolic Disorders • Pediatrics

Comparative effects of growth hormone, testosterone, and aromatase inhibitors on height gain in children and adolescents with idiopathic short statures: a network meta-analysis. (PubMed, Ann Hum Biol) - "All the treatment groups (GH, anastrozole, letrozole, AI+GH) demonstrated significantly greater height gains than did the placebo group. Oxandrolone did not significantly differ from the placebo (SMD = 0.52, 95% CI = -0.03-1.07). GH, AIs, and combination therapies improve height in children and adolescents with ISS, with letrozole showing a modest advantage but no clear superiority, highlighting the need for individualised treatment."

Clinical • Journal • Retrospective data • Review • Idiopathic Short Stature

The efficacy and safety of androgen analog oxandrolone in improving clinical outcomes in burn patients: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Front Med (Lausanne)) - "Our meta-analysis showed that oxandrolone supplements are beneficial for burn patients as they significantly reduce the weight loss in catabolic phase, operation times, LOS/TBSA%, LOS, mortality and increase weight gain and lean body mass in recovery phase. However, this intervention has minimal impact on healing time of donor area, side effects and infection."

Clinical data • Journal • Retrospective data • Review • Infectious Disease

A Preliminary Analysis of the Incidence of Transaminitis Observed in Oxandrolone Versus Testosterone Therapy in Major Burn Injury. (PubMed, J Burn Care Res) - "The median length of stay was 28 and 36 days, respectively, with a mortality rate of 21% and 6% in each group. Preliminary data from this study demonstrate a trend to higher incidence of oxandrolone transaminitis in comparison to testosterone, without statistical significance."

Journal • Thermal Injury