Te'erjin (filgrastim biosimilar) / Dongbao Enterprise Group - LARVOL DELTA

Prospective Randomized Study of Cell Therapy for Metastatic Melanoma Using Short-Term Cultured Tumor Infiltrating Lymphocytes Plus IL-2 Following Either a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen Alone or in Conjunction w/1200 TBI (clinicaltrials.gov) - P2; N=94; Active, not recruiting; Sponsor: National Cancer Institute (NCI); Trial primary completion date: May 2014 ->May 2019

Trial primary completion date • Biosimilar • Colorectal Cancer • Melanoma • Oncology • Renal Cell Carcinoma

Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IIIB-IV Non-Small Cell Lung Cancer (clinicaltrials.gov) - P2/3; N=10000; Not yet recruiting; Sponsor: Southwest Oncology Group

New P2/3 trial • Biosimilar • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma

AZD9291 Versus Platinum-Based Doublet-Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (clinicaltrials.gov) - P3; N=1540; Not yet recruiting; Sponsor: AstraZeneca

New P3 trial • Biosimilar • Growth Hormone • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma

Temsirolimus and Pemetrexed for Recurrent or Refractory Non-Small Cell Lung Cancer (clinicaltrials.gov) - P1/2; N=12; Completed; Sponsor: Washington University School of Medicine; Active, not recruiting -> Completed

Trial completion • Biosimilar • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma

A Study of LY2157299 in Participants With Pancreatic Cancer That is Advanced or Has Spread to Another Part of the Body (clinicaltrials.gov) - P1; N=6; Not yet recruiting; Sponsor: Eli Lilly and Company

New P1 trial • Biosimilar • Oncology • Pancreatic Cancer • Renal Cell Carcinoma

Autologous Transplant in HIV Patients (BMT CTN 0803) (clinicaltrials.gov) - P2; N=40; Active, not recruiting; Sponsor: Medical College of Wisconsin; Trial primary completion date: Jun 2013 ->May 2015

Trial primary completion date • Biosimilar • Hematological Malignancies • Human Immunodeficiency Virus • Non-Hodgkin’s Lymphoma • Oncology • Renal Cell Carcinoma

Allogeneic Transplant in HIV Patients (BMT CTN 0903) (clinicaltrials.gov) - P2; N=15; Recruiting; Sponsor: Medical College of Wisconsin; Trial primary completion date: Nov 2013 ->Nov 2015

Trial primary completion date • Biosimilar • Human Immunodeficiency Virus • Leukemia • Non-Hodgkin’s Lymphoma • Oncology • Renal Cell Carcinoma

Phase I/II Study of Lapatinib in Combination With Paclitaxel as 1L Chemotherapy for ErbB2-positive MBC (clinicaltrials.gov) - P2; N=12; Completed; Sponsor: GlaxoSmithKline; Active, not recruiting -> Completed

Trial completion • Biosimilar • Breast Cancer • Oncology • Renal Cell Carcinoma • Triple Negative Breast Cancer

A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline (clinicaltrials.gov) - P=N/A; N=3226; Active, not recruiting; Sponsor: Brigham and Women's Hospital; Enrolling by invitation -> Active, not recruiting

Enrollment closed • Biosimilar • Renal Cell Carcinoma

Safety and Efficacy Study of Romiplostim to Treat ITP in Pediatric Subjects (clinicaltrials.gov) - P3; N=60; Recruiting; Sponsor: Amgen; Trial primary completion date: Apr 2015 ->Oct 2015

Trial primary completion date • Biosimilar • Growth Hormone • Immunology • Renal Cell Carcinoma

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure. (clinicaltrials.gov) - P2; N=570; Recruiting; Sponsor: Amgen; Trial primary completion date: Oct 2014 ->Apr 2015

Trial primary completion date • Acute Coronary Syndrome • Biosimilar • Heart Failure • Renal Cell Carcinoma

Phenotypical Approach of the Drug Metabolizing Hormones Activity Before and After Roux-en Y-Gastric Bypass (clinicaltrials.gov) - P1; N=10; Active, not recruiting; Sponsor: Assistance Publique - Hôpitaux de Paris; Recruiting -> Active, not recruiting

Enrollment closed • Biosimilar • Obesity • Oncology • Renal Cell Carcinoma

Using Ultrasound to Predict the Results of Draining Pleural Effusions (clinicaltrials.gov) - P=N/A; N=50; Not yet recruiting; Sponsor: University of Oxford; Initiation date: Nov 2013 ->Jun 2014

Trial initiation date • Biosimilar • Renal Cell Carcinoma

Glycerin Suppositories for Premature Infants (clinicaltrials.gov) - P=N/A; N=30; Not yet recruiting; Sponsor: McMaster University

New trial • Biosimilar • Renal Cell Carcinoma

Workers' Acceptability of a Prototype Integrated and Interactive Pedal Desk (clinicaltrials.gov) - P=N/A; N=44; Completed; Sponsor: Pennington Biomedical Research Center; Recruiting -> Completed

Trial completion • Biosimilar • Renal Cell Carcinoma

PGL5001 Proof of Concept Study in Inflammatory Endometriosis (clinicaltrials.gov) - P2a; N=24; Completed; Sponsor: PregLem SA; Recruiting -> Completed

Trial completion • Biosimilar • Endometriosis • Immunology • Oncology • Renal Cell Carcinoma

Nicotine Delivery Systems: Research & Treatment (clinicaltrials.gov) - P=N/A; N=25; Terminated; Sponsor: Department of Veterans Affairs; Trial primary completion date: Sep 2011 ->Sep 2009

Trial primary completion date • Biosimilar • Renal Cell Carcinoma

A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma (clinicaltrials.gov) - P2; N=10; Recruiting; Sponsor: New York Glaucoma Research Institute

New P2 trial • Biosimilar • Renal Cell Carcinoma

Non-culprit Vessels for ST-Segment Elevation Myocardial Infarction (clinicaltrials.gov) - P=N/A; N=306; Completed; Sponsor: Beijing Shijitan Hospital

New trial • Acute Coronary Syndrome • Atherosclerosis • Biosimilar • Renal Cell Carcinoma • Reperfusion Injury

Acupuncture Versus IV Morphine in the Treatment of Acute Renal Colic (clinicaltrials.gov) - P0; N=100; Recruiting; Sponsor: University of Monastir

New trial • Biosimilar • Heart Failure • Pain • Renal Cell Carcinoma

Efficacy and Safety Study of EscharEx to Treat (Debride) Hard to Heal Wounds (clinicaltrials.gov) - P2; N=72; Recruiting; Sponsor: MediWound Ltd; Trial primary completion date: Mar 2014 ->May 2015

Trial primary completion date • Biosimilar • Diabetes • Renal Cell Carcinoma

Treatment With PTH After Sternotomy in Cardiac Surgery Patients (clinicaltrials.gov) - P3; N=20; Completed; Sponsor: University of Aarhus; Trial primary completion date: Oct 2013 ->Mar 2014

Trial primary completion date • Biosimilar • Renal Cell Carcinoma

Improving Functions in MTBI Patients With Headache by rTMS (clinicaltrials.gov) - P=N/A; N=52; Recruiting; Sponsor: Department of Veterans Affairs; Trial primary completion date: Sep 2015 ->Mar 2016

Trial primary completion date • Biosimilar • Pain • Renal Cell Carcinoma

Changes in Taste Perception and Preference in the Peri-operative Patient (clinicaltrials.gov) - P=N/A; N=30; Completed; Sponsor: Plymouth Hospitals NHS Trust

New trial • Biosimilar • Renal Cell Carcinoma

Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery (clinicaltrials.gov) - P2a; N=210; Not yet recruiting; Sponsor: Novartis Pharmaceuticals

New P2a trial • Biosimilar • Renal Cell Carcinoma