FAPXIL (encapsulated IL-10) / Therapyx - LARVOL DELTA

AJRI AWARD LECTURE: Revisiting the Utility of Interleukin-10 using New Approach Methods: Old Wine in a New Bottle (ASRI 2025) - "Transfection of human decidual cells produced exosomal encapsulated IL-10 (tIL-10)... Exosomal IL-10 avoids the need for intraamniotic administration of the drug to treat feto-maternal inflammation associated with adverse pregnancies. tIL-10 is effective, noncytotoxic, and does not cause long-term immunosuppression to the mother or fetus. The humanized models of reproductive organs on a chip can accelerate preclinical trials and reduce, refine, and replace animal models in pregnancy research."

Infectious Disease • Inflammation • CD63 • CD81 • CD9 • IL10

PLGA-Chitosan Encapsulated IL-10 Nanoparticles Modulate Chlamydia Inflammation in Mice. (PubMed, Int J Nanomedicine) - "Collectively, our results show the successful IL-10 encapsulation, slow release to prolong its biological half-life and reduce inflammatory cytokines IL-6 and TNF production in vitro and in mice. Our results serve as proof of concept to further explore the therapeutic prospective of encapsulated IL-10 for biomedical applications, including inflammatory diseases."

Journal • Preclinical • Infectious Disease • Inflammation • Oncology • IL10 • IL6 • TNFA

Sustained delivery of IL-10 by self-assembling peptide hydrogel to reprogram macrophages and promote diabetic alveolar bone defect healing. (PubMed, Dent Mater) - "This study highlights that the SAP hydrogel is a promising drug delivery platform for treatment of alveolar bone defects, which might have translational potential in future clinical applications."

Journal • Diabetes • Inflammation • IL10