propofol MCT LCT / Generic mfg. - LARVOL DELTA

Haisco plans to raise no more than 1.365 billion yuan through a private placement to invest in new drug research and development projects and replenish cash flow [Google translation] (STCN) - "On the evening of February 27, Haisco (002653) announced its plan to issue A-shares to specific objects in 2025. The company plans to issue no more than 70 million shares to specific objects, and the total amount of funds raised will not exceed 1.365 billion yuan....According to the plan, the research and development of innovative drugs raised by Haisco this time include HSK31679 (non-alcoholic fatty hepatitis), HSK31858 (respiratory diseases), propofol (general anesthesia), HSK39297 (paroxysmal nocturnal hemoglobinuria, primary IgA nephropathy), HSK21542 (postoperative pain, postoperative nausea and vomiting) and HL231 (respiratory diseases) and other drugs for subsequent domestic and overseas clinical research and market registration."

Financing • Anesthesia • Metabolic Dysfunction-Associated Steatohepatitis • Paroxysmal Nocturnal Hemoglobinuria • Respiratory Diseases

Learning in the Single-Cell Organism Physarum polycephalum: Effect of Propofol. (PubMed, Int J Mol Sci) - "The model consists of a labyrinth of subsequent bifurcations in which food (oat flakes soaked with coconut oil-derived medium chain triglycerides [MCT] and soybean oil-derived long chain triglycerides [LCT]) or propofol in MCT/LCT) is placed in one of each Y-branch...In contrast, when oat flakes were soaked with propofol, Physarum's preference for oat flakes declined significantly. Several possible actions, including the blocking of gamma-aminobutyric acid (GABA) receptor signaling, are suggested to account for this behavior, many of which can be tested in our new model."

Journal • Anesthesia

Efficacy and Safety of Fospropofol Disodium for Injection in General Anesthesia Induction for Adult Patients: A Phase 3 Trial. (PubMed, Front Pharmacol) - "Objective: This study aimed to assess the efficacy and safety of Fospropofol in comparison with propofol medium/long-chain fat emulsion injections (propofol-MCT/LCT) for general anesthesia induction in adult patients undergoing elective surgeries...It is safe and effective for clinical use under anesthesiologist monitoring. Impact on Practice Statement: Fospropofol can produce a general anesthesia effect and reduce the incidence of pain at the site of injection."

Clinical • Journal • P3 data • Anesthesia • Pain

"As my name suggests I LOVE PROPOFOL. Burning aside man it is such a good drug." (@Smooshfacepug)

"Propofol for consciousness" (@DrSandman11)

"Propofol for anesthesia" (@letterstoyou24)

Anesthesia

Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy. (PubMed, Drug Des Devel Ther) - "Induction of anesthesia was preformed using propofol, sufentanil, and rocuronium. Additionally, in Group S, the APTT was prolonged in T1 and returned to normal in T2. The result showed that sugammadex provided transient efficacy in prolonging the coagulation parameters, while neostigmine did not change the coagulation profile."

Clinical • Anesthesia • Endocrine Cancer • Oncology • Solid Tumor • Thyroid Gland Anaplastic Carcinoma • Thyroid Gland Carcinoma

Diagnosis and Treatment of Status Epilepticus. (PubMed, J Epilepsy Res) - "The second-line treatment comprises intravenous (IV) doses of fosphenytoin (phenytoin), valproate, phenobarbital, levetiracetam, or midazolam...New AEDs such as IV levetiracetam and lacosamide can also be used to treat NCSE with fewer side effects and drug-drug interactions. For refractory SE, general anesthesia with IV midazolam, propofol, pentobarbital, or thiopental could be applied. Use of ketamine, megadose phenobarbital therapy, and multiple combinations of various AEDs including high doses of oral AEDs can also be considered...AEDs alone are poorly effective in the treatment of SE in autoimmune encephalitis. Immunotherapy such as steroids, immunoglobulin, rituximab, or tocilizumab can be effective."

Journal • Review • Anesthesia • CNS Disorders • Epilepsy • Immunology

High quantities: Evaluating the association between cannabis use and propofol anesthesia during endoscopy. (PubMed, PLoS One) - "Our data suggest that cannabis use is significantly associated with the quantity of propofol needed for sedation at endoscopy. Further study is needed to better understand the molecular basis for this possible drug-drug interaction."

Journal • Anesthesia

Comparison of predicted and real propofol and remifentanil concentrations in plasma and brain tissue during target-controlled infusion: a reply. (PubMed, Anaesthesia) - No abstract available

Journal

Does Peritraumatic Ketamine Reduce Symptoms of Post-Traumatic Stress Disorder? (PubMed, Spartan Med Res J) - "Based on the literature to date, peritraumatic ketamine does not appear to influence the prevention nor development of ASD and subsequent PTSD. More research is needed to clarify the psychopharmacologic effects of ketamine when used in the management of reactions to acute trauma experiences. Based on the results of the two later works, future research is indicated considering whether propofol may contribute to PTSD development."

Journal • Anesthesia • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca Response in Mice. (PubMed, Neurochem Res) - "These findings demonstrated that dexmedetomidine caused stronger inhibitory effects on GIT motility in sedative mice, which may involve impaired Ca response in enteric glia. Hence, dexmedetomidine should be carefully applied especially for potential GIT dysmotility patient."

Journal • Anesthesia • CNS Disorders • Gastrointestinal Disorder

A Multicenter Investigation of the Hemodynamic Effects of Induction Agents for Trauma Rapid Sequence Intubation. (PubMed, J Trauma Acute Care Surg) - "Contrary to our hypothesis, there was no difference in the hemodynamic effect for etomidate vs. ketamine vs. propofol during RSI in trauma patients."

Clinical • Journal • Hypotension • Mood Disorders

Differential effect of anesthetics on mucociliary clearance in vivo in mice. (PubMed, Sci Rep) - "Our results indicate that anesthetics containing ketamine (ketamine/xylazine and ketamine/dexmedetomidine) significantly depress MCC, while combinations containing fentanyl (fentanyl/isoflurane, fentanyl/midazolam/dexmedetomidine) and propofol do not. Our method for assessing MCC is reproducible and has utility for studying the effects of other drug combinations."

Journal • Preclinical • Anesthesia

Low dose dexmedetomidine reduces median effective concentration (EC 50) of propofol more than fentanyl in unparalysed anaesthetised patients for I-gel insertion: a randomised controlled trial. (PubMed, Anaesth Crit Care Pain Med) - "Low dose dexmedetomidine when compared with fentanyl significantly reduce the EC50 and dose of propofol required for I-gel insertion with propofol TCI, without much change in the hemodynamic profile."

Clinical • Journal • Anesthesia

Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry. (PubMed, Br J Anaesth) - "Repeated exposure of neonatal mice to propofol anaesthesia during early development causes cortical circuit dysfunction and behavioural impairments in later life. Potentiation of neuronal activity during recovery from anaesthesia reduces these adverse effects of early-life anaesthesia."

Journal • Anesthesia

Pediatric characteristics and the dose of propofol for sedation during radiological examinations: a retrospective analysis. (PubMed, J Int Med Res) - "A child's age, height, and body surface area should be considered when deciding the induction dose of propofol. Additionally, the formula that we have proposed can be used to estimate the dose of propofol required to induce sedation in children undergoing imaging."

Journal • Retrospective data • Anesthesia • Pediatrics

The impact of a stress-reducing protocol on the quality of pre-anaesthesia in cats. (PubMed, Vet Rec) - "These results suggest that, in cats, pre-anaesthetic and induction requirements are influenced by lower-stress transport and handling."

Clinical • Journal • Anesthesia

Etomidate vs propofol in coronary heart disease patients undergoing major noncardiac surgery: A randomized clinical trial. (PubMed, World J Clin Cases) - "In patients with CHD undergoing noncardiac major surgery, etomidate-based anesthesia is associated with fewer cardiovascular events and smaller hemodynamic changes than propofol-based anesthesia."

Clinical • Anesthesia • Cardiovascular • Coronary Artery Disease • Heart Failure • Hypotension • TNNI3

Comparison between dexmedetomidine and acepromazine in combination with methadone for premedication in brachycephalic dogs undergoing surgery for brachycephalic obstructive airway syndrome. (PubMed, Vet Anaesth Analg) - "Dexmedetomidine 2 μg kg produces more sedation but similar recovery quality to acepromazine 20 μg kg combined with methadone in dogs undergoing BOAS surgery."

Combination therapy • Journal • Anesthesia • Hypotension

Evaluation of Propofol in Inhibiting Proliferation of Cardiac Fibroblasts in Angiotensin II-Induced Mouse. (PubMed, Crit Rev Eukaryot Gene Expr) - "Propofol exerts effect in inhibiting ET-1 and fibronectin expression and the formation of ROS induced by Ag II. Moreover, Akt-eNOS-nitric oxide signaling pathway may be involved in the effect of propofol on the proliferation of CFs induced by Ag II."

Journal • FN1 • NOS3

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery. (PubMed, Anesthesiology) - "This trial refuted the hypothesis that balanced opioid-free anesthesia with dexmedetomidine, compared with remifentanil, would result in fewer postoperative opioid-related adverse events. Conversely, it did result in a greater incidence of serious adverse events, especially hypoxemia and bradycardia."

Journal • Anesthesia • Cardiovascular • Cognitive Disorders • Pain

A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly. (PubMed, Sci Rep) - "This study provides the first direct and comparative account of three key anesthetics (desflurane, propofol, and ketamine) when used under identical conditions, and demonstrates their impact on neonatal, rat cortical neuronal viability, neurite outgrowth and synaptic assembly. Furthermore, we discovered that inhibiting Fis1-mediated mitochondrial fission reverses anesthetic-induced aberrations in an agent-specific manner. This study underscores the importance of designing mitigation strategies invoking mitochondria-mediated protection from anesthetic-induced toxicity in both animals and humans."

Journal • Anesthesia

A Case Report of Sedation Strategy for a Patient With Coronavirus Disease 2019 Supported by Extracorporeal Membrane Oxygenation After Cesarean Section. (PubMed, Heart Surg Forum) - "Nevertheless, the patient successfully was treated with a continuous single/combined application of propofol, midazolam, dexmedetomidine, hibernation mixture, and other drugs for several days (maintaining RASS -2 to -4) and provided with anti-infection, mechanical ventilation, nutritional support, fluid balance under hemodynamic monitoring, liver support, and other organ function support treatments. ECMO-assisted sedation strategy for patients was introduced and discussed in this case to provide a certain reference for the clinical diagnosis and treatment of such patients."

Clinical • Journal • Anesthesia • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Comments on comparison of propofol and sevoflurane for postoperative pain control in total knee arthroplasty patients. (PubMed, Pain Pract) - No abstract available

Clinical • Journal • Orthopedics • Pain