Impracor (ketoprofen) / Harrow Health - LARVOL DELTA

Comparative evaluation of the effect of various transdermal patches and oral nonsteroidal anti-inflammatory drugs on postoperative endodontic pain and quality of life - A placebo-controlled randomized clinical trial. (PubMed, J Conserv Dent Endod) - "Oral ibuprofen is most effective at the 4-h interval, whereas transdermal ketoprofen has the best pain reduction in the 12-24-h window due to its sustained-release pharmacokinetics. A ketoprofen patch is a promising alternative for postoperative pain management."

Clinical • HEOR • Journal • Dental Disorders • Pain • Periodontitis

REB methodology application on topical and oral NSAIDS' therapeutic benefit evaluation on acute pain related to musculoskeletal injuries (PubMed, Therapie) - "According to REB methodology, topical NSAIDs, unlike oral formulations, have demonstrated efficacy in managing acute pain related to musculoskeletal injuries. These results reinforce recent meta-analyses favoring topical NSAIDs and recommending to limit the use of oral NSAIDs due to a lack of proof in this indication. Finally, NSAIDs impact on tissue healing has not been objectively studied by RCTs in humans, so further research is warranted. The use of NSAIDs in trauma care may potentially evolve as new data and knowledge emerge."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Comparative Efficacy of Transdermal Ketoprofen and Diclofenac Sodium in the Management of Post-Endodontic Pain: A Prospective In Vivo Study. (PubMed, Cureus) - "Sabharwal's Wound Care, Delhi, India), and Group 2 received transdermal ketoprofen patches (30 mg, Speedser, Troikaa Pharmaceuticals Ltd., Ahmedabad, India). Conclusions Transdermal ketoprofen (30 mg) outperformed diclofenac sodium (100 mg) in the management of post-endodontic pain, offering rapid and sustained relief. These findings support ketoprofen as the preferred analgesic in endodontic practice, highlighting the need for tailored pain management strategies."

Journal • Preclinical • Anesthesia • Dental Disorders • Inflammation • Pain

Evaluation of Awareness of Photosensitivity Risk and Additional Risk Minimisation Measures for Ketoprofen Gel in Belgium and Luxembourg. (PubMed, Drugs Real World Outcomes) - "The results indicate a high level of awareness of the photosensitivity risk of Fastum gel among participating HCPs. Notably, a majority of HCPs expressed the need for an annual DHPC. This study also underscores the importance of using multiple channels of information to increase the opportunities for reaching HCPs. Nevertheless, the survey revealed limited use of the checklist and the patient card among HCPs."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Comparison of analgesic efficacy of pain patches in post-orthodontic extraction-a pilot study. (PubMed, Natl J Maxillofac Surg) - "To investigate the efficacy of a single-dose transdermal patch of ketoprofen compared with that of diclofenac postoperatively after therapeutic extraction of first premolar teeth for patients undergoing orthodontic treatment...A single diclofenac patch was applied for the first and fourth quadrant extractions, and ketoprofen patch was applied for the second and third quadrant extractions after atraumatic therapeutic exodontia at two consecutive appointments with the patient under local anesthesia...No complications were observed among the two groups postoperatively. Both the ketoprofen and diclofenac transdermal patches were effective in achieving postoperative analgesia in patients after therapeutic extraction, with ketoprofen superior to diclofenac."

Journal • Anesthesia • Pain

Photodistributed cutaneous vasculitis: An uncommon side effect for topical ketoprofen. (PubMed, Therapie) - No abstract available

Adverse events • Journal • Vasculitis

Efficacy of transdermal ketoprofen on surgical inflammation in dogs. (PubMed, Res Vet Sci) - "All dogs were castrated using standard surgical protocols, administered with pre-medication, consisting of acepromazine (0.055 mg/kg) and methadone (0.5 mg/kg) intramuscularly (IM) 30 min prior to induction of general anaesthesia. All dogs were then anaesthetised by injecting alfaxalone (2 mg/kg IV) via a 20 G 3 cm catheter in the left cephalic vein and subsequently maintained using isoflurane...Bloods were collected at 0 - hour (pre-surgery), and 1 and 2-h post-surgery and analysed for circulating eicosanoids using liquid chromatography mass spectrometry (LCMS) methods. Measured levels of Thromboxane B2 (TXB2) at both 1 and 2 h and Prostaglandin E2 (PGE2) at 2 h post-surgery were higher in the Control group compared to the TD group, suggesting pre-operative application of TD ketoprofen has a possible inhibitory effect on systemic inflammation and could be used to treat pain and inflammation in dogs."

Journal • Anesthesia • Inflammation • Pain

Transdermal Ketoprofen Versus Fentanyl Patches for Pain Management Post-cesarean Section: A Comparative, Randomized, Double-Blind Study. (PubMed, Cureus) - "Both the ketoprofen patch (30 mg) and the fentanyl patch (25 mcg) provided comparable analgesia for the first 12 hours. However, at 16 and 20 hours, the ketoprofen patch was more effective than the fentanyl patch in providing analgesia. More patients in the fentanyl group were drowsy after 16 hours, though normal sleep patterns may have contributed to this observation."

Clinical • Journal • Anesthesia • Pain

Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen. (PubMed, Contact Dermatitis) - "Contact allergy to fragrance mix I, Myroxylon pereirae, black rubber mix, PFR-2, PTBP-FR, and to a somewhat lower extent, to fragrance mix II and budesonide, is common in individuals photoallergic to ketoprofen. It remains to be seen whether sensitisation to ketoprofen leads to simultaneous sensitisation to a number of other, chemically non-related, substances."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Design and evaluation of a drug-in-adhesive patch for the transdermal delivery of ketoprofen. (PubMed, Drug Deliv Transl Res) - "The purpose of this study was to design a drug-in-adhesive (DIA) patch for transdermal delivery of ketoprofen, using hot-melt pressure-sensitive adhesive as the matrix of the patch. Pharmacokinetic and the tissue distribution study showed no matter in plasma, muscle or skin, the drug concentration of self-made ketoprofen patch was equivalent to that of commercial patch. These data indicated that the self-made patch provided a new reference for the development of ketoprofen dosage forms and promising alternative strategy for analgesic treatment."

Journal • Pain

Evaluation of the in vitro human skin percutaneous absorption of ketoprofen in topical anhydrous and aqueous gels. (PubMed, Skin Res Technol) - "The anhydrous gel can be used as a base to facilitate the transdermal delivery of ketoprofen. Although the anhydrous and aqueous gels can deliver a similar amount of ketoprofen, the anhydrous gel (water activity below 0.6) allows for extended default beyond-use-date of compounding preparations."

Journal • Preclinical • Pain

Comparative evaluation of efficacy of diclofenac and ketoprofen administered using transdermal drug delivery route in management of post endodontic pain: A randomized controlled clinical trial. (PubMed, J Conserv Dent Endod) - "Oral diclofenac for Group I and transdermal diclofenac patch for Group II and transdermal ketoprofen patch for Group III were administered as postendodontic analgesics. Six out of ten patients who had received diclofenac tablets complained of gastric discomfort. Both transdermal ketoprofen and diclofenac patches were effective than oral diclofenac tablet and can be used as an alternative and effective analgesic for postendodontic pain management, especially in patients with gastric discomfort."

Clinical • Journal • Dental Disorders • Pain

Comparative Evaluation of Efficacy of Ketoprofen and Diclofenac Transdermal Patches with Oral Diclofenac Tablet on Postoperative Endodontic Pain- A Randomized Clinical Trial. (PubMed, Patient Prefer Adherence) - "Groups A and B received transdermal patches with Ketoprofen and diclofenac sodium, respectively, applied to the right forearm for 24 hours, with an additional patch on the left forearm for the next day. Group C received four diclofenac sodium oral tablets, twice daily for two days...Notably, the Ketoprofen patch group exhibited superior performance compared to the diclofenac transdermal patch and oral diclofenac tablet groups at 48 hours, with statistical significance (p=0.047). The present evidence substantiates the efficacy of transdermal patches containing diclofenac and ketoprofen in managing postoperative pain arising from symptomatic irreversible pulpitis in single-rooted teeth. By avoiding the use of oral NSAIDs, these patches provide effective pain relief while minimizing the risk of adverse effects, presenting a favorable option for patients."

Clinical • Journal • Dental Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Influence of iontophoresis on delivery of NSAID-loaded deformable liposomal dispersions: in vitro and in vivo evaluation. (PubMed, Ther Deliv) - "Conventional and deformable liposomes exhibited relatively higher iontophoretic flux values than passive flux; Iontophoretic delivery enhanced KP availability in the synovial fluid (1.34 ± 0.12 μg.h/ml) fourfold over passive delivery (0.329 ± 0.15 μg.h/ml). Iontophoretic mediated transport of deformable liposomes could improve transdermal delivery of ketoprofen into the synovial joints than conventional liposomes."

Journal • Preclinical

Analgesic Efficacy of Ketoprofen Transdermal Patch versus Ibuprofen Oral Tablet on Postendodontic Pain in Patients with Irreversible Pulpitis: A Randomized Clinical Trial. (PubMed, Pain Res Manag) - "Both KTP and ibuprofen effectively decreased postendodontic pain. Considering the comparable pattern of pain reduction, KTP can be used as an alternative to ibuprofen tablets for effective pain control after endodontic treatment of mandibular first and second molars with irreversible pulpitis."

Clinical • Journal • Dental Disorders • Pain

Evaluation of the in vitro permeation parameters of topical ketoprofen and lidocaine hydrochloride from transdermal Pentravan products through human skin. (PubMed, Front Pharmacol) - "A similar tendency was observed in the case of LH, where the addition of Tinctura capsici, menthol and camphor led to a statistically significant higher penetration. Adding certain drugs such as KET and LH to Pentravan, and substances such as menthol, camphor or capsaicin, can be an interesting alternative to administered enteral drugs especially in the group of patients with multiple diseases and polypragmasy."

Journal • Preclinical • Pain

Efficacy of Transdermal Ketoprofen Patch in Comparison to Transdermal Diclofenac Patch in Postoperative Analgesia for Orthodontic Extractions: A Randomized Split-Mouth Study. (PubMed, Cureus) - "Conclusion Ketoprofen and diclofenac transdermal patches provide similar analgesia post orthodontic extraction. The patients required rescue analgesics only during the initial hours of the postoperative follow-up period."

Journal • Allergy • Anesthesia • Gastrointestinal Disorder • Pain

Design and Development of Functionalized Single-walled Carbon Nanotube-ethosomes for Transdermal Delivery of Ketoprofen. (PubMed, Pharmazie) - "The characterization results consistently showed f-SWCNTs is a promising drug carrier. The hybrid nanocarrier prepared by the combination of f-SWCNTs and ethosomes can enhance the transdermal absorption of drugs and improve the bioavailability of drugs, which has a certain significance for the development of advanced hybrid nano-preparations."

Journal

Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen. (PubMed, Pharmaceuticals (Basel)) - "The cumulative amounts of drug permeated after 24 h for F5-MN-NS and F11-MN-CG were 3.88 ± 0.46 µg and 8.73 ± 1.40 µg, respectively. In conclusion, the combination of DMN with nanosuspension or a co-grinding system may be a promising strategy for delivering ketoprofen transdermally."

Journal

Ketoprofen-induced Photoallergic Reaction. (PubMed, Acta Dermatovenerol Croat) - "For the last twenty years, the patient had been struggling with chronic back pain and was frequently taking different NSAIDs (ibuprofen, diclofenac, etc.). The patient also suffered from essential hypertension and was regularly taking ramipril...Two months later, we performed patch and photopatch tests to baseline series and topical ketoprofen...Due to their similar biochemical structure, patients with ketoprofen photoallergy should avoid using some drugs such as some NSAIDs (suprofen, tiaprofenic acid), antilipidemic agent (fenofibrate) and sunscreens based on benzophenones (6,9). Physicians and pharmacists should advise patients of the potential risks when topical NSAIDs are applied on the photoexposed skin."

Journal • Allergy • Atopic Dermatitis • Back Pain • Cardiovascular • Contact Dermatitis • Dermatitis • Dermatology • Hypertension • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

An evaluation of ketoprofen as an intranasal anti-inflammatory agent. (PubMed, Eur Rev Med Pharmacol Sci) - "Ketoprofen, when applied topically for 24 hours to nasal epithelial cells in cell culture, does not cause any alterations in cellular appearance which would suggest impairment of the ability to proliferate or indicate a cytotoxic effect. Extrapolating from these results, it appears acceptable to use ketoprofen topically within the nose in cases of rhinosinusitis (acute or chronic) or nasal pain since there is minimal risk of local toxic injury."

Journal • Otorhinolaryngology • Pain • Respiratory Diseases • Sinusitis

Bioinspired ketoprofen-incorporated polyvinylpyrrolidone/polyallylamine/ polydopamine hydrophilic pressure-sensitive adhesives patches with improved adhesive performance for transdermal drug delivery. (PubMed, Eur J Pharm Biopharm) - "Inspired by the natural mussel adhesive mechanism, three different materials-polydopamine (PDA), polyvinylpyrrolidone (PVP), and polyallylamine (PAM)-were used to make innovative pressure-sensitive adhesives (PSAs) for transdermal delivery of ketoprofen...In addition, the patches were stable for six months. Consequently, the PVP/PAM/PDA patches exhibited outstanding tissue adhesiveness, enabling universal tissue adherence while causing no skin tissue irritation or inflammatory reaction."

Journal

Mussel-inspired poly(hydroxyethyl acrylate-co-itaconic acid)-catechol/hyaluronic acid drug-in-adhesive patches for transdermal delivery of ketoprofen. (PubMed, Int J Pharm) - "Furthermore, the patches had good physical and chemical stability. Therefore, these catechol-functionalized patches may be potential transdermal drug delivery systems with excellent adhesive properties for the delivery of a drug through the skin."

Journal

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field. (PubMed, Bioengineering (Basel)) - "Clinical validation on 22 patients with lower back pain was managed using diamagnetic therapy plus topical ketoprofen or KiOil...SF-36 showed statistical significance for all items except limitations due to emotional problems. A high-intensity pulsed magnetic field is an adjunct to topical treatment in patients with localized pain, and the effect of MF does not evidence significant effects on the molecules."

Journal • Back Pain • Musculoskeletal Pain • Pain

Pre-emptive Analgesic Efficacy of Single-Dose Transdermal Ketoprofen and Diclofenac Patches in Post-operative Pain Management Following Open Treatment of Mandibular Fractures: A Randomized Controlled Study. (PubMed, Cureus) - "The ketoprofen transdermal patch was found to be superior in comparison to the diclofenac patch in terms of providing optimal post-operative analgesia with a reduced requirement for post-operative rescue analgesics and minimal adverse events."

Journal • Musculoskeletal Diseases • Orthopedics • Pain