desoximetasone cream/gel/ointment / Generic mfg. - LARVOL DELTA

Familial Reactive Perforating Collagenosis with Adolescence-Onset: A Rare Case Report and Literature Review. (PubMed, Clin Cosmet Investig Dermatol) - "Unlike the majority of FRPC patients who had their disease onsets during infancy or early childhood, FRPC skin manifestations in our patient started during the adolescence period. The resolution of skin manifestations after daily application of topical desoximetasone suggests that topical corticosteroids are a potential treatment option for FRPC patients."

Journal • Review • Dermatology

Enhanced the therapeutic effects of desoximetasone by inhibiting cytochrome P450 3A4 metabolism in the imiquimod-induced psoriasis animal model (ISID 2023) - "Our results show that topical 0.05% desoximetasone loaded in a cytochromes P450 3A4 enzyme inhibitor excipient base emollient formulation restores imiquimod induced barrier disruption and showed fewer severe clinical and pathological features than commercial 0.25% desoximetasone ointment and 0.5% clobetasol ointment. The results might provide a new concept of topical drug development for inflammatory skin diseases treatment."

Preclinical • Allergy • Dermatology • Immunology • Inflammation • Psoriasis

A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products. (PubMed, Front Pharmacol) - "The current work considers the Topicort Spray formulation, which contains 0.25% desoximetasone (DSM), as an example formulation...The tested dosing scenarios showed decreased sensitivity for all formulation parameters with a decreased dose. The relative formulation bioequivalence was insensitive to vasoconstriction, but the safe space became wider with decreased barrier function for all parameters, except viscosity that was unaffected."

Journal • Dermatology

Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy®) in the Treatment of Scalp Psoriasis (clinicaltrials.gov) - P3; N=105; Not yet recruiting; Sponsor: Siriraj Hospital

New P3 trial • Biosimilar • Immunology • Psoriasis

Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema. (PubMed, Dermatol Ther) - "In conclusion, calcipotriol ointment is safe and as effective as desoximetasone ointment. Calcipotriol ointment may be an alternative treatment option for CHE."

Clinical • Journal

Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis (clinicaltrials.gov) - P4; N=100; Recruiting; Sponsor: Taro Pharmaceuticals USA; Trial completion date: Dec 2018 ➔ Dec 2019; Trial primary completion date: Nov 2018 ➔ Nov 2019

Clinical • Trial completion date • Trial primary completion date