MIV-247 / Medivir - LARVOL DELTA

Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis. (PubMed, J Cell Physiol) - "These abovementioned changes were blocked by two different selective cathepsin S inhibitors, LY3000328 or MIV-247. Moreover, Kaplan-Meier survival plot showed that cathepsin S inhibition improved 21-day survival rate following myocardial I/R injury. This study demonstrated that the inhibition of cathepsin S alleviated myocardial I/R-induced injury by suppressing inflammation and apoptosis, which may be used in clinical applications of cardioprotection."

Journal • Cardiovascular • Gene Therapies • Immunology • Ischemic stroke • Myocardial Ischemia • Reperfusion Injury • CASP3 • CASP8 • IL6 • TNFA • TNNI3