GSK143 / GSK - LARVOL DELTA

Effect of human breast milk derived-exosomes in ameliorating neonatal necrotizing enterocolitis (AAP-NCE 2025) - "Erk Inhibition: IEC-6 cells treated with LPS, C-exos, and Erk inhibitor (GSK143) to evaluate migration (scratch assay) and p-Erk/Erk expression. 1... 1. Therapeutic Potential: C-exos and M-exos equally alleviate NEC-induced inflammation and intestinal damage, but C-exos excel in restoring barrier proteins (ZO-1/E-cad) and promoting epithelial migration. 2."

Cardiovascular • Developmental Disorders • Gastrointestinal Disorder • Inflammation • Inflammatory Bowel Disease • IGF1 • IL6 • MAPK1 • TJP1

Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases. (PubMed, Expert Opin Investig Drugs) - "The search terms used were SYK inhibitors, R406, fostamatinib (R788), P505-15 (PRT062607), entospletinib (GS-9973), R112, lanraplenib (GS-9876), cerdulatinib, R343, BAY-61-3606, GSK compound 143 (GSK143), R211, SKI-G-618, SKI-O-85, ER-27319, YM193306, RO9021 in conjunction with autoimmune disease using electronic databases including PubMed, EMBASE, MEDLINE and Google Scholar. However, the difficulties in developing highly selective SYK inhibitors and the unknown effects are challenges. Long term and real-world data are essential to determine the risk-benefit ratio and true role of SYK inhibitors in the therapy of ADs."

Journal • Immunology • Inflammation • SYK

Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a Chronic Mouse Model of Allergic Airways Inflammation. (PubMed) - PLoS One - "Syk inhibitors may play a role in the management of neutrophilic asthma."

Journal • Asthma • Biosimilar • Immunology