Daren (emedastine) / Kowa, Merck (MSD) - LARVOL DELTA

Efficacy of Intense Pulsed Light combined with emedastine difumarate eye drops in the treatment of Allergic Conjunctivitis and analysis of the impact on Cytokine Levels in Tears (IL-4, IL-5, IL-13) (ChiCTR) - P=N/A | N=80 | Recruiting | Sponsor: Guigang Donghui Hospital; Guigang Donghui Hospital

New trial • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology • IL13 • IL4 • IL5

RETRACTION: NIK-Mediated Reactivation of SIX2 Enhanced the CSC-like Traits of Hepatocellular Carcinoma Cells Through Suppressing Ubiquitin-Proteasome System. (PubMed, Environ Toxicol) - "Daren, Y. Dan, W. Jinhong, and L. Chao, "NIK-Mediated Reactivation of SIX2 Enhanced the CSC-like Traits of Hepatocellular Carcinoma Cells Through Suppressing Ubiquitin-Proteasome System," Environmental Toxicology 39, no...The above article, published online on 17 July 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted."

Journal • Hepatocellular Cancer • Oncology • Solid Tumor • Targeted Protein Degradation

Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells. (PubMed, Biol Pharm Bull) - "This suppression was associated with inhibition of CD86 expression on mast cells, and mast cells treated with emedastine were shown to obstruct the differentiation of both Th1 and Th2 cells by down-regulating their cell surface expression of CD86. The present data provide additional information that topical application of emedastine to the lesional skin of patients with atopic dermatitis (AD) would reduce not only LC- but also mast cell-mediated skin inflammation."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Oncology • CD4 • CD86 • TNFA

Comparative Safety Profiles of Individual Second-Generation H1-Antihistamines for the Treatment of Chronic Urticaria: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. (PubMed, J Allergy Clin Immunol Pract) - "These findings suggest evidence of variations in safety profiles among sgAHs for CU treatment, particularly in terms of adverse events and CNS side effects."

Clinical • Journal • Retrospective data • Review • Dermatology • Immunology • Urticaria

Identification of lncRNA-miRNA-mRNA Regulatory Network and Therapeutic Agents for Skin Aging by Bioinformatics Analysis. (PubMed, Biochem Genet) - "Finally, ten significant potential small molecules mitigating skin aging were screened using CMAP platform, including tretinoin, pifithrin, selamectin, entinostat, bretazenil, syringic-acid, BRD-K96475865, emedastine, abacavir, and rotenone, and their reliability was verified by molecular docking experiments. The present study provided basis for revealing the molecular mechanism of skin aging and identified the potential candidate drugs for mitigating skin aging."

Journal

Case presentation and panel discussion: Micronutrient therapy in critical illness. (PubMed, JPEN J Parenter Enteral Nutr) - "Here, the case presentation and discussion from the postsession question and answer period are presented. The moderator for this session was Jose Pimiento, MD, and the speakers and panelists were Christian Stoppe, MD, Todd Rice, MD, and Daren Heyland, MD."

Journal • Critical care • Infectious Disease • Septic Shock

Protective effect of biogenic selenium nanoparticles against diquat-induced acute toxicity via regulation of gut microbiota and its metabolites. (PubMed, Food Chem Toxicol) - "Microbiome-metabolome correlation analysis suggested that Parabacteroides was the key bacteria for the SeNPs intervention, which might upregulate the levels of metabolites such as trimethaphan, emedastine, berberine, desoxycortone, tetrahydrocortisone. This study demonstrated that dietary SeNPs supplementation can extensively modulate the gut microbiota and its metabolism, thereby alleviating diquat-induced acute toxicity."

Journal

Efficacy of Artemisia Pollen Specific Allergen Immunotherapy (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: Beijing Tongren Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Jun 2024 ➔ Nov 2024 | Trial primary completion date: Mar 2024 ➔ Oct 2024

Enrollment open • IO biomarker • Trial completion date • Trial primary completion date • Allergic Rhinitis • Immunology • Inflammation • TNFA • TSLP

Ophthalmic Drugs: In vitro paraoxonase 1 inhibition and molecular docking studies. (PubMed, Biotechnol Appl Biochem) - "This study was tested some ophthalmic drugs used to treat the diseases, such as glaucoma and allergic conjunctivitis, mentioned above, travoprost, latanoprost, ketotifen, emedastine, and olopatadine, for their inhibition activities against PON1. Besides, the molecular docking analyses of the competitive inhibitors, travoprost, emedastine, and olopatadine, were performed to understand the binding interactions on the enzyme's binding site. According to both in vitro and in silico analysis results, travoprost had the most potent effect on PON1 enzyme activity."

Journal • Preclinical • Atherosclerosis • Cardiovascular • Chronic Kidney Disease • Conjunctivitis • Diabetes • Dyslipidemia • Endocrine Disorders • Glaucoma • Hematological Disorders • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Renal Disease • PON1

"امداستین یک آنتی هیستامین است که 2 بار در روز به صورت فومارات و به طریق قطره چشمی حاوی 05/0 درصد Emedastine در درمان علامتی ملتحمه آلرژیک داده می شود..سعی کنید از این دارو به دقت استفاده کنید@merck" (@jimmy91225943)

"I guess you daren't cross the M11 'cause of the angry giraffes on the far side" (@alastairw1)

Discovery to Launch of Anti-allergy (Emadine; Patanol/Pataday/Pazeo) and Anti-glaucoma (Travatan; Simbrinza) Ocular Drugs, and Generation of Novel Pharmacological Tools Such as AL-8810. (PubMed, ACS Pharmacol Transl Sci) - "Herein, I will describe the collective efforts of many researchers whose industrious, diligent, and dedicated team work resulted in the discovery, biochemical/pharmacological characterization, development and eventual launch of drugs to treat AC (e.g., olopatadine [Patanol/Pataday/Pazeo] and emedastine [Emedine]), and for treating ocular hypertension and POAG (e.g., travoprost [Travatan ] and Simbrinza). This represents a personal perspective."

Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Glaucoma • Hypertension • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

"Thanks for sharing Daren!" (@Dr_AmandaAdams)

"I’ve always assumed vit D was a broader marker of health; that a low #vitD was a correlate of immobility, isolation, illness, etc I daren’t check mine. 😳" (@drdavidwjg)

"Sorry bucko- you failed us in early PCR, failed us in aerosol transmission, and you daren't condemn another child to covid-induced cognitive impairment." (@fitterhappierAJ)

Clinical • Alzheimer's Disease • Cognitive Disorders

"Big Run Studios Names Daren Chencinski SVP of Games https://t.co/L0HPYVwEJH" (@NewsFromBW)

Effects of anti-allergy drugs on Th1 cell and Th2 cell development mediated by Langerhans cells. (PubMed, J Pharm Pharm Sci) - "These results suggest that topical application of emedastine to skin lesions of patients with AD may provide clinical benefits through the inhibition of both Th1 cell and Th2 cell development mediated by LCs."

IO Biomarker • Journal • Allergy • Atopic Dermatitis • Dermatitis • Dermatology • Immune Modulation • Immunology • Inflammation • IFNG • IL4 • PCR

"I daren’t reply further... 😂😂😂😂😂" (@DrAndrewChoong)

Emedastine During Pregnancy and Lactation: Emedastine Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum. (PubMed, Breastfeed Med) - "Rates of emedastine transfer into placenta and breast milk were low. Further study is required to assess the safety of emedastine in fetuses and breastfed infants."

Journal • Allergic Rhinitis • Immunology

Repurposing Low-Molecular-Weight Drugs Against the Main Protease of Severe Acute Respiratory Syndrome Coronavirus 2. (PubMed, J Phys Chem Lett) - "We further searched for low-molecular-weight drugs containing niacin or hit 1 pharmacophores with enhanced inhibiting activity, e.g., carmofur, bendamustine, triclabendazole, emedastine and omeprazole, in which omeprazole is the only one binding to the C-terminal domain of SARS-CoV-2 Mpro. Our study demonstrates that the fragment-based approach is a feasible strategy for identifying low-molecular-weight drugs against the SARS-CoV-2 and other potential targets lacking specific drugs."

Journal • Infectious Disease • Novel Coronavirus Disease

Photodegradation of the H Antihistaminic Topical Drugs Emedastine, Epinastine, and Ketotifen and ROS Tests for Estimations of Their Potent Phototoxicity. (PubMed, Pharmaceutics) - "Finally, our ROS assays showed a potent phototoxic risk in the following drug order: EPI < EME < KET. All of these results may be helpful for manufacturing, storing, and applying these substantial drugs, especially in their ocular formulations."

Journal

"After Bloodborne, I daren't try Sekiro..." (@bobbybalmoral)

"OH FFS!! I’m so sorry for Daren. 🤬🤬🤬🤬" (@JazzTehara)

Mechanism of the Ullmann Biaryl Ether Synthesis Catalyzed by Complexes of Anionic Ligands. Evidence for the Reaction of Iodoarenes With Ligated Anionic CuI Intermediates. (PubMed, J Am Chem Soc) - "...The heteroleptic complexes generated in situ react with iododarenes to form biaryl ethers in high yields without evidence for an aryl radical intermediate...A Hammett analysis of the effect of phenoxide electronic properties on the rate of the reaction of [Cu(LX)OAr]- with iodotoluene also is consistent with oxidative addition of the iodoarene to an anionic phenoxide complex. Calculations by DFT suggest that this oxidative addition is followed by dissociation of I- and reductive elimination of the biaryl ether from the resulting neutral Cu(III) complex."

Journal • Biosimilar

"We're at @SheffieldArena for the @steelershockey cup game and to mark the end of the fantastic #60600 challenge in aid of @alzheimerssoc" (@AlzSocEMidlands)

Alzheimer's Disease • Biosimilar • CNS Disorders