diphenhydramine / Generic mfg. - LARVOL DELTA

Serendipitous Diagnosis: Gastrointestinal Stromal Tumor Identified During Recurrent Anaphylaxis Workup (ACG 2026) - "On arrival, she was hypotensive (74/56 mmHg), and due to suspicion for anaphylactic shock; she was given diphenhydramine, epinephrine, solumedrol, IV fluids, and Zofran resulting in symptom resolution. Management includes surgical resection for localized disease or use of targeted drug therapy with tyrosine kinase inhibitors. Figure: (Fig 1) Figure: (Fig 2)"

Stroma • Cardiovascular • Diabetes • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Gastrointestinal Stromal Tumor • Immunology • Oncology • Pruritus • Pulmonary Disease • Respiratory Diseases • Sarcoma • Type 1 Diabetes Mellitus • ANO1 • KIT

Herbal but Harmful: Black Seed and Oregano Supplement-Associated Drug-Induced Liver Injury (ACG 2026) - "Case Description/ A 45-year-old female with hepatic steatosis and prediabetes presented with 2 weeks of fatigue and diffuse pruritus refractory to diphenhydramine...It is important that they recognize black seed oil and oregano as a rare, but clinically important cause of DILI. Figure: Table 1: Demonstrating the clinical course and timeline of patient liver enzymes after discontinuation of supplement."

Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Metabolic Disorders • Primary Biliary Cholangitis • Pruritus

Acute Hepatocellular Drug-induced Liver Injury following Cosmetic Liquid Lipo Injection Complicated by Anaphylactic Reaction to N-acetylcysteine. (PubMed, Ann Afr Med) - "Intravenous N-acetylcysteine (NAC) was initiated for suspected severe DILI, but the patient developed an acute anaphylactic reaction requiring discontinuation of the infusion and treatment with epinephrine, diphenhydramine, and methylprednisolone. Cosmetic liquid lipo injection may be associated with severe hepatocellular DILI. Clinicians should obtain a detailed cosmetic procedure exposure history in unexplained acute liver injury and remain alert to hypersensitivity reactions during intravenous NAC therapy."

Journal • Aesthetic Medicine • CNS Disorders • Cytomegalovirus Infection • Dermatology • Epstein-Barr Virus Infections • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Liver Failure • Pruritus

Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats. (PubMed, Methods Protoc) - "The training set, relative to which the effects of the pharmacological agents from the test set were classified, were the matrices of effects of 12 pharmacological agents: the NMDA antagonist dizocilpine, the D2/D3 antagonists haloperidol and sulpiride, the M-anticholinergic tropicamide, the H1/5HT2A receptor blocker hydroxyzine, the acetylcholinesterase inhibitor galantamine, the alpha-2 adrenergic agonist dexmedetomidine, the alpha-2 adrenergic antagonist atipamezole, the adenosine receptor blocker caffeine and the GABA-mimetics aminophenylbutyric acid (phenibut), bromdihydrochlorophenylbenzodiazepine (phenazepam) and 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione. The test set included various drugs with tropism for the targets of the training set drugs: dopamine receptor antagonists chlorpromazine, droperidol, tiapride and raclopride, H1-histamine blockers diphenhydramine and promethazine, 5-HT2-receptor blockers ritanserin and glemenserin, acetylcholinesterase..."

Journal • Preclinical • Pain

Premedication Use and Infusion-Related Reactions in Patients Treated with Subcutaneous Isatuximab: A Pooled Post Hoc Safety Analysis (IMS 2026) - " Pts with RRMM in IRAKLIA (Isa SC: n=263; Isa IV: n=264) and the Phase 1b TCD15484 trial (Isa SC dose-expansion cohort: n=22; Isa IV: n=12) received 1400 mg Isa SC OBI or 10 mg/kg Isa IV plus pomalidomide and dexamethasone (d). In IZALCO, pts with RRMM (n=74) received 1400 mg Isa SC OBI or manual injection plus carfilzomib (K)-d...Premedications included montelukast (C1 only per protocol), steroids (excluding dexamethasone), acetaminophen, H1 antihistamines, and others...In C2, most pts received 2 unique premedications, acetaminophen (Isa SC: 99.0%; Isa IV: 97.5%) and diphenhydramine (or equivalent) (Isa SC: 91.9%; Isa IV: 93.3%); some pts continued montelukast beyond C1, with use declining each cycle... Isa SC injections without premedication were more frequent than Isa IV injections without premedication, and no IRRs occurred with Isa SC injections delivered without premedications. The results support Isa SC as a safe delivery option with low incidence of IRRs."

Clinical • Retrospective data • Hematological Malignancies • Multiple Myeloma

Life-threatening anaphylactic shock induced by cadonilimab (AK104), a PD-1/CTLA-4 bispecific antibody: a case report. (PubMed, Front Pharmacol) - "Emergency treatment included subcutaneous epinephrine 0.5 mg, intramuscular diphenhydramine 20 mg, intravenous dexamethasone 10 mg, aggressive fluid resuscitation, and supplemental oxygen...The patient had a documented prior hypersensitivity to paclitaxel but no prior exposure to immune checkpoint inhibitors...Cadonilimab may rarely cause rapid-onset, life-threatening anaphylactic shock during the first infusion. Careful monitoring, immediate access to emergency management-including vasopressor support-and heightened awareness of bispecific antibody-associated hypersensitivity are essential."

Journal • Allergy • Cardiovascular • Cervical Cancer • Cervical Squamous Cell Carcinoma • Dermatology • Hypotension • Immunology • Infectious Disease • Oncology • Pruritus • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Solid Tumor • Squamous Cell Carcinoma • CTLA4 • PD-1

Subcutaneous (SC) Mosunetuzumab (mosun) As First-Line Therapy for Patients (pts) with High Tumor-Burden Follicular Lymphoma (FL): First Results of a Multicenter Phase 2 Study (ASH 2023) - "Premedication consisted of dexamethasone, diphenhydramine, and acetaminophen before each mosun dose during C1 and on C2D1 if cytokine release syndrome (CRS) occurred in C1...Hospitalization and tocilizumab were only required in the two pts who experienced G2 CRS... SC mosun demonstrated a manageable safety profile and highly encouraging efficacy in pts with newly diagnosed high-burden FL, including those with higher-risk disease. Assessment of durability of responses will require additional follow-up. Enrollment continues and updated data will be presented."

Clinical • P2 data • Dermatology • Diffuse Large B Cell Lymphoma • Fatigue • Follicular Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Neutropenia • Oncology • Pneumonia • Respiratory Diseases

Single-Agent Mosunetuzumab Produces High Complete Response Rates in Patients with Newly Diagnosed Follicular Lymphoma: Primary Analysis of the Mithic-FL1 Trial (ASH 2024) - "Premedication with single-dose dexamethasone, diphenhydramine, and acetaminophen was mandatory before each mosun dose in C1 (and C2 if cytokine release syndrome (CRS) occurred in C1), optional thereafter...Hospitalization and tocilizumab were only required in the two pts with G2 CRS and all events resolved fully...AE were manageable, without new safety signals. Our data support further evaluation of this off-the-shelf drug as 1L therapy for high-burden FL."

Clinical • B Cell Lymphoma • B Cell Non-Hodgkin Lymphoma • Dermatology • Diffuse Large B Cell Lymphoma • Fatigue • Febrile Neutropenia • Follicular Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Musculoskeletal Diseases • Musculoskeletal Pain • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Pain • Pneumonia • Respiratory Diseases • CD20

Mitigating the Risk of Cytokine Release Syndrome (CRS): Preliminary Results from a DLBCL Cohort of Epcore NHL-1 (ASH 2023) - P1/2 | "Background: Epcoritamab SC, a CD3xCD20 T-cell–engaging bispecific antibody, has recently been approved by the US FDA for the treatment of adults with relapsed/refractory (R/R) diffuse large B‑cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from indolent lymphoma, and high-grade B-cell lymphoma after ≥2 lines of systemic therapy...To further mitigate CRS, C1 of the optimization cohort included mandatory administration of dexamethasone 15 mg as premedication on D1, D8, D15, and D22 and as prophylaxis on D2–4, D9–11, D16–18, and D23–25, and diphenhydramine and acetaminophen as premedication on D1, D8, D15, and D22 with each dose...All CRS events were G1; 1 patient was treated with anticytokine therapy (tocilizumab); there were no treatment discontinuations due to CRS... Encouraging preliminary data from this DLBCL CRS optimization cohort, which incorporates prophylactic dexamethasone and hydration of patients during cycle 1, indicate that this..."

Cytokine release syndrome • Anemia • B Cell Lymphoma • Cardiovascular • CNS Disorders • Constipation • Diffuse Large B Cell Lymphoma • Fatigue • Febrile Neutropenia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Hematological Malignancies • High-grade B-cell lymphoma • Indolent Lymphoma • Infectious Disease • Inflammation • Insomnia • Large B Cell Lymphoma • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Pulmonary Disease • Sleep Disorder • CD20 • IL6

A multi-angle continuous-flow injection analysis turbidimetric method for the determination of diphenhydramine hydrochloride. (PubMed, R Soc Open Sci) - "Diphenhydramine hydrochloride in pharmaceutical tablets was successfully determined using the method. The method was found to be accurate, reliable and suitable for pharmaceutical quality control, as demonstrated by statistical comparisons with a conventional spectrophotometric technique using a paired t-test and a one-way ANOVA at the 95% confidence level."

Journal

Structure-guided parameter optimization of feature-based molecular networking for DIA-HRMS screening of antihistamines in cosmetics. (PubMed, Anal Bioanal Chem) - "In 120 commercial cosmetics, in-house library screening detected diphenhydramine in one sample; authentic-standard comparison confirmed the retention time, precursor ion, and MS/MS evidence, and post-confirmation measurement gave 3.28 mg kg-1...In a separate library-absent proof-of-concept experiment, buclizine fortified into blank cream satisfied the predefined three-anchor prioritization rule, ranked first with SIRIUS/CSI:FingerID, and was subsequently confirmed with an authentic standard. These results support the optimized FBMN as a complementary approach for structural-context assessment and library-absent candidate prioritization under the evaluated DIA-HRMS conditions."

Journal

Severe Serotonin Syndrome With Acute Respiratory Failure Following Ayahuasca and Dextromethorphan Use: A Case Report. (PubMed, Cureus) - "Ayahuasca is a psychoactive botanical brew originating from Amazonian ceremonial traditions, containing monoamine oxidase inhibitors (MAOIs) derived from Banisteriopsis caapi and N,N-dimethyltryptamine from Psychotria viridis or Diplopterys cabrerana. Severe SS attributable to ayahuasca is rarely documented, and to our knowledge this is the first report of ayahuasca combined with over-the-counter DXM and diphenhydramine producing SS severe enough to cause acute respiratory failure. This case highlights the life-threatening potential of combining ayahuasca with commonly available serotonergic medications and underscores the need for clinician awareness of these interactions."

Journal • CNS Disorders • Critical care • Respiratory Diseases

Mosunetuzumab Plus Polatuzumab Vedotin Induces Early Complete Responses in Previously Untreated High Tumor Burden Follicular Lymphoma (ASH 2024) - "Polatuzumab vedotin (Pola) is an anti-CD79b antibody-drug conjugate approved as IV treatment in combination with rituximab and chemotherapy in frontline and r/r diffuse large B cell lymphoma...Premedications are acetaminophen and diphenhydramine on all treatment days, with palonosetron added before Pola doses. Dexamethasone 20 mg is mandated before all C1 Mosun doses and optional thereafter...Conclusions : Analysis of Mosun plus Pola for frontline systemic treatment in high tumor burden FL demonstrates a high CR rate and toxicity profile aligning with prior studies. With 19 of the first 23 patients having achieved CR as best response, this phase 2 trial has met its prespecified primary endpoint, and this regimen appears encouraging for further study."

Clinical • B Cell Lymphoma • B Cell Non-Hodgkin Lymphoma • Constipation • Diffuse Large B Cell Lymphoma • Fatigue • Febrile Neutropenia • Follicular Lymphoma • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Pneumonia • Respiratory Diseases • CD79B

Combined mosunetuzumab and zanubrutinib for the treatment of patients with newly diagnosed high-burden follicular lymphoma: First results of the multicenter phase 2 mithic-FL2 trial (ASH 2025) - "Premedication with single-dose dexamethasone, diphenhydramine, andacetaminophen was mandatory before each mosun dose in C1 (and C2 if cytokine release syndrome(CRS) occurred in C1), optional thereafter. We report the first study of combined zanubrutinib and mosunetuzumab in pts withpreviously untreated high-burden FL. AEs were manageable and the safety profile was as expected forthe individual agents, with no new safety signals observed. Most patients achieved a complete metabolicresponse."

Clinical • P2 data • Acute Kidney Injury • Atrial Fibrillation • B Cell Lymphoma • Cardiovascular • Dermatology • Diffuse Large B Cell Lymphoma • Follicular Lymphoma • Hematological Disorders • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Lymphoma • Nephrology • Neutropenia • Non-Hodgkin’s Lymphoma • Rare Diseases • Renal Disease • CD20

Pharmacology of Commonly Used Sedative Agents. (PubMed, Dent Clin North Am) - "The article discusses commonly used sedative and adjunct medications, including midazolam, remimazolam, propofol, ketamine, opioids such as fentanyl and remifentanil, and supportive drugs like dexmedetomidine, diphenhydramine, atropine, glycopyrrolate, and ondansetron. Newer agents such as remimazolam and ketofol combinations may offer improved safety and recovery profiles. Overall, the article emphasizes individualized patient care and thorough pharmacologic knowledge to ensure safe and effective outpatient dental sedation."

Journal • Review • Anesthesia • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry

Single-System Laryngeal Anaphylaxis Following Gadobutrol Administration. (PubMed, Cureus) - "He was treated proactively with epinephrine, diphenhydramine, and methylprednisolone, and transferred to the intensive care unit (ICU) for close monitoring. This case underscores a highly atypical presentation of GBCA-induced anaphylaxis localized entirely to the upper airway, manifesting solely as hoarseness and coughing. As an isolated respiratory reaction to a known non-inhaled allergen, this case shows how the absence of classic multisystem involvement can easily mask a severe allergic reaction."

Journal • Allergy • Cardiovascular • Cough • Critical care • Hypotension • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases

Web Monitoring as an Early Warning System: "Benadryl Challenge" Online Mentions Correlate With Diphenhydramine Overdoses Reported to US Poison Centers. (PubMed, Pharmacoepidemiol Drug Saf) - "PC call volume and web mentions demonstrate a reciprocal relationship and PC call volume remained elevated for over 25 days after the spike in web mentions. Emergency services/departments and public health efforts can be informed real-time by these relationships as an early warning to healthcare facilities and professionals and may justify integration within these spaces to educate and prevent harm."

Journal

Exploring the use of copper (II) nitrogen ligated complexes for the design of cocaine sensing metal complexes | Poster Board #1499 (ACS-Fall 2026) - "These copper(II) complexes were tested for their interactions with cocaine, and a family of known cocaine false positives, including lidocaine, procaine, and diphenhydramine, to study their spectroscopic changes and colorimetric response to each drug. Preliminary work suggests these complexes form covalent interactions with copper and provide a more simple metal based presumptive test with a greater capacity for specificity than the tests used presently."

Topical Tripelennamine 1% Cream Versus Diphenhydramine 1% Cream for the Relief of Histamine-Induced Itching: A Proof Concept Study in Healthy Adults. (clinicaltrials.gov) - P1 | N=37 | Completed | Sponsor: Palm Beach Atlantic University

New P1 trial • Pruritus

Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions (clinicaltrials.gov) - P4 | N=98 | Recruiting | Sponsor: University of Rochester | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia • Mood Disorders • Pain • Psychiatry

Intraoperative Cardiac Arrest due to Chlorhexidine Anaphylaxis (ASA 2026) - "The patient was stabilized with high-dose vasopressors, methylprednisolone, diphenhydramine, and 4L of crystalloid. Tryptase was elevated at 68.1, and skin prick test was positive for chlorhexidine. Perioperative chlorhexidine anaphylaxis is most often associated with urological and cardiothoracic surgeries, and with urinary catheter lubricant, CVC coating, and topical solutions."

Cardiovascular

Rare Disease and Allergic Reactions: Maintaining Vigilance in Uncertainty (ASA 2026) - "His anesthetic regimen included flumazenil, etomidate, and rocuronium. Diphenhydramine was administered empirically, and tryptase was sent for analysis. This diagnostic uncertainty highlights a key challenge in managing patients with MC and NMS, as the underlying autonomic instability and vasomotor changes overlap with features observed during perioperative drug reactions."

Allergy • Rare Diseases

Anesthetic Management of a Patient with Systemic Mastocytosis: Navigating Perioperative Anaphylaxis Risk (ASA 2026) - "Premedication included famotidine, diphenhydramine, acetaminophen, and midazolam. Anesthesia was induced with fentanyl, propofol, rocuronium, and maintained with remifentanil and sevoflurane. Normothermia achieved with active warming. The perioperative course was uneventful without mast cell-mediated reactions."

Clinical • Cardiovascular • Hypertension • Immunology

Latex-Induced Anaphylaxis Following Foley Catheter Placement In Patient Undergoing Coronary Artery Bypass Grafting (ASA 2026) - "Administration of IV epinephrine, diphenhydramine and methylprednisolone improved hemodynamics and the case proceeded. Foley catheter was exchanged for a silicone catheter and the patient's rash improved rapidly. No recurrent episodes were noted with additional methylprednisolone taper, underscoring latex exposure as a potential perioperative trigger for anaphylaxis."

Clinical • Genito-urinary Cancer • Hypotension • Prostate Cancer • Solid Tumor

Alpha-Gal Syndrome in Cardiac Surgery: Clinical Tolerance Despite Serologic Sensitization (ASA 2026) - "After premedication with diphenhydramine and hydrocortisone, he received intravenous porcine heparin (400 units/kg) for cardiopulmonary bypass. Surgery proceeded uneventfully with no signs of anaphylaxis or hypersensitivity. This case highlights that elevated alpha-gal IgE may not consistently predict clinical reactivity and supports individualized perioperative risk assessment."

Clinical • Surgery • Cardiovascular • Immunology