diphenhydramine / Generic mfg. - LARVOL DELTA

CLINICAL RESPONSE, EFFICACY AND CHANGES OF IMMUNE FUNCTION WITH RITUXIMAB TREATMENT IN CHILDHOOD DIFFICULT NEPHROTIC SYNDROME (ISN-WCN 2026) - "SDNS patients with lack of steroid sparing effect (inability to sustain remission at a prednisone dose of 0.5 mg/kg every other day) or presence of significant steroid toxicity, despite treatment with oral cyclophosphamide (2 mg/kg per day for 12 weeks), levamisole (2.5 mg/kg for 6 months), mycophenolate mofetil (1200 mg/m2/day for 6 months), and calcineurin inhibitors (CNI) or those showing CNI induced nephrotoxicity were included...Premedication with oral acetaminophen (15 mg/kg), diphenhydramine (0.5 mg/ kg), intravenous hydrocortisone (4 mg/kg) was given 30 minutes before infusion of the RTX...Only one third of the cases developed B-cell depletion initially but typically recovered at 9-12 months of 1st dose of rituximab therapy. Serum IgG level was maintained but IgM level was reduced upto 12months."

Clinical • Chronic Kidney Disease • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease • Respiratory Diseases • CD20

From sedation to stimulation: anecdotal case reports of enhanced sexual arousal in men and women taking diphenhydramine hydrochloride. (PubMed, Sex Med) - "These observations suggest a paradoxical pharmacological action of DPH, potentially involving dopaminergic and/or histaminergic pathways. While DPH itself is not a recognized therapeutic agent for the treatment of sexual dysfunctions, these unexpected effects may point toward a novel neurochemical mechanism of sexual excitation in some individuals that warrants further investigation."

Journal • Anesthesia • Sexual Disorders

EVALUATING ANTIHISTAMINE TREATMENT TO REDUCE VASCULAR INFLAMMATION IN AN AMYLOID MOUSE MODEL OF ANTI-AMYLOID-BETA ANTIBODY-INDUCED ARIA (ADPD 2026) - "Lecanemab, which has the lowest ARIA incidence rates among approved anti-Abeta immunotherapies, caused infusion reactions in ~26.4% of patients, leading to clinical guidelines for pretreatment with antihistamine diphenhydramine and acetaminophen in those who develop symptoms...We hypothesize that mast cell activation contributes to the vascular inflammation associated with anti-Abeta antibody treatment and that inhibition of histamine signaling may mitigate these effects. Eight-month-old BxW.APP/PS1 mice are being treated with weekly intraperitoneal injections for eight weeks of either 3D6 (20mg/kg; n=20), the murine precursor of bapineuzumab, or IgG2a-isotype control (20mg/kg; n=20), each given with (n=10) or without (n=10) oral diphenhydramine (50mg/kg) and acetaminophen (200mg/kg) pretreatment... Diphenhydramine and acetaminophen are safe and well-tolerated over-the-counter medications. This work explores the translational potential of combining these drugs with..."

Preclinical • Alzheimer's Disease • CNS Disorders • Hematological Disorders • Inflammation

Combined mosunetuzumab and zanubrutinib for the treatment of patients with newly diagnosed high-burden follicular lymphoma: First results of the multicenter phase 2 mithic-FL2 trial (ASH 2025) - "Premedication with single-dose dexamethasone, diphenhydramine, andacetaminophen was mandatory before each mosun dose in C1 (and C2 if cytokine release syndrome(CRS) occurred in C1), optional thereafter. We report the first study of combined zanubrutinib and mosunetuzumab in pts withpreviously untreated high-burden FL. AEs were manageable and the safety profile was as expected forthe individual agents, with no new safety signals observed. Most patients achieved a complete metabolicresponse."

Clinical • P2 data • Acute Kidney Injury • Atrial Fibrillation • B Cell Lymphoma • Cardiovascular • Dermatology • Diffuse Large B Cell Lymphoma • Follicular Lymphoma • Hematological Disorders • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Lymphoma • Nephrology • Neutropenia • Non-Hodgkin’s Lymphoma • Rare Diseases • Renal Disease • CD20

Over-the-Counter Loperamide Overdose Resulting in Cardiac Arrest. (PubMed, JACC Case Rep) - "In cases of cardiac arrest in patients where overdose is suspected, untargeted urine testing through mass spectrometry may be helpful in determining the etiology to guide therapies and prevent unnecessary medical interventions."

Journal • Anesthesia • Cardiovascular • Ventricular Tachycardia

Real-World Incidence of Infusion-Related Reactions With Sacituzumab Govitecan and Opportunities for Premedication De-Escalation (HOPA 2026) - "Most patients also received the appropriate premedications, including diphenhydramine (98.8%), famotidine (97.6%), and acetaminophen (97.6%), along with dexamethasone (98.8%) already included in their antiemetic regimen. In this real-world cohort, no IRRs were observed with sacituzumab govitecan, which suggests greater tolerability than in clinical trials. Some patients tolerated premedication de-escalation, with de-escalation occurring as early as dose 3. Given the low incidences of IRRs, these findings support further investigation into developing protocols to safely reduce premedication requirements and potentially shorten observation times."

Clinical • Late-breaking abstract • Real-world • Real-world evidence • Breast Cancer • Solid Tumor

The Hidden Dangers of Dental Trauma: A Case of Foreign Body Aspiration in Complex Airway Management (SCCM 2026) - "Initial treatment was with IV Diphenhydramine and Epinephrine. Previous studies on the use of dental devices during endotracheal intubation are limited. Future research should focus on larger cohort studies to evaluate the safety and efficacy of protective devices during difficult airway management to improve patient outcomes especially in the setting of poor oral hygiene or prior trauma."

Clinical • Acute Respiratory Distress Syndrome • Cardiovascular • Mood Disorders • Otorhinolaryngology • Respiratory Diseases

Facial Swelling and Stridor Post-Thoracotomy: A False Alarm for Anaphylaxis (SCCM 2026) - "Patient was given two doses of epinephrine, Solu-Medrol, and Benadryl en route by EMS for suspected anaphylactic reaction as she was eating at the time of calling 911. It highlights the importance of early recognition and differentiation from anaphylaxis which may look similar (facial swelling, airway compromise) and prompt thoracic surgery consultation for decompression. Unlike many reported cases our patient survived and recovered without long-term sequelae though nonadherence and early AMA discharge remain risk factors for complications."

Chronic Obstructive Pulmonary Disease • Immunology • Lung Cancer • Non Small Cell Lung Cancer • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Fatal Diphenhydramine Overdose Resulting in Cardiac Arrest and Cerebral Edema (SCCM 2026) - "She underwent CPR, IV administration of lidocaine, amiodarone, and a sodium bicarbonate drip...Seizure activity was managed with midazolam and levetiracetam...Lipid emulsion therapy may provide benefit in severe cases, but its lipophilic nature can reduce the efficacy of other similarly lipophilic medications, such as lidocaine. This case highlights the lethality of diphenhydramine overdose, the complexity of its pharmacologic effects, and the importance of early and targeted interventions."

Cardiovascular • CNS Disorders • Epilepsy • Hypotension • Immunology • Insomnia • Sleep Disorder

Acute Dystonia From Metoclopramide Unresponsive to Diphenhydramine, Resolved With Lorazepam (SCCM 2026) - "They typically respond to anticholinergic or antihistaminic agents such as diphenhydramine or benztropine. The precise mechanism may involve GABAergic inhibition of excessive dopaminergic blockade or modulation of muscle tone. Recognizing refractory dystonia early and promptly escalating therapy is essential in preventing further complications, including airway compromise or prolonged hospitalization.This case underscores the importance of identifying acute dystonic reactions in the inpatient setting and highlights lorazepam as a viable rescue therapy when diphenhydramine fails."

Acute Kidney Injury • CNS Disorders • Dystonia • Gastroenterology • Gastrointestinal Disorder • Immunology • Movement Disorders • Nephrology • Renal Disease

Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project (clinicaltrials.gov) - P3 | N=60 | Not yet recruiting | Sponsor: University of Miami

New P3 trial • CNS Disorders • Multiple Sclerosis

NAVIGATING PROTAMINE-INDUCED ANAPHYLAXIS IN CARDIAC SURGERY: DECISION MAKING, RESUSCITATION AND OPEN CHEST MANAGEMENT (ACC 2026) - "Case: A 49-year-old woman with hypertension, hyperlipidemia, coronary artery disease, prior deep vein thrombosis on apixaban, obesity, and type 1 diabetes mellitus underwent elective CABG with left atrial appendage occlusion...Despite diphenhydramine, methylprednisolone, and famotidine, the patient required cardiac massage and return to bypass... Protamine anaphylaxis can complicate CABG with life-threatening hemorrhage and shock. Rapid recognition, multidisciplinary decision making, and staged operative management are essential for survival."

Surgery • Cardiovascular • Cognitive Disorders • Coronary Artery Disease • Diabetes • Dyslipidemia • Genetic Disorders • Hematological Disorders • Hypertension • Hypotension • Metabolic Disorders • Obesity • Thrombosis • Type 1 Diabetes Mellitus

MID CAVITY TAKOTSUBO CARDIOMYOPATHY IN ANTISYNTHETASE SYNDROME TRIGGERED BY RITUXIMAB INDUCED ANGIOEDEMA (ACC 2026) - "In the ED she received IV diphenhydramine, solumedrol, famotidine, fluids and IM epinephrine. This case highlights the intersection of autoimmune disease, biologic infusion reactions, and catecholamine toxicity. To our knowledge, this is the first reported case of mid-cavity TCM in ASS triggered by rituximab-induced angioedema treated with epinephrine."

Cardiomyopathy • Cardiovascular • Hypertension • Hypotension • Immunology • Rare Diseases

TRANSPLANT ACQUIRED FOOD ALLERGY (TAFA) LEADING TO ANAPHYLACTIC SHOCK IN ORTHOTOPIC HEART TRANSPLANT RECIPIENT (ACC 2026) - "She had received peri-operative basiliximab induction and was maintained on standard immunosuppression...She was treated with epinephrine, methylprednisolone, and diphenhydramine. Her immunosuppression regimen was adjusted, and tacrolimus was switched to cyclosporine... TAFA is a rare but potentially fatal complication in HTx recipients. Further research is needed to clarify its pathogenesis, including the role of immunosuppression, donor immune cell transfer, and dysbiosis, to improve prevention and risk stratification."

Clinical • Allergy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Food Hypersensitivity • Heart Failure • Immunology • Solid Organ Transplantation • Transplantation • Vascular Neurology

TOXIC RESILIENCE: REVERSAL OF MYOCARDIAL STUNNING AND MULTI-ORGAN RECOVERY FOLLOWING BENADRYLINDUCED CARDIAC ARREST AND BRAIN INJURY (ACC 2026) - "Background: Diphenhydramine (DPH) toxicity can lead to anticholinergic toxidrome, seizures, arrhythmias, and cardiac arrest...He achieved ROSC after 55 minutes of CPR and epinephrine infusions., and remained hypotensive, requiring multiple vasopressors, and developed metabolic acidosis (pH 6.77, lactate 26)... The case demonstrates the dramatic reversibility of DHP-induced myocardial stunning, with recovery of EF from 20% to 55% despite prolonged CPR, severe metabolic acidosis, and multi-organ damage. It also raises important questions about neurotoxicity versus true anoxic brain injury, as initial EEG showed diffuse slowing without clear evidence of brain death. Finally, it introduces a rare ethical challenge in organ donation, where full cardiac recovery and hemodynamic stability deferred donation despite established brain death criteria."

Bipolar Disorder • Cardiovascular • CNS Disorders • Epilepsy • Hypotension • Metabolic Disorders • Vascular Neurology

CORONARY ARTERY BYPASS GRAFTING IN COLD-INDUCED URTICARIA USING PREMEDICATION AND STRICT THERMAL MANAGEMENT: A CASE REPORT (ACC 2026) - "Premedication included fexofenadine, cetirizine, famotidine, montelukast, prednisolone, and diphenhydramine. Omalizumab was administered preoperatively. Epinephrine pen was available during the procedure... CABG can be safely accomplished in patients with cold-induced urticaria by combining structured premedication with vigilant thermal control. This case adds intraoperative temperature and cardioplegia parameters demonstrating safe on-pump CABG with moderate systemic cooling, cold cardioplegia, and elimination of topical ice, supported by structured premedication."

Case report • Clinical • Cardiovascular • Dermatology • Dyslipidemia • Hypertension • Hypotension • Immunology • Nicotine Addiction • Peripheral Arterial Disease • Urticaria

PULSELESS ELECTRICAL ACTIVITY CARDIAC ARREST SECONDARY TO ANAPHYLAXIS FOLLOWING LUMASON CONTRAST ECHOCARDIOGRAPHY (ACC 2026) - "Cardiopulmonary resuscitation was initiated with intravenous epinephrine, methylprednisolone, diphenhydramine, famotidine, and fluids, achieving return of spontaneous circulation within two minutes. Although rare, UEAs can provoke life-threatening anaphylaxis despite prior tolerance. This case illustrates progressive immune sensitization across structurally distinct UEAs, culminating in cardiac arrest. To our knowledge, this is the tenth documented Lumason-induced anaphylaxis and the first with cross-reactivity resulting in cardiac arrest."

Asthma • Back Pain • Cardiovascular • Complement-mediated Rare Disorders • Coronary Artery Disease • Dyslipidemia • Hereditary Angioedema • Hypertension • Hypotension • Immunology • Musculoskeletal Pain • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Reactive Infectious Mucocutaneous Eruption Mimicking Stevens–Johnson Syndrome in a Pediatric Patient: A Diagnostic and Therapeutic Challenge (AAD 2026) - "He was admitted with suspected RIME and started on IV azithromycin, IV fluids, antipyretics, antiemetics, ocular lubricants, topical erythromycin, and diphenhydramine. Misclassification can delay appropriate management and increase morbidity. Early recognition, escalation of care, and specialist input are essential for favorable outcomes, especially where subspecialty resources are limited."

Clinical • Conjunctivitis • Cough • Hematological Disorders • Infectious Disease • Mucositis • Ocular Infections • Ocular Inflammation • Ophthalmology • Pediatrics • Pneumonia • Respiratory Diseases • Steven-Johnson Syndrome

POSITIVE OUTCOMES AMONG PEDIATRIC HCT PATIENTS TREATED WITH DARATUMUMAB FOR AUTO-IMMUNE HEMOLYTIC ANEMIA (EBMT 2026) - "Premedication for daratumumab infusion included diphenhydramine, solumedrol, acetaminophen and famotidine. The majority of patients with AIHA post-HCT were refractory to initial treatment with corticosteroids and rituximab. Daratumumab was well tolerated in this patient cohort. All patients with refractory AIHA treated with daratumumab achieved resolution."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Immunology • Metabolic Disorders • Pediatrics • Primary Immunodeficiency

POSITIVE OUTCOMES AMONG PEDIATRIC HCT PATIENTS TREATED WITH DARATUMUMAB FOR AUTO-IMMUNE HEMOLYTIC ANEMIA (EBMT 2026) - "Premedication for daratumumab infusion included diphenhydramine, solumedrol, acetaminophen and famotidine. The majority of patients with AIHA post-HCT were refractory to initial treatment with corticosteroids and rituximab. Daratumumab was well tolerated in this patient cohort. All patients with refractory AIHA treated with daratumumab achieved resolution."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Immunology • Metabolic Disorders • Pediatrics • Primary Immunodeficiency

Delayed-Onset Cariprazine-Induced Akathisia: A Case Report. (PubMed, Clin Neuropharmacol) - "This case highlights the challenge of distinguishing akathisia from primary anxiety disorders, in addition to considering this diagnosis beyond the initial treatment period. Akathisia symptoms most commonly present within 4 weeks of initiation or titration of antidopaminergic treatment. However, this timeline may be delayed with cariprazine due to its pharmacokinetic and pharmacodynamic properties."

Journal • Bipolar Disorder • CNS Disorders • General Anxiety Disorder • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder

R5458-ONC-2246: A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy with Standard-of-Care Combination Regimens in Adult Participants with Relapsed/Refractory Multiple Myeloma (RRMM) (clinicaltrialsregister.eu) - P2/3 | N=315 | Not yet recruiting | Sponsor: Regeneron Pharmaceuticals Inc.

Monotherapy • New P2/3 trial • Hematological Malignancies • Multiple Myeloma • Oncology

Drugs Most Frequently Involved in Drug Overdose Deaths: United States, 2017-2023. (PubMed, Natl Vital Stat Rep) - "Among drug overdose deaths with mention of at least one specific drug, the most frequently mentioned drugs during 2017-2023 included: fentanyl, heroin, oxycodone, morphine, methadone, hydrocodone, alprazolam, diphenhydramine, cocaine, methamphetamine, amphetamine, gabapentin, and xylazine. In 2023, the most frequently mentioned drugs in unintentional drug overdose deaths were fentanyl, methamphetamine, and cocaine, while the most frequently mentioned drugs for suicide-related drug overdoses were diphenhydramine, oxycodone, and bupropion. This report identifies patterns in the specific drugs most frequently involved in drug overdose deaths from 2017 through 2023."

Journal

POSTERITY: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: Hoffmann-La Roche | Trial completion date: Sep 2029 ➔ Jun 2030 | Trial primary completion date: Aug 2027 ➔ Jun 2028

Trial completion date • Trial primary completion date • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pediatrics

NATIONAL TRENDS IN OPIOID, BENZODIAZEPINE AND ANTICHOLINERGIC ORDERS IN LONG-TERM CARE (ISPOR 2026) - "The most common drugs ordered for the 657,915 residents with OB use were lorazepam (66.4%) and morphine (47.0%), which was the most common medication combination (28.5%). The most common orders for the 333,264 residents with ACH use were hydroxyzine (29.1%), diphenhydramine (23.6%), and oxybutynin (20.8%)... High-risk prescribing and significant geographic variation underscore the need for accurate documentation, targeted deprescribing, and monitoring. Leveraging regional data enables focused quality improvement and resource allocation. Proactive, data-driven strategies tailored to local trends are critical for safer medication management and achieving Star Ratings success."