vitamin A / Advent Therap - LARVOL DELTA

Inhaled vitamin A mitigates hyperoxia-induced acute and chronic lung damage in a neonatal rat model of bronchopulmonary dysplasia. (PubMed, Am J Respir Cell Mol Biol) - "Inhaled vitamin A suppressed hyperoxia-induced lung damage, with key hallmarks of BPD, including lung morphometrics and biomarkers associated with lung damage and inflammation, being effectively indistinguishable from healthy controls at both PD 7 and 21, Natural reparative processes were enhanced, with normal alveolarization and pulmonary function at PD 21. Despite raising hepatic vitamin A levels, enteral dosing was ineffective in restoring alveolar morphology at PD 7. Consistent with previous reporting, IM dosing yielded modest effect at PD 7 but with little evidence of benefit to pulmonary function at PD 21. Observation of dose-dependent effects with aerosolized vitamin A strengthens the evidence of the benefits of lung-targeted delivery, supporting further development of inhaled vitamin A as a BPD preventive strategy."

Journal • Preclinical • Bronchopulmonary Dysplasia • Inflammation • Pulmonary Disease • Respiratory Diseases

A Rapid Fluorescence Method for In Vivo Quantitation of Lung Deposition of a Nebulized Drug: Multiple Uses for Advancing Aerosolized Drug Development and Specific Insight Regarding Aerosolized Vitamin A for Preventing Bronchopulmonary Dysplasia. (PubMed, Methods Protoc) - "The ease of use of the method facilitated various aspects of our project, including the transition to more clinically relevant animal models and aerosol exposure systems. The formulation of this approach could be spiked into other formulations, allowing application of the method to other aerosol drug development programs."

Journal • Preclinical • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

Take a deep breath: the important role of vitamin a in neonatal lung development and visiting the potential of aerosolized delivery for bronchopulmonary dysplasia prevention. (PubMed, Expert Rev Respir Med) - No abstract available

Journal • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases