VT-01 / Vivace Therap - LARVOL DELTA

Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition. (PubMed, EMBO J) - "While VT01454 did not inhibit Golgi PI4P formation nor reduce resting PM PI(4,5)P2 levels, the recovery of the PM pool of PI(4,5)P2 after receptor-mediated hydrolysis required both class I and class II PITPs. Overall, these studies show that class I PITPs differentially regulate phosphoinositide pools and affect the overall cellular lipid landscape."

Journal • Metabolic Disorders