Keral (dexketoprofen trometamol) / Menarini - LARVOL DELTA

Taste Masking of Dexketoprofen Trometamol Orally Disintegrating Granules by High-Shear Coating with Glyceryl Distearate. (PubMed, Pharmaceutics) - "The coated granules were characterized for their morphology and solid-state properties by SEM, BET, XRPD, DSC, and NIR analyses. A human taste panel test confirmed the masking of DXKT taste in the selected batch granules."

Journal

Dante: Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain (clinicaltrials.gov) - P4 | N=544 | Completed | Sponsor: Menarini International Operations Luxembourg SA | Recruiting ➔ Completed | N=816 ➔ 544

Enrollment change • Trial completion • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Dante: Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain (clinicaltrials.gov) - P4; N=816; Recruiting; Sponsor: Menarini International Operations Luxembourg SA

Clinical • New P4 trial • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar (clinicaltrials.gov) - P4; N=654; Completed; Sponsor: Menarini Group; Active, not recruiting ➔ Completed

Clinical • Trial completion • Pain

Ultrasound-guided erector spinae block versus mid-transverse process to pleura block for postoperative analgesia in lumbar spinal surgery. (PubMed, Anaesthesist) - "Both ESP and MTP blocks provided effective pain relief after lumbar spinal surgery but the ESP block was superior to MTP block regarding postoperative analgesia in the first 24 h."

Journal • Anesthesia • Pain

[VIRTUAL] EVALUATION OF ORAL USE OF DEXKETOPROFEN/TRAMADOL IN ACUTE POSTOPERATIVE PAIN IN PATIENTS UNDERGOING TOTAL HIP REPLACEMENT WITH A MINIMALLY INVASIVE ANTERIOR APPROACH (AMIS) (WIP 2020) - "All patients were under spinal anesthesia and all patients were given intra-articular injection with a dilution of 100 mL N/S 0.9% with 300 mg ropivacaine and 0.5 mg epinephrine. Fixed-dose combination of dexketoprofen and tramadol provides a com- prehensive multimodal approach for moderate to severe acute pain in patients undergoing unilateral total hip arthroplasty thanks to central analgesic effect, peripheral analgesic action and anti-inflammatory activity. The combination shows a good tolerability profile."

Clinical • Anesthesia • Orthopedics • Pain

Efficacy and tolerability of orally administered tramadol/dexketoprofen fixed- dose combination compared to diclofenac/thiocolchicoside in acute low back pain: experience from an Italian, single-centre, observational study. (PubMed, Curr Med Res Opin) - "Orally administered TRAM/DKP 75/25 mg can be a valuable and effective option in patients with acute LBP."

Clinical • Journal • Observational data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study. (PubMed, Adv Ther) - "The agreed consensus statements may assist clinicians in applying the results of clinical studies and clinical experience to routine care settings, providing guidance for use of this new analgesic combination in moderate-to-severe post-operative and non-surgical acute pain."

Clinical • Journal • Pain

Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty. (PubMed) - Br J Anaesth - "The efficacy results confirmed the superiority of dexketoprofen/tramadol over its single components, even at higher doses (tramadol), with a safety profile fully in line with that previously known for these agents in monotherapy."

Journal • Biosimilar • Pain

Prospective, randomized comparative study of ultrasound-guided blocking of the lateral cutaneous branches of the intercostal nerves versus conventional analgesia in non-reconstructive breast surgery. (PubMed, Rev Esp Anestesiol Reanim) - "In non-reconstructive breast surgery, performing a BRILMA block allows obtaining lower pain scores, which implies less need for rescue analgesics and a significant saving of tramadol in the study period."

Clinical • Journal

Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). (PubMed, BMJ Open) - P4; "TRAM/DKP (75/25 mg) is effective and superior to TRAM/paracetamol (75/650 mg) in relieving moderate to severe acute pain following surgical removal of impacted lower third molar, with a faster onset of action, greater and durable analgesia, together with a favourable safety profile."

Clinical • Journal

Evaluation of ultrasound-guided rhomboid intercostal nerve block for postoperative analgesia in breast cancer surgery: a prospective, randomized controlled trial. (PubMed, Reg Anesth Pain Med) - "In the current study, ultrasound-guided RIB promoted enhanced recovery and decreased opioid consumption after mastectomy surgery."

Clinical • Journal

Compatibility of acetaminophen with central nervous system medications during simulated Y-site injection. (PubMed, Anaesthesiol Intensive Ther) - "Nine of 15 common CNS medications in critical care tested with acetaminophen were physically incompatible for 24 hours."

Journal

Ultrasound guided erector spinae plane block for postoperative analgesia after augmentation mammoplasty: case series (PubMed, Rev Bras Anestesiol) - "Then, induction of anesthesia was performed with propofol, fentanyl, and rocuronium bromide. At the postoperative 24th hour, the mean Numerical Rating Scale score was 1. The mean intravenous tramadol consumption was 70.8±15.3mg in the first 24 h. None of the patients had any complications related to erector spinae plane block."

Clinical • Journal

Oh what a headache! (EUSEM 2019) - "No improvement with analgesic medication (naproxen 550 mg + tramadol 50 mg during a week)...Tretatment strategies include: dieta and weight loss, medications as diuretics, painkillersand surgery. It is an important disease to know by the physician in the emergency department."

"Spinal, TXA ev. LIA (ropi)+ TXA local. No drainage. Elastomeric pump (dexketoprofen/tramadol)+Paracetamol. Opiates (morfine) only rescue" (@corralmunar)

Correction: Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). (PubMed, BMJ Open) - No abstract available.

Clinical • Journal