deoxyglucose / Generic mfg. - LARVOL DELTA

Glycolytic reprogramming mediated by the ADAM12/IGF1 axis promotes ossification of the posterior longitudinal ligament. (PubMed, Cell Death Discov) - "This glycolytic reprogramming was functionally indispensable for ossification, as its inhibition with 2-deoxy-D-glucose robustly attenuated osteogenic differentiation in vitro and ectopic bone formation in vivo...Crucially, the pro-ossific effects of ADAM12 were reversed by inhibition of either IGF1R or glycolysis. Taken together, our study establishes the ADAM12-IGF1-glycolysis axis as a central pathogenic mechanism and a promising therapeutic target for OPLL."

Journal • CNS Disorders • ADAM12 • IGF1 • IGFBP5

LOSS OF SGLT1 REDUCES GLUCOSE UPTAKE IN RAT PERITONEAL MESOTHELIAL CELLS (ISN-WCN 2026) - "Cellular glucose uptake was examined using flow cytometry under incubation with 2-NBDG [2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose], a fluorescently labeled glucose analog...A better understanding of glucose handling in peritoneal mesothelial cells may provide new insights for optimizing PD therapy and improving osmotic ultrafiltration efficiency in patients with heart failure and volume overload.I have potential conflict of interest to disclose.The Division of Integrative Renal Replacement Therapy was financially supported by JMS Co. Ltd., Terumo Corporation, and Southern TOHOKU Hospital Group (STHG).I did not use generative AI and AI-assisted technologies in the writing process."

Preclinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

MONDOA MITIGATES AGE-RELATED PROXIMAL TUBULAR ATROPHY BY MAINTAINING LIPID METABOLISM AND MITOCHONDRIAL HOMEOSTASIS (ISN-WCN 2026) - "Glycolytic dependence was examined by treatment with 2-deoxyglucose...Its deficiency impairs AMPK activation, suppresses FAO, increases oxidative stress, and promotes fibrotic and metabolic aging of the kidney. Thus, MondoA protects against metabolic stress and age-related renal deterioration through preservation of energy homeostasis."

Acute Kidney Injury • Chronic Kidney Disease • Fibrosis • Immunology • Metabolic Disorders • Nephrology • Renal Disease

HIF-1-MEDIATED MACROPHAGE METABOLIC REPROGRAMMING PROMOTES AKI TO CKD TRANSITION (ISN-WCN 2026) - "Macrophage depletion was performed with clodronate liposomes. To investigate molecular mechanisms, myeloid-specific HIF-1α knockout mice and the NF-κB inhibitor BAY11-7082 were employed in vivo, while in vitro studies included co-culture of TECs and bone marrow–derived macrophages under prolonged hypoxia–reoxygenation. Glycolysis was modulated with 2-deoxy-D-glucose, and chromatin immunoprecipitation combined with database analysis was used to confirm transcriptional regulation of HIF-1α by NF-κB.Results Both I/RI and UUO models exhibited impaired recovery with tubular injury and interstitial fibrosis...The NF-κB–HIF-1α signaling axis governs this process and represents a critical pathogenic pathway in AKI to CKD transition. Targeting macrophage metabolism by disrupting NF-κB–HIF-1α signaling provides a promising therapeutic strategy to mitigate maladaptive repair and slow CKD progression following AKI."

Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Fibrosis • Immunology • Nephrology • Reperfusion Injury • HIF1A • HK1 • IL1B • TNFA

Mfn1-mediated imbalanced mitochondrial dynamics promotes ovarian cancer stemness by inducing metabolic reprogramming. (PubMed, J Physiol Biochem) - No abstract available

Journal • Oncology • Ovarian Cancer • Solid Tumor

Development of a high-throughput label-free method for enrichment of antimetabolite-resistant yeast strains using pico-litre agarose beads. (PubMed, Appl Microbiol Biotechnol) - "The potential of this microbead-based, label-free selection method was demonstrated by enriching a G418 (geneticin) antibiotic-resistant and a glucose analogue (2-deoxyglucose) resistant Saccharomyces cerevisiae strains by 16,000-fold and 600-fold, respectively, in single-step enrichment experiments...• Autofluorescence-based screening enables label-free detection of resistant mutants. • 104- and 103-fold enrichment of antibiotic- and glucose analogue-resistant strains."

Journal • Metabolic Disorders

Melanocyte proliferation gene 1 regulated metabolic reprogramming in acute myocardial infarction based on the AMPK/mTOR pathway. (PubMed, Toxicol Appl Pharmacol) - "In parallel, an oxygen-glucose deprivation (OGD) model was generated in H9C2 cells, in which MYG1 was overexpressed alone or in combination with the glycolysis inhibitor 2-deoxy-d-glucose (2-DG), the AMPK activator AICAR, or the mTOR inhibitor rapamycin. Furthermore, modulation of the AMPK/mTOR pathway influenced MYG1-associated metabolic alterations, as evidenced by changes in cellular metabolic flux and improved mitochondrial autophagy and ultrastructural integrity. These findings suggest that MYG1 participates in cardiomyocyte metabolic reprogramming during AMI, potentially through regulation of the AMPK/mTOR pathway, and may represent a candidate target for therapeutic intervention."

Journal • Cardiovascular • Myocardial Infarction • ENO1 • HK2

IL-33 is Required for Behavioral Deficits in a Murine Model of Systemic Lupus Erythematosus Through Regulation of Microglia Glycolysis. (PubMed, CNS Neurol Disord Drug Targets) - "Our findings identify IL-33 as a key contributor to dNPSLE pathogenesis, driving microglial activation and phagocytosis via glycolytic reprogramming. These results highlight IL-33 as a potential therapeutic target for dNPSLE, warranting further investigation into its clinical translation."

Journal • Preclinical • CNS Disorders • Cognitive Disorders • Immunology • Inflammatory Arthritis • Lupus • Mood Disorders • Psychiatry • Systemic Lupus Erythematosus • IL33 • LDHA • PKM

A thermosensitive hydrogel encapsulating 2-DG alleviates periodontitis by inhibiting glycolysis and effector response of Th17 cells. (PubMed, Front Pharmacol) - "The glycolysis inhibitor 2-deoxy-D-glucose (2-DG) was used to assess its ability to suppress CD4+ T-cell proliferation and Th17 differentiation...Th17-cell differentiation exacerbates periodontitis progression, and glycolysis inhibition effectively modulates Th17-driven immunity. The localized 2-DG hydrogel delivery system presents a promising translational strategy for periodontitis management."

Journal • Dental Disorders • Immunology • Inflammation • Periodontitis • CD4 • IL17A

Pristimerin ameliorates spasmolytic polypeptide-expressing metaplasia by modulating Cdkn1c (p57)-mediated glycolytic reprogramming. (PubMed, World J Gastroenterol) - "Pristimerin effectively ameliorates gastric mucosal pathological damage and oxyntic atrophy in high-dose tamoxifen-induced SPEM mice, and improves SPEM progression by modulating Cdkn1c (p57)-mediated glycolytic reprogramming."

Journal • Gastric Cancer • Infectious Disease • Oncology • Solid Tumor • CDKN1C

FFAR4 negatively regulates colorectal cancer growth via blocking oxidative phosphorylation. (PubMed, J Transl Med) - "FFAR4 suppresses CRC growth by modulating mitochondrial function and cellular metabolism, supporting its potential as a diagnostic biomarker and therapeutic strategy for CRC."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Investigating the In Vitro Mitochondria-Mediated Anticancer Activity of the Plant Metabolite Ursolic Acid. (PubMed, Int J Mol Sci) - "The data show that when MDA-MB-231 and MCF7 cells were treated with UA in combination with either 2-deoxy-D-glucose or 3-bromopyruvate, two inhibitors of glycolysis, the resulting cytotoxicity was greater than that induced by any of the compounds used independently. The results of this study are important in that they demonstrate direct mitochondrial targets of UA and suggest the possibility of using this natural, plant-derived metabolite in combination with glycolytic inhibitors as a novel and effective dual treatment strategy for breast cancer cell killing."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor

Anticancer Effect of Pacificusoside D from the Starfish Solaster pacificus in Combination with 2-Deoxy-D-glucose on Oxidative Phosphorylation in Triple-Negative Breast Cancer Cells MDA-MB-231. (PubMed, Mar Drugs) - "Mechanistically, SpD increased tumor suppressor VHL expression level, down-regulated expression level of electron transport chain enzymes, generated reactive oxygen species, induced mitochondrial dysfunction, and triggered Bax/Bak-mediated apoptosis. These findings highlighted the synergistic anticancer potential of SpD in combination with 2-DG in aggressive breast cancer, offering insights into improved clinical outcomes in the future."

Journal • Breast Cancer • Metabolic Disorders • Oncology • Solid Tumor • Triple Negative Breast Cancer • VHL

2-Deoxyglucose dendrimer-enabled niclosamide delivery to FRβ-expressing macrophages alleviates endometriosis progression and associated hyperalgesia. (PubMed, bioRxiv) - "A single intraperitoneal dose of FA-2DG-D-Niclo (25 or 50 mg/kg/bw of niclosamide) significantly reduced FRβ⁺ macrophage burden, suppressed lesion number and volume, and markedly improved endometriosis-associated hyperalgesia at two weeks post-treatment. Together, these findings establish FRβ⁺ macrophages as a potential target in endometriosis and present FA-2DG-D-Niclo as a non-hormonal, macrophage-focused nanomedicine for precise and effective endometriosis treatment."

Journal • Endometriosis • Gynecology • Inflammation • Women's Health

Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle. (PubMed, Diabetologia) - "Exercise induces skeletal muscle-derived thromboxane production through macrophage-specific COX-2 activation. Thromboxane receptor stimulation enhances glucose uptake and glycogen storage via cytoskeletal remodelling, partially mimicking the acute exercise transcriptomic response. In vivo, thromboxane receptor activation improves glucose tolerance and skeletal muscle glucose uptake, with preserved efficacy in obesity. These findings identify thromboxane signalling as a previously unrecognised immunometabolic axis linking inflammation to glucose regulation and highlight the thromboxane receptor as a potential therapeutic target for metabolic disease."

Journal • Diabetes • Genetic Disorders • Inflammation • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus • PACERR • PTGS2 • SLC2A4

Signaling pathway underlying autocrine activation of ecdysteroidogenesis in prothoracic glands of Bombyx mori. (PubMed, Insect Biochem Mol Biol) - "Treatment with LY294002 and rapamycin reduced 4E-BP phosphorylation, indicating the involvement of the PI3K/TOR pathway...Treatment with either validamycin A or the glycolysis inhibitor 2-deoxy-D-glucose (2-DG) suppressed autocrine activation of ecdysteroidogenesis, clearly indicating that both Treh activity and glycolysis are involved...Using a specifically generated anti-bombyxin-Z1 antibody, the presence of bombyxin-Z1 protein was confirmed. To my knowledge, this is the first study to elucidate the signaling cascade involved in autocrine activation of ecdysteroidogenesis in an insect system."

Journal • EGF

A TXNIP-driven bioluminescent reporter for high-throughput discovery of glycolytic inhibitors against renal cell carcinoma. (PubMed, BMC Biotechnol) - No abstract available

Journal • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • TXNIP

Exofacial Epitope-Specific Antibodies Detect GLUT4 Translocation in Adult Human, Rat, and Mouse Skeletal Muscle. (PubMed, Diabetes) - "Insulin-stimulated translocation correlated with 2-deoxyglucose uptake and was abolished in TBC1D4-knockout muscle. Exofacial GLUT4 antibodies enable straightforward, specific quantification of endogenous GLUT4 translocation in rodent and human muscles in healthy and insulin-resistant states."

Journal • Preclinical • SLC2A4

CRIP1 knockdown enhances glycolytic dependence and increases sensitivity to 2-Deoxy-D-Glucose in acute myeloid leukemia. (PubMed, Mol Biol Rep) - "Our findings indicate that CRIP1 knockdown induces a glycolytic switch in AML cells, rendering them exquisitely sensitive to glycolytic inhibition by 2-DG. This suggests that CRIP1 status could serve as a biomarker for predicting response to metabolic therapies and highlights 2-DG as a promising therapeutic agent for a subset of AML characterized by glycolytic dependency."

Journal • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • CRIP1 • LDHA

Adult-Onset Diffuse Midline Glioma, H3K27-Altered: A Genomics-Guided, Individualized, Multimodal Treatment Approach. (PubMed, Brain Sci) - "The individualized regimen comprised trametinib and everolimus for dual pathway inhibition, the tissue-agnostic agent dordaviprone (ONC201), metabolic modulation with 2-deoxy-D-glucose, and electric field-based therapy. The systematic integration of comprehensive molecular profiling with mechanistically rational treatment selection may contribute to meaningful radiological and clinical benefit in this otherwise uniformly fatal disease. These observations support further investigation of individualized, pathway-targeted approaches in prospective studies and N-of-1 trial frameworks."

Journal • Brain Cancer • Diffuse Midline Glioma • Glioma • Oncology • Solid Tumor • ATRX • H3-3A • NF1

BRG1 orchestrates diabetic corneal neuropathy via PI3K/AKT-mediated glycolytic reprogramming. (PubMed, Eye Vis (Lond)) - "Glycolytic reprogramming is a critical driver of DCN progression. BRG1 activates PI3K/AKT signaling to enhance glycolytic flux, thereby regulating DCN pathogenesis. Targeting this axis may offer novel therapeutic strategies."

Journal • CNS Disorders • Diabetes • Diabetic Neuropathy • Metabolic Disorders • Pain • Type 1 Diabetes Mellitus • AKT1 • SMARCA4

BMAL1 Downregulation Exacerbates Age-related Nonalcoholic Steatohepatitis by Promoting NLRP3 Inflammasome Activation via HIF-1ɑ-mediated Glycolysis. (PubMed, Free Radic Biol Med) - "This study revealed a novel mechanism in which BMAL1 downregulation under aging and HFD conditions promotes NASH progression by binding to HIF-1α and modulating the glycolysis-NLRP3 inflammasome axis."

Journal • Acute Myelogenous Leukemia • Fibrosis • Hepatitis B • Hepatology • Immunology • Inflammation • Metabolic Dysfunction-Associated Steatohepatitis • ARNTL • BMAL1 • HIF1A • NLRP3

Glycolytic reprogramming of resident alveolar macrophages contributes to reduced SOCS3 secretion in non-small cell lung cancer. (PubMed, Front Immunol) - "Importantly, the pharmacologic inhibition of glycolysis with 2-deoxy-d-glucose restored SOCS3 secretion in these AMs. Together, our findings demonstrate that lung tumor-associated AMs undergo a time-dependent metabolic shift toward glycolysis, resulting in impaired SOCS3 secretion-a phenotype that can be reversed by targeting glycolytic flux. These results highlight a potential therapeutic approach for modulating immune suppression in the tumor microenvironment."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • KRAS • SOCS3

Comparison of postprocessing metrics in multimetabolic APT-weighted CEST and 2-deoxy-D-glucose-CEST-MRI for differentiating breast cancer subtypes in a murine model. (PubMed, Eur Radiol Exp) - "Advanced multimetabolic APTw-CEST and 2-deoxy-D-glucose-CEST postprocessing metrics allowed adequate preclinical murine BC subtyping. AREX showed potential for 2-deoxy-D-glucose-CEST in tumor characterization; however, APTw-CEST remains superior. MTRasym failed to distinguish between tumor subtypes in CEST-MRI."

Clinical • Journal • Preclinical • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • HER-2

Baicalin attenuates HIF-1α-driven histone lactylation and neutrophil extracellular trap (NET) formation in autoimmune uveitis. (PubMed, Int J Biol Macromol) - "Pharmacological inhibition of glycolysis (2-deoxy-d-glucose) or oxidative stress (Tempol) similarly attenuated NET formation...Collectively, our findings establish a mechanistic axis in which HIF-1α-driven glycolysis promotes lactate-dependent histone lactylation, which facilitates NET formation in AU. These findings reveal a novel immunometabolic pathway and highlight baicalin as a potential therapeutic agent targeting HIF-1α-mediated NETosis."

Journal • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis • ELANE • HIF1A • LDHA • MPO