RSS0343 / Jiangsu Hengrui Pharma - LARVOL DELTA

A Clinical Study of RSS0343 in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Completed | Sponsor: Reistone Biopharma Company Limited | Recruiting ➔ Completed

Trial completion • Bronchiectasis • Genetic Disorders • Immunology • Non‐Cystic Fibrosis Bronchiectasis • Pulmonary Disease • Respiratory Diseases

Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet (clinicaltrials.gov) - P1 | N=40 | Not yet recruiting | Sponsor: Reistone Biopharma Company Limited

New P1 trial • Bronchiectasis • Chronic Obstructive Pulmonary Disease • Genetic Disorders • Immunology • Nasal Polyps • Non‐Cystic Fibrosis Bronchiectasis • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Sinusitis

A Study to Evaluate the Efficacy and Safety of RSS0343 Tablets in Patients With Chronic Obstructive Pulmonary Disease (clinicaltrials.gov) - P2 | N=237 | Recruiting | Sponsor: Reistone Biopharma Company Limited | Not yet recruiting ➔ Recruiting

Enrollment open • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

A Clinical Study of RSS0343 in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Recruiting | Sponsor: Reistone Biopharma Company Limited | Not yet recruiting ➔ Recruiting

Enrollment open • Bronchiectasis • Genetic Disorders • Immunology • Non‐Cystic Fibrosis Bronchiectasis • Pulmonary Disease • Respiratory Diseases

A Study to Evaluate the Efficacy and Safety of RSS0343 Tablets in Patients With Chronic Obstructive Pulmonary Disease (clinicaltrials.gov) - P2 | N=237 | Not yet recruiting | Sponsor: Reistone Biopharma Company Limited

New P2 trial • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

A Clinical Study of RSS0343 in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Not yet recruiting | Sponsor: Reistone Biopharma Company Limited

New P1 trial • Bronchiectasis • Genetic Disorders • Immunology • Non‐Cystic Fibrosis Bronchiectasis • Pulmonary Disease • Respiratory Diseases

Phase I Clinical Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RSS0343 Tablets in Healthy Subjects After Single and Multiple Oral Administration and the Effect of Food on the Pharmacokinetics of RSS0343 (clinicaltrials.gov) - P1 | N=72 | Completed | Sponsor: Jiangsu HengRui Medicine Co., Ltd.

New P1 trial

Study of RSS0343 Tablets in Patients With Non-cystic Fibrosis Bronchiectasis (clinicaltrials.gov) - P2 | N=252 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting ➔ Recruiting | N=18 ➔ 252 | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Nov 2025 ➔ Nov 2027

Enrollment change • Enrollment open • Trial completion date • Trial primary completion date • Asthma • Bronchiectasis • Genetic Disorders • Immunology • Non‐Cystic Fibrosis Bronchiectasis • Pulmonary Disease • Respiratory Diseases

Study of RSS0343 Tablets in Patients With Non-cystic Fibrosis Bronchiectasis (clinicaltrials.gov) - P2 | N=18 | Not yet recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd.

New P2 trial • Asthma • Bronchiectasis • Genetic Disorders • Immunology • Non‐Cystic Fibrosis Bronchiectasis • Pulmonary Disease • Respiratory Diseases