MSM-707 / MSM Protein Technologies - LARVOL DELTA

The C2 domain augments Ras GTPase-activating protein catalytic activity. (PubMed, Proc Natl Acad Sci U S A) - "This is achieved by an evolutionarily conserved surface centered around RasGAP residue R707, point mutation of which impairs the catalytic advantage conferred by the C2 domain in vitro...In SynGAP, mutation of the equivalent conserved C2 domain surface impairs catalytic activity. Our results indicate that the C2 domain is required to achieve full catalytic activity of GAPs for Ras."

Journal • RASA1

Multiple Symmetric Lipomatosis as a Model for Understanding The Importance of Mitochondria Function on Adipose Tissue Biology. (ENDO 2023) - "Although the mechanism of disease is not clear, R707 is in the carboxy-terminal coiled-coil domain HR2 of MFN2 and may regulate mitochondrial membrane fusion...Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*"

Diabetes • Genetic Disorders • Hepatology • Lipodystrophy • Metabolic Disorders • Myositis • Obesity • Obstructive Sleep Apnea • Pain • Rare Diseases • Respiratory Diseases • Sleep Disorder • GDF15 • IGF1 • LEP