DS-1471 / Daiichi Sankyo - LARVOL DELTA

A first-in-human (FIH) Phase 1 dose-escalation study of DS-1471 in patients (pts) with advanced/metastatic (adv/met) solid tumors (ESMO 2026) - No abstract available

Clinical • First-in-human • Metastases • P1 data • Oncology • Solid Tumor

Preclinical evaluation and mechanistic analysis of antitumor effects of the novel anti-CD147 antibody DS-1471a in liver cancer models. (PubMed, Invest New Drugs) - "Although direct causal relationships remain to be fully established, these results suggest possible mechanisms underlying DS-1471a efficacy involving not only CD147 expression but also FBXO22 and p21. Taken together, these preclinical findings indicate a potential clinical benefit of DS-1471a and provide useful mechanistic insights for liver cancer treatment."

Journal • Preclinical • Liver Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • BSG • CDKN1A • FBXO22 • SMAD4

DS1471-079: A Study of DS-1471a In Subjects With Advanced Solid Tumors (clinicaltrials.gov) - P1 | N=17 | Terminated | Sponsor: Daiichi Sankyo Co., Ltd. | N=80 ➔ 17 | Trial completion date: Jun 2027 ➔ Jul 2025 | Recruiting ➔ Terminated | Trial primary completion date: Jun 2027 ➔ Jul 2025; The study was terminated by the sponsor due to a business decision.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Oncology • Solid Tumor

A phase I, first-in-human study of DS-1471 in patients with advanced/metastatic solid tumors (ESMO 2024) - P1 | "Safety measures for primary outcomes in this study include dose-limiting toxicities and treatment-emergent adverse events. Secondary outcome measures for both parts include best overall response, time to response, duration of response, progression-free survival, and overall survival."

Clinical • Metastases • P1 data • Oncology • Solid Tumor • BSG

A Study of DS-1471a In Subjects With Advanced Solid Tumors (clinicaltrials.gov) - P1 | N=80 | Recruiting | Sponsor: Daiichi Sankyo Co., Ltd.

Metastases • New P1 trial • Gastrointestinal Cancer • Oncology • Solid Tumor

Preclinical pharmacokinetic-pharmacodynamic modeling guides setting of the human starting dose of DS-1471a, a novel anti-CD147 antibody. (AACR-NCI-EORTC 2023) - No abstract available

PK/PD data • Preclinical • Oncology

Novel Anti-CD147 Antibody DS-1471a Exerts Antitumor Effect in Hepatocellular Carcinoma Patient Derived Xenograft Models and its Efficacy Correlates with the Expression of CD147. (AACR-NCI-EORTC 2023) - No abstract available

Preclinical • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor