somatropin (CP-024) / Critical Pharma - LARVOL DELTA

Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs. (PubMed, BMC Microbiol) - "A new incompatible group, IncFIIp23141-CTXM, was identified, alongside five newly designated Inc groups based on previously determined sequences, namely IncFIIpKPC2_EC14653, IncFIIpCP020359, IncFIIpCP024509, IncFIIpKOX-137, and IncFIIpKDO1...At least 49 ARGs conferring resistance against 11 different categories of antimicrobials were identified on these 13 plasmids. Overall, this research deepens the understanding of incompatible plasmids in Raoultella, serving as a reference for exploring antibiotic resistance profiles and plasmid diversity in MDR Raoultella."

Journal

16S rRNA gene sequencing data of plant growth-promoting jute-associated endophytic and rhizobacteria from coastal-environment of Ondo State, Nigeria. (PubMed, Data Brief) - "The identifiable bacteria include the rhizobacteria, Citrobacter fruendii RZS23 (accession number: CP024673.1), endophytic bacteria, Bacillus cereus EDR23 (accession number: LN890242.1), and Morganella morganii EDS23 (accession number: KR094121.1). The plant growth-promoting traits exhibited by these bacteria suggest their future exploration as bioinoculants."

Journal

Reply to the 'Comment on "Perturbation theory of scattering for grazing-incidence fast-atom diffraction"' by G. A. Bocan, H. Breiss, S. Szilasi, A. Momeni, E. M. S. Casagrande, E. A. Sánchez, M. S. Gravielle and H. Khemliche, Phys. Chem. Chem. Phys., 2023, 25, DOI: 10.1039/D3CP02486E. (PubMed, Phys Chem Chem Phys) - "Since that is the main criterion to distinguish between methods, it seems reasonable to conclude that the perturbation approach using a Morse-type potential reproduces the essential aspects of the dynamics correctly. In addition we expand on the historical context and summarize the physical insights provided by our methods."

Journal

SELISARC: A Spanish Sarcoma Group (GEIS) phase I/II trial of selinexor plus gemcitabine in selected sarcoma subtypes—Results of the phase I part. (ASCO 2023) - P1/2 | "In vitro cell viability studies shown that S+G was synergistic in the majority of LMS cell lines tested (combination index of 0.789 for CP0024, 0.791 for SK-UT-1, 0.604 for AA and 1.186 for IEC005). At the RP2D, S 80 mg + G 1,200 mg/m2 (10 mg/m2/min) is a feasible scheme with manageable toxicity. S+G has shown promising clinical activity for LMS, which warrants further investigation in a phase II. Preclinical studies shown the synergy and the antagonism of S+G in LMS and OS, respectively."

IO biomarker • P1/2 data • Alopecia • Alveolar Soft Tissue Sarcoma • Anemia • Febrile Neutropenia • Hematological Disorders • Leiomyosarcoma • Neutropenia • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • Synovial Sarcoma • Thrombocytopenia • Undifferentiated Pleomorphic Sarcoma • XPO1

Alternative splicing (AS) regulation as a novel therapeutic target in soft-tissue sarcoma (STS). (ASCO 2023) - "Background: There is an urgent clinical need to identify novel treatments for advanced STS, since all the clinical trials testing chemotherapy combinations have failed to improve survival compared to doxorubicin (dox) alone... A panel of 9 STS cell lines, including LMS (CP0024, IEC005, AA, SK-UT-1), LPS (93T449), synovial sarcoma (MCP037) and UPS (MCP016, MCP021, MCP025) were used to analyse the effect of SM09419 (provided by Biosplice) or PRI-724 (Wnt/β-catenin inhibitor) on cell viability (MTS assays)... The effects of pan CLK/DYRK inhibition on growth and survival of STS cancer cell lines and PDX models, indicate that can STS may be therapeutically addressed with these AS-modulators. The combination of SM09419 with dox was active in STS preclinical models known for their resilience toward treatment. Based on these results, the exploration of such combinations in clinical trials is warranted."

Oncology • Sarcoma • Soft Tissue Sarcoma • Solid Tumor • Synovial Sarcoma

Predictive value of MRP-1 in localized high-risk soft tissue sarcomas: a translational research associated to ISG-STS 1001 randomized phase III trial. (PubMed, Mol Cancer Ther) - "In vitro studies tested the efficacy of MRP-1 inhibitors (nilotinib, ripretinib, selumetinib and avapritinib) in sarcoma cell lines...In vitro studies showed that the addition of MRP-1 inhibitors (nilotinib or avapritinib) to doxorubicin plus palifosfamide, significantly increased cell death in SK-UT-1 and CP0024 cell lines. MRP-1 is an adverse predictive factor in localized high-risk STS patients treated with neoadjuvant anthracyclines plus ifosfamide followed by surgery. In vitro findings support the clinical assessment of the combination of chemotherapy and MRP-1 inhibitors as a promising strategy to overcome the drug ceiling effect for chemotherapy."

Clinical • Journal • P3 data • Oncology • Sarcoma • Soft Tissue Sarcoma • Solid Tumor

First report of Pectobacterium versatile causing blackleg of potato in Serbia. (PubMed, Plant Dis) - "CP034276 and CP024842, respectively) as well as SCC1 from Finland (Acc...2021). Findings achieved in this study are highly relevant, as they point to the diversity in potato blackleg pathogens, likely due to the increasingly widespread distribution of imported seed potatoes."

Journal • Infectious Disease • PCR

Citrobacter freundii causing Ginger (Zingiber officinale Rosc.) Rot in Tangshan, China. (PubMed, Plant Dis) - "The obtained 16S, rpoB and gyrB sequences (GenBank accession MN148645, MN158728 and MW199734) of the isolate showed 99.93%, 99.51% and 99.82% identity to the corresponding sequences of C. freundii in GenBank (CP024679.1, CP024677.1 and KM509081.1)...Pathogens were reisolated from symptomatic plants and rhizomes and identified as C. freundii based on the morphological, biochemical and molecular methods described previously, fulfilling Koch's hypothesis. To our knowledge, this is the first report of ginger rot caused by C. freundii in China."

Journal • Infectious Disease

Reply to the 'Comment on "Extent of conjugation in diazonium-derived layers in molecular junction devices determined by experiment and modelling"' by R. L. McCreery, S. K. Saxena, M. Supur and U. Tefashe, Phys. Chem. Chem. Phys., 2020, 22, DOI: 10.1039/d0cp02412k. (PubMed, Phys Chem Chem Phys) - "Taken together, this shows that models presented in the literature may benefit from including more fine structure details, as better understanding may emerge from such considerations. This was the intent of our original article, and we thank the comment authors for the chance to clarify these points."

Journal

Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing. (PubMed, Front Cell Infect Microbiol) - "Four plasmids, CP002474.1, CP006799.1, CP018455.1, and CP025459.1, were detected among the 9 isolates...We found that two clades of CP-Kp were responsible for this nosocomial outbreak and demonstrated the transmission route from two index patients. Plasmid carriage and phylogeny are a useful tool for identifying clades involved in disease transmission."

Journal • Retrospective data • Immunology • Respiratory Diseases

Identification and Functional Analysis of Temperate Siphoviridae Bacteriophages of Acinetobacter baumannii. (PubMed, Viruses) - "CP024576.1)...The phages showed a very narrow host range infecting only two A.baumannii strains. In conclusion, we have isolated and characterized three novel temperate Siphoviridae phages that infect A.baumannii."

Journal • Immunology

Growth hormone receptor polymorphism and growth hormone therapy response in children: A Bayesian meta-analysis (Am J Epidemiol) - The GHR(d)(3) polymorphism inheritance is codominant, contrasting with previous reports; GHR(d)(3) genotypes account for modest increases in rhGH effects in children; & considerable unexplained variability in responsiveness remains

Meta analysis • Growth Hormone