Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma, Pharmbio - LARVOL DELTA

Effect of oliceridine on hypoxia during sedated hysteroscopy: a Phase 4 randomized clinical trial. (PubMed, Commun Med (Lond)) - P4 | "Oliceridine reduces the incidence of intraoperative hypoxia during hysteroscopic surgery under sedation, suggesting it may be a safer alternative to sufentanil."

Clinical • Journal • P4 data • Anesthesia • CNS Disorders • Depression • Gynecology • Pain • Psychiatry

Oliceridine versus Sufentanil for Postoperative Recovery and Opioid-Related Adverse Events in Patients Undergoing Thoracoscopic Lobectomy: A Randomized Double-Blind Controlled Trial. (PubMed, Drug Des Devel Ther) - "Oliceridine provides safe and effective perioperative analgesia for patients undergoing thoracoscopic lobectomy. It maintains stable hemodynamics, achieves analgesic efficacy comparable to sufentanil, and demonstrates a superior profile in reducing opioid-related adverse events while promoting postoperative recovery."

Adverse events • Clinical • Journal • Anesthesia • CNS Disorders • Constipation • Depression • Dermatology • Gastroenterology • Gastrointestinal Disorder • Pain • Pruritus • Psychiatry

Effect of oliceridine pretreatment on etomidate-induced myoclonus: a prospective, randomized, double-blind, controlled study. (PubMed, Front Med (Lausanne)) - P4 | "Therefore, oliceridine can be used as a new pretreatment strategy when etomidate is employed for anesthetic induction. https://www.chictr.org.cn/searchproj.html, identifier ChiCTR2500108944."

Clinical • Journal • Anesthesia • Movement Disorders

Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery (clinicaltrials.gov) - P=N/A | N=174 | Not yet recruiting | Sponsor: Xuanwu Hospital, Beijing

New trial • Oncology

Comparison of Postoperative Analgesic Efficacy of Oliceridine and Sufentanil in Total Laparoscopy Hysterectomy, a Clinical Double-Blind Controlled Trial. (PubMed, Drug Des Devel Ther) - "No significant differences were found between groups in resting or cough NRS scores at any time point, PCIA attempts, rescue analgesia requirement, rescue tramadol dose, emergence time, or extubation time. However, Group O had a significantly shorter time to first flatus (18.63 ± 3.51 vs 24.70 ± 3.26 hours, P < 0.001) and time to first ambulation (17.95 ± 3.30 vs 20.28 ± 3.76 hours, P = 0.004), a lower overall incidence of adverse events (32.5% vs 62.5%, P = 0.007), and a higher QoR-15 score (120.85 ± 7.15 vs.115.63 ± 6.74, P = 0.001). Additionally, Group O demonstrated better hemodynamic stability than Group S. For patients undergoing total laparoscopy hysterectomy, oliceridine provides postoperative analgesic efficacy comparable to sufentanil but is associated with a lower incidence of adverse events and better recovery quality."

Clinical • Journal • Anesthesia • Cough • Gynecology • Pain • Respiratory Diseases

A randomized double-blind placebo-controlled trial of oliceridine, a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy. (PubMed, Curr Med Res Opin) - P3 | "No serious adverse events occurred in the oliceridine groups. Oliceridine provided rapid and significant pain relief after bunionectomy in Korean patients, with no serious adverse events reported, supporting its potential as an effective and well-tolerated analgesic option."

Clinical • Journal • Pain

EC50 of Remifentanil for Inhibiting Cardiovascular Responses to Tracheal Intubation in Patients Treated by Different Doses of Oliceridine: A Randomized Controlled Trial Using Up-and-Down Sequential Allocation Methodology. (PubMed, Drug Des Devel Ther) - "The EC50 values of remifentanil was 3.728 ng/mL (95% CI: 3.536-3.943 ng/mL), 2.824 ng/mL (95% CI: 2.620-3.015 ng/mL), 3.045 ng/mL (95% CI: 2.852-3.239 ng/mL) and 2.887 ng/mL (95% CI: 2.689-3.085 ng/mL) in the control, sufentanil, oliceridine 0.015 mg/kg group and oliceridine 0.03 mg/kg group, respectively. The effect of 0.03 mg/kg oliceridine is similar to 0.15 μg/kg sufentanil in reducing the EC50 of remifentanil in inhibiting the cardiovascular responses induced by trachea intubation."

Clinical • Intubation • Journal • Anesthesia • Cardiovascular • Dysphonia • Otorhinolaryngology

Effect of oliceridine versus morphine on the quality of early recovery after thoracoscopic surgery: a randomized, controlled clinical trial. (PubMed, BMC Anesthesiol) - No abstract available

Clinical • Journal

A Comparison of the Efficacy of Novel G-Protein Biased µ-Opioid Receptor Agonists and Traditional Opioids in Chronic Postoperative Pain Following Thoracoscopic Surgery (ChiCTR) - P=N/A | N=180 | Not yet recruiting | Sponsor: Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital); Central Hospital of Dalian University of Technology (Dalian M

New trial • Pain

A study on the efficacy of Tegileridine and Oliceridine for patient-controlled analgesia after urological laparoscopic surgery in elderly patients (ChiCTR) - P=N/A | N=168 | Not yet recruiting | Sponsor: Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital); Central Hospital of Dalian University of Technology (Dalian M

New trial • Pain

A Comparative Study of Oliceridine versus Alfentanil and Sufentanil in Clinical Application for Painless Gastrointestinal Endoscopy (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Qingdao Binhai University Affiliated Hospital; Qingdao Binhai University Affiliated Hospital

New trial • Pain

Study of PBK_L1704 for the Treatment of Moderate to Severe Acute Pain After Bunionectomy in South Korea (clinicaltrials.gov) - P3 | N=182 | Completed | Sponsor: Pharmbio Korea Co., Ltd. | Recruiting ➔ Completed | Trial completion date: Dec 2022 ➔ Feb 2025 | Trial primary completion date: Dec 2022 ➔ Feb 2025

Trial completion • Trial completion date • Trial primary completion date • Pain

Observation on the Efficacy of Oliceridine for Patient-Controlled Analgesia after Maxillofacial Surgery (ChiCTR) - P=N/A | N=210 | Recruiting | Sponsor: Beijing Zhongguancun Hospital; Beijing Zhongguancun Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

Determination of ED90 of Oliceridine combined with Propofol in inhibiting responses to laryngeal mask insertion in Elderly Patients: a biased coin up-and-down design (ChiCTR) - P=N/A | N=60 | Recruiting | Sponsor: Eye & ENT Hospital of Fudan University; Eye & ENT Hospital of Fudan University | Not yet recruiting ➔ Recruiting

Enrollment open

Application of Oliceridine Combined with Fascia Iliaca Compartment Block for Patient-Controlled Analgesia in Elderly Frail Patients after Total Hip Arthroplasty (ChiCTR) - P4 | N=60 | Recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New P4 trial • Geriatric Disorders • Orthopedics

Application Research of Oliceridine in Pain Management for Elderly Patients after Laparoscopic Cholecystectomy (ChiCTR) - P4 | N=72 | Recruiting | Sponsor: Shenzhen People's Hospital; Shenzhen People's Hospital

New P4 trial • Pain

The effect of intravenous patient-controlled analgesia with oxycodone or sufentanil on postoperative recovery in patients undergoing knee arthroscopic surgery: A randomized controlled clinical trial (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Longhua District People's Hospital, Shenzhen; Longhua District People's Hospital, Shenzhen

New P4 trial • Orthopedics

Fumarate oliceridine ED50 and ED95 required for suppression of bronchoscopy response under remimazolam sedation: a sequential dose exploration study (ChiCTR) - P4 | N=40 | Not yet recruiting | Sponsor: The Affiliated Hospital of Guizhou Medical University; The First People's Hospital of Guiyang

New P4 trial • Anesthesia • Pain

Effect of oliceridine vs sufentanil on propofol demand during hysteroscopy (ChiCTR) - P4 | N=122 | Not yet recruiting | Sponsor: Zhejiang Provincial Hospital of TCM; Zhejiang Provincial Hospital of TCM

New P4 trial • Gynecology • Pain

Application of Oxalidine in Gynecological Endoscopic Surgery (ChiCTR) - P4 | N=272 | Not yet recruiting | Sponsor: The First Affiliated Hospital of University of Science and Technology of China; The First Affiliated Hospital of University of Science and Technology

New P4 trial • Pain

Comparison of Oliceridine and Hydromorphone for Nausea and Vomiting in Patient-Controlled Intravenous Analgesia After Orthopedic Surgery Under Multimodal Analgesia: A Prospective Cohort Study (ChiCTR) - P4 | N=216 | Recruiting | Sponsor: The Second Affiliated Hospital, Zhejiang University School of Medicine; The Second Affiliated Hospital, Zhejiang University School of Medicine

New P4 trial • Orthopedics • Pain

Study on the Dose-Response Relationship of Respiratory Depression Induced by Single Bolus Injection of Sevoflurane Combined with Oliceridine in Elderly Patients: A Randomized, Double-Blind, Controlled Trial Protocol (ChiCTR) - P4 | N=78 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Wenzhou Medical University; The Second Affiliated Hospital of Wenzhou Medical University

New P4 trial • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry

Clinical study on the safety and efficacy of oliceridine for tracheal intubation in children (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine; Shanghai Children's Medical Center, Shanghai Jiao Tong Universit

New P4 trial • Anesthesia

nalgesic Efficacy and Effect on Postoperative Delirium of Oliceridine in a Multimodal Analgesia Regimen for Elderly Patients Undergoing Surgery for Hip Fracture: A Multicenter, Randomized, Double-Blind, Controlled Trial (ChiCTR) - P4 | N=616 | Not yet recruiting | Sponsor: Henan Provincial People's Hospita,medical; Henan Provincial People's Hospita,medical

New P4 trial • CNS Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Comparison of Oliceridine and Sufentanil in Postoperative Analgesia in Laparoscopic Cholecystectomy:a Randomized Double-Blind Controlled Trial (ChiCTR) - P4 | N=308 | Not yet recruiting | Sponsor: Tongling People's Hospital; Tongling People's Hospital

New P4 trial • Pain