Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma, Pharmbio - LARVOL DELTA

Establishing the Median and 95% Effective Doses of Oliceridine for Immediate Post-Surgical Analgesia Following Laparoscopic Cholecystectomy: A Double-Blind, Sequential Dose-Finding Study. (PubMed, Drug Des Devel Ther) - "Pain management satisfaction assessment at 24 hours post-LC revealed high approval rates in the oliceridine group, with 90% of patients (36/40, p=0.31) and 97.5% of surgeons (39/40, p=0.03) expressing satisfaction, regardless of administered dose. Our findings establish that for early postoperative pain management, oliceridine demonstrates optimal therapeutic efficacy at an ED50 of 18.45 ug/kg, with the ED95 determined to be 22.39 ug/kg."

Clinical • Journal • Anesthesia • Pain

Determination of ED90 and ED99 of Oliceridine combined with Propofol in inhibiting responses to gastroscope insertion: a biased coin up-and-down design. (PubMed, BMC Anesthesiol) - P=N/A | "The combination of 2 mg·kg- 1 Propofol and 23.8 µg·kg- 1 Oliceridine is effective in suppressing the responses during the gastroscopy procedure."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry

Impact of Oliceridine On the Incidence of postoperative nausea and vomiting in pain management after bimaxillary surgery: A prospective, randomized, controlled, double-blind exploratory study (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Peking University Hospital of Stomatology; Peking University Hospital of Stomatology

New P4 trial • Pain

Effect of Intraoperative Oliceridine versus Fentanyl on Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=130 | Not yet recruiting | Sponsor: Changshu Second People's Hospital; Affiliated Changshu Hospital of Nantong University

New trial

Efficacy of oliceridine on quality of patients early recovery in video-assisted thoracoscopic surgery: a prospective clinical trial (ChiCTR) - P4 | N=96 | Recruiting | Sponsor: The Second Affiliated Hospital of Kunming Medical University; The Second Affiliated Hospital of Kunming Medical University

New P4 trial

Application of the G-Protein Biased Receptor Agonist Oliceridine in Gynecological Surgery: A Series of Studies Based on the ERAS Concept (ChiCTR) - P4 | N=186 | Not yet recruiting | Sponsor: Second Xiangya Hospital of CSU; Second Xiangya Hospital of CSU

New P4 trial • Gynecology

Effect of Oliceridine Versus Fentanyl Combined with Propofol on Respiratory Depression during gastrointestinal endoscopy: A Prospective Randomized Controlled Trial (ChiCTR) - P4 | N=228 | Not yet recruiting | Sponsor: Changshu NO.2 people's Hospital; Changshu NO.2 people's Hospital

New P4 trial • CNS Disorders • Depression • Gastrointestinal Disorder • Mood Disorders • Pain • Psychiatry

Application of G-protein-biased μ-opioid receptor agonists in postoperative pain management of day surgery patients (ChiCTR) - P4 | N=300 | Recruiting | Sponsor: Shenzhen People's Hospital; Shenzhen People's Hospital

New P4 trial • Pain

Determination of the 90% Effective Dose of Propofol Combined with Oliceridine or Fentanyl for Inhibiting the Insertion Response in Upper Gastrointestinal Endoscopy: A Biased-Coin Up-and-Down Sequential Dose-Finding Trial (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Changshu NO.2 people's Hospital; Changshu NO.2 people's Hospital

New P4 trial • Gastrointestinal Disorder

The effect of G protein-biased μ-opioid receptor agonists on postoperative gastrointestinal function recovery in elderly patients undergoing abdominal surgery: a multicenter, randomized, controlled clinical trial (ChiCTR) - P=N/A | N=588 | Not yet recruiting | Sponsor: Zhongda Hospital affiliated to Southeast University; Zhongda Hospital affiliated to Southeast University

New trial • Gastrointestinal Disorder

Study on the anesthetic effect of oliceridine compounded with propofol for painless gastroscopy (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Dazhou Central Hospital; Dazhou Central Hospital

New P4 trial • Anesthesia • Pain

Comparison of the anesthetic effects of oliceridine-propofol and fentanyl-propofol anesthetic regimens for painless abortion (ChiCTR) - P4 | N=140 | Not yet recruiting | Sponsor: Dazhou Central Hospital; Dazhou Central Hospital

New P4 trial • Anesthesia • Pain

A study of the safety and efficacy of oliceridine versus hydromorphone for analgesia in postoperative mechanically ventilated patients in the ICU (ChiCTR) - P4 | N=122 | Not yet recruiting | Sponsor: Affiliated Hospital of Southwest Medical University; Affiliated Hospital of Southwest Medical University

New P4 trial

Comparison of Oliceridine and Alfentanil in Fiberoptic Bronchoscopy under General Anesthesia with Laryngeal Mask Airway (ChiCTR) - P=N/A | N=90 | Not yet recruiting | Sponsor: Anshan Central Hospital; Anshan Central Hospital

New trial • Anesthesia • Lung Cancer • Oncology • Pulmonary Disease

ED50 and ED95 of Oseltamivir Fumarate Injection for preventing coughing during extubation after thyroidectomy (ChiCTR) - P4 | N=30 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xinxiang Medical University; The First Affiliated Hospital of Xinxiang Medical University

New P4 trial

Evaluation of the safety and effectiveness of oliceridine (TRV130), a G-protein selective agonist at the µ-opioid receptor, and sufentanil for postoperative analgesia in elderly patients undergoing knee arthroplasty: a randomized controlled trial (ChiCTR) - P4 | N=68 | Not yet recruiting | Sponsor: Shanghai Sixth People's Hospital; Shanghai Sixth People's Hospital

New P4 trial • Orthopedics

Oliceridine combined with propofol-etomidate sedation in geriatric outpatients undergoing painless gastroscopy: a randomized controlled trial (ChiCTR) - P=N/A | N=112 | Not yet recruiting | Sponsor: Weihai Central Hospital; Weihai Central Hospital

New trial • Anesthesia • Geriatric Disorders • Pain

Tolerability of different doses of oliceridine versus traditional opioids in acute pain management: a systematic review and meta-analysis. (PubMed, Sci Rep) - "Our findings demonstrate that oliceridine recipients had a significant decline in the incidence of both sedation and dizziness (sedation: RR = 0.64, 95% CI 0.45-0.91, P = 0.01; dizziness: RR = 0.71, 95% CI 0.57-0.88, P = 0.002).Moreover, the oliceridine group recorded a lower incident of hypoxemia showcasing a favorable safety profile (RR = 0.52, 95% CI 0.41-0.65, P < 0.001).Sensitivity analyses confirmed the robustness of these findings. The systematic review and meta-analysis reveal that oliceridine is a well-tolerated and safe intravenous analgesic for acute pain patients, often reducing the incidence of adverse events in comparison to morphine."

Journal • Retrospective data • Anesthesia • Dermatology • Pain • Pruritus

Determining the 90% Effective Dose of Oliceridine for Inhibiting Endotracheal Intubation and Laryngeal Mask Airway Insertion Responses : A Biased-Coin Sequential Dose-Finding Trial (ChiCTR) - P=N/A | N=240 | Not yet recruiting | Sponsor: Changshu Second People's Hospital; Changshu Second People's Hospital

New trial

A comparison of the efficacy and safety between equivalent - dose oliceridine and sufentanil for gastrointestinal endoscopy. (ChiCTR) - P=N/A | N=160 | Not yet recruiting | Sponsor: The Second People's Hospital of Hefei City.; The Second People's Hospital of Hefei City.

New trial • Anesthesia • Gastrointestinal Disorder

Efficacy of Oliceridine and sufentanil in patient-controlled analgesia after Knee unicompartmental arthroplasty (ChiCTR) - P4 | N=90 | Not yet recruiting | Sponsor: Suzhou Municipal Hospital; Suzhou Municipal Hospital

New P4 trial • Musculoskeletal Pain • Orthopedics • Pain

To compare the effect of oliceridine and sufentanil on the postoperative recovery quality of patients undergoing laparoscopic cholecystectomy during the day (ChiCTR) - P4 | N=200 | Not yet recruiting | Sponsor: Affiliated Hospital of Guizhou Medical University; The Affiliated Hospital of Guizhou Medical University

New P4 trial • Gastroenterology • Hepatology

Application of oliceridine to inhibit sufentanil-induced cough response (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: The Second People's Hospital of Hefei; The Second People's Hospital of Hefei

New trial • Cough • Respiratory Diseases

Oliceridine versus sufentanil hyperalgesia for laparoscopic cholecystectomy: a randomized controlled, double-blind study (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Nanchong Central Hospital; Nanchong Central Hospital

New trial • Pain

Efficacy of intravenous oliceridine on preventing sufentanil-­induced cough during general anaesthesia induction:A single-center, double-blind, randomized, controlled clinical trial. (ChiCTR) - P=N/A | N=530 | Not yet recruiting | Sponsor: Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Renji Hospital, Shanghai Jiao Tong U

New trial • Anesthesia • Cough • Respiratory Diseases