Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma, Pharmbio - LARVOL DELTA

Comparison of oliceridine and fentanyl intraoperative analgesia on postoperative nausea and vomiting in female patients undergoing laparoscopic cholecystectomy: study protocol for a randomized, double-blind, controlled trial. (PubMed, Trials) - P=N/A | "We hypothesize that oliceridine may offer effective analgesia and a lower incidence of PONV than fentanyl in intraoperative pain management for this high-risk group. The findings may provide valuable insights into optimizing perioperative pain management strategies and enhancing patient recovery."

Clinical • Journal • Anesthesia • Pain

Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial. (PubMed, Drug Des Devel Ther) - P=N/A | "The ED90 of oliceridine for inhibiting LMA insertion responses, when combined with 0.25 mg/kg etomidate, was 0.0246 mg/kg in young-to-middle-aged patients and 0.0229 mg/kg in elderly patients. The study was registered with the Chinese Clinical Trial Registry (ChiCTR2500095893) on January 25, 2025."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Psychiatry

Effect of Oliceridine Combined with Sufentanil on Patient-Controlled Intravenous Analgesia in Elderly Patients After Laparoscopic Radical Resection of Rectal Cancer: A Prospective Randomized Controlled Study. (PubMed, Drug Des Devel Ther) - "Meanwhile, this combination regimen significantly decreased the AIS scores (P < 0.001), the times of analgesia pump pressing (p < 0.01), the times of rescue analgesia (p < 0.05), and the rescue analgesia rate (P < 0.001). In the pain management after laparoscopic radical resection of rectal cancer in elderly patients, oliceridine combined with sufentanil provides the best analgesic effect and has the lowest incidence of adverse reactions associated with opioids."

Clinical • Journal • CNS Disorders • Colorectal Cancer • Depression • Insomnia • Oncology • Pain • Psychiatry • Rectal Cancer • Sleep Disorder • Solid Tumor

Determination of the effective dose of oliceridine combined with propofol using the modified Dixon's up-and-down method in painless gastroscopy. (PubMed, Front Pharmacol) - P=N/A | "The use of oliceridine (13.19-14.46 μg·kg-1) and propofol was associated with safety, efficacy, and lower complication rates during painless gastroscopy. https://www.chictr.org.cn/showproj.html?proj=249883, identifier ChiCTR2400093609."

Journal • Cardiovascular • CNS Disorders • Depression • Fatigue • Hypotension • Pain • Psychiatry

The Effect of Oliceridine on Postoperative Pain and Gastrointestinal Function Recovery in Gynecologic Laparoscopic Surgery: A Double-Blind Randomized Controlled Trial (ChiCTR) - P4 | N=566 | Not yet recruiting | Sponsor: Anqing Municipal Hospital; Anqing Municipal Hospital

New P4 trial • Pain • CXCL8

Efficacy and Safety of Oliceridine Combined with Remimazolam for Fiberoptic Bronchoscopy (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Gansu Provincial Hospital; Gansu Provincial Hospital

New P4 trial • Pain

The efficacy and safety of oliceridine in analgesic treatment of critically ill mechanically ventilated patients: a multicenter, randomized, positive controlled, single blind trial (ChiCTR) - P4 | N=248 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New P4 trial • Pain

Application of oliceridine, a biased μ-opioid receptor agonist, in the perioperative period of elderly patients undergoing total knee arthroplasty (ChiCTR) - P4 | N=80 | Not yet recruiting | Sponsor: The Sixth People's Hospital of Shanghai; The Sixth People's Hospital of Shanghai

New P4 trial • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology

Oliceridine versus Sufentanil in Reducing Postoperative Nausea and Vomiting in Patients Undergoing Gynecologic Laparoscopic Surgery: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=340 | Not yet recruiting | Sponsor: Shanghai East Hospital; Shanghai East Hospital

New trial

Study on the Efficacy of Oliceridine in Intravenous Patient-Controlled Analgesia (IV-PCA) for Patients After Cesarean Section (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Yongzhou Central Hospital; Yongzhou Central Hospital

New P4 trial

A Study on the Efficacy and Safety of Oliceridine Fumarate Injection in Painless Bronchoscopy (ChiCTR) - P=N/A | N=502 | Not yet recruiting | Sponsor: Zhejiang Provincial People's Hospital; Zhejiang Provincial People's Hospital

New trial • Pain

Comparison of Oliceridine versus Sufentanil on Laryngeal Mask Airway Insertion Conditions during Anesthesia Induction: A Randomized Controlled Trial (ChiCTR) - P1 | N=100 | Not yet recruiting | Sponsor: The Navy Specialized Medical Center of the People's Liberation Army of China; The Navy Specialized Medical Center of the People's Liberation Army of C

New P1 trial • Anesthesia

Effect of Oxelidine on early postoperative pain and quality of recovery in patients undergoing thoracoscopic pneumonectomy: a randomized double-blind controlled trial (ChiCTR) - P4 | N=150 | Not yet recruiting | Sponsor: Tianjin Cancer Hospital Airport Hospital; Tianjin Cancer Hospital Airport Hospital

New P4 trial • Lung Cancer • Oncology • Pain • Solid Tumor

Observation on the Efficacy of Oliceridine for Patient-Controlled Analgesia after Maxillofacial Surgery (ChiCTR) - P=N/A | N=210 | Not yet recruiting | Sponsor: Beijing Zhongguancun Hospital; Beijing Zhongguancun Hospital

New trial • Pain

Effect of Oliceridine Injection on Post-TURP Catheter-Related Bladder Discomfort: A Randomized Controlled Trial (ChiCTR) - P4 | N=138 | Not yet recruiting | Sponsor: Deyang People's Hospital; Deyang People's Hospital

New P4 trial

The effective dose of oliceridine for postoperative analgesia in children after laparoscopic hernia repair: A dose-finding study based on the biased coin design sequential method (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine; Shanghai Children's Medical Center, Shanghai Jiaotong University

New P4 trial • Gastroenterology

The Effect of Oliceridine versus Hydromorphone on Gastrointestinal Tolerability in Patients Undergoing Major Abdominal Surgery with Multimodal Analgesia: A Prospective, Randomized Controlled Study (ChiCTR) - P4 | N=310 | Not yet recruiting | Sponsor: The Second Affiliated Hospital, Zhejiang University School of Medicine; Department of Anesthesiology, the Second Affiliated Hospital, Zhejiang Univers

New P4 trial • Pain

Study on the Effect of Different Doses of Oliceridine on the ED50 of Propofol for Painless Gastroscopy in Elderly Patients (ChiCTR) - P1 | N=80 | Not yet recruiting | Sponsor: Central Hospital Affiliated to Shandong First Medical University; Central Hospital Affiliated to Shandong First Medical University

New P1 trial • Pain

Assessment of the Safety and Efficacy of Oliceridine in Elderly Patients Undergoing Transurethral Laser Enucleation of the Prostate under General Anesthesia: A Randomized, Double-Blind, Controlled Exploratory Study (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Renjin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Renjin Hospital Affiliated to Shanghai Jiao Tong University School of

New trial • Anesthesia

Effect of Pretreatment with Low-Dose Oliceridine on Etomidate-Induced Myoclonus During Anesthesia Induction (ChiCTR) - P4 | N=90 | Not yet recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New P4 trial • Anesthesia • Movement Disorders

Clinical Analysis of Oliceridine Combined with Dexmedetomidine for Patient-Controlled Intravenous Analgesia (PCIA) After Cesarean Section (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Hanzhong Central Hospital; Hanzhong Central Hospital

New trial • Pain

Median effective dose of oliceridine inhibiting the intubation response when combined with propofol during rigid bronchoscopy in elderly patients with lung cancer (ChiCTR) - P4 | N=36 | Completed | Sponsor: Xianyang Central Hospital; Xianyang Central Hospital

Intubation • New P4 trial • Lung Cancer • Oncology • Solid Tumor

The prevention of postoperative nausea and vomiting following general anesthesia and the monitoring of intraoperative QTc safety (ChiCTR) - P4 | N=420 | Not yet recruiting | Sponsor: Wang Chenggang(Study sponsor); Shanxi Provincial Hospital of Traditional Chinese Medicine / Shanxi Provincial Institute of Traditional Chinese Medicin

New P4 trial • Anesthesia

Efficacy and safety of oliceridine in peri-operative analgesia for patients with urethral stricture: A single-center, randomized, double-blind, positive drug standard-controlled clinical trial (The OliUS Trial) (ChiCTR) - P=N/A | N=188 | Not yet recruiting | Sponsor: Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Sixth People's Hospital Affiliated to Shangh

New trial • Pain • Urology

The Effect of Oliceridine Infusion on Hemodynamics During ERCP: A Randomized Clinical Trial (ChiCTR) - P=N/A | N=118 | Not yet recruiting | Sponsor: Shanghai East Hospital; Shanghai East Hospital

New trial