Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma, Pharmbio - LARVOL DELTA

A comparison of the effects of oliceridine and sufentanil on the quality of recovery after hysteroscopic surgery: a prospective double-blind randomized controlled trial. (PubMed, J Anesth) - "When compared with sufentanil, oliceridine significantly enhanced early postoperative recovery quality in patients undergoing hysteroscopic surgery while reducing the incidence of respiratory depression and nausea/vomiting."

Journal • Anesthesia • CNS Disorders • Depression • Psychiatry

Oliceridine Dose for Tracheal Intubation Hemodynamic Elevation: Up-and-Down Trial (clinicaltrials.gov) - P=N/A | N=58 | Completed | Sponsor: Shiyou Wei | Recruiting ➔ Completed

Intubation • Trial completion

Oliceridine Dose for Tracheal Intubation Hemodynamic Elevation: Up-and-Down Trial (clinicaltrials.gov) - P=N/A | N=70 | Recruiting | Sponsor: Shiyou Wei | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2025 ➔ Sep 2025 | Trial primary completion date: Dec 2025 ➔ Sep 2025

Enrollment open • Intubation • Trial completion date • Trial primary completion date

Oliceridine Dose for Tracheal Intubation Hemodynamic Elevation: Up-and-Down Trial (clinicaltrials.gov) - P=N/A | N=70 | Not yet recruiting | Sponsor: Shiyou Wei

Intubation • New trial

Therapeutic exploration of biased ligands at class A G protein-coupled receptors over the past 20 years. (PubMed, Pharmacol Ther) - "The regulatory approval of the opioid biased agonist TRV130 for pain management, along with the growing number of biased drugs tested in clinical trials, heralds a new era in GPCR drug development. Additionally, various natural product biased ligands have been identified. A deeper understanding of the biological functions and pharmacological effects of biased ligands will support future advancements in GPCR drug development."

Journal • Review • Cardiovascular • Inflammation • Pain

Half effective dose of oliceridine combined with propofol for bidirectional endoscopy in subclinically obese patients (ChiCTR) - P4 | N=80 | Recruiting | Sponsor: The Fifth People's Hospital of Huai'an; The Fifth People's Hospital of Huai'an | -> Recruiting | N=200 ➔ 80

Enrollment change • Enrollment open • Genetic Disorders • Obesity

Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy (clinicaltrials.gov) - P=N/A | N=120 | Not yet recruiting | Sponsor: Henan Provincial People's Hospital

New trial • Pain

Intravenous Oliceridine and Opioid-related Complications (clinicaltrials.gov) - P4 | N=111 | Completed | Sponsor: The Cleveland Clinic | Recruiting ➔ Completed

Trial completion

Efficacy of Oxalidine and Sufentanil in Strabismus Correction (clinicaltrials.gov) - P=N/A | N=290 | Not yet recruiting | Sponsor: Henan Provincial People's Hospital

Head-to-Head • New trial • Ophthalmology • Strabismus

Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery (clinicaltrials.gov) - P4 | N=96 | Recruiting | Sponsor: YanYing Xiao | Not yet recruiting ➔ Recruiting

Enrollment open • Gynecology

Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial. (PubMed, Drug Des Devel Ther) - "Meanwhile, group M demonstrated transient heart rate (HR) elevation at 5 min postloading dose, whereas group O exhibited no significant HR increases at any time point. Oliceridine demonstrates analgesic efficacy comparable to morphine after laparoscopic total hysterectomy but exhibits superior safety by significantly reducing opioid-related adverse events and potentially accelerating postoperative recovery."

Clinical • Journal • Constipation • Cough • Gastroenterology • Gastrointestinal Disorder • Gynecology • Pain • Respiratory Diseases

the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery (clinicaltrials.gov) - P4 | N=606 | Not yet recruiting | Sponsor: Xiangya Hospital of Central South University | Trial completion date: Dec 2025 ➔ May 2026 | Trial primary completion date: Dec 2025 ➔ Apr 2026

Trial completion date • Trial primary completion date • Pain

The Impact of Oliceridine on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital;; Affiliated Qingyuan Hospital, Guangzhou Medical University,Qin

New trial • CNS Disorders • Geriatric Disorders

Study on the Dose-Effect Relationship of Oliceridine in Inhibiting Cough Induced by Sufentanil during the Induction Period (ChiCTR) - P=N/A | N=210 | Not yet recruiting | Sponsor: The First People's Hospital of Tianshui; The First People's Hospital of Tianshui

New trial • Anesthesia • Cough • Respiratory Diseases

Evaluation of the Efficacy and Safety of Oliceridine Combined with Propofol for Anesthesia in Elderly Patients Undergoing Endoscopic Mucosal Resection of Colorectal Polyps (ChiCTR) - P=N/A | N=123 | Not yet recruiting | Sponsor: Jurong People's Hospital; Jurong People's Hospital

New trial • Anesthesia • Colonic Polyps

Determination of ED90 of Oliceridine combined with Propofol in inhibiting responses to laryngeal mask insertion in Elderly Patients: a biased coin up-and-down design (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Eye & ENT Hospital of Fudan University; Eye & ENT Hospital of Fudan University

New trial

The Effect of Low-Dose Oxycodone on the ED₅₀ of Ciprofol for Suppressing Laryngeal Mask Airway Insertion Responses (ChiCTR) - P=N/A | N=20 | Not yet recruiting | Sponsor: Nanshan District People's Hospital of Shenzhen; Nanshan District People's Hospital of Shenzhen

New trial • Anesthesia

Effect of Oliceridine on the Incidence of Intraoperative Hypoxia in Patients Undergoing Gastroscopy (ChiCTR) - P4 | N=1224 | Not yet recruiting | Sponsor: Renji Hospital,Shanghai Jiao Tong University School of Medicine; Renji Hospital,Shanghai Jiao Tong University School of Medicine

New P4 trial • Pain

Median Effective Dose of Oliceridine Combined with Remimazolam for Inhibiting Laryngeal Mask Insertion Responses in Adults of Different Ages (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Changshu Second People's Hospital; Changshu NO.2 people's Hospital

New trial

Effect of oliceridine for patient-controlled intravenous analgesia in patients after total knee arthroplasty (ChiCTR) - P=N/A | N=84 | Not yet recruiting | Sponsor: The Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University

New trial • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology

The efficacy and safety of Oselidine in laparoscopic cholecystectomy. (ChiCTR) - P4 | N=60 | Recruiting | Sponsor: Qiandongnan Prefecture People's Hospital, Kaili City, Guizhou Province; People's Hospital of Qiandongnan Miao and Dong Autonomous Prefecture

New P4 trial

Observation and Research on the Clinical Effect of Oliceridine Fumarate Injection in General Anesthesia (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Sir Run Run Hospital Affiliated to Nanjing Medical University; Sir Run Run Hospital Affiliated to Nanjing Medical University

New trial • Anesthesia

Effect of oliceridine versus sufentanil for patient-controlled intravenous analgesia after laparoscopic radical resection for colorectal cancer (ChiCTR) - P4 | N=200 | Not yet recruiting | Sponsor: Gansu Provincial Hospital; Gansu Provincial Hospital

New P4 trial • Colorectal Cancer • Oncology • Pain • Solid Tumor

Safety and Efficacy of Oliceridine intravenous self-controlled analgesia in patients undergoing thoracoscopic lobectomy (ChiCTR) - P=N/A | N=520 | Not yet recruiting | Sponsor: The Second Hospital of Anhui Medical University; The Second Hospital of Anhui Medical University

New trial • Pulmonary Disease • Respiratory Diseases

Study on the application of intravenous oliceridine in hysteroscopic surgery (ChiCTR) - P=N/A | N=180 | Not yet recruiting | Sponsor: Women’s Hospital, Zhejiang University School of Medicine; Women’s Hospital, Zhejiang University School of Medicine

New trial