Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma, Pharmbio - LARVOL DELTA

The Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lobectomy (clinicaltrials.gov) - P4 | N=320 | Not yet recruiting | Sponsor: Tianjin Medical University General Hospital

New P4 trial • Pain

The Impact of Oliceridine on Postoperative Catheter-Related Bladder Discomfort in Patients Undergoing Laparoscopic Radical Resection for Digestive Tract Tumors (ChiCTR) - P=N/A | N=182 | Not yet recruiting | Sponsor: DEYANG PEOPLE'S HOSPITAL; DEYANG PEOPLE'S HOSPITAL

New trial • Gastrointestinal Cancer

The Impact of Postoperative Oliceridine Use on the Quality of Recovery in Patients Undergoing Lumbar Surgery (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: The Affiliated Hospital of Panzhihua University; The Affiliated Hospital of Panzhihua University

New P4 trial • Musculoskeletal Diseases • Orthopedics

Comparison of respiratory adverse events of oliceridine, esketamine and sufentanil in hysteroscopy :a prospective, randomized, controlled trial (ChiCTR) - P=N/A | N=180 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University

Adverse events • New trial • Gynecology • Women's Health

Effect of Oliceridine on Postoperative Quality of Recovery and Analgesia in Patients Undergoing Surgery for Gynecologic Malignancies: A Multicenter, Randomized, Double-blind,Controlled trial (ChiCTR) - P=N/A | N=190 | Not yet recruiting | Sponsor: The Second Hospital of Anhui Medical University; The Second Hospital of Anhui Medical University

New trial • Gynecologic Cancers • Oncology

Comparison of the efficacy and safety of different doses of oliceridine in combination with propofol in patients undergoing painless gastrointestinal endoscopy (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Nanchang University; The Second Affiliated Hospital of Nanchang University

New P4 trial • Gastrointestinal Disorder • Pain

Pretreatment with oliceridine reduces etomidate-induced myoclonus in gastroscopy (ChiCTR) - P4 | N=150 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University

New P4 trial • Movement Disorders

Efficacy and safety of Oliceridine for postoperative analgesia in patients undergoing bariatric surgery: A randomized controlled trial (ChiCTR) - P=N/A | N=128 | Recruiting | Sponsor: The First Hospital of Hebei Medical University; The First Hospital of Hebei Medical University

New trial • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Comparison of oliceridine and sufentanil in total laparoscopic hysterectomy, a clinical double-blind controlled trial (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Anqing Municipal Hospital; Anqing Municipal Hospital

New trial • Gynecology

Comparison of the effects of oliceridine and sufentanil on postoperative nausea and vomiting in patient-controlled intravenous analgesia: A single-center, triple-blind, randomized controlled trial (ChiCTR) - P=N/A | N=66 | Not yet recruiting | Sponsor: Guangzhou First People‘s Hospital; Guangzhou First People‘s Hospital

New trial

The role of biased µ-opioid receptor agonists in postoperative pain management for obstetrical patients (ChiCTR) - P=N/A | N=160 | Not yet recruiting | Sponsor: Lianyungang First People's Hospital; Lianyungang First People's Hospital

New trial • Obstetrics • Pain

Efficacy and Safety of Different Doses of Oliceridine Fumarate Injection Combined with Propofol for Painless Gastrointestinal Endoscopy:A Randomized Controlled Trial (ChiCTR) - P4 | N=200 | Not yet recruiting | Sponsor: Wenzhou Medical University Lishui Hospital, Lishui People's Hospital, Lishui, Zhejiang 323000, China; Wenzhou Medical University Lishui Hospital, Lish

New P4 trial • Anesthesia • Pain

Clinical Study of Oliceridine in Outpatient Elderly Patients Undergoing Cystoscopy (ChiCTR) - P4 | N=114 | Not yet recruiting | Sponsor: The Second Hospital of Jilin University; The Second Hospital of Jilin University

New P4 trial

Application of Oliceridine in complex bronchoscopy under deep sedation/general anesthesia (ChiCTR) - P4 | N=180 | Not yet recruiting | Sponsor: Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences); Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sci

New P4 trial • Anesthesia • CNS Disorders • Depression • Mood Disorders • Psychiatry

Median effective dose and 90% effective dose of oliceridine to inhibit duodenoscope implantation reaction in ERCP patients (ChiCTR) - P=N/A | N=158 | Not yet recruiting | Sponsor: Tianjin Nankai Hospital; Tianjin Nankai Hospital

New trial

Comparison of the Preventive Effect of Oliceridine and Sufentanil on Myoclonus Induced by Etomidate (ChiCTR) - P=N/A | N=90 | Not yet recruiting | Sponsor: The Third Affiliated Hospital of CQMU(Gener Hospital); The Third Affiliated Hospital of CQMU(Gener Hospital)

New trial • Movement Disorders

Research on Determining the Appropriate Dose of a New Anesthetic Combination(Oliceridine+Esketamine)for Hysteroscopy Surgery (ChiCTR) - P4 | N=90 | Not yet recruiting | Sponsor: Shanghai Changhai Hospital; Changhai Hospital,Shanghai

New P4 trial • Anesthesia • Gynecology

Study on the Safety and Efficacy of Oliceridine for Postoperative Analgesia After Coronary Artery Bypass Grafting (ChiCTR) - P4 | N=98 | Not yet recruiting | Sponsor: Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen Hospital; Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen Hospital

New P4 trial

The effect of oliceridine on postoperative nausea and vomiting in patients undergoing thyroid or parathyroid surgery: a randomized controlled trial (ChiCTR) - P=N/A | N=400 | Not yet recruiting | Sponsor: Shanghai East Hospital; Shanghai East Hospital

New trial • Endocrine Disorders

Efficacy and Safety of G Protein-Biased μ-Opioid Receptor Agonists in the Treatment of Moderate-to-Severe Pain Following Off-Pump Coronary Artery Bypass Grafting: A Randomized Blinded Study (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Qilu Hospital of Shandong University Dezhou Hospital; Qilu Hospital of Shandong University Dezhou Hospital

New trial • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Heart Failure • Pain

Determining the optimal dose of oliceridine combined with propofol during day-surgery hysteroscopy (ChiCTR) - P4 | N=100 | Recruiting | Sponsor: Zhejiang Xiaoshan Hospital; Zhejiang Xiaoshan Hospital

New P4 trial • Gynecology

A Comparative Study of Oliceridine and Sufentanil on Postoperative Pain Following Posterior Lumbar Spinal Fusion (ChiCTR) - P4 | N=90 | Not yet recruiting | Sponsor: Shanghai Yangpu District Central Hospital (Yangpu Hospital Affiliated to Tongji University); Shanghai Yangpu District Central Hospital (Yangpu Hospita

New P4 trial • Pain

Oliceridine Infusion Modes for Postoperative Pain in Elderly Lung Cancer Patients: Analgesic Efficacy and Nausea/Vomiting Incidence (ChiCTR) - P=N/A | N=372 | Not yet recruiting | Sponsor: The First Affiliated Hospital with Nanjing Medical University; The First Affiliated Hospital with Nanjing Medical University

New trial • Lung Cancer • Oncology • Pain • Solid Tumor

The effect of different background doses of oliceridine PCIA following bone tumor excision:a prospective double-blind randomized controlled trial (Euroanaesthesia 2025) - "No statistically significant differences were noted in resting NRS scores, the need for rescue analgesia, or the incidence of other opioid-related adverse events among the four groups (P>0.05).Conclusion(s): Oliceridine can be safely and effectively utilized for postoperative analgesia in orthopedic patients, providing analgesic efficacy comparable to sufentanil, with a significantly reduced incidence of adverse effects. A background infusion of 0.2 mg/h offers the optimal balance by reducing opioid consumption, minimizing opioid-related adverse effects, enhancing patient satisfaction, and promoting early postoperative recovery, while maintaining effective analgesia."

Clinical • Anesthesia • Oncology • Orthopedics • Osteosarcoma • Pain • Solid Tumor

HSK21542 in patients with postoperative pain: one phase 3, multicentre, double-blind, randomized, controlled trials (Euroanaesthesia 2025) - "This was assessed in a phase 3, multicentre, randomized, double-blind, controlled trials (HSK21542-303) in China.​​​​​Materials and HSK21542-303 was a three-arms study comparing HSK21542 1.0 μg/kg with tramadol 50 mg/dose and placebo. This magnitude of improvement was consistent with other trials of novel analgesics such as VX-548 (NaV1.8 inhibitor), meloxicam (COX-2 inhibitor) and oliceridine (µ-receptor G-protein pathway modulator) that utilized SPID24 as efficacy endpoint in abdominoplasty and bunionectomy (1-3).Conclusion(s): In conclusion, HSK21542 showed potent analgesic effect and was well tolerated in patients who underwent abdominal surgery and experienced postoperative pain.Figure 1. SPID0-24h after the post-operative administration of the first dose in HSK21542-303."

Clinical • P3 data • Aesthetic Medicine • Pain • NAV1