GS-156 / Gene Signal - LARVOL DELTA

Bioinformatic gene analysis for possible biomarkers and therapeutic targets of hypertension-related renal cell carcinoma. (PubMed, Transl Androl Urol) - "We identified the differentially expressed genes (DEGs) of HN and RCC through analyzing Gene Expression Omnibus (GEO) datasets GSE99339, GSE99325, GSE53757 and GSE15641 by means of bioinformatics analysis, respectively...CRIP1 and ESRRG and their corresponding predicted miRNAs, especially hsa-miR-221-5p, hsa-miR-205-5p, hsa-miR-152-3p and hsa-miR-137 may be notably related to hypertension-related RCC. CRIP1 and ESRRG genes have great potential to become novel biomarkers and therapeutic targets concerning hypertension-related RCC."

Biomarker • Journal • Genito-urinary Cancer • Hypertension • Kidney Cancer • Nephrology • Oncology • Renal Cell Carcinoma • Renal Disease • Solid Tumor • BCAT1 • MIR205 • MIR221

Identification and validation of key genes mediating intracranial aneurysm rupture by weighted correlation network analysis. (PubMed, Ann Transl Med) - "We used the Gene Expression Omnibus (GEO) datasets GSE13353, GSE15629, and GSE54083 in our study...All these key genes were validated by another GEO dataset and might serve as potential targets for pharmacological therapies and diagnostic markers in predicting IA rupture. Further studies are needed to elucidate the detailed molecular mechanisms and biological functions of these key genes which underlie the rupture of IA."

Journal • Hematological Disorders • Immunology • Inflammation • Subarachnoid Hemorrhage • CXCR4

Comprehensive analysis and identification of key genes and signaling pathways in the occurrence and metastasis of cutaneous melanoma. (PubMed, PeerJ) - "Three gene expression profiles (GSE7553, GSE15605 and GSE46517) were downloaded from the GEO database, which contained 225 tissue samples...In this study, several hub genes were found from normal skin, primary melanoma and metastatic melanoma samples. These hub genes may play an important role in the production, invasion, recurrence or death of CM, and may provide new ideas and potential targets for its diagnosis or treatment."

Journal • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor

Bioinformatic Analysis Identifies Potential Key Genes in the Pathogenesis of Melanoma. (PubMed, Front Oncol) - "The differentially expressed genes (DEGs) of melanoma in GSE15605, GSE46517, GSE7553, and the Cancer Genome Atlas (TCGA) datasets were analyzed...The results suggested that FLG, DSG1, DSG3, IVL, and EGFR might play important roles and potentially be valuable in the prognosis and treatment of melanoma. These hub genes might well have clinical significance as diagnostic markers."

Journal • Melanoma • Oncology • Skin Cancer • Solid Tumor

Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients. (PubMed, Aging (Albany NY)) - "In this study, three expression profile data sets (GSE15641, GSE16441 and GSE66270) were integrated to identify candidate genes that could elucidate functional pathways in ccRCC...In summary, integrated bioinformatics analysis identified candidate DEGs and pathways in ccRCC that could improve our understanding of the causes and underlying molecular events of ccRCC. These candidate genes and pathways could be therapeutic targets for ccRCC."

Clinical • Journal • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor

Prognostic Implications of Metabolism Related Gene Signature in Cutaneous Melanoma. (PubMed, Front Oncol) - "Eighteen prognostic MRGs between melanoma and normal samples were identified using The Cancer Genome Atlas (TCGA) and GSE15605...The receiver operating characteristic curve and decision curve analysis indicated that MRGs nomogram had better OS prediction and clinical net benefit than the stage system. To our knowledge, we are the first to develop a prognostic nomogram based on MRGs signature with better predictive power than the current staging system, which could assist individualized prognosis prediction and improve treatment."

Journal • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor • MGST1

[VIRTUAL] The pharmacokinetics, pharmacodynamics, and short-term safety of cilofexor, a nonsteroidal farnesoid X receptor agonist, in subjects with hepatic impairment (EASL-ILC-I 2020) - "Safety was monitored and the effect of HI on PK parameters (AUC, Cmax, free fraction [fu]) of CILO and its major circulating metabolites (GS-716070 and GS-156765), as well as PD parameters (C4 and FGF19), were evaluated. CILO was generally well tolerated in this study. The moderate (<2-fold) changes in CILO PK in subjects with mild HI is unlikely to be clinically relevant and support administration without dose modification in this population. Reduced PD response in severe HI is likely related to baseline activation of the FXR pathway."

Clinical • PK/PD data • Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Non-alcoholic Steatohepatitis • FGF19

Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis. (PubMed, Cell Death Dis) - "Melanoma cases from The Cancer Genome Atlas (TCGA), GEO#GSE15605 and GEO#GSE24469 were included in this study...This result elucidates a new mechanism for LICN00518 in the metastasis of melanoma. LICN00518 may serve as a survival indicator and potential therapeutic target in melanoma patients."

Journal • Lung Cancer • Melanoma • Oncology • Solid Tumor

[VIRTUAL] Screening, identification and validation of CCND1 and PECAM1/CD31 in predicting prognosis for renal cell carcinoma patients (EAU-I 2020) - "Materials & In this study, three expression profile data sets (GSE15641, GSE16441 and GSE66270) were integrated to identify candidate genes that explain the pathways and functions of kidney cancer... In summary, using integrated bioinformatics analysis, candidate DEGs and pathways in ccRCC that could improve our understanding of the causes and underlying molecular events of ccRCC, and these candidate genes and pathways could be therapeutic targets for ccRCC were identified."

Clinical • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • CAV1 • CCND1 • CD31 • CXCR4 • EGF • ICAM1

Long non-coding RNA LINC00520 promotes the proliferation and metastasis of malignant melanoma by inducing the miR-125b-5p/EIF5A2 axis. (PubMed, J Exp Clin Cancer Res) - "All results elucidated the role and molecular mechanism of LINC00520 in the malignant development of melanoma. LINC00520, a new oncogene in melanoma, maybe serve as a survival biomarkers or therapeutic target for melanoma patients."

Journal • Melanoma • Oncology • Solid Tumor • LINC00520 • miR-125b

The genetic association between type 2 diabetic and hepatocellular carcinomas. (PubMed, Ann Transl Med) - "In order to identify differentially expressed genes (DEGs) in T2DM and HCC, gene expression datasets for T2DM (GSE15653), HCC (GSE60502) and metformin-treated cells (GSE69850) were obtained from the Gene Expression Omnibus database repository. This study identified a number of genes that may play important roles in the association of T2DM and HCC, including four genes which may be the target of metformin treatment for diabetes and HCC. The specific mechanisms involved remain to be identified."

Journal • Diabetes • Gastrointestinal Cancer • Hepatocellular Cancer • Liver Cancer • Metabolic Disorders • Oncology • Solid Tumor • Type 2 Diabetes Mellitus • CCNA2 • CCNB1 • CHEK1 • RACGAP1

Key genes associated with diabetes mellitus and hepatocellular carcinoma. (PubMed, Pathol Res Pract) - "The GSE64998 and GSE15653 datasets (for T2DM), the GSE121248 dataset and the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset (for HCC) were downloaded...Our study identified nine hub genes that might play a critical role in both T2DM and HCC. However, more studies are warranted to clarify the mechanisms of these genes."

Journal

CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells. (PubMed, Hepatobiliary Pancreat Dis Int) - "CCL16 could be a feasible plasma marker to predict the occurrence and progression of liver cirrhosis. CCL16 might impact liver cirrhosis through inactivating hepatic stellate cells."

Journal

Key Genes and Co-Expression Network Analysis in Liver of Type 2 Diabetes. (PubMed, J Diabetes Investig) - "These results would offer new insights into hepatic insulin resistance, type 2 diabetes pathogenesis, development and drug discovery."

Clinical • Journal

Differentially expressed genes associated with the estrogen receptor pathway in cerebral aneurysms. (PubMed, World Neurosurg) - "The analysis of 6 GEO databases revealed 4 differentially expressed genes (PIK3R1, HBEGF, ADCY7, and ADCY9) in cerebral aneurysm tissue that are associated with the estrogen receptor pathway. Further analysis of estrogen-associated differentially expressed genes may provide information about the protective effects of estrogen on cerebral aneurysm development."

Journal

The screening of pivotal gene expression signatures and biomarkers in renal carcinoma. (PubMed, J Cancer) - "The RCC GEO Datasets GSE15641 was featured to screen differentially expressed genes (DEGs)...In summary, our findings discovered pivotal gene expression signatures and signaling pathways in the progression of ccRCC. TGFB1, TIMP1 and VIM might contribute to the progression of ccRCC, which could have potential as biomarkers or therapeutic targets for ccRCC."

Biomarker • Journal • TIMP1

Screening of immunosuppressive factors for biomarkers of breast cancer malignancy phenotypes and subtype-specific targeted therapy. (PubMed, PeerJ) - "...The mRNA microarray datasets, GSE40057 and GSE1561, were downloaded and remodeled, and differentially expressed genes were identified...Such molecules could be used as biomarkers for breast cancer prognosis. However, because individual immune-related factors can play several biological roles, the mechanistic relationship between immunosuppressive factors and breast cancer malignant phenotypes and the feasibility of their application as drug targets require further investigation."

Biomarker • IO Biomarker • Journal • PD(L)-1 Biomarker

Gene expression profile and gender differences related with immune processes in solid tumors (AACR 2019) - "...Data was pre-processed and gene-set enrichment analysis (GSEA) was conducted individually in the datasets GSE6791, GSE30784, GSE78060, GSE34105, GSE65858 (HNC); GSE73731, GSE36895, GSE11904, GSE40435 (CCRCC); GSE26899, GSE26901 (GAC) and GSE15605 (melanoma)... We find strong patterns of GEP of immune genes in tumors from female patients, suggesting gender-specific patterns of response to ICI. This pool of immune genes differentially expressed could be used as candidate biomarkers for prediction of response to immunotherapy."

Gene Expression Profile • IO Biomarker