HANP (carperitide) / Zeria Pharma, Daiichi Sankyo - LARVOL DELTA

Effect of Low-dose Administration of Carperitide for Acute Heart Failure: the LASCAR-AHF trial. (PubMed, Eur Heart J Acute Cardiovasc Care) - "In patients with AHF, low-dose carperitide did not reduce long-term mortality or hospitalisation events when combined with standard treatment. Because patient enrolment was terminated prematurely, the study was underpowered and inconclusive."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Disease • CST3 • NPPB

Advancing drug development for atrial fibrillation by prioritising findings from human genetic association studies. (PubMed, EBioMedicine) - "Our systematic approach, combining evidence from different bioinformatics platforms, identified drug repurposing opportunities and druggable targets for AF."

Journal • Atrial Fibrillation • Cardiovascular

Low-dose administration of carperitide for Acute Heart Failure (HEART FAILURE 2024) - No abstract available

Late-breaking abstract • Cardiovascular • Congestive Heart Failure • Heart Failure

Predictors of a Good Diuretic Response and Administration Methods for Carperitide in Patients With Acute Heart Failure. (PubMed, Clin Ther) - "The 4 predictors (age, no prior use of loop diuretics, blood urea nitrogen, and white blood cell count) of good diuretic response are useful indicators to support decision-making for carperitide administration. Additionally, the administration of carperitide within 2 hours of intravenous furosemide may lead to the improvement of pulmonary congestion."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure: A Scientific Statement From the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society. (PubMed, J Card Fail) - "The present document is the result of the Trilateral Cooperation Project among the Heart Failure Association of the European Society of Cardiology, the Heart Failure Society of America and the Japanese Heart Failure Society. It represents an expert consensus that aims to provide a comprehensive, up-to-date perspective on natriuretic peptides in the diagnosis and management of HF, with a focus on the following main issues: (1) history and basic research: discovery, production and cardiovascular protection; (2) diagnostic and prognostic biomarkers: acute HF, chronic HF, inclusion/endpoint in clinical trials, and natriuretic peptides-guided therapy; (3) therapeutic use: nesiritide (BNP), carperitide (ANP) and ARNIs; and (4) gaps in knowledge and future directions."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • NPPB

Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure: A Scientific Statement From the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society. (PubMed, Eur J Heart Fail) - "The present document is the result of the Trilateral Cooperation Project among the Heart Failure Association of the European Society of Cardiology, the Heart Failure Society of America and the Japanese Heart Failure Society. It represents an expert consensus that aims to provide a comprehensive, up-to-date perspective on natriuretic peptides in the diagnosis and management of HF, with a focus on the following main issues: (1) history and basic research: discovery, production and cardiovascular protection; (2) diagnostic and prognostic biomarkers: acute HF, chronic HF, inclusion/endpoint in clinical trials, and natriuretic peptides-guided therapy; (3) therapeutic use: nesiritide (BNP), carperitide (ANP) and ARNIs; and (4) gaps in knowledge and future directions."

Journal • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • NPPB

Impact of the time-to-target rate of urine volume concept on the outcome of acute decompensated heart failure. (PubMed, Int J Cardiol) - "T2TUV of less than day 1 was associated with lower in-hospital mortality and decreased mortality and re-hospitalization at 1 year."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure. (PubMed, ESC Heart Fail) - "Vasopressin status was significantly associated with the diuretic response to exogenous ANP in AHF, independent of plasma ANP status. The results may provide a better understanding of the actions of sacubitril/valsartan."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Association Between the Presence of Pulmonary Hypertension Before Cardiovascular Surgery and the Nephroprotective Effect of Carperitide: A Retrospective Cohort Study. (PubMed, Cureus) - "Additionally, the use of renal replacement therapy, urine volume at 24 hours postoperatively, and the difference in serum creatinine concentrations were not different between the two groups. Conclusions Our results suggest that the effect of carperitide during cardiovascular surgery is not affected by the presence or absence of pulmonary hypertension."

Journal • Retrospective data • Acute Kidney Injury • Cardiovascular • Critical care • Hypertension • Nephrology • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Disease • Respiratory Diseases

Effect of carperitide on the 1 year prognosis of patients with acute decompensated heart failure. (PubMed, ESC Heart Fail) - "Low-dose carperitide was significantly associated with lower cardiovascular and all-cause mortality within 1 year after admission. Our results suggest the necessity for well-designed randomized controlled trials to determine the doses of carperitide that could improve clinical outcomes in patients with AHF."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

A goal-directed therapy protocol for preventing acute kidney injury after laparoscopic liver resection: a retrospective observational cohort study. (PubMed, Surg Today) - "GDT reduced the AKI rates post-LLR."

Journal • Observational data • Retrospective data • Acute Kidney Injury • Anesthesia • Cardiovascular • Nephrology • Renal Disease

Moderate potassium lowering effect of exogenous atrial natriuretic peptide in patients with acute heart failure. (PubMed, J Cardiol) - "Methods We performed a post-hoc analysis of a multicenter prospective cohort study in 162 patients with acute HF (74.2 ± 13.3 years, 64.2% male, left ventricular ejection fraction 44 ± 15%) treated with intravenous carperitide, an exogenous atrial natriuretic peptide. Conclusions Serum potassium level decreased after HF treatment with exogenous atrial natriuretic peptide, with a significant correlation to urine volume. The risk of hypokalemia was low, unless treated with additional furosemide."

Clinical • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Disease Management and Outcomes in Patients Hospitalized for Acute Heart Failure in Japan. (PubMed, Cardiol Ther) - "Contemporary treatment for AHF hospitalization in Japan comprises a long duration of IV therapy followed by extended use of oral medications and in-hospital cardiac rehabilitation prior to discharge. Patients requiring intensified therapies had much longer LOS and higher in-hospital mortality."

Clinical • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Predictors of responders for low-dose carperitide monotherapy in patients with acute heart failure. (PubMed, Heart Vessels) - "SBP and serum creatinine levels on admission might be useful for predicting the diuretic response to low-dose carperitide monotherapy in patients with AHF. Initial use of low-dose carperitide therapy does not have adverse effects on renal function."

Clinical • Journal • Monotherapy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension

Efficacy of exogenous atrial natriuretic peptide in patients with heart failure with preserved ejection fraction: deficiency of atrial natriuretic peptide and replacement therapy. (PubMed, ESC Heart Fail) - "Patients with HFpEF might have an aspect of ANP deficiency and represent a promising therapeutic target for modulating circulating ANP."

Clinical • Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

Three cases of late-onset anthracycline-related cardiomyopathy due to chemotherapies for hematological malignancy. (PubMed, J Echocardiogr) - "Our study indicates that late-onset (4 to 5 years) anthracycline-related cardiomyopathy can develop, though range of anthracycline accumulation is in proper range. Thus, a cautious follow-up by ECG and UCG is required. Furthermore, the early treatment after the onset of anthracycline-related cardiomyopathy should be also needed to improve the poor outcome."

Clinical • Journal • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Follicular Lymphoma • Heart Failure • Hematological Disorders • Hematological Malignancies • Leukemia • Lymphoma • Oncology • Ventricular Tachycardia

Early Blood Pressure Reduction by Intravenous Vasodilators Is Associated With Acute Kidney Injury in Patients With Hypertensive Acute Decompensated Heart. (PubMed, Circ J) - "Larger SBP-fall from excessive vasodilator use is associated with increased incidence of AKI in patients with hypertensive ADHF."

Clinical • Journal • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Therapeutic strategy using low-dose carperitide in patients with acute heart failure. (PubMed, Heart Vessels) - No abstract available

Clinical • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Therapeutic strategy using low-dose carperitide monotherapy in patients with acute heart failure. (PubMed, Heart Vessels) - No abstract available

Clinical • Journal • Monotherapy • Cardiovascular • Congestive Heart Failure • Heart Failure

Trends in the Management of Acute Heart Failure Requiring Intensive Care. (PubMed, Am J Cardiol) - "The use of intra-aortic balloon pumping and noninvasive positive pressure ventilation increased significantly, whereas the need for endotracheal intubation and administration of furosemide and carperitide in the 2010s group decreased significantly compared with the 2000s group. Tolvaptan therapy was introduced from 2010...In conclusion, the condition of AHF patients became more critical year by year, leading to poorer long-term prognosis despite improved treatment strategy. These findings will be useful for managing AHF in the next pandemic era."

Journal

Effect of low-dose atrial natriuretic peptide in critically ill patients with acute kidney injury: a retrospective, single-center study with propensity-score matching. (PubMed, BMC Nephrol) - "Low-dose ANP showed no treatment effect in general critically ill patients who developed AKI."

Journal • Retrospective data

Benefit and harm of intravenous vasodilators across the clinical profile spectrum in acute cardiogenic pulmonary oedema patients. (PubMed, Eur Heart J Acute Cardiovasc Care) - "Furthermore, when compared to nitrates, the use of carperitide (natriuretic peptide agent) was significantly associated with worse outcomes, especially in patients with intermediate systolic blood pressures. In acute heart failure patients, vasodilator use was not universally associated with improved inhospital outcomes; rather, its effect depended on individual clinical presentation: patients with higher systolic blood pressure and no atrial fibrillation seemed to benefit maximally from vasodilators. UMIN-CTR identifier, UMIN000013128."

Clinical • Journal

Effect of intravenous carperitide versus nitrates as first-line vasodilators on in-hospital outcomes in hospitalized patients with acute heart failure: Insight from a nationwide claim-based database. (PubMed, Int J Cardiol) - "In Japanese AHF patients during their early inpatient care, carperitide use was significantly associated with worse outcomes when compared to nitrates use, suggesting the routine use of carperitide might not be recommended as a first-line vasodilator for AHF."

Clinical • Journal

Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease. (PubMed, Clin J Gastroenterol) - "Since his liver and cardiac function markedly improved after commencing furosemide and carperitide, we considered congestive hepatopathy due to MCTD and accompanying heart failure. Heart failure and congestive hepatopathy recurred and he was treated with diuretics and prednisolone, but he passed away by co-occurrence of acute hemorrhagic pancreatitis. Necropsy revealed chronic hepatic congestion but not accompanying autoimmune hepatitis and hepatic vasculitis. We should consider congestive hepatopathy and hemorrhagic pancreatitis as serious complications of MCTD."

Journal

Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis. (PubMed, Crit Care) - "Low-dose ANP might be effective in preventing or treating AKI. However, the evidence accumulated so far is not strong enough to demonstrate ANP's beneficial effects. The next step is to elucidate the effects of low-dose ANP by conducting multicenter, high-quality, large-sample RCTs."

Journal • Retrospective data • Review